{"id":"https://openalex.org/W4414419213","doi":"https://doi.org/10.1016/j.expneurol.2025.115478","title":"Therapeutic doses of methylphenidate following repetitive mild traumatic brain injury transiently disrupts risk/reward decision making in a sex dependent manner.","display_name":"Therapeutic doses of methylphenidate following repetitive mild traumatic brain injury transiently disrupts risk/reward decision making in a sex dependent manner.","publication_year":2025,"publication_date":"2025-09-23","ids":{"openalex":"https://openalex.org/W4414419213","doi":"https://doi.org/10.1016/j.expneurol.2025.115478","pmid":"https://pubmed.ncbi.nlm.nih.gov/40992615"},"language":"en","primary_location":{"id":"doi:10.1016/j.expneurol.2025.115478","doi":"https://doi.org/10.1016/j.expneurol.2025.115478","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.expneurol.2025.115478","pdf_url":null,"source":{"id":"https://openalex.org/S165592611","display_name":"Experimental Neurology","issn_l":"0014-4886","issn":["0014-4886","1090-2430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.expneurol.2025.115478","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032452184","display_name":"Eleni Papadopoulos","orcid":"https://orcid.org/0000-0001-8328-2928","observed_orcids":["https://orcid.org/0000-0001-8328-2928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eleni Papadopoulos","raw_affiliation_strings":["Department of Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA; Rowan-Virtua School of Translational Biomedical Engineering and Sciences, Stratford, NJ, USA. Electronic address: papado19@rowan.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA; Rowan-Virtua School of Translational Biomedical Engineering and Sciences, Stratford, NJ, USA. Electronic address: papado19@rowan.edu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119700258","display_name":"Samantha Walkow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samantha Walkow","raw_affiliation_strings":["Department of Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA. Electronic address: walkow17@rowan.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA. Electronic address: walkow17@rowan.edu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052846659","display_name":"Anna Abrimian","orcid":"https://orcid.org/0000-0002-4522-0627","observed_orcids":["https://orcid.org/0000-0002-4522-0627"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Abrimian","raw_affiliation_strings":["Department of Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA. Electronic address: abrimi58@rowan.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA. Electronic address: abrimi58@rowan.edu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013276695","display_name":"Christopher P. Knapp","orcid":"https://orcid.org/0000-0003-1066-6255","observed_orcids":["https://orcid.org/0000-0003-1066-6255"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher P. Knapp","raw_affiliation_strings":["Department of Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA; Rowan-Virtua School of Translational Biomedical Engineering and Sciences, Stratford, NJ, USA. Electronic address: knappc0@rowan.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA; Rowan-Virtua School of Translational Biomedical Engineering and Sciences, Stratford, NJ, USA. Electronic address: knappc0@rowan.edu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051628746","display_name":"Jessica A. Loweth","orcid":"https://orcid.org/0000-0001-8697-3898","observed_orcids":["https://orcid.org/0000-0001-8697-3898"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica A. Loweth","raw_affiliation_strings":["Department of Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA; Rowan-Virtua School of Translational Biomedical Engineering and Sciences, Stratford, NJ, USA. Electronic address: loweth@rowan.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA; Rowan-Virtua School of Translational Biomedical Engineering and Sciences, Stratford, NJ, USA. Electronic address: loweth@rowan.edu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077490102","display_name":"Barry D. Waterhouse","orcid":"https://orcid.org/0000-0002-2086-4290","observed_orcids":["https://orcid.org/0000-0002-2086-4290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barry D. Waterhouse","raw_affiliation_strings":["Department of Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA; Rowan-Virtua School of Translational Biomedical Engineering and Sciences, Stratford, NJ, USA. Electronic address: waterhouse@rowan.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA; Rowan-Virtua School of Translational Biomedical Engineering and Sciences, Stratford, NJ, USA. Electronic address: waterhouse@rowan.edu","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075647442","display_name":"Rachel L. Navarra","orcid":"https://orcid.org/0000-0002-4893-5468","observed_orcids":["https://orcid.org/0000-0002-4893-5468"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rachel L. Navarra","raw_affiliation_strings":["Department of Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA; Rowan-Virtua School of Translational Biomedical Engineering and Sciences, Stratford, NJ, USA. Electronic address: navarra@rowan.