{"id":"https://openalex.org/W4414409683","doi":"https://doi.org/10.1128/mbio.01932-25","title":"Collective dynamics of Escherichia coli growth under near-lethal acid stress","display_name":"Collective dynamics of Escherichia coli growth under near-lethal acid stress","publication_year":2025,"publication_date":"2025-09-22","ids":{"openalex":"https://openalex.org/W4414409683","doi":"https://doi.org/10.1128/mbio.01932-25","pmid":"https://pubmed.ncbi.nlm.nih.gov/40981417","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12607569"},"language":"en","primary_location":{"id":"doi:10.1128/mbio.01932-25","doi":"https://doi.org/10.1128/mbio.01932-25","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.01932-25","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1128/mbio.01932-25","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060448837","display_name":"Rafael R. Segura Mu\u00f1oz","orcid":"https://orcid.org/0000-0001-7330-8549","observed_orcids":["https://orcid.org/0000-0001-7330-8549"]},"institutions":[{"id":"https://openalex.org/I4210144801","display_name":"Loewe Center for Synthetic Microbiology","ror":"https://ror.org/04e209f39","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210144801"]},{"id":"https://openalex.org/I4210166203","display_name":"Max Planck Institute for Terrestrial Microbiology","ror":"https://ror.org/05r7n9c40","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210166203"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rafael R. Segura Munoz","raw_affiliation_strings":["Center for Synthetic Microbiology (SYNMIKRO), 35043 Marburg, Germany","Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany","Center for Synthetic Microbiology (SYNMIKRO), Marburg, Germany","Max Planck Institute for Terrestrial Microbiology, Marburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7330-8549","affiliations":[{"raw_affiliation_string":"Center for Synthetic Microbiology (SYNMIKRO), 35043 Marburg, Germany","institution_ids":["https://openalex.org/I4210144801"]},{"raw_affiliation_string":"Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany","institution_ids":["https://openalex.org/I4210166203"]},{"raw_affiliation_string":"Center for Synthetic Microbiology (SYNMIKRO), Marburg, Germany","institution_ids":["https://openalex.org/I4210144801"]},{"raw_affiliation_string":"Max Planck Institute for Terrestrial Microbiology, Marburg, Germany","institution_ids":["https://openalex.org/I4210166203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039785599","display_name":"Victor Sourjik","orcid":"https://orcid.org/0000-0003-1053-9192","observed_orcids":["https://orcid.org/0000-0003-1053-9192"]},"institutions":[{"id":"https://openalex.org/I4210144801","display_name":"Loewe Center for Synthetic Microbiology","ror":"https://ror.org/04e209f39","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210144801"]},{"id":"https://openalex.org/I4210166203","display_name":"Max Planck Institute for Terrestrial Microbiology","ror":"https://ror.org/05r7n9c40","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210166203"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Victor Sourjik","raw_affiliation_strings":["Center for Synthetic Microbiology (SYNMIKRO), 35043 Marburg, Germany","Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany","Center for Synthetic Microbiology (SYNMIKRO), Marburg, Germany","Max Planck Institute for Terrestrial Microbiology, Marburg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1053-9192","affiliations":[{"raw_affiliation_string":"Center for Synthetic Microbiology (SYNMIKRO), 35043 Marburg, Germany","institution_ids":["https://openalex.org/I4210144801"]},{"raw_affiliation_string":"Max Planck Institute for Terrestrial Microbiology, 35043 Marburg, Germany","institution_ids":["https://openalex.org/I4210166203"]},{"raw_affiliation_string":"Center for Synthetic Microbiology (SYNMIKRO), Marburg, Germany","institution_ids":["https://openalex.org/I4210144801"]},{"raw_affiliation_string":"Max Planck Institute for Terrestrial Microbiology, Marburg, Germany","institution_ids":["https://openalex.org/I4210166203"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039785599"],"corresponding_institution_ids":["https://openalex.org/I4210144801","https://openalex.org/I4210166203"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":2.7328,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.89897564,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"16","issue":"11","first_page":"e0193225","last_page":"e0193225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9940000176429749},{"id":"https://openalex.org/keywords/acid-stress","display_name":"acid stress","score":0.8889999985694885},{"id":"https://openalex.org/keywords/collective-dynamics","display_name":"collective dynamics","score":0.5849999785423279},{"id":"https://openalex.org/keywords/cell-elongation","display_name":"cell elongation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cell-density-dependence","display_name":"cell density dependence","score":0.7570000290870667},{"id":"https://openalex.org/keywords/acid-tolerance","display_name":"acid resistance","score":0.4490000009536743},{"id":"https://openalex.org/keywords/cad-systems","display_name":"CAD