{"id":"https://openalex.org/W4414429237","doi":"https://doi.org/10.1080/09553002.2025.2561808","title":"Factors governing individual response to ionizing radiation and risk of diseases of the circulatory system: human epidemiological studies","display_name":"Factors governing individual response to ionizing radiation and risk of diseases of the circulatory system: human epidemiological studies","publication_year":2025,"publication_date":"2025-09-23","ids":{"openalex":"https://openalex.org/W4414429237","doi":"https://doi.org/10.1080/09553002.2025.2561808","pmid":"https://pubmed.ncbi.nlm.nih.gov/40986757"},"language":"en","primary_location":{"id":"doi:10.1080/09553002.2025.2561808","doi":"https://doi.org/10.1080/09553002.2025.2561808","is_oa":false,"landing_page_url":"https://doi.org/10.1080/09553002.2025.2561808","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002103948","display_name":"Preetha Rajaraman","orcid":"https://orcid.org/0000-0001-6649-999X","observed_orcids":["https://orcid.org/0000-0001-6649-999X"]},"institutions":[{"id":"https://openalex.org/I21578748","display_name":"Radiation Effects Research Foundation","ror":"https://ror.org/01fmtas32","country_code":"JP","type":"facility","lineage":["https://openalex.org/I21578748"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Preetha Rajaraman","raw_affiliation_strings":["Vice Chair and Executive Director, Radiation Effects Research Foundation","Vice Chair and Executive Director, Radiation Effects Research Foundation, Hiroshima, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6649-999X","affiliations":[{"raw_affiliation_string":"Vice Chair and Executive Director, Radiation Effects Research Foundation","institution_ids":["https://openalex.org/I21578748"]},{"raw_affiliation_string":"Vice Chair and Executive Director, Radiation Effects Research Foundation, Hiroshima, Japan","institution_ids":["https://openalex.org/I21578748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113726392","display_name":"Andreas K. Breitbarth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Klaus Breitbarth","raw_affiliation_strings":["Independent researcher"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Independent researcher","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044287668","display_name":"Mai Utada","orcid":"https://orcid.org/0000-0002-9178-3252","observed_orcids":["https://orcid.org/0000-0002-9178-3252"]},"institutions":[{"id":"https://openalex.org/I21578748","display_name":"Radiation Effects Research Foundation","ror":"https://ror.org/01fmtas32","country_code":"JP","type":"facility","lineage":["https://openalex.org/I21578748"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mai Utada","raw_affiliation_strings":["Department of Epidemiology, Radiation Effects Research Foundation","Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan"],"raw_orcid":"https://orcid.org/0000-0002-9178-3252","affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Radiation Effects Research Foundation","institution_ids":["https://openalex.org/I21578748"]},{"raw_affiliation_string":"Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan","institution_ids":["https://openalex.org/I21578748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006947853","display_name":"Syed Asrafuzzaman","orcid":"https://orcid.org/0000-0002-8940-3126","observed_orcids":["https://orcid.org/0000-0002-8940-3126"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Syed Asrafuzzaman","raw_affiliation_strings":["Independent researcher"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Independent researcher","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054794121","display_name":"Amy Berrington de Gonz\u00e1lez","orcid":"https://orcid.org/0000-0002-7332-8387","observed_orcids":["https://orcid.org/0000-0002-7332-8387"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210090991","display_name":"Institute of Cancer Research","ror":"https://ror.org/00dpztj76","country_code":"CA","type":"facility","lineage":["https://openalex.org/I176337269","https://openalex.org/I4210090991"]}],"countries":["CA","GB"],"is_corresponding":false,"raw_author_name":"Amy Berrington de Gonzalez","raw_affiliation_strings":["Centre for Trials & Population Data Science, Division of Genetics & Epidemiology, The Institute of Cancer Research","Centre for Trials & Population Data Science, Division of Genetics & Epidemiology, The Institute of Cancer Research, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-7332-8387","affiliations":[{"raw_affiliation_string":"Centre for Trials & Population Data Science, Division of Genetics & Epidemiology, The Institute of Cancer Research","institution_ids":["https://openalex.org/I142947616","https://openalex.org/I4210090991"]},{"raw_affiliation_string":"Centre for Trials & Population Data Science, Division of Genetics & Epidemiology, The Institute of Cancer Research, London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087740365","display_name":"Nobuyuki Hamada","orcid":"https://orcid.org/0000-0003-2518-6131","observed_orcids":["https://orcid.org/0000-0003-2518-6131"]},"institutions":[{"id":"https://openalex.org/I130416959","display_name":"Central Research Institute of Electric Power Industry","ror":"https://ror.org/041jswc25","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I130416959"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyuki Hamada","raw_affiliation_strings":["Biology and Environmental Chemistry Division, Sustainable System Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI)","Biology and Environmental Chemistry Division, Sustainable System Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI), Chiba, Japan"],"raw_orcid":"https://orcid.org/0000-0003-2518-6131","affiliations":[{"raw_affiliation_string":"Biology