{"id":"https://openalex.org/W4414215580","doi":"https://doi.org/10.1051/bioconf/202518703004","title":"Ultrasound-Assisted Extraction of Antioxidants and Neuroprotective Compounds from Banana Flowers via Simplex-Centroid Solvent Optimization","display_name":"Ultrasound-Assisted Extraction of Antioxidants and Neuroprotective Compounds from Banana Flowers via Simplex-Centroid Solvent Optimization","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4414215580","doi":"https://doi.org/10.1051/bioconf/202518703004"},"language":"en","primary_location":{"id":"doi:10.1051/bioconf/202518703004","doi":"https://doi.org/10.1051/bioconf/202518703004","is_oa":true,"landing_page_url":"https://doi.org/10.1051/bioconf/202518703004","pdf_url":null,"source":{"id":"https://openalex.org/S4210168758","display_name":"BIO Web of Conferences","issn_l":"2117-4458","issn":["2117-4458","2273-1709"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1"],"host_organization":"https://openalex.org/P4310319748","host_organization_name":"EDP Sciences","host_organization_lineage":["https://openalex.org/P4310319748","https://openalex.org/P4310319982"],"host_organization_lineage_names":["EDP Sciences","Science Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BIO Web of Conferences","raw_type":"journal-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1051/bioconf/202518703004","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089308517","display_name":"Nurul Mutmainah Diah Oktaviani","orcid":"https://orcid.org/0000-0002-7025-0481","observed_orcids":["https://orcid.org/0000-0002-7025-0481"]},"institutions":[{"id":"https://openalex.org/I165230279","display_name":"Universitas Gadjah Mada","ror":"https://ror.org/03ke6d638","country_code":"ID","type":"education","lineage":["https://openalex.org/I165230279"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Nurul Mutmainah Diah Oktaviani","raw_affiliation_strings":["Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Gadjah Mada University, Jalan Flora No. 1, Bulaksumur, Sleman, 55281, Yogyakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Gadjah Mada University, Jalan Flora No. 1, Bulaksumur, Sleman, 55281, Yogyakarta, Indonesia","institution_ids":["https://openalex.org/I165230279"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Umar Harun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165230279","display_name":"Universitas Gadjah Mada","ror":"https://ror.org/03ke6d638","country_code":"ID","type":"education","lineage":["https://openalex.org/I165230279"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"M. Umar Harun","raw_affiliation_strings":["Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Gadjah Mada University, Jalan Flora No. 1, Bulaksumur, Sleman, 55281, Yogyakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Gadjah Mada University, Jalan Flora No. 1, Bulaksumur, Sleman, 55281, Yogyakarta, Indonesia","institution_ids":["https://openalex.org/I165230279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066111681","display_name":"Viki Oktavirina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165230279","display_name":"Universitas Gadjah Mada","ror":"https://ror.org/03ke6d638","country_code":"ID","type":"education","lineage":["https://openalex.org/I165230279"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Viki Oktavirina","raw_affiliation_strings":["Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Gadjah Mada University, Jalan Flora No. 1, Bulaksumur, Sleman, 55281, Yogyakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Gadjah Mada University, Jalan Flora No. 1, Bulaksumur, Sleman, 55281, Yogyakarta, Indonesia","institution_ids":["https://openalex.org/I165230279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040543305","display_name":"Nadhila B. Prabawati","orcid":"https://orcid.org/0000-0003-2012-6420","observed_orcids":["https://orcid.org/0000-0003-2012-6420"]},"institutions":[{"id":"https://openalex.org/I165230279","display_name":"Universitas Gadjah Mada","ror":"https://ror.org/03ke6d638","country_code":"ID","type":"education","lineage":["https://openalex.org/I165230279"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Nadhila B Prabawati","raw_affiliation_strings":["Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Gadjah Mada University, Jalan Flora No. 1, Bulaksumur, Sleman, 55281, Yogyakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Gadjah Mada University, Jalan Flora No. 1, Bulaksumur, Sleman, 55281, Yogyakarta, Indonesia","institution_ids":["https://openalex.org/I165230279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042109529","display_name":"Manikharda Manikharda","orcid":"https://orcid.org/0000-0002-5916-0549","observed_orcids":["https://orcid.org/0000-0002-5916-0549"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manikharda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001299861","display_name":"Widiastuti Setyaningsih","orcid":"https://orcid.org/0000-0002-4316-8888","observed_orcids":["https://orcid.org/0000-0002-4316-8888"]},"institutions":[{"id":"https://openalex.org/I165230279","display_name":"Universitas Gadjah