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA; Rowan-Virtua School of Translational Biomedical Engineering and Sciences, Stratford, NJ, USA. Electronic address: navarra@rowan.edu","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5075647442"],"corresponding_institution_ids":[],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":{"value":4110,"currency":"USD","value_usd":4110},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27624845,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"395","issue":null,"first_page":"115478","last_page":"115478"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/repetitive-mild-traumatic-brain-injury","display_name":"repetitive mild traumatic brain injury","score":0.8849999904632568},{"id":"https://openalex.org/keywords/methylphenidate","display_name":"methylphenidate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/probabilistic-discounting","display_name":"probabilistic discounting","score":0.7910000085830688},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.968999981880188},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9419999718666077},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.718999981880188},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/catecholamine-transporters","display_name":"catecholamine transporters","score":0.9300000071525574},{"id":"https://openalex.org/keywords/psychostimulants","display_name":"psychostimulants","score":0.7730000019073486},{"id":"https://openalex.org/keywords/risk-taking","display_name":"risk-taking","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C2777112843","wikidata":"https://www.wikidata.org/wiki/Q422112","display_name":"Methylphenidate","level":3,"score":0.7753999829292297},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.6697999835014343},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6320000290870667},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.6194000244140625},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.6060000061988831},{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.5577999949455261},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.48989999294281006},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4724000096321106},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45980000495910645},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4496999979019165},{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.42399999499320984},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.400299996137619},{"id":"https://openalex.org/C2780714222","wikidata":"https://www.wikidata.org/wiki/Q410441","display_name":"Modafinil","level":2,"score":0.3840000033378601},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3785000145435333},{"id":"https://openalex.org/C2776889708","wikidata":"https://www.wikidata.org/wiki/Q1048728","display_name":"Iowa gambling task","level":3,"score":0.3310999870300293},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.32339999079704285},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32179999351501465},{"id":"https://openalex.org/C2779818104","wikidata":"https://www.wikidata.org/wiki/Q5135341","display_name":"Closed head injury","level":3,"score":0.30880001187324524},{"id":"https://openalex.org/C3017567848","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Hypertonic saline","level":2,"score":0.28450000286102295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2750000059604645},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26600000262260437},{"id":"https://openalex.org/C2780749935","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive deficit","level":4,"score":0.25940001010894775},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.2549000084400177},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.2535000145435333}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.expneurol.2025.115478","doi":"https://doi.org/10.1016/j.expneurol.2025.115478","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.expneurol.2025.115478","pdf_url":null,"source":{"id":"https://openalex.org/S165592611","display_name":"Experimental Neurology","issn_l":"0014-4886","issn":["0014-4886","1090-2430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Neurology","raw_type":"journal-article"},{"id":"pmid:40992615","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40992615","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental neurology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.expneurol.2025.115478","doi":"https://doi.org/10.1016/j.expneurol.2025.115478","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.expneurol.2025.115478","pdf_url":null,"source":{"id":"https://openalex.org/S165592611","display_name":"Experimental Neurology","issn_l":"0014-4886","issn":["0014-4886","1090-2430"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Neurology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3344560803","display_name":null,"funder_award_id":"CBIR19IRG025","funder_id":"https://openalex.org/F4320310550","funder_display_name":"New Jersey Commission on Brain Injury Research"},{"id":"https://openalex.org/G4877615391","display_name":null,"funder_award_id":"CBIR20PIL004","funder_id":"https://openalex.org/F4320310550","funder_display_name":"New Jersey Commission on Brain Injury Research"},{"id":"https://openalex.org/G5515681335","display_name":"Psychostimulant Effects on Cognitive Flexibility and Risk-Based Decision-Making Behavior Following Repetitive Mild Traumatic Brain Injury","funder_award_id":"W81XWH-22-1-0616","funder_id":"https://openalex.org/F4320338273","funder_display_name":"Congressionally Directed Medical Research Programs"},{"id":"https://openalex.org/G711909886","display_name":null,"funder_award_id":"CBIR25FEL015","funder_id":"https://openalex.org/F4320310550","funder_display_name":"New Jersey Commission on Brain Injury Research"},{"id":"https://openalex.org/G7789599534","display_name":"Psychostimulant Effects on Cognitive Flexibility and Risk-Based Decision-Making Behavior Following Repetitive Mild Traumatic Brain Injury","funder_award_id":"W81XWH-22-1-0618","funder_id":"https://openalex.org/F4320338273","funder_display_name":"Congressionally Directed Medical Research Programs"}],"funders":[{"id":"https://openalex.org/F4320310550","display_name":"New Jersey Commission on Brain Injury Research","ror":"https://ror.org/03kmrjq19"},{"id":"https://openalex.org/F4320311270","display_name":"Osteopathic Heritage Foundation","ror":"https://ror.org/00ps0j197"},{"id":"https://openalex.org/F4320338273","display_name":"Congressionally Directed Medical Research Programs","ror":"https://ror.org/03g2zjp07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":130,"referenced_works":["https://openalex.org/W63074263","https://openalex.org/W1485810257","https://openalex.org/W1728714594","https://openalex.org/W1964309132","https://openalex.org/W1964332391","https://openalex.org/W1968838822","https://openalex.org/W1972653515","https://openalex.org/W1974958759","https://openalex.org/W1975401347","https://openalex.org/W1975682352","https://openalex.org/W1976244656","https://openalex.org/W1980839525","https://openalex.org/W1982091038","https://openalex.org/W1985078521","https://openalex.org/W1985336514","https://openalex.org/W1986133498","https://openalex.org/W1988378704","https://openalex.org/W1992212001","https://openalex.org/W1992695208","https://openalex.org/W1994733572","https://openalex.org/W1995992264","https://openalex.org/W1999987205","https://openalex.org/W2000655626","https://openalex.org/W2004159545","https://openalex.org/W2005391856","https://openalex.org/W2005427299","https://openalex.org/W2006233145","https://openalex.org/W2006760790","https://openalex.org/W2012561037","https://openalex.org/W2012862495","https://openalex.org/W2014100689","https://openalex.org/W2016584120","https://openalex.org/W2023946047","https://openalex.org/W2025299152","https://openalex.org/W2027504242","https://openalex.org/W2027917639","https://openalex.org/W2032517670","https://openalex.org/W2033200028","https://openalex.org/W2036435581","https://openalex.org/W2039888412","https://openalex.org/W2042181575","https://openalex.org/W2046957890","https://openalex.org/W2048760683","https://openalex.org/W2051157298","https://openalex.org/W2053937389","https://openalex.org/W2054917279","https://openalex.org/W2055471036","https://openalex.org/W2056669048","https://openalex.org/W2060917675","https://openalex.org/W2062419575","https://openalex.org/W2062990061","https://openalex.org/W2063906089","https://openalex.org/W2071256705","https://openalex.org/W2073481291","https://openalex.org/W2074489720","https://openalex.org/W2076976327","https://openalex.org/W2077171496","https://openalex.org/W2078379881","https://openalex.org/W2079279420","https://openalex.org/W2090107670","https://openalex.org/W2090123298","https://openalex.org/W2091646494","https://openalex.org/W2092350133","https://openalex.org/W2097467766","https://openalex.org/W2097485712","https://openalex.org/W2106261260","https://openalex.org/W2117911988","https://openalex.org/W2122638098","https://openalex.org/W2123429050","https://openalex.org/W2132469266","https://openalex.org/W2133425596","https://openalex.org/W2134320198","https://openalex.org/W2136942291","https://openalex.org/W2141437797","https://openalex.org/W2142732083","https://openalex.org/W2145191694","https://openalex.org/W2164214901","https://openalex.org/W2168100629","https://openalex.org/W2169519