and Environmental Chemistry Division, Sustainable System Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI)","institution_ids":["https://openalex.org/I130416959"]},{"raw_affiliation_string":"Biology and Environmental Chemistry Division, Sustainable System Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI), Chiba, Japan","institution_ids":["https://openalex.org/I130416959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086676933","display_name":"Mark P. Little","orcid":"https://orcid.org/0000-0003-0980-7567","observed_orcids":["https://orcid.org/0000-0003-0980-7567"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I124261462","display_name":"Oxford Brookes University","ror":"https://ror.org/04v2twj65","country_code":"GB","type":"education","lineage":["https://openalex.org/I124261462"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Mark P. Little","raw_affiliation_strings":["Faculty of Health and Life Sciences, Oxford Brookes University","Feinberg School of Medicine, Northwestern University","Radiation Epidemiology Branch, U.S. National Cancer Institute","Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK","Feinberg School of Medicine, Northwestern University, Evanston, IL, USA","Radiation Epidemiology Branch, U.S. National Cancer Institute, Bethesda, MD, USA"],"raw_orcid":"https://orcid.org/0000-0003-0980-7567","affiliations":[{"raw_affiliation_string":"Faculty of Health and Life Sciences, Oxford Brookes University","institution_ids":["https://openalex.org/I124261462"]},{"raw_affiliation_string":"Feinberg School of Medicine, Northwestern University","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Radiation Epidemiology Branch, U.S. National Cancer Institute","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, UK","institution_ids":["https://openalex.org/I124261462"]},{"raw_affiliation_string":"Feinberg School of Medicine, Northwestern University, Evanston, IL, USA","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Radiation Epidemiology Branch, U.S. National Cancer Institute, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5002103948"],"corresponding_institution_ids":["https://openalex.org/I21578748"],"apc_list":null,"apc_paid":null,"fwci":0.313,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.37907728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"101","issue":"11","first_page":"1085","last_page":"1097"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.05640000104904175,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10946","display_name":"Radioactivity and Radon Measurements","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3614","display_name":"Radiological and Ultrasound Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.6190000176429749},{"id":"https://openalex.org/keywords/effect-modification","display_name":"effect modification","score":0.878000020980835},{"id":"https://openalex.org/keywords/anthracyclines","display_name":"anthracyclines","score":0.6779999732971191},{"id":"https://openalex.org/keywords/age-at-exposure","display_name":"age at exposure","score":0.8220000267028809},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7749999761581421},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.6959999799728394},{"id":"https://openalex.org/keywords/japanese-atomic-bomb-survivors","display_name":"Japanese atomic bomb survivors","score":0.7549999952316284},{"id":"https://openalex.org/keywords/occupational-radiation-exposure","display_name":"occupational radiation exposure","score":0.9169999957084656},{"id":"https://openalex.org/keywords/medical-radiation-exposure","display_name":"medical radiation exposure","score":0.7990000247955322},{"id":"https://openalex.org/keywords/environmental-radiation-exposure","display_name":"environmental radiation exposure","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6881999969482422},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.6628999710083008},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.5651000142097473},{"id":"https://openalex.org/C2779925993","wikidata":"https://www.wikidata.org/wiki/Q336938","display_name":"Radiation exposure","level":2,"score":0.5557000041007996},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.5019999742507935},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4959000051021576},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.49230000376701355},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.4902999997138977},{"id":"https://openalex.org/C2987845665","wikidata":"https://www.wikidata.org/wiki/Q17072363","display_name":"Occupational exposure","level":2,"score":0.47440001368522644},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4521999955177307},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.4316999912261963},{"id":"https://openalex.org/C2987851454","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Biological effect","level":2,"score":0.42579999566078186},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.38089999556541443},{"id":"https://openalex.org/C2993278735","wikidata":"https://www.wikidata.org/wiki/Q275459","display_name":"Radiation injury","level":3,"score":0.305400013923645},{"id":"https://openalex.org/C2777620619","wikidata":"https://www.wikidata.org/wiki/Q1574099","display_name":"Radiation protection","level":2,"score":0.295199990272522},{"id":"https://openalex.org/C2778421134","wikidata":"https://www.wikidata.org/wiki/Q628764","display_name":"Occupational medicine","level":3,"score":0.29420000314712524},{"id":"https://openalex.org/C2987700449","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Radiation