{"id":"https://openalex.org/W4414291069","doi":"https://doi.org/10.55563/clinexprheumatol/7sz0zp","title":"Avacopan with combined cyclophosphamide and rituximab for induction therapy in severe ANCA-associated vasculitis: retrospective observational study of 30 patients in two German referral centres","display_name":"Avacopan with combined cyclophosphamide and rituximab for induction therapy in severe ANCA-associated vasculitis: retrospective observational study of 30 patients in two German referral centres","publication_year":2024,"publication_date":"2024-12-05","ids":{"openalex":"https://openalex.org/W4414291069","doi":"https://doi.org/10.55563/clinexprheumatol/7sz0zp","pmid":"https://pubmed.ncbi.nlm.nih.gov/40964814"},"language":"en","primary_location":{"id":"doi:10.55563/clinexprheumatol/7sz0zp","doi":"https://doi.org/10.55563/clinexprheumatol/7sz0zp","is_oa":true,"landing_page_url":"https://doi.org/10.55563/clinexprheumatol/7sz0zp","pdf_url":"https://www.clinexprheumatol.org/article.asp?a=21987","source":{"id":"https://openalex.org/S165438840","display_name":"Clinical and Experimental Rheumatology","issn_l":"0392-856X","issn":["0392-856X","1593-098X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321666","host_organization_name":"Springer Vienna","host_organization_lineage":["https://openalex.org/P4310321666","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Vienna","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.clinexprheumatol.org/article.asp?a=21987","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043709743","display_name":"Gunter Assmann","orcid":"https://orcid.org/0000-0002-3216-9340","observed_orcids":["https://orcid.org/0000-0002-3216-9340"]},"institutions":[{"id":"https://openalex.org/I4210162969","display_name":"Johannes Wesling Klinikum Minden","ror":"https://ror.org/05d89kr76","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210162969"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gunter Assmann","raw_affiliation_strings":["Department of Rheumatology, RUB University Hospital Minden JWK, Minden; and Jose-Carreras Centre for Immunogenetics and Gene Therapy, University Medical School of Saarland, Germany. gunter.assmann@muehlenkreiskliniken.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, RUB University Hospital Minden JWK, Minden; and Jose-Carreras Centre for Immunogenetics and Gene Therapy, University Medical School of Saarland, Germany. gunter.assmann@muehlenkreiskliniken.de","institution_ids":["https://openalex.org/I4210162969","https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060168070","display_name":"El\u2010Baraa Adjailia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"El-Baraa Adjailia","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, University of Luebeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, University of Luebeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065777204","display_name":"Sebastian Klapa","orcid":"https://orcid.org/0000-0002-0012-0163","observed_orcids":["https://orcid.org/0000-0002-0012-0163"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Klapa","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, University of Luebeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, University of Luebeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092114059","display_name":"Katja von Allw\u00f6rden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katja von Allwoerden","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, University of Luebeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, University of Luebeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051985691","display_name":"Kerstin Amann","orcid":"https://orcid.org/0000-0001-6116-8315","observed_orcids":["https://orcid.org/0000-0001-6116-8315"]},"institutions":[{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kerstin Amann","raw_affiliation_strings":["Department of Nephropathology, University Hospital of Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephropathology, University Hospital of Erlangen, Germany","institution_ids":["https://openalex.org/I4210088053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074896956","display_name":"Ryszard Turkiewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162969","display_name":"Johannes Wesling Klinikum Minden","ror":"https://ror.org/05d89kr76","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210162969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ryszard Turkiewicz","raw_affiliation_strings":["Department of Pulmonology, RUB University Hospital Minden JWK, Minden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology, RUB University Hospital Minden JWK, Minden, Germany","institution_ids":["https://openalex.org/I4210162969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111977250","display_name":"J. Radermacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162969","display_name":"Johannes