{"id":"https://openalex.org/W4414220199","doi":"https://doi.org/10.7783/kjmcs.2025.33.4.244","title":"Anti-adipogenic and Lipid-modulating Effect of Tanshinone IIA-Enriched Salviamiltiorrhiza Extract in 3T3-L1 Cells and a P-407-induced Dyslipidemic Mouse Model","display_name":"Anti-adipogenic and Lipid-modulating Effect of Tanshinone IIA-Enriched Salviamiltiorrhiza Extract in 3T3-L1 Cells and a P-407-induced Dyslipidemic Mouse Model","publication_year":2025,"publication_date":"2025-08-31","ids":{"openalex":"https://openalex.org/W4414220199","doi":"https://doi.org/10.7783/kjmcs.2025.33.4.244"},"language":"en","primary_location":{"id":"doi:10.7783/kjmcs.2025.33.4.244","doi":"https://doi.org/10.7783/kjmcs.2025.33.4.244","is_oa":false,"landing_page_url":"https://doi.org/10.7783/kjmcs.2025.33.4.244","pdf_url":null,"source":{"id":"https://openalex.org/S2911370914","display_name":"Korean Journal of Medicinal Crop Science","issn_l":"1225-9306","issn":["1225-9306","2288-0186"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4362643794","host_organization_name":"Korean Society of Medicinal Crop Science","host_organization_lineage":["https://openalex.org/P4362643794"],"host_organization_lineage_names":["Korean Society of Medicinal Crop Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Medicinal Crop Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ye Rim Shin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ye Rim Shin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001035895","display_name":"Sohee Jang","orcid":"https://orcid.org/0000-0001-8579-5719","observed_orcids":["https://orcid.org/0000-0001-8579-5719"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"So Hee Jang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074661510","display_name":"Byeong Ryeol Ryu","orcid":"https://orcid.org/0000-0002-1949-0156","observed_orcids":["https://orcid.org/0000-0002-1949-0156"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Byeong Ryeol Ryu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074200743","display_name":"Minji Kang","orcid":"https://orcid.org/0000-0003-0015-7430","observed_orcids":["https://orcid.org/0000-0003-0015-7430"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Ji Kang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100406595","display_name":"Minjun Kim","orcid":"https://orcid.org/0000-0002-0165-5282","observed_orcids":["https://orcid.org/0000-0002-0165-5282"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Jun Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102790598","display_name":"Eun\u2010Hwa Sohn","orcid":"https://orcid.org/0000-0003-0084-6586","observed_orcids":["https://orcid.org/0000-0003-0084-6586"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eun Hwa Sohn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049843579","display_name":"Jung Dae Lim","orcid":"https://orcid.org/0000-0002-5668-3432","observed_orcids":["https://orcid.org/0000-0002-5668-3432"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jung Dae Lim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29685096,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"4","first_page":"244","last_page":"255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13651","display_name":"Medicinal Plants and Bioactive Compounds","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tanshinone-iia","display_name":"tanshinone IIA","score":0.9940000176429749},{"id":"https://openalex.org/keywords/salvia-miltiorrhiza","display_name":"Salvia miltiorrhiza","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cloud-point-extraction","display_name":"cloud point extraction","score":0.9399999976158142},{"id":"https://openalex.org/keywords/anti-adipogenic-effect","display_name":"anti-adipogenic effect","score":0.859000027179718},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.5109999775886536},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.8240000009536743},{"id":"https://openalex.org/keywords/serum-triglycerides","display_name":"serum triglycerides","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.49799999594688416},{"id":"https://openalex.org/keywords/3t3-l1-preadipocytes","display_name":"3T3-L1 preadipocytes","score":0.9269999861717224},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.39500001072883606},{"id":"https://openalex.org/keywords/lipophilic-bioactive-compounds","display_name":"lipophilic bioactive compounds","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C2776332195","wikidata":"https://www.wikidata.org/wiki/Q1000854","display_name":"Salvia miltiorrhiza","level":4,"score":0.8431000113487244},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7235000133514404},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6983000040054321},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5407999753952026},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.44530001282691956},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.4277999997138977},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.40880000591278076},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.3846000134944916},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.3391999900341034},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3359000086784363},{"id":"https://openalex.org/C2780541478","wikidata":"https://www.wikidata.org/wiki/Q410020","display_name":"High-density