{"id":"https://openalex.org/W4414205276","doi":"https://doi.org/10.7150/jca.113576","title":"The Role of P53 in Immune Evasion and Therapeutic Strategies in Hematologic Malignancies","display_name":"The Role of P53 in Immune Evasion and Therapeutic Strategies in Hematologic Malignancies","publication_year":2025,"publication_date":"2025-08-28","ids":{"openalex":"https://openalex.org/W4414205276","doi":"https://doi.org/10.7150/jca.113576","pmid":"https://pubmed.ncbi.nlm.nih.gov/41049014"},"language":"en","primary_location":{"id":"doi:10.7150/jca.113576","doi":"https://doi.org/10.7150/jca.113576","is_oa":true,"landing_page_url":"https://doi.org/10.7150/jca.113576","pdf_url":"https://www.jcancer.org/v16p3899.pdf","source":{"id":"https://openalex.org/S200072998","display_name":"Journal of Cancer","issn_l":"1837-9664","issn":["1837-9664"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jcancer.org/v16p3899.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083368899","display_name":"Jing Wen","orcid":"https://orcid.org/0000-0001-8169-7740","observed_orcids":["https://orcid.org/0000-0001-8169-7740"]},"institutions":[{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3017480383"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wen","raw_affiliation_strings":["School of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan, China","institution_ids":["https://openalex.org/I3017480383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100598389","display_name":"Linlin Fu","orcid":"https://orcid.org/0009-0009-0499-5133","observed_orcids":["https://orcid.org/0009-0009-0499-5133"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linlin Fu","raw_affiliation_strings":["Department of Hematology, Chongqing University Three Gorges Hospital, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Chongqing University Three Gorges Hospital, Chongqing, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101480438","display_name":"Hui Zhong","orcid":"https://orcid.org/0000-0002-1933-3046","observed_orcids":["https://orcid.org/0000-0002-1933-3046"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Zhong","raw_affiliation_strings":["Department of Hematology, Chongqing University Three Gorges Hospital, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Chongqing University Three Gorges Hospital, Chongqing, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100738455","display_name":"Hongxia Chen","orcid":"https://orcid.org/0000-0003-2400-9061","observed_orcids":["https://orcid.org/0000-0003-2400-9061"]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongxia Chen","raw_affiliation_strings":["Department of Hematology, Chongqing University Three Gorges Hospital, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Chongqing University