dose","level":2,"score":0.2865999937057495},{"id":"https://openalex.org/C2994136483","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Medical radiation","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27480000257492065},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.2646999955177307},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.26429998874664307},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.2529999911785126}],"mesh":[{"descriptor_ui":"D000069079","descriptor_name":"Radiation Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011832","descriptor_name":"Radiation Injuries","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D011839","descriptor_name":"Radiation, Ionizing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/09553002.2025.2561808","doi":"https://doi.org/10.1080/09553002.2025.2561808","is_oa":false,"landing_page_url":"https://doi.org/10.1080/09553002.2025.2561808","pdf_url":null,"source":{"id":"https://openalex.org/S44383424","display_name":"International Journal of Radiation Biology","issn_l":"0955-3002","issn":["0955-3002","1362-3095"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Biology","raw_type":"journal-article"},{"id":"pmid:40986757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40986757","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of radiation biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1967498888","https://openalex.org/W1985128974","https://openalex.org/W1992028388","https://openalex.org/W2003897619","https://openalex.org/W2017139388","https://openalex.org/W2024136031","https://openalex.org/W2024169861","https://openalex.org/W2028921257","https://openalex.org/W2033004269","https://openalex.org/W2036791873","https://openalex.org/W2066617715","https://openalex.org/W2078007296","https://openalex.org/W2101119007","https://openalex.org/W2114738305","https://openalex.org/W2125148104","https://openalex.org/W2126680401","https://openalex.org/W2127826761","https://openalex.org/W2132107602","https://openalex.org/W2143327181","https://openalex.org/W2151585080","https://openalex.org/W2154375587","https://openalex.org/W2154505306","https://openalex.org/W2162584451","https://openalex.org/W2173784372","https://openalex.org/W2219287799","https://openalex.org/W2267944621","https://openalex.org/W2536010737","https://openalex.org/W2584614071","https://openalex.org/W2587088513","https://openalex.org/W2595850032","https://openalex.org/W2735713229","https://openalex.org/W2899170819","https://openalex.org/W2907776162","https://openalex.org/W2952155820","https://openalex.org/W2970754556","https://openalex.org/W2984297246","https://openalex.org/W2999651175","https://openalex.org/W3112053934","https://openalex.org/W3137370776","https://openalex.org/W3205395017","https://openalex.org/W4206391321","https://openalex.org/W4213062631","https://openalex.org/W4282828844","https://openalex.org/W4295752425","https://openalex.org/W4308058329","https://openalex.org/W4318983725","https://openalex.org/W4323539333","https://openalex.org/W4399706091","https://openalex.org/W4401643396"],"related_works":["https://openalex.org/W7084600105","https://openalex.org/W7162560207","https://openalex.org/W2172749242","https://openalex.org/W3094683316","https://openalex.org/W2078007296","https://openalex.org/W2115204805","https://openalex.org/W2071667477","https://openalex.org/W2491457635","https://openalex.org/W3125028810","https://openalex.org/W579649039"],"abstract_inverted_index":{"Purpose:":[0],"Growing":[1],"evidence":[2],"from":[3],"the":[4,21,27,43,54,85,136,180],"Japanese":[5],"atomic":[6],"bomb":[7],"survivors,":[8],"and":[9,11,84,92,132,150],"occupationally":[10],"medically":[12],"exposed":[13],"groups":[14],"indicates":[15],"that":[16,56,114],"ionizing":[17],"radiation":[18,38,47,82],"could":[19],"increase":[20],"risk":[22,86,120],"of":[23,26,35,45,53,81,87,105,135,142,153,169,182],"various":[24,122],"diseases":[25],"circulatory":[28],"system":[29],"(DCS),":[30],"even":[31],"at":[32,117],"low":[33],"levels":[34],"exposure.":[36],"As":[37],"protection":[39],"systems":[40],"increasingly":[41],"consider":[42],"possibility":[44],"individualized":[46],"protection,":[48],"better":[49,178],"understanding":[50],"is":[51,138],"needed":[52],"factors":[55],"may":[57],"impact":[58],"radiation-related":[59],"risk,":[60],"whether":[61],"intrinsic":[62],"(such":[63,71],"as":[64,72],"age,":[65],"sex":[66],"or":[67,69],"genetics),":[68],"extrinsic":[70],"smoking).":[73],"Here,":[74],"we":[75],"comprehensively":[76],"review":[77],"potential":[78,98,156],"effect":[79,99],"modification":[80],"exposure":[83,118,154,164],"DCS":[88,123],"in":[89,107,146],"medical,":[90],"occupational":[91],"environmental":[93],"settings.Conclusion:":[94],"Several":[95],"studies":[96,131,161],"indicate":[97],"modification,":[100],"usually":[101],"detrimental,":[102],"with":[103,162,172],"use":[104],"anthracycline":[106],"medical":[108],"settings.":[109,133],"There":[110],"was":[111,127],"some":[112],"indication":[113],"younger":[115],"age":[116],"increased":[119],"for":[121],"outcomes,":[124,149],"but":[125],"this":[126],"less":[128],"consistent":[129],"across":[130],"Interpretation":[134],"data":[137],"complicated":[139],"by":[140],"considerations":[141],"statistical":[143],"power,":[144],"differences":[145],"specific":[147],"disease":[148],"narrow":[151],"ranges":[152],"and/or":[155],"modifiers":[157],"within":[158],"studies.":[159],"Future":[160],"well-defined":[163],"over":[165],"a":[166],"wide":[167],"range":[168],"ages,":[170],"along":[171],"biological":[173],"samples,":[174],"are":[175],"required":[176],"to":[177],"inform":[179],"nature":[181],"these":[183],"interactions.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-10T00:00:00"}