{"id":"https://openalex.org/W4414420780","doi":"https://doi.org/10.1016/j.bpsgos.2025.100616","title":"Clinical Insights Into the Mechanistic Crossroads of Lamotrigine and Therapeutic Ketosis in Bipolar Depression","display_name":"Clinical Insights Into the Mechanistic Crossroads of Lamotrigine and Therapeutic Ketosis in Bipolar Depression","publication_year":2025,"publication_date":"2025-09-23","ids":{"openalex":"https://openalex.org/W4414420780","doi":"https://doi.org/10.1016/j.bpsgos.2025.100616","pmid":"https://pubmed.ncbi.nlm.nih.gov/41321428","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12663626"},"language":"en","primary_location":{"id":"doi:10.1016/j.bpsgos.2025.100616","doi":"https://doi.org/10.1016/j.bpsgos.2025.100616","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpsgos.2025.100616","pdf_url":null,"source":{"id":"https://openalex.org/S4210179861","display_name":"Biological Psychiatry Global Open Science","issn_l":"2667-1743","issn":["2667-1743"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry Global Open Science","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.bpsgos.2025.100616","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003019031","display_name":"Dina N. Ali","orcid":"https://orcid.org/0009-0005-1309-0177","observed_orcids":["https://orcid.org/0009-0005-1309-0177"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dina N. Ali","raw_affiliation_strings":["Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0009-0005-1309-0177","affiliations":[{"raw_affiliation_string":"Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083128969","display_name":"Iain H. Campbell","orcid":"https://orcid.org/0000-0001-8756-1326","observed_orcids":["https://orcid.org/0000-0001-8756-1326"]},"institutions":[{"id":"https://openalex.org/I2801618995","display_name":"Royal Edinburgh Hospital","ror":"https://ror.org/04jxcef68","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2801618995"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Iain H. Campbell","raw_affiliation_strings":["Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I2801618995","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073734580","display_name":"Jonathan G. Leung","orcid":"https://orcid.org/0000-0003-3836-9375","observed_orcids":["https://orcid.org/0000-0003-3836-9375"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan G. Leung","raw_affiliation_strings":["Department of Pharmacy Services, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Services, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117083420","display_name":"Tamahara Gonz\u00e1lez-Campos","orcid":"https://orcid.org/0000-0001-6342-0596","observed_orcids":["https://orcid.org/0000-0001-6342-0596"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamahara Gonzalez Campos","raw_affiliation_strings":["Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100645937","display_name":"Duan Liu","orcid":"https://orcid.org/0000-0003-1065-246X","observed_orcids":["https://orcid.org/0000-0003-1065-246X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duan Liu","raw_affiliation_strings":["Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058530892","display_name":"Mete Ercis","orcid":"https://orcid.org/0000-0003-1272-5503","observed_orcids":["https://orcid.org/0000-0003-1272-5503"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mete Ercis","raw_affiliation_strings":["Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065470901","display_name":"Matej Markota","orcid":"https://orcid.org/0000-0002-0437-5497","observed_orcids":["https://orcid.org/0000-0002-0437-5497"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matej Markota","raw_affiliation_strings":["Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007739489","display_name":"Deniz Ceylan","orcid":"https://orcid.org/0000-0002-1438-8240","observed_orcids":["https://orcid.org/0000-0002-1438-8240"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deniz Ceylan","raw_affiliation_strings":["Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002878961","display_name":"Kyla M. Lara-Breitinger","orcid":"https://orcid.org/0000-0001-9724-3065","observed_orcids":["https://orcid.org/0000-0001-9724-3065"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyla Lara-Breitinger","raw_affiliation_strings":["Department of Cardiology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001963115","display_name":"Francisco Alejandro L\u00f3pez-Jim\u00e9nez","orcid":"https://orcid.org/0000-0001-5788-9734","observed_orcids":["https://orcid.org/0000-0001-5788-9734"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francisco Lopez-Jimenez","raw_affiliation_strings":["Department of Cardiology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026390561","display_name":"Allie Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam S. Anderson","raw_affiliation_strings":["Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076244290","display_name":"Ay\u015feg\u00fcl \u00d6zerdem","orcid":"https://orcid.org/0000-0002-9455-5896","observed_orcids":["https://orcid.org/0000-0002-9455-5896"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aysegul Ozerdem","raw_affiliation_strings":["Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026326407","display_name":"Stacey J. Winham","orcid":"https://orcid.org/0000-0002-8492-9102","observed_orcids":["https://orcid.org/0000-0002-8492-9102"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacey J. Winham","raw_affiliation_strings":["Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029433360","display_name":"Mark A. Frye","orcid":"https://orcid.org/0000-0001-6997-4215","observed_orcids":["https://orcid.org/0000-0001-6997-4215"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark A. Frye","raw_affiliation_strings":["Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0000-0001-6997-4215","affiliations":[{"raw_affiliation_string":"Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029433360"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":{"value":3700,"currency":"USD","value_usd":3700},"fwci":0.3163,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.39600494,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"6","issue":"1","first_page":"100616","last_page":"100616"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lamotrigine","display_name":"lamotrigine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bipolar-depression","display_name":"bipolar depression","score":0.8989999890327454},{"id":"https://openalex.org/keywords/ketogenic-diet","display_name":"ketogenic diet","score":0.6729999780654907},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.6970000267028809},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.7039999961853027},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.9079999923706055},{"id":"https://openalex.org/keywords/mood-regulation","display_name":"mood regulation","score":0.6570000052452087},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.7979999780654907},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.6079999804496765},{"id":"https://openalex.org/keywords/cardiometabolic-burden","display_name":"cardiometabolic burden","score":0.6840000152587891},{"id":"https://openalex.org/keywords/antipsychotic-side-effects","display_name":"antipsychotic adverse effects","score":0.7400000095367432},{"id":"https://openalex.org/keywords/neuronal-stability","display_name":"neuronal stability","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2778802184","wikidata":"https://www.wikidata.org/wiki/Q410346","display_name":"Lamotrigine","level":3,"score":0.8962000012397766},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.7340999841690063},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.640500009059906},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.5586000084877014},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.5194000005722046},{"id":"https://openalex.org/C3018162438","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Adjunctive treatment","level":2,"score":0.4733000099658966},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.47110000252723694},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.46050000190734863},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4587000012397766},{"id":"https://openalex.org/C2776731943","wikidata":"https://www.wikidata.org/wiki/Q1123139","display_name":"Ketosis","level":3,"score":0.42250001430511475},{"id":"https://openalex.org/C2780550438","wikidata":"https://www.wikidata.org/wiki/Q2622367","display_name":"Mood stabilizer","level":4,"score":0.41780000925064087},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.4025999903678894},{"id":"https://openalex.org/C2778587478","wikidata":"https://www.wikidata.org/wiki/Q1070684","display_name":"Ketogenic diet","level":3,"score":0.38679999113082886},{"id":"https://openalex.org/C2777134132","wikidata":"https://www.wikidata.org/wiki/Q188638","display_name":"Mood disorders","level":3,"score":0.35760000348091125},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.35179999470710754},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3384999930858612},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.3174999952316284},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3125999867916107},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.2906000018119812},{"id":"https://openalex.org/C2777683783","wikidata":"https://www.wikidata.org/wiki/Q221174","display_name":"Topiramate","level":3,"score":0.2897999882698059},{"id":"https://openalex.org/C2781246090","wikidata":"https://www.wikidata.org/wiki/Q7836908","display_name":"Treatment of bipolar