447","https://openalex.org/W2169683381","https://openalex.org/W2170256757","https://openalex.org/W2185982181","https://openalex.org/W2219559188","https://openalex.org/W2253811371","https://openalex.org/W2399127861","https://openalex.org/W2404592340","https://openalex.org/W2413632673","https://openalex.org/W2413634334","https://openalex.org/W2417613454","https://openalex.org/W2479260850","https://openalex.org/W2503817556","https://openalex.org/W2509415340","https://openalex.org/W2517975703","https://openalex.org/W2525609444","https://openalex.org/W2557419490","https://openalex.org/W2598022966","https://openalex.org/W2767306984","https://openalex.org/W2794227021","https://openalex.org/W2795711486","https://openalex.org/W2911035337","https://openalex.org/W2917677704","https://openalex.org/W2939832482","https://openalex.org/W2941140846","https://openalex.org/W2944852931","https://openalex.org/W2946428204","https://openalex.org/W2948605482","https://openalex.org/W2964824489","https://openalex.org/W2973817837","https://openalex.org/W2982265393","https://openalex.org/W3004756564","https://openalex.org/W3037898540","https://openalex.org/W3119340803","https://openalex.org/W3128677789","https://openalex.org/W3145824211","https://openalex.org/W3184705939","https://openalex.org/W3195506311","https://openalex.org/W3210226858","https://openalex.org/W4206233669","https://openalex.org/W4224217647","https://openalex.org/W4281703296","https://openalex.org/W4283720090","https://openalex.org/W4297983178","https://openalex.org/W4307841261","https://openalex.org/W4313643875","https://openalex.org/W4318541747","https://openalex.org/W4394843704","https://openalex.org/W4399067289","https://openalex.org/W4402224532","https://openalex.org/W4405016602","https://openalex.org/W4414421978"],"related_works":[],"abstract_inverted_index":{"Mild":[0],"traumatic":[1],"brain":[2],"injury":[3],"(mTBI)":[4],"can":[5],"often":[6,70],"impair":[7],"prefrontal":[8],"cortex":[9],"(PFC)-mediated":[10],"higher-order":[11],"decision":[12,54,99],"making":[13,238],"processes":[14],"that":[15,240],"lead":[16],"to":[17,27,73,79,87,115,143,146,237,248],"increased":[18,164],"risk-taking":[19],"behaviors,":[20],"and":[21,30,37,45,68,103,160,196],"repetitive":[22],"mTBIs":[23],"(rmTBIs)":[24],"increase":[25],"susceptibility":[26],"more":[28],"severe":[29],"lasting":[31],"symptoms.":[32,77,252],"The":[33,56,156],"catecholamine":[34,46,61,202],"transmitters,":[35],"dopamine":[36],"norepinephrine,":[38],"modulate":[39],"neural":[40],"activity":[41],"within":[42,185,206],"the":[43,109,120,144,186,209],"PFC":[44,210],"dysregulation":[47],"associated":[48],"with":[49],"TBI":[50],"may":[51],"underly":[52],"aberrant":[53],"making.":[55,100],"psychostimulant,":[57],"methylphenidate":[58],"(MPH),":[59],"elevates":[60],"levels":[62,205],"by":[63,119],"blocking":[64],"their":[65,148],"reuptake":[66],"transporters":[67],"is":[69,85],"used":[71],"off-label":[72],"treat":[74,249],"post-injury":[75],"cognitive":[76,251],"However,":[78],"establish":[80],"a":[81],"treatment":[82,162,195,217],"regimen,":[83],"it":[84],"necessary":[86],"characterize":[88],"how":[89],"chronic":[90,193],"therapeutic":[91],"doses":[92],"of":[93,98,131,158,192,208],"MPH":[94,135,161,175,194,216,247],"affect":[95],"rmTBI-induced":[96],"disruptions":[97],"Here,":[101],"male":[102],"female":[104],"rodents":[105],"were":[106,211],"trained":[107],"on":[108],"probabilistic":[110],"discounting":[111],"task":[112],"(PDT)":[113],"prior":[114],"receiving":[116],"rmTBI":[117,159],"induced":[118],"closed":[121],"head-controlled":[122],"cortical":[123],"impact":[124],"model.":[125],"Rats":[126],"then":[127],"received":[128],"daily":[129],"administration":[130],"saline":[132],"or":[133,137],"low-dose":[134],"(0.5":[136],"2":[138,171],"mg/kg,":[139],"i.p.)":[140],"upon":[141],"return":[142],"PDT":[145,197],"assess":[147],"risk/reward":[149,243],"decision-making":[150],"behavior":[151,221],"for":[152,170,234],"4":[153],"weeks":[154],"post-surgery.":[155,189],"combination":[157],"significantly":[163],"risky":[165,220],"choice":[166,179],"preference":[167,180],"in":[168,182,201,222],"males":[169,235],"weeks.":[172],"In":[173],"contrast,":[174],"(2":[176],"mg/kg)":[177],"disrupted":[178],"only":[181],"uninjured":[183],"females":[184],"first":[187],"week":[188],"Upon":[190],"completion":[191],"testing,":[198],"no":[199],"changes":[200],"transporter":[203],"protein":[204],"subregions":[207],"observed.":[212],"These":[213,229],"results":[214],"indicate":[215],"transiently":[218],"exacerbates":[219],"males,":[223],"but":[224],"not":[225],"females,":[226],"following":[227],"rmTBI.":[228],"sex-specific":[230],"responses":[231],"advise":[232],"caution":[233],"exposed":[236],"decisions":[239],"involve":[241],"uncertain":[242],"outcomes":[244],"when":[245],"considering":[246],"post-rmTBI":[250]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