lipoprotein","level":3,"score":0.3269999921321869},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.31279999017715454},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.3028999865055084},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.29179999232292175},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.29159998893737793},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.29030001163482666},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.2840000092983246},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2816999852657318},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2590000033378601},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.2578999996185303}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7783/kjmcs.2025.33.4.244","doi":"https://doi.org/10.7783/kjmcs.2025.33.4.244","is_oa":false,"landing_page_url":"https://doi.org/10.7783/kjmcs.2025.33.4.244","pdf_url":null,"source":{"id":"https://openalex.org/S2911370914","display_name":"Korean Journal of Medicinal Crop Science","issn_l":"1225-9306","issn":["1225-9306","2288-0186"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4362643794","host_organization_name":"Korean Society of Medicinal Crop Science","host_organization_lineage":["https://openalex.org/P4362643794"],"host_organization_lineage_names":["Korean Society of Medicinal Crop Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Medicinal Crop Science","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1969209081","https://openalex.org/W1985978432","https://openalex.org/W2002420834","https://openalex.org/W2020476431","https://openalex.org/W2025236117","https://openalex.org/W2032367651","https://openalex.org/W2035284209","https://openalex.org/W2039470592","https://openalex.org/W2042259482","https://openalex.org/W2058736844","https://openalex.org/W2090477760","https://openalex.org/W2094530181","https://openalex.org/W2104022273","https://openalex.org/W2104608518","https://openalex.org/W2120779865","https://openalex.org/W2128677082","https://openalex.org/W2137721964","https://openalex.org/W2154066769","https://openalex.org/W2232647672","https://openalex.org/W2252031101","https://openalex.org/W2340699148","https://openalex.org/W2466598932","https://openalex.org/W2749975732","https://openalex.org/W2760106690","https://openalex.org/W2907054749","https://openalex.org/W2936944023","https://openalex.org/W2974251680","https://openalex.org/W2998953838","https://openalex.org/W3011747422","https://openalex.org/W3096697022","https://openalex.org/W3174838504","https://openalex.org/W3213994487","https://openalex.org/W4288454780","https://openalex.org/W4309315201","https://openalex.org/W4311451027","https://openalex.org/W4381889694","https://openalex.org/W4385185910","https://openalex.org/W4386420853","https://openalex.org/W4396874092","https://openalex.org/W4400605891"],"related_works":[],"abstract_inverted_index":{"Background:":[0],"This":[1],"study":[2],"aimed":[3],"to":[4,29,76,83,91,172],"evaluate":[5],"the":[6,31,54,92,232],"anti-adipogenic":[7,200],"and":[8,38,112,170,183,201,207],"lipid-modulating":[9],"effects":[10,203],"of":[11,33,95,150,153,167,174,235],"tanshinone":[12],"IIA":[13,52,63,132,176],"(Tan":[14],"IIA)-enriched":[15],"Salvia":[16],"miltiorrhiza":[17],"extract":[18,57],"(SM-CPE)":[19],"prepared":[20],"using":[21],"cloud-point":[22],"extraction":[23],"(CPE),":[24],"an":[25],"eco-friendly":[26],"method":[27],"designed":[28],"enhance":[30],"yield":[32],"hydrophobic":[34],"bioactive":[35,241],"compounds.":[36],"Methods":[37],"Results:":[39],"High-performance":[40],"liquid":[41],"chromatography":[42],"confirmed":[43],"that":[44,102,166,173],"SM-CPE":[45,81,103,154,178,197],"contained":[46],"approximately":[47],"35":[48],"times":[49],"more":[50,163],"Tan":[51,62,96,131,175,208,245],"than":[53,164],"conventional":[55],"water":[56],"(SMW).":[58],"In":[59,79,119,142],"3T3-L1":[60],"preadipocytes,":[61],"showed":[64,122],"cytotoxicity":[65,85],"at":[66,109,116,127,139],"concentrations":[67],"\u2265":[68],"5":[69],"\u03bcM,":[70],"while":[71,130],"SMW":[72,121,168,206],"was":[73,162],"non-cytotoxic":[74],"up":[75],"200":[77,87,117,128],"\u338d/\u3396.":[78,118],"contrast,":[80],"began":[82],"show":[84],"from":[86],"\u338d/\u3396,":[88],"likely":[89],"due":[90],"high":[93],"concentration":[94],"IIA.":[97,246],"An":[98],"adipogenesis":[99],"assay":[100],"revealed":[101],"inhibited":[104],"lipid":[105],"accumulation":[106],"by":[107,113,159,238],"17.6%":[108],"100":[110],"\u338d/\u3396":[111],"81.0%":[114],"inhibition":[115,125],"comparison,":[120],"relatively":[123],"weak":[124],"(19.9%":[126],"\u338d/\u3396),":[129],"exhibited":[133],"a":[134,143,214,227],"dose-dependent":[135],"inhibition,":[136],"reaching":[137],"64.4%":[138],"20":[140],"\u03bcM.":[141],"P-407-induced":[144],"dyslipidemic":[145],"mouse":[146],"model,":[147],"14":[148],"days":[149],"oral":[151],"administration":[152],"significantly":[155],"reduced":[156],"serum":[157],"triglycerides":[158],"54.2%,":[160],"which":[161],"double":[165],"(23.9%)":[169],"similar":[171],"(65.6%).":[177],"also":[179],"lowered":[180],"total":[181],"cholesterol":[182],"low-density":[184],"lipoprotein":[185],"levels,":[186],"whereas":[187],"HDL":[188],"levels":[189],"increased":[190],"slightly,":[191],"although":[192],"not":[193],"statistically":[194],"significant.":[195],"Conclusions:":[196],"demonstrated":[198],"superior":[199],"lipid-lowering":[202],"compared":[204],"with":[205],"IIA,":[209],"supporting":[210],"its":[211],"potential":[212],"as":[213,223,244],"natural":[215],"agent":[216],"for":[217,230],"treating":[218],"obesity-related":[219],"metabolic":[220],"disorders,":[221],"such":[222,243],"dyslipidemia.":[224],"CPE":[225],"offers":[226],"practical":[228],"strategy":[229],"enhancing":[231],"functional":[233],"efficacy":[234],"herbal":[236],"extracts":[237],"concentrating":[239],"lipophilic":[240],"compounds":[242]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}