disorder","level":5,"score":0.2892000079154968},{"id":"https://openalex.org/C2776809841","wikidata":"https://www.wikidata.org/wiki/Q185935","display_name":"Mania","level":4,"score":0.28760001063346863},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27459999918937683},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26930001378059387},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.2676999866962433},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.260699987411499},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.2531000077724457}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.bpsgos.2025.100616","doi":"https://doi.org/10.1016/j.bpsgos.2025.100616","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpsgos.2025.100616","pdf_url":null,"source":{"id":"https://openalex.org/S4210179861","display_name":"Biological Psychiatry Global Open Science","issn_l":"2667-1743","issn":["2667-1743"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry Global Open Science","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11469752","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12663626","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41321428","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41321428","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological psychiatry global open science","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ca6e43bddd9e4261aaeec559209fb3ef","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ca6e43bddd9e4261aaeec559209fb3ef","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biological Psychiatry Global Open Science, Vol 6, Iss 1, Pp 100616- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.bpsgos.2025.100616","doi":"https://doi.org/10.1016/j.bpsgos.2025.100616","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bpsgos.2025.100616","pdf_url":null,"source":{"id":"https://openalex.org/S4210179861","display_name":"Biological Psychiatry Global Open Science","issn_l":"2667-1743","issn":["2667-1743"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry Global Open Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306143","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320309464","display_name":"Mayo Foundation for Medical Education and Research","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320316444","display_name":"Assurex Health","ror":"https://ror.org/02jdgc236"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":141,"referenced_works":["https://openalex.org/W39288719","https://openalex.org/W78243157","https://openalex.org/W1558050204","https://openalex.org/W1582652025","https://openalex.org/W1859478462","https://openalex.org/W1941950939","https://openalex.org/W1948904820","https://openalex.org/W1966279131","https://openalex.org/W1979037241","https://openalex.org/W1979223417","https://openalex.org/W1979557683","https://openalex.org/W1991621530","https://openalex.org/W2001142313","https://openalex.org/W2004347369","https://openalex.org/W2008565079","https://openalex.org/W2012091005","https://openalex.org/W2018213236","https://openalex.org/W2021674703","https://openalex.org/W2026664943","https://openalex.org/W2032551488","https://openalex.org/W2034665339","https://openalex.org/W2043129828","https://openalex.org/W2043595793","https://openalex.org/W2045334667","https://openalex.org/W2046597861","https://openalex.org/W2050508296","https://openalex.org/W2053465680","https://openalex.org/W2056328685","https://openalex.org/W2061120947","https://openalex.org/W2064018009","https://openalex.org/W2068432022","https://openalex.org/W2070376390","https://openalex.org/W2071493584","https://openalex.org/W2072073590","https://openalex.org/W2075824844","https://openalex.org/W2077363857","https://openalex.org/W2082434739","https://openalex.org/W2083823016","https://openalex.org/W2086281632","https://openalex.org/W2086593869","https://openalex.org/W2097197370","https://openalex.org/W2098249941","https://openalex.org/W2103127225","https://openalex.org/W2107892828","https://openalex.org/W2109360212","https://openalex.org/W2114940817","https://openalex.org/W2121009723","https://openalex.org/W2129527456","https://openalex.org/W2130526286","https://openalex.org/W2153413087","https://openalex.org/W2161282771","https://openalex.org/W2162821981","https://openalex.org/W2184290988","https://openalex.org/W2259851886","https://openalex.org/W2339088835","https://openalex.org/W2403348153","https://openalex.org/W2414753374","https://openalex.org/W2419218120","https://openalex.org/W2433005520","https://openalex.org/W2586320622","https://openalex.org/W2624736840","https://openalex.org/W2736059261","https://openalex.org/W2765377828","https://openalex.org/W2765691797","https://openalex.org/W2784209649","https://openalex.org/W2792206068","https://openalex.org/W2807927299","https://openalex.org/W2842573454","https://openalex.org/W2883458662","https://openalex.org/W2887934928","https://openalex.org/W2892119394","https://openalex.org/W2900384992","https://openalex.org/W2905993438","https://openalex.org/W2907030367","https://openalex.org/W2908928386