systems","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cross-protection","display_name":"cross-protection","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.6050000190734863},{"id":"https://openalex.org/keywords/salmonella-typhimurium","display_name":"Salmonella typhimurium","score":0.8790000081062317},{"id":"https://openalex.org/keywords/enteric-pathogens","display_name":"enteric pathogens","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5548999905586243},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.5360000133514404},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5299000144004822},{"id":"https://openalex.org/C75235859","wikidata":"https://www.wikidata.org/wiki/Q582659","display_name":"Exponential growth","level":2,"score":0.5026999711990356},{"id":"https://openalex.org/C33947775","wikidata":"https://www.wikidata.org/wiki/Q271439","display_name":"Elongation","level":3,"score":0.4625000059604645},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4618000090122223},{"id":"https://openalex.org/C2778312390","wikidata":"https://www.wikidata.org/wiki/Q4139973","display_name":"Growth rate","level":2,"score":0.45719999074935913},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.45489999651908875},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44940000772476196},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.436599999666214},{"id":"https://openalex.org/C17741926","wikidata":"https://www.wikidata.org/wiki/Q762045","display_name":"Bacterial growth","level":3,"score":0.40290001034736633},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36320000886917114},{"id":"https://openalex.org/C2780919596","wikidata":"https://www.wikidata.org/wiki/Q575920","display_name":"Growth medium","level":3,"score":0.35269999504089355},{"id":"https://openalex.org/C65590680","wikidata":"https://www.wikidata.org/wiki/Q909482","display_name":"Volume fraction","level":2,"score":0.35190001130104065},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.34619998931884766},{"id":"https://openalex.org/C19655278","wikidata":"https://www.wikidata.org/wiki/Q3293735","display_name":"Bacterial cell structure","level":3,"score":0.34470000863075256},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.34130001068115234},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.32519999146461487},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.2937000095844269},{"id":"https://openalex.org/C3019461541","wikidata":"https://www.wikidata.org/wiki/Q1320100","display_name":"Slow growth","level":2,"score":0.28940001130104065},{"id":"https://openalex.org/C2986039202","wikidata":"https://www.wikidata.org/wiki/Q123414","display_name":"Environmental stress","level":2,"score":0.2761000096797943},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.26660001277923584},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.26409998536109924},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2612999975681305},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.2599000036716461}],"mesh":[{"descriptor_ui":"D000143","descriptor_name":"Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000143","descriptor_name":"Acids","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1128/mbio.01932-25","doi":"https://doi.org/10.1128/mbio.01932-25","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.01932-25","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},{"id":"doi:10.1101/2024.10.17.618973","doi":"https://doi.org/10.1101/2024.10.17.618973","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.10.17.618973","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/10/18/2024.10.17.618973.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:11418780","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12607569","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40981417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40981417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12607569","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12607569/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:29e493e1a0cc4241840fb40b9476f1e2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/29e493e1a0cc4241840fb40b9476f1e2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mBio, Vol 16, Iss 11 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1128/mbio.01932-25","doi":"https://doi.org/10.1128/mbio.01932-25","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.01932-25","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308269","display_name":"Alexander von Humboldt-Stiftung","ror":"https://ror.org/012kf4317"},{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414409683.pdf","grobid_xml":"https://content.openalex.org/works/W4414409683.