{"id":"https://openalex.org/W4414431007","doi":"https://doi.org/10.1080/09553002.2025.2561816","title":"Pre-irradiation administration of nilestriol promotes hematopoietic recovery but increases early mortality risk and impairs wound healing after total-body irradiation combined with wound trauma","display_name":"Pre-irradiation administration of nilestriol promotes hematopoietic recovery but increases early mortality risk and impairs wound healing after total-body irradiation combined with wound trauma","publication_year":2025,"publication_date":"2025-09-23","ids":{"openalex":"https://openalex.org/W4414431007","doi":"https://doi.org/10.1080/09553002.2025.2561816","pmid":"https://pubmed.ncbi.nlm.nih.gov/40986783"},"language":"en","primary_location":{"id":"doi:10.1080/09553002.2025.2561816","doi":"https://doi.org/10.1080/09553002.2025.2561816","is_oa":false,"landing_page_url":"https://doi.org/10.1080/09553002.2025.2561816","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051021582","display_name":"Guojian Wang","orcid":"https://orcid.org/0000-0001-5934-4594","observed_orcids":["https://orcid.org/0000-0001-5934-4594"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guojian Wang","raw_affiliation_strings":["Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University)","Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University)","institution_ids":["https://openalex.org/I151075929"]},{"raw_affiliation_string":"Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022199214","display_name":"Xiaofan Lv","orcid":"https://orcid.org/0000-0002-0085-9507","observed_orcids":["https://orcid.org/0000-0002-0085-9507"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofan Lv","raw_affiliation_strings":["Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University)","Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University)","institution_ids":["https://openalex.org/I151075929"]},{"raw_affiliation_string":"Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040897632","display_name":"Na Zhao","orcid":"https://orcid.org/0000-0001-8648-9422","observed_orcids":["https://orcid.org/0000-0001-8648-9422"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Zhao","raw_affiliation_strings":["Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University)","Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Army Medical University (Third Military Medical University)","Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University)","institution_ids":["https://openalex.org/I151075929"]},{"raw_affiliation_string":"Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Army Medical University (Third Military Medical University)","institution_ids":["https://openalex.org/I151075929"]},{"raw_affiliation_string":"Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Army Medical University (Third Military Medical University), Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022236270","display_name":"Jining Gao","orcid":"https://orcid.org/0000-0002-6435-4903","observed_orcids":["https://orcid.org/0000-0002-6435-4903"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jining Gao","raw_affiliation_strings":["Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University)","Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University)","institution_ids":["https://openalex.org/I151075929"]},{"raw_affiliation_string":"Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112126261","display_name":"Xinze Ran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinze Ran","raw_affiliation_strings":["Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University)","Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University)","institution_ids":["https://openalex.org/I151075929"]},{"raw_affiliation_string":"Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100670730","display_name":"Junping Wang","orcid":"https://orcid.org/0000-0001-5905-0940","observed_orcids":["https://orcid.org/0000-0001-5905-0940"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junping Wang","raw_affiliation_strings":["Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University)","Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University)","institution_ids":["https://openalex.org/I151075929"]},{"raw_affiliation_string":"Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100568536","display_name":"Shuang Long","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuang Long","raw_affiliation_strings":["Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University)","Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University)","institution_ids":["https://openalex.org/I151075929"]},{"raw_affiliation_string":"Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100453652","display_name":"Tao