","https://openalex.org/W2910549174","https://openalex.org/W2921045261","https://openalex.org/W2922473333","https://openalex.org/W2946013240","https://openalex.org/W2955444284","https://openalex.org/W2979493890","https://openalex.org/W2982553818","https://openalex.org/W2986294418","https://openalex.org/W2995385188","https://openalex.org/W3004000132","https://openalex.org/W3012149251","https://openalex.org/W3015799659","https://openalex.org/W3030920112","https://openalex.org/W3043074855","https://openalex.org/W3048936470","https://openalex.org/W3080376907","https://openalex.org/W3089296348","https://openalex.org/W3092727772","https://openalex.org/W3097126680","https://openalex.org/W3112345822","https://openalex.org/W3130595866","https://openalex.org/W3135259783","https://openalex.org/W3164181487","https://openalex.org/W3168889116","https://openalex.org/W3186181241","https://openalex.org/W3197339932","https://openalex.org/W3199792850","https://openalex.org/W3204839307","https://openalex.org/W4200050093","https://openalex.org/W4205343758","https://openalex.org/W4213269251","https://openalex.org/W4225635610","https://openalex.org/W4229023343","https://openalex.org/W4229336638","https://openalex.org/W4293664442","https://openalex.org/W4295922808","https://openalex.org/W4307862389","https://openalex.org/W4310796429","https://openalex.org/W4311280069","https://openalex.org/W4312095548","https://openalex.org/W4317436574","https://openalex.org/W4319318571","https://openalex.org/W4360615534","https://openalex.org/W4367856949","https://openalex.org/W4383818962","https://openalex.org/W4385623896","https://openalex.org/W4385805346","https://openalex.org/W4387472241","https://openalex.org/W4387865290","https://openalex.org/W4390858277","https://openalex.org/W4391229442","https://openalex.org/W4391684811","https://openalex.org/W4391885697","https://openalex.org/W4392979640","https://openalex.org/W4396936983","https://openalex.org/W4396975621","https://openalex.org/W4399696973","https://openalex.org/W4401749892","https://openalex.org/W4402230362","https://openalex.org/W4402597461","https://openalex.org/W4403277679","https://openalex.org/W4403645899","https://openalex.org/W4407929099","https://openalex.org/W4410708147","https://openalex.org/W4413980946","https://openalex.org/W7167208285"],"related_works":["https://openalex.org/W4409281503","https://openalex.org/W7124291198","https://openalex.org/W4310796429","https://openalex.org/W2765757146","https://openalex.org/W3197339932","https://openalex.org/W2105670269","https://openalex.org/W1995503554","https://openalex.org/W4213025458","https://openalex.org/W4312061450","https://openalex.org/W2078807225"],"abstract_inverted_index":{"There":[0,58],"are":[1],"substantial":[2,26],"care":[3],"gaps":[4],"in":[5,23,43,50,87,97,131,145,168],"optimizing":[6],"treatment":[7,21,107,177],"response":[8],"for":[9,108],"bipolar":[10,47,52],"depression":[11,53],"given,":[12],"at":[13],"best,":[14],"a":[15,25,60,104,171],"modicum":[16],"of":[17,142,155],"benefit":[18],"from":[19,55],"antidepressant":[20],"and,":[22],"contrast,":[24],"cardiometabolic":[27],"burden":[28],"associated":[29],"with":[30,39,93],"regulatory-approved":[31],"antipsychotic":[32],"treatment.":[33],"Lamotrigine":[34],"(LGT)":[35],"is":[36,59],"an":[37,40,83],"anticonvulsant":[38],"evidence":[41,95],"base":[42,96],"both":[44,117],"epilepsy":[45],"and":[46,66,75,110,114,125,134,157,160],"disorder":[48],"(BD),":[49],"particular":[51],"\"stabilizing":[54],"down":[56],"under.\"":[57],"well-established":[61],"bidirectional":[62],"relationship":[63],"between":[64,72],"BD":[65],"epilepsy.":[67],"Recognizing":[68],"the":[69,140,152],"complex":[70],"interplay":[71],"mood,":[73],"diet,":[74],"energy":[76,123],"metabolism,":[77],"lifestyle":[78],"interventions":[79],"have":[80],"emerged":[81],"as":[82,103],"adjunctive":[84,106],"therapeutic":[85,91,115,158],"approach":[86],"BD.":[88,146],"Among":[89],"these,":[90],"ketosis,":[92],"century-old":[94],"epilepsy,":[98],"has":[99],"regained":[100],"new":[101],"interest":[102],"promising":[105],"mood":[109,132],"metabolic":[111],"comorbidities.":[112],"LGT":[113,156],"ketosis":[116,159],"target":[118],"neurobiological":[119],"pathways":[120],"that":[121],"regulate":[122],"metabolism":[124],"promote":[126],"neuronal":[127,135],"stability-key":[128],"processes":[129],"implicated":[130],"regulation":[133],"protection.":[136],"This":[137],"alignment":[138],"suggests":[139],"possibility":[141],"synergistic":[143],"effects":[144],"In":[147],"this":[148,175],"review,":[149],"we":[150],"explore":[151],"overlapping":[153],"mechanisms":[154],"provide":[161],"clinical":[162],"insights":[163],"into":[164],"their":[165],"combined":[166],"use":[167],"BD,":[169],"offering":[170],"comprehensive":[172],"perspective":[173],"on":[174],"innovative":[176],"strategy.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-09-23T00:00:00"}