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1512810258","https://openalex.org/W1533135048","https://openalex.org/W1551233459","https://openalex.org/W1693303585","https://openalex.org/W1907149689","https://openalex.org/W1918771405","https://openalex.org/W1976954198","https://openalex.org/W2041054048","https://openalex.org/W2060587237","https://openalex.org/W2071674927","https://openalex.org/W2079900468","https://openalex.org/W2095449747","https://openalex.org/W2114448039","https://openalex.org/W2136806453","https://openalex.org/W2143767550","https://openalex.org/W2151645494","https://openalex.org/W2152434411","https://openalex.org/W2153139855","https://openalex.org/W2165407078","https://openalex.org/W2316907692","https://openalex.org/W2336046394","https://openalex.org/W2901025133","https://openalex.org/W2990434592","https://openalex.org/W3012078265","https://openalex.org/W3027089923","https://openalex.org/W3028913864","https://openalex.org/W4223554762","https://openalex.org/W4229933927","https://openalex.org/W4288705885","https://openalex.org/W4296164585","https://openalex.org/W4297238535","https://openalex.org/W4310700083","https://openalex.org/W4323533996","https://openalex.org/W4376132136","https://openalex.org/W4382138531","https://openalex.org/W4386132021","https://openalex.org/W4401813009"],"related_works":["https://openalex.org/W1978818956","https://openalex.org/W2082691121","https://openalex.org/W2016556365","https://openalex.org/W2004254961","https://openalex.org/W2095824985","https://openalex.org/W4401978412","https://openalex.org/W2090825043","https://openalex.org/W1592537566","https://openalex.org/W2587399356","https://openalex.org/W123500387"],"abstract_inverted_index":{"ABSTRACT":[0],"Many":[1],"neutralophilic":[2],"bacteria,":[3],"including":[4,147],"Escherichia":[5],"coli":[6,25,44,57,172,257,294],",":[7],"can":[8],"withstand":[9],"acidic":[10,275,298,348],"conditions":[11,276,299],"due":[12],"to":[13,83,188,198,228,270,325],"the":[14,21,38,86,91,109,117,120,125,130,133,144,148,161,194,201,204,207,212,279,283,347,351],"action":[15],"of":[16,23,42,55,67,77,93,103,108,119,129,136,160,203,219,350],"several":[17],"protective":[18],"mechanisms.":[19],"While":[20],"survival":[22],"E.":[24,43,56,171,256,293],"under":[26,45,243,274,296],"growth-inhibitory":[27],"extreme":[28],"acid":[29,190,245],"stress":[30,246],"is":[31,35,268,300,315],"well":[32],"understood,":[33],"less":[34],"known":[36],"about":[37],"physiology":[39,281],"and":[40,100,174,247,258,286,310,314,338,355],"ecology":[41],"severe":[46],"but":[47,122],"growth-permissive":[48],"acidity.":[49,327],"Here,":[50],"we":[51,290],"observed":[52,166],"that":[53,292,304],"growth":[54,73,98,110,142,230,242,273,295],"MG1655":[58],"in":[59,90,151,183,206,231,240,282,319,335,346],"a":[60,64,70,216,301,323],"rich":[61],"medium":[62,205],"with":[63,155,211,361],"pH":[65,118,202],"value":[66],"4.1\u20134.4":[68],"exhibits":[69],"characteristic":[71],"multiphasic":[72,141],"pattern,":[74],"which":[75],"consists":[76],"an":[78,237],"initial":[79,126,149],"exponential":[80,104],"elongation,":[81],"up":[82],"10":[84],"times":[85],"normal":[87],"cell":[88,94,127,152,162,308,320],"length,":[89],"absence":[92],"division,":[95],"followed":[96],"by":[97,278,317],"arrest":[99,111],"subsequent":[101],"resumption":[102],"growth.":[105],"The":[106],"duration":[107],"phase":[112],"was":[113,164],"strongly":[114],"dependent":[115],"on":[116,124,307,311],"medium,":[121],"also":[123,165,357],"density":[128,309],"culture,":[131],"suggesting":[132],"collective":[134,213,234,302,329],"nature":[135],"this":[137],"phenomenon.":[138],"Cell":[139],"density-dependent":[140,208],"at":[143],"near-lethal":[145,244,297],"pH,":[146],"increase":[150,182],"volume":[153,184],"associated":[154],"either":[156],"elongation":[157],"or":[158],"widening":[159],"body,":[163],"for":[167,175,265,343,358],"all":[168],"tested":[169],"natural":[170],"isolates":[173,261],"Salmonella":[176],"enterica":[177],"serovar":[178],"Typhimurium.":[179],"A":[180],"transient":[181],"apparently":[185],"enables":[186,331],"bacteria":[187,334],"induce":[189],"resistance":[191],"systems,":[192],"primarily":[193],"lysine-dependent":[195],"Cad":[196],"system,":[197],"subsequently":[199],"modify":[200],"manner.":[209],"Consistent":[210],"recovery,":[214],"even":[215],"minor":[217],"fraction":[218],"acid-tolerant":[220],"cells":[221],"could":[222],"cross-protect":[223],"acid-sensitive":[224],"cells,":[225],"enabling":[226],"them":[227],"resume":[229],"coculture.":[232],"Thus,":[233],"dynamics":[235],"plays":[236],"important":[238,250,269],"role":[239],"bacterial":[241],"has":[248],"potentially":[249],"ecological":[251],"consequences.":[252],"IMPORTANCE":[253],"Since":[254],"many":[255],"other":[259],"Enterobacteriaceae":[260],"are":[262],"gastrointestinal":[263,353],"pathogens":[264],"humans,":[266],"it":[267,339],"understand":[271],"their":[272,359],"imposed":[277],"host":[280],"stomach,":[284],"colon,":[285],"inside":[287],"macrophages.":[288],"Here":[289],"show":[291],"phenomenon":[303],"critically":[305],"depends":[306],"acid-resistance":[312],"systems":[313],"favored":[316],"changes":[318],"morphology":[321],"as":[322],"response":[324],"high":[326],"This":[328],"behavior":[330],"cross-protection":[332],"between":[333],"microbial":[336],"communities,":[337],"might":[340],"have":[341],"implications":[342],"pathogen":[344],"proliferation":[345],"environment":[349],"human":[352],"tract":[354],"possibly":[356],"interactions":[360],"immune":[362],"cells.":[363]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-09-23T00:00:00"}