Wang","orcid":"https://orcid.org/0000-0003-0975-8072","observed_orcids":["https://orcid.org/0000-0003-0975-8072"]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tao Wang","raw_affiliation_strings":["Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University)","Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China"],"raw_orcid":"https://orcid.org/0000-0003-0975-8072","affiliations":[{"raw_affiliation_string":"Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University)","institution_ids":["https://openalex.org/I151075929"]},{"raw_affiliation_string":"Institute of Combined Injury, School of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing, China","institution_ids":["https://openalex.org/I151075929"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100453652","https://openalex.org/A5100568536"],"corresponding_institution_ids":["https://openalex.org/I151075929"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24726641,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"101","issue":"12","first_page":"1196","last_page":"1210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11089","display_name":"Radioactive contamination and transfer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2306","display_name":"Global and Planetary Change"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nilestriol","display_name":"nilestriol","score":0.972000002861023},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.5040000081062317},{"id":"https://openalex.org/keywords/radioprotectors","display_name":"radioprotective agents","score":0.8320000171661377},{"id":"https://openalex.org/keywords/total-body-irradiation","display_name":"total body irradiation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.8539999723434448},{"id":"https://openalex.org/keywords/hematopoietic-recovery","display_name":"hematopoietic recovery","score":0.9879999756813049},{"id":"https://openalex.org/keywords/early-mortality","display_name":"early mortality","score":0.7429999709129333},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.9559999704360962},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8610000014305115},{"id":"https://openalex.org/keywords/nuclear-emergency","display_name":"nuclear emergency","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8278999924659729},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.6913999915122986},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5688999891281128},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5419999957084656},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4918999969959259},{"id":"https://openalex.org/C2993278735","wikidata":"https://www.wikidata.org/wiki/Q275459","display_name":"Radiation injury","level":3,"score":0.38989999890327454},{"id":"https://openalex.org/C2780765947","wikidata":"https://www.wikidata.org/wiki/Q12033531","display_name":"Administration (probate law)","level":2,"score":0.3734000027179718},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3443000018596649},{"id":"https://openalex.org/C25938499","wikidata":"https://www.wikidata.org/wiki/Q7663812","display_name":"Systemic administration","level":3,"score":0.31769999861717224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29170000553131104},{"id":"https://openalex.org/C2780913535","wikidata":"https://www.wikidata.org/wiki/Q2140674","display_name":"Gunshot wound","level":2,"score":0.2678000032901764},{"id":"https://openalex.org/C136948725","wikidata":"https://www.wikidata.org/wiki/Q1458306","display_name":"Soft tissue","level":2,"score":0.2669000029563904}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011837","descriptor_name":"Radiation-Protective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011837","descriptor_name":"Radiation-Protective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011837","descriptor_name":"Radiation-Protective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011837","descriptor_name":"Radiation-Protective Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011837","descriptor_name":"Radiation-Protective Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011837","descriptor_name":"Radiation-Protective Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/09553002.2025.2561816","doi":"https://doi.org/10.1080/09553002.2025.2561816","is_oa":false,"landing_page_url":"https://doi.org/10.1080/09553002.2025.2561816","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},{"id":"pmid:40986783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40986783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of radiation biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5053608833","display_name":null,"funder_award_id":"82203975","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G584412181","display_name":null,"funder_award_id":"82172219","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7594421005","display_name":null,"funder_award_id":"CSTB2022NSCQ-MSX1673","funder_id":"https://openalex.org/F4320323172","funder_display_name":"Natural Science Foundation of Chongqing"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323172","display_name":"Natural Science Foundation of Chongqing","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1979553162","https://openalex.org/W1991432514","https://openalex.org/W1993376911","https://openalex.org/W2019996789","https://openalex.org/W2023102471","https://openalex.org/W2041982733","https://openalex.org/W2045395105","https://openalex.org/W2107500186","https://openalex.org/W2128685751","https://openalex.org/W2147798868","https://openalex.org/W2275130278","https://openalex.org/W2752843030","https://openalex.org/W2912233162","https://openalex.org/W2974660899","https://openalex.org/W3015379792","https://openalex.org/W3030560995","https://openalex.org/W3046964644","https://openalex.org/W3093053701","https://openalex.org/W3095661830","https://openalex.org/W3118954573","https://openalex.org/W3124535932","https://openalex.org/W3125843349","https://openalex.org/W3142660110","https://openalex.org/W3154676795","https://openalex.org/W3163281674","https://openalex.org/W3180276831","https://openalex.org/W3205295484","https://openalex.org/W4281872461","https://openalex.org/W4300008791","https://openalex.org/W4324305993","https://openalex.org/W4353040698","https://openalex.org/W4360873416","https://openalex.org/W4381248209","https://openalex.org/W4386886640","https://openalex.org/W4394725783","https://openalex.org/W4400325888","https://openalex.org/W4400482468"],"related_works":[],"abstract_inverted_index":{"PURPOSE:":[0],"Estrogens":[1],"are":[2,19],"frequently":[3],"employed":[4],"as":[5],"radioprotective":[6],"agents":[7],"in":[8,117,128,183,196,205,216],"nuclear":[9],"emergencies,":[10],"yet":[11],"their":[12],"effects":[13,190,207,232],"on":[14,29,191,242],"radiation":[15],"combined":[16,31],"injury":[17,32],"(RCI)":[18],"poorly":[20],"understood.":[21],"This":[22],"study":[23],"evaluated":[24],"the":[25,50,156,162,192,206],"impact":[26],"of":[27,49,100,164,198,208,227],"nilestiol":[28],"radiation-wound":[30],"(R-W-CI).":[33],"MATERIALS":[34],"AND":[35],"METHODS:":[36],"Mouse":[37],"models":[38],"included":[39,83],"6.0":[40,132,170],"and":[41,59,76,103,106,124,143,245],"8.0":[42,63,121,151],"Gy":[43,64,122,133],"total":[44,51],"body":[45,52],"irradiation":[46],"(TBI),":[47],"2.0%":[48],"surface":[53],"area":[54],"(TBSA)":[55],"skin":[56],"wound":[57,91,145,184],"trauma,":[58],"R-W-CI":[60,148,168,231],"(6.0":[61],"or":[62],"TBI":[65,123],"followed":[66],"by":[67,186],"a":[68,180],"2%":[69],"TBSA":[70],"wound).":[71],"Nilestriol":[72,111],"was":[73,214],"administered":[74],"3":[75],"1":[77],"day":[78],"pre-injury.":[79],"The":[80],"outcomes":[81],"assessed":[82],"30-day":[84,114,157],"survival,":[85],"weight":[86],"changes,":[87],"peripheral":[88],"blood":[89],"analysis,":[90],"closure,":[92],"bone":[93],"marrow-derived":[94],"clonogenic":[95],"activity,":[96],"flow":[97],"cytometric":[98],"analysis":[99],"hematopoietic":[101,126,175],"stem":[102],"progenitor":[104],"cells,":[105],"splenic":[107],"extramedullary":[108,212],"hematopoiesis.":[109],"RESULTS:":[110],"significantly":[112,154,173],"improved":[113,155],"survival":[115,158],"rate":[116,159],"mice":[118],"subjected":[119],"to":[120,131,179,238],"enhanced":[125],"recovery":[127],"those":[129],"exposed":[130],"TBI.":[134],"In":[135],"wound-only":[136],"models,":[137],"nilestriol":[138,153,172,217,228],"suppressed":[139],"early":[140,165,193],"inflammatory":[141,194],"cytokines":[142],"impaired":[144],"closure.":[146],"For":[147,167],"model":[149],"with":[150,169],"Gy,":[152,171],"but":[160,177,233],"increased":[161],"risk":[163],"mortality.":[166],"promoted":[174],"recovery,":[176],"led":[178],"significant":[181],"delay":[182],"healing":[185],"more":[187],"pronounced":[188],"inhibitory":[189],"response":[195],"wounds":[197],"R-W-CI.":[199],"No":[200],"gender":[201],"differences":[202],"were":[203],"observed":[204],"nilestriol.":[209],"Additionally,":[210],"Splenic":[211],"hematopoiesis":[213],"inhibited":[215],"pretreatment":[218],"groups.":[219],"CONCLUSION:":[220],"These":[221],"findings":[222],"suggest":[223],"that":[224],"pre-irradiation":[225],"administration":[226],"can":[229],"mitigate":[230],"requires":[234],"careful":[235],"consideration":[236],"due":[237],"potential":[239],"negative":[240],"impacts":[241],"both":[243],"systemic":[244],"local":[246],"levels.":[247]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}