{"id":"https://openalex.org/W4414207648","doi":"https://doi.org/10.1192/j.eurpsy.2025.1020","title":"Neuroprotective effects of EDTA on manganese-induced neuroaffective disorders: Implications for anxiety and depressive disorders","display_name":"Neuroprotective effects of EDTA on manganese-induced neuroaffective disorders: Implications for anxiety and depressive disorders","publication_year":2025,"publication_date":"2025-04-01","ids":{"openalex":"https://openalex.org/W4414207648","doi":"https://doi.org/10.1192/j.eurpsy.2025.1020","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12437005"},"language":"en","primary_location":{"id":"doi:10.1192/j.eurpsy.2025.1020","doi":"https://doi.org/10.1192/j.eurpsy.2025.1020","is_oa":true,"landing_page_url":"https://doi.org/10.1192/j.eurpsy.2025.1020","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/8EB5AC3827BC7EFA586483A48E0AB968/S092493382501020Xa.pdf/div-class-title-neuroprotective-effects-of-edta-on-manganese-induced-neuroaffective-disorders-implications-for-anxiety-and-depressive-disorders-div.pdf","source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4414207648"],"child_works_count":0,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/8EB5AC3827BC7EFA586483A48E0AB968/S092493382501020Xa.pdf/div-class-title-neuroprotective-effects-of-edta-on-manganese-induced-neuroaffective-disorders-implications-for-anxiety-and-depressive-disorders-div.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5099471848","display_name":"Hala Harifi","orcid":"https://orcid.org/0009-0008-0301-8608","observed_orcids":["https://orcid.org/0009-0008-0301-8608","https://orcid.org/0009-0007-6259-5774"]},"institutions":[{"id":"https://openalex.org/I3121676899","display_name":"Universit\u00e9 Ibn-Tofail","ror":"https://ror.org/02wj89n04","country_code":"MA","type":"education","lineage":["https://openalex.org/I3121676899"]}],"countries":["MA"],"is_corresponding":true,"raw_author_name":"H. Harifi","raw_affiliation_strings":["Ibn Tofail University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ibn Tofail University","institution_ids":["https://openalex.org/I3121676899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067068027","display_name":"Hinde Hami","orcid":"https://orcid.org/0000-0002-1803-0115","observed_orcids":["https://orcid.org/0000-0002-1803-0115"]},"institutions":[{"id":"https://openalex.org/I3121676899","display_name":"Universit\u00e9 Ibn-Tofail","ror":"https://ror.org/02wj89n04","country_code":"MA","type":"education","lineage":["https://openalex.org/I3121676899"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"H. Hami","raw_affiliation_strings":["Ibn Tofail University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ibn Tofail University","institution_ids":["https://openalex.org/I3121676899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040123496","display_name":"Leila Bikjdaouene","orcid":"https://orcid.org/0009-0000-5347-7273","observed_orcids":["https://orcid.org/0009-0000-5347-7273"]},"institutions":[{"id":"https://openalex.org/I3121676899","display_name":"Universit\u00e9 Ibn-Tofail","ror":"https://ror.org/02wj89n04","country_code":"MA","type":"education","lineage":["https://openalex.org/I3121676899"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"L. Bikjdaouene","raw_affiliation_strings":["Ibn Tofail University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ibn Tofail University","institution_ids":["https://openalex.org/I3121676899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5099471848"],"corresponding_institution_ids":["https://openalex.org/I3121676899"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":{"value":3300,"currency":"USD","value_usd":3300},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"68","issue":"S1","first_page":"S490","last_page":"S490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/manganese-toxicity","display_name":"manganese toxicity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/edta","display_name":"EDTA","score":0.8690000176429749},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.953000009059906},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.8690000176429749},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8920000195503235},{"id":"https://openalex.org/keywords/anhedonia","display_name":"anhedonia","score":0.843999981880188},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.8980000019073486},{"id":"https://openalex.org/keywords/sucrose-preference","display_name":"sucrose preference","score":0.8299999833106995},{"id":"https://openalex.org/keywords/elevated-plus-maze","display_name":"elevated plus maze","score":0.7829999923706055},{"id":"https://openalex.org/keywords/open-field-test","display_name":"open field test","score":0.8830000162124634},{"id":"https://openalex.org/keywords/metal-neurotoxicity","display_name":"metal neurotoxicity","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2778941446","wikidata":"https://www.wikidata.org/wiki/Q545365","display_name":"Anhedonia","level":3,"score":0.9059000015258789},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8100000023841858},{"id":"https://openalex.org/C2778973965","wikidata":"https://www.wikidata.org/wiki/Q408032","display_name":"Ethylenediaminetetraacetic acid","level":3,"score":0.6991000175476074},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.6895999908447266},{"id":"https://openalex.org/C2779085643","wikidata":"https://www.wikidata.org/wiki/Q7096029","display_name":"Open field","level":2,"score":0.6546000242233276},{"id":"https://openalex.org/C173586616","wikidata":"https://www.wikidata.org/wiki/Q5359685","display_name":"Elevated