Mada","ror":"https://ror.org/03ke6d638","country_code":"ID","type":"education","lineage":["https://openalex.org/I165230279"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Widiastuti Setyaningsih","raw_affiliation_strings":["Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Gadjah Mada University, Jalan Flora No. 1, Bulaksumur, Sleman, 55281, Yogyakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Gadjah Mada University, Jalan Flora No. 1, Bulaksumur, Sleman, 55281, Yogyakarta, Indonesia","institution_ids":["https://openalex.org/I165230279"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047824689","display_name":"Miguel Palma","orcid":"https://orcid.org/0000-0001-8509-4226","observed_orcids":["https://orcid.org/0000-0001-8509-4226"]},"institutions":[{"id":"https://openalex.org/I39147953","display_name":"Universidad de C\u00e1diz","ror":"https://ror.org/04mxxkb11","country_code":"ES","type":"education","lineage":["https://openalex.org/I39147953"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel Palma","raw_affiliation_strings":["Department of Analytical Chemistry, Faculty of Science, IVAGRO, University of Cadiz, Campus de Excelencia Internacional Agroalimentario (CeiA3), Campus del Rio San Pedro, 11510 Puerto Real, Cadiz, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Analytical Chemistry, Faculty of Science, IVAGRO, University of Cadiz, Campus de Excelencia Internacional Agroalimentario (CeiA3), Campus del Rio San Pedro, 11510 Puerto Real, Cadiz, Spain","institution_ids":["https://openalex.org/I39147953"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21527778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"187","issue":null,"first_page":"03004","last_page":"03004"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12181","display_name":"Agricultural and Biological Research","score":0.05999999865889549,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/banana-flower","display_name":"banana flower","score":0.8109999895095825},{"id":"https://openalex.org/keywords/ultrasound-assisted-extraction","display_name":"ultrasound-assisted extraction","score":0.8970000147819519},{"id":"https://openalex.org/keywords/solvent-optimization","display_name":"solvent optimization","score":0.7879999876022339},{"id":"https://openalex.org/keywords/simplex-centroid-design","display_name":"simplex centroid design","score":0.9139999747276306},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9670000076293945},{"id":"https://openalex.org/keywords/phenolic-acids","display_name":"phenolic acids","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tryptophan","display_name":"tryptophan","score":0.8059999942779541},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":1.0},{"id":"https://openalex.org/keywords/neuroprotective-compounds","display_name":"neuroprotective compounds","score":0.9070000052452087},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.8820000290870667},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.7156000137329102},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6952000260353088},{"id":"https://openalex.org/C17857428","wikidata":"https://www.wikidata.org/wiki/Q533025","display_name":"Nutraceutical","level":2,"score":0.6725000143051147},{"id":"https://openalex.org/C2779383672","wikidata":"https://www.wikidata.org/wiki/Q408428","display_name":"Syringic acid","level":4,"score":0.6365000009536743},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.5759999752044678},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5551999807357788},{"id":"https://openalex.org/C2777725935","wikidata":"https://www.wikidata.org/wiki/Q3733583","display_name":"Accelerated solvent extraction","level":3,"score":0.49300000071525574},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.43470001220703125},{"id":"https://openalex.org/C2777728882","wikidata":"https://www.wikidata.org/wiki/Q407142","display_name":"Phenols","level":2,"score":0.3788999915122986},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.33340001106262207},{"id":"https://openalex.org/C81426234","wikidata":"https://www.wikidata.org/wiki/Q1408763","display_name":"Solid phase extraction","level":3,"score":0.31790000200271606},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.30709999799728394},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.26930001378059387},{"id":"https://openalex.org/C2778778762","wikidata":"https://www.wikidata.org/wiki/Q419836","display_name":"Phenolic acid","level":3,"score":0.26829999685287476},{"id":"https://openalex.org/C2992805683","wikidata":"https://www.wikidata.org/wiki/Q866399","display_name":"Solvent extraction","level":3,"score":0.2653999924659729}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1051/bioconf/202518703004","doi":"https://doi.org/10.1051/bioconf/202518703004","is_oa":true,"landing_page_url":"https://doi.org/10.1051/bioconf/202518703004","pdf_url":null,"source":{"id":"https://openalex.org/S4210168758","display_name":"BIO Web of Conferences","issn_l":"2117-4458","issn":["2117-4458","2273-1709"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1"],"host_organization":"https://openalex.org/P4310319748","host_organization_name":"EDP