{"id":"https://openalex.org/W4414366339","doi":"https://doi.org/10.1158/2767-9764.30162547","title":"Figure 3 from Prognostic Impact of Immune-Related Adverse Events on Combination Immune Checkpoint/Tyrosine Kinase Inhibition for Metastatic Renal Cancer","display_name":"Figure 3 from Prognostic Impact of Immune-Related Adverse Events on Combination Immune Checkpoint/Tyrosine Kinase Inhibition for Metastatic Renal Cancer","publication_year":2025,"publication_date":"2025-09-19","ids":{"openalex":"https://openalex.org/W4414366339","doi":"https://doi.org/10.1158/2767-9764.30162547"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.30162547","doi":"https://doi.org/10.1158/2767-9764.30162547","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.30162547","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.30162547","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025066095","display_name":"Bunpei Isoda","orcid":"https://orcid.org/0009-0008-6483-3032","observed_orcids":["https://orcid.org/0009-0008-6483-3032"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bunpei Isoda","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-6483-3032","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069098509","display_name":"Masanobu Shiga","orcid":"https://orcid.org/0000-0001-8610-0149","observed_orcids":["https://orcid.org/0000-0001-8610-0149"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masanobu Shiga","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8610-0149","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003028689","display_name":"Shuya Kandori","orcid":"https://orcid.org/0000-0003-4621-8470","observed_orcids":["https://orcid.org/0000-0003-4621-8470"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuya Kandori","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4621-8470","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110113174","display_name":"Shigeru Takahashi","orcid":"https://orcid.org/0009-0001-5673-3559","observed_orcids":["https://orcid.org/0009-0001-5673-3559"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shota Takahashi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-5673-3559","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111247404","display_name":"Akifumi Omiya","orcid":"https://orcid.org/0009-0009-1397-9792","observed_orcids":["https://orcid.org/0009-0009-1397-9792"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akifumi Omiya","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-1397-9792","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069048786","display_name":"Tomoki Ishida","orcid":"https://orcid.org/0009-0009-1261-0766","observed_orcids":["https://orcid.org/0009-0009-1261-0766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomoki Ishida","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-1261-0766","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113280511","display_name":"Kotoe Matsuda","orcid":"https://orcid.org/0009-0004-6941-0750","observed_orcids":["https://orcid.org/0009-0004-6941-0750"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kotoe Matsuda","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-6941-0750","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006883712","display_name":"Hiromichi Sakurai","orcid":"https://orcid.org/0009-0004-1254-0001","observed_orcids":["https://orcid.org/0009-0004-1254-0001"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiromichi Sakurai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-1254-0001","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042897629","display_name":"Bryan James Mathis","orcid":"https://orcid.org/0000-0002-9879-8289","observed_orcids":["https://orcid.org/0000-0002-9879-8289"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bryan J. Mathis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9879-8289","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ken Tanaka","orcid":"https://orcid.org/0000-0003-4350-4156","observed_orcids":["https://orcid.org/0000-0003-4350-4156"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ken Tanaka","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4350-4156","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077668498","display_name":"Manabu Komine","orcid":"https://orcid.org/0009-0005-5184-1250","observed_orcids":["https://orcid.org/0009-0005-5184-1250"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manabu Komine","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-5184-1250","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075529362","display_name":"Masahiro Iinuma","orcid":"https://orcid.org/0000-0003-1777-1525","observed_orcids":["https://orcid.org/0000-0003-1777-1525"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masahiro Iinuma","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1777-1525","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069020781","display_name":"Akira Joraku","orcid":"https://orcid.org/0000-0001-8589-9737","observed_orcids":["https://orcid.org/0000-0001-8589-9737"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akira Joraku","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8589-9737","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027612764","display_name":"Hiromitsu Negoro","orcid":"https://orcid.org/0000-0003-1144-2755","observed_orcids":["https://orcid.org/0000-0003-1144-2755"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiromitsu Negoro","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1144-2755","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Masakazu Tsutsumi","orcid":"https://orcid.org/0009-0000-6556-2862","observed_orcids":["https://orcid.org/0009-0000-6556-2862"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masakazu Tsutsumi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-6556-2862","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059104414","display_name":"Takamitsu Inoue","orcid":"https://orcid.org/0000-0002-1362-4344","observed_orcids":["https://orcid.org/0000-0002-1362-4344"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takamitsu Inoue","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1362-4344","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114376114","display_name":"Jun Miyazaki","orcid":"https://orcid.org/0000-0002-3618-0432","observed_orcids":["https://orcid.org/0000-0002-3618-0432"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Miyazaki","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3618-0432","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5071455815","display_name":"Hiroyuki Nishiyama","orcid":"https://orcid.org/0000-0001-7423-596X","observed_orcids":["https://orcid.org/0000-0001-7423-596X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroyuki Nishiyama","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7423-596X","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6538000106811523,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.6538000106811523,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.3393999934196472,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.9559999704360962},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.996999979019165},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.781000018119812},{"id":"https://openalex.org/keywords/metastatic-renal-cell-carcinoma","display_name":"metastatic renal cell carcinoma","score":0.949999988079071},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9409999847412109},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":1.0},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9049999713897705},{"id":"https://openalex.org/keywords/kaplan-meier-curves","display_name":"Kaplan-Meier curves","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8672999739646912},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6743000149726868},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6345000267028809},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6075999736785889},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5871000289916992},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49810001254081726},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.4731999933719635},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.384799987077713},{"id":"https://openalex.org/C2993493390","wikidata":"https://www.wikidata.org/wiki/Q5453208","display_name":"First line","level":2,"score":0.3790000081062317},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.364300012588501},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.3359000086784363},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.29030001163482666},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.2757999897003174},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2538999915122986},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2522999942302704}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2767-9764.30162547","doi":"https://doi.org/10.1158/2767-9764.30162547","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.30162547","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.30162547","doi":"https://doi.org/10.1158/2767-9764.30162547","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.30162547","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4414366331","https://openalex.org/W4414366332","https://openalex.org/W4414366328","https://openalex.org/W4414366321","https://openalex.org/W4414016993","https://openalex.org/W4414366356","https://openalex.org/W4414366357","https://openalex.org/W4400722689","https://openalex.org/W4367680192","https://openalex.org/W4312196108"],"abstract_inverted_index":{"Survival":[0],"outcomes":[1],"and":[2,17,31,43,58],"multivariable":[3],"analysis":[4,24,55],"of":[5,21,56,60],"prognostic":[6],"factors":[7],"in":[8],"the":[9,27,38,44,48,61],"ICI\u2013TKI":[10,28,62],"group.":[11,63],"A,":[12],"Kaplan\u2013Meier":[13],"curves":[14],"for":[15],"OS":[16,57],"PFS.":[18],"The":[19,34],"results":[20],"a":[22],"survival":[23],"conducted":[25],"on":[26],"group":[29,40,50],"with":[30,51],"without":[32,41],"irAEs.":[33,52],"red":[35],"line":[36,46],"represents":[37,47],"patient":[39,49],"irAEs,":[42],"blue":[45],"B,":[53],"Multivariable":[54],"PFS":[59],"NA,":[64],"not":[65],"available.":[66]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-10-10T00:00:00"}