plus maze","level":3,"score":0.5813999772071838},{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.5184999704360962},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4878000020980835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4729999899864197},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4316999912261963},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4036000072956085},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.3652999997138977},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32760000228881836},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32109999656677246},{"id":"https://openalex.org/C3019858935","wikidata":"https://www.wikidata.org/wiki/Q4340209","display_name":"Depressive symptoms","level":3,"score":0.27790001034736633},{"id":"https://openalex.org/C2778597767","wikidata":"https://www.wikidata.org/wiki/Q4027534","display_name":"Sucrose","level":2,"score":0.27730000019073486},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.25600001215934753},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.25040000677108765}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1192/j.eurpsy.2025.1020","doi":"https://doi.org/10.1192/j.eurpsy.2025.1020","is_oa":true,"landing_page_url":"https://doi.org/10.1192/j.eurpsy.2025.1020","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/8EB5AC3827BC7EFA586483A48E0AB968/S092493382501020Xa.pdf/div-class-title-neuroprotective-effects-of-edta-on-manganese-induced-neuroaffective-disorders-implications-for-anxiety-and-depressive-disorders-div.pdf","source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11246974","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12437005","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12437005","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12437005/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eur Psychiatry","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1192/j.eurpsy.2025.1020","doi":"https://doi.org/10.1192/j.eurpsy.2025.1020","is_oa":true,"landing_page_url":"https://doi.org/10.1192/j.eurpsy.2025.1020","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/8EB5AC3827BC7EFA586483A48E0AB968/S092493382501020Xa.pdf/div-class-title-neuroprotective-effects-of-edta-on-manganese-induced-neuroaffective-disorders-implications-for-anxiety-and-depressive-disorders-div.pdf","source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414207648.pdf","grobid_xml":"https://content.openalex.org/works/W4414207648.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7160925271","https://openalex.org/W2296317125","https://openalex.org/W7120302476","https://openalex.org/W2128465640","https://openalex.org/W3001778484","https://openalex.org/W4408597553","https://openalex.org/W3193399523","https://openalex.org/W1975375810","https://openalex.org/W2332326360","https://openalex.org/W4414207838"],"abstract_inverted_index":{"Introduction":[0],"Manganese":[1],"(Mn),":[2],"an":[3],"essential":[4],"yet":[5],"potentially":[6],"toxic":[7],"metal":[8],"found":[9],"naturally":[10],"in":[11,17,132,140,184,201],"the":[12,34,84,104,123,133,141,171],"environment,":[13],"has":[14],"been":[15],"implicated":[16],"various":[18],"neurodegenerative":[19],"and":[20,54,83,102,117,138,155,162,176,198],"neuroaffective":[21],"disorders":[22,200],"due":[23],"to":[24,51,114],"its":[25,49,212],"propensity":[26],"for":[27,94],"chronic":[28],"intoxication.":[29],"Objectives":[30],"This":[31],"study":[32],"explores":[33],"neuroprotective":[35,216],"effects":[36],"of":[37,60,111,146,205,222],"Ethylenediaminetetraacetic":[38],"acid":[39],"(EDTA)":[40],"against":[41,218],"Mn-induced":[42],"toxicity,":[43],"with":[44,70,75,153],"a":[45,109,215],"specific":[46],"focus":[47],"on":[48],"potential":[50,213],"mitigate":[52],"anxiety":[53,116,183,197],"depressive":[55,118,147,199],"disorders.":[56],"Methods":[57],"Three":[58],"groups":[59],"male":[61],"Wistar":[62],"rats":[63,107,151],"were":[64,90,99],"used:":[65],"one":[66],"group":[67,86],"was":[68,188],"injected":[69],"25":[71,76,124],"mg/kg":[72,77,81,125],"Mn,":[73],"another":[74],"Mn":[78,126,154,194,219],"plus":[79,178],"4":[80],"EDTA,":[82],"control":[85],"received":[87],"NaCl.":[88],"Injections":[89],"administered":[91],"intraperitoneally":[92],"daily":[93],"12":[95],"weeks.":[96],"Rat":[97],"weights":[98],"monitored":[100],"weekly,":[101],"following":[103],"exposure":[105,195],"period,":[106],"underwent":[108],"series":[110],"neurobehavioral":[112],"tests":[113],"assess":[115],"behaviors.":[119,148],"Results":[120],"Rats":[121],"receiving":[122],"dose":[127],"alone":[128],"exhibited":[129],"increased":[130,182],"immobility":[131,160],"forced":[134],"swimming":[135],"test":[136,174],"(FST)":[137],"anhedonia":[139],"sucrose":[142,165],"preference":[143],"test,":[144],"indicative":[145],"In":[149],"contrast,":[150],"treated":[152],"EDTA":[156,191,206],"displayed":[157],"significantly":[158,207],"reduced":[159],"times":[161],"maintained":[163],"normal":[164],"water":[166],"consumption.":[167],"Behavioral":[168],"tests,":[169],"including":[170],"open":[172],"field":[173],"(OFT)":[175],"elevated":[177],"maze":[179],"(EPM),":[180],"indicated":[181],"Mn-exposed":[185],"rats,":[186,202],"which":[187],"mitigated":[189],"by":[190],"treatment.":[192],"Conclusions":[193],"induces":[196],"but":[203],"coadministration":[204],"mitigates":[208],"these":[209],"effects,":[210],"suggesting":[211],"as":[214],"agent":[217],"toxicity.":[220],"Disclosure":[221],"Interest":[223],"None":[224],"Declared":[225]},"counts_by_year":[],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2025-10-10T00:00:00"}