Sciences","host_organization_lineage":["https://openalex.org/P4310319748","https://openalex.org/P4310319982"],"host_organization_lineage_names":["EDP Sciences","Science Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BIO Web of Conferences","raw_type":"journal-article"},{"id":"pmh:oai:rodin.uca.es:10498/39374","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10498/39374","pdf_url":"https://rodin.uca.es/bitstream/10498/39374/1/bioconf_isph-isnpr2025_03004.pdf","source":{"id":"https://openalex.org/S4306400506","display_name":"RODIN (Universidad de C\u00e1diz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39147953","host_organization_name":"Universidad de C\u00e1diz","host_organization_lineage":["https://openalex.org/I39147953"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BIO Web of Conferences 2025, Vol. 187, 03004","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:88aa394618ba4165a59627bd146209f8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/88aa394618ba4165a59627bd146209f8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BIO Web of Conferences, Vol 187, p 03004 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1051/bioconf/202518703004","doi":"https://doi.org/10.1051/bioconf/202518703004","is_oa":true,"landing_page_url":"https://doi.org/10.1051/bioconf/202518703004","pdf_url":null,"source":{"id":"https://openalex.org/S4210168758","display_name":"BIO Web of Conferences","issn_l":"2117-4458","issn":["2117-4458","2273-1709"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1"],"host_organization":"https://openalex.org/P4310319748","host_organization_name":"EDP Sciences","host_organization_lineage":["https://openalex.org/P4310319748","https://openalex.org/P4310319982"],"host_organization_lineage_names":["EDP Sciences","Science Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BIO Web of Conferences","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W2044380869","https://openalex.org/W2146217077","https://openalex.org/W2165875059","https://openalex.org/W2936082691","https://openalex.org/W2970222036","https://openalex.org/W3026833994","https://openalex.org/W3082115983","https://openalex.org/W3115653194","https://openalex.org/W3157470701","https://openalex.org/W3193063948","https://openalex.org/W4289174576","https://openalex.org/W4292553119","https://openalex.org/W4313405078","https://openalex.org/W4388833076","https://openalex.org/W4389977596","https://openalex.org/W4391544552","https://openalex.org/W4399480340","https://openalex.org/W4403221652"],"related_works":[],"abstract_inverted_index":{"Banana":[0],"(Musa":[1],"paradisiaca)":[2],"flowers":[3],"are":[4],"rich":[5],"in":[6,53,73,133,182],"bioactive":[7,57,176],"compounds":[8,58,118],"with":[9,40,56,65,78],"antioxidant,":[10],"anti-inflammatory,":[11],"and":[12,24,33,50,96,104,110,113,120,185],"neuroprotective":[13,29,117],"potential.":[14],"This":[15],"study":[16],"optimized":[17],"the":[18,139,156,165],"extraction":[19,37],"of":[20],"flavonoids,":[21],"phenolic":[22,102],"acids,":[23],"aldehyde,":[25,107],"as":[26,28],"well":[27],"compounds,":[30,177],"specifically":[31],"tryptophan":[32],"serotonin,":[34],"using":[35],"ultrasound-assisted":[36],"(UAE)":[38],"coupled":[39,64],"a":[41,170],"simplex-centroid":[42],"solvent":[43,87,157],"mixture":[44],"design.":[45],"Four":[46],"solvents\u2014water,":[47],"methanol,":[48],"ethanol,":[49],"acetonitrile\u2014were":[51],"evaluated":[52],"15":[54],"combinations,":[55],"quantified":[59],"via":[60],"Ultra-Performance":[61],"Liquid":[62],"Chromatography":[63],"Photodiode":[66],"Array":[67],"detection.":[68],"The":[69],"quadratic":[70],"model":[71],"used":[72],"optimization":[74,150],"achieved":[75],"high":[76],"regression,":[77],"R\u00b2":[79],"values":[80],"ranging":[81],"from":[82],"91":[83],"to":[84,141],"98%.":[85],"Optimal":[86],"ratios":[88],"were":[89],"water:acetonitrile":[90,114],"(51:49)":[91],"for":[92,101,116,145,174],"flavonoids":[93],"(hesperidin,":[94],"quercetin-3-glucoside,":[95],"epigallocatechin":[97],"gallate),":[98],"water:methanol:ethanol":[99],"(32:63:5)":[100],"acids":[103],"aldehyde":[105],"(protocatechuic":[106],"syringic":[108],"acid,":[109],"isoferulic":[111],"acid),":[112],"(84:16)":[115],"(tryptophan":[119],"serotonin).":[121],"Quantification":[122],"was":[123,151],"conducted":[124],"across":[125,162],"seven":[126],"banana":[127],"flower":[128],"varieties,":[129],"revealing":[130],"substantial":[131],"differences":[132],"compound":[134],"levels.":[135],"These":[136],"variations":[137],"suggest":[138],"potential":[140,180],"select":[142],"superior":[143],"varieties":[144],"targeted":[146],"functional":[147],"uses.":[148],"While":[149],"based":[152],"on":[153],"pooled":[154],"data,":[155],"system":[158],"is":[159],"broadly":[160],"applicable":[161],"cultivars.":[163],"Overall,":[164],"developed":[166],"UAE":[167],"method":[168],"provides":[169],"high-efficiency,":[171],"eco-friendly":[172],"approach":[173],"extracting":[175],"highlighting":[178],"its":[179],"applications":[181],"food,":[183],"pharmaceutical,":[184],"nutraceutical":[186],"industries.":[187]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}