Wesling Klinikum Minden","ror":"https://ror.org/05d89kr76","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799784675","https://openalex.org/I4210162969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joerg Radermacher","raw_affiliation_strings":["Department of Nephrology, RUB University Hospital Minden JWK, Minden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, RUB University Hospital Minden JWK, Minden, Germany","institution_ids":["https://openalex.org/I4210162969"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034748843","display_name":"Peter Lamprecht","orcid":"https://orcid.org/0000-0001-5929-868X","observed_orcids":["https://orcid.org/0000-0001-5929-868X"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Lamprecht","raw_affiliation_strings":["Department of Rheumatology and Clinical Immunology, University of Luebeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Clinical Immunology, University of Luebeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5103,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.69248072,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"44","issue":"4","first_page":"670","last_page":"677"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/avacopan","display_name":"avacopan","score":0.996999979019165},{"id":"https://openalex.org/keywords/anca-associated-vasculitis","display_name":"ANCA-associated vasculitis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":1.0},{"id":"https://openalex.org/keywords/induction-therapy","display_name":"induction therapy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/complement-c5a-receptor-inhibition","display_name":"complement C5a receptor inhibition","score":0.8759999871253967},{"id":"https://openalex.org/keywords/steroid-sparing-therapy","display_name":"steroid-sparing therapy","score":0.8820000290870667},{"id":"https://openalex.org/keywords/remission-induction","display_name":"remission induction","score":0.8790000081062317},{"id":"https://openalex.org/keywords/renal-involvement","display_name":"renal involvement","score":0.8059999942779541},{"id":"https://openalex.org/keywords/dialysis-dependence","display_name":"dialysis dependence","score":0.7919999957084656},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9842000007629395},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.8360000252723694},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.8115000128746033},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.6348999738693237},{"id":"https://openalex.org/C2991767035","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Induction therapy","level":3,"score":0.5892999768257141},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5449000000953674},{"id":"https://openalex.org/C154775046","wikidata":"https://www.wikidata.org/wiki/Q188","display_name":"German","level":2,"score":0.5224999785423279},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4472000002861023},{"id":"https://openalex.org/C2776135927","wikidata":"https://www.wikidata.org/wiki/Q5242559","display_name":"Referral","level":2,"score":0.44339999556541443},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.43470001220703125},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.38100001215934753},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.31929999589920044},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.31520000100135803},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3109000027179718},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3109000027179718},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2703000009059906},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.2662999927997589},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.2614000141620636},{"id":"https://openalex.org/C2778283404","wikidata":"https://www.wikidata.org/wiki/Q6736822","display_name":"Maintenance therapy","level":3,"score":0.26100000739097595},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.2558000087738037}],"mesh":[{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005858","descriptor_name":"Germany","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005858","descriptor_name":"Germany","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056648","descriptor_name":"Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D056648","descriptor_name":"Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D056648","descriptor_name":"Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D056648","descriptor_name":"Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D056648","descriptor_name":"Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D056648","descriptor_name":"Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D060828","descriptor_name":"Induction Chemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060828","descriptor_name":"Induction Chemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.55563/clinexprheumatol/7sz0zp","doi":"https://doi.org/10.55563/clinexprheumatol/7sz0zp","is_oa":true,"landing_page_url":"https://doi.org/10.55563/clinexprheumatol/7sz0zp","pdf_url":"https://www.clinexprheumatol.org/article.asp?a=21987","source":{"id":"https://openalex.org/S165438840","display_name":"Clinical and Experimental Rheumatology","issn_l":"0392-856X","issn":["0392-856X","1593-098X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321666","host_organization_name":"Springer Vienna","host_organization_lineage":["https://openalex.org/P4310321666","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Vienna","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Rheumatology","raw_type":"journal-article"},{"id":"pmid:40964814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40964814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.55563/clinexprheumatol/7sz0zp","doi":"https://doi.org/10.55563/clinexprheumatol/7sz0zp","is_oa":true,"landing_page_url":"https://doi.org/10.55563/clinexprheumatol/7sz0zp","pdf_url":"https://www.clinexprheumatol.org/article.asp?a=21987","source":{"id":"https://openalex.org/S165438840","display_name":"Clinical and Experimental Rheumatology","issn_l":"0392-856X","issn":["0392-856X","1593-098X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321666","host_organization_name":"Springer Vienna","host_organization_lineage":["https://openalex.org/P4310321666","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Vienna","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Experimental Rheumatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320323901","display_name":"Bundesministerium der Verteidigung","ror":"https://ror.org/03g7eh380"},{"id":"https://openalex.org/F4320323906","display_name":"Vifor Pharma","ror":"https://ror.org/0185z7g17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414291069.pdf","grobid_xml":"https://content.openalex.org/works/W4414291069.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"OBJECTIVES:":[0],"Combination":[1],"therapy":[2],"of":[3,15,34,59,67,147,157,184,239,249],"rituximab":[4],"(RTX)":[5],"and":[6,32,52,65,73,84,154,211,217,237,245],"cyclophosphamide":[7],"(CYC)":[8],"can":[9],"be":[10],"considered":[11],"for":[12,219,247],"the":[13,30,35,43,60,235],"induction":[14,221],"remission":[16,110,220],"in":[17,42,54,69,75,92,145,155,181,213,222,241],"severe":[18,46,79,223],"anti-neutrophil":[19],"cytoplasmic":[20],"antibody":[21],"(ANCA)-associated":[22],"vasculitis":[23,48,81],"(AAV).":[24],"The":[25,98],"presented":[26],"study":[27],"reports":[28],"on":[29],"safety":[31,66,238],"efficacy":[33,236],"complement":[36],"C5a":[37],"receptor":[38],"inhibition":[39],"with":[40,45,50,71,78,82,215,243],"avacopan":[41,68,166,205,240],"patients":[44,77,108,150,186,189],"ANCA-associated":[47,80,224],"treated":[49,91],"RTX":[51,72,216,244],"CYC":[53,74,218,246],"combination.":[55],"METHODS:":[56],"Retrospective":[57],"analysis":[58],"clinical":[61],"course,":[62],"response":[63],"to":[64,133,169,173,233],"combination":[70,214,242],"30":[76],"renal":[83],"at":[85,121,131,190],"least":[86],"two":[87,93],"further":[88],"organ-threatening":[89],"involvement":[90],"German":[94],"referral":[95],"centres.":[96],"RESULTS:":[97],"median":[99],"observation":[100],"time":[101],"was":[102,117,143,177],"49":[103],"weeks":[104],"(range":[105,119],"26-52).":[106],"All":[107],"achieved":[109],"by":[111,138,151,160],"week":[112,139,152,161,191],"24.":[113],"Mean":[114],"BVAS":[115],"score":[116],"22.8":[118],"12-53)":[120],"baseline;":[122],"mean":[123],"eGFR":[124],"increased":[125],"from":[126],"44.0":[127],"ml/min":[128,135],"per":[129,136],"1.73m2":[130,137],"baseline":[132],"57.6":[134],"52.":[140,162],"GC":[141],"comedication":[142],"discontinued":[144,165],"17":[146],"29":[148],"(58.6%)":[149],"24,":[153],"23":[156],"28":[158],"(82.1%)":[159],"One":[163],"patient":[164],"treatment":[167],"due":[168,172],"urosepsis,":[170],"another":[171],"refractory":[174],"disease.":[175],"There":[176],"a":[178,250],"significant":[179],"difference":[180],"dialysis":[182],"dependency":[183],"GC-free":[185],"versus":[187],"GC-treated":[188],"24":[192],"(n=1":[193],"vs.":[194],"4,":[195],"p=0.048,":[196],"OR":[197],"0.12,":[198],"CI:0.01-1.25).":[199],"CONCLUSIONS:":[200],"In":[201,226],"this":[202,227],"observational":[203],"study,":[204],"as":[206],"GC-sparing":[207,251],"agent":[208],"appeared":[209],"safe":[210],"efficacious":[212],"vasculitis.":[225],"subgroup,":[228],"prospective":[229],"studies":[230],"are":[231],"needed":[232],"determine":[234],"guidance":[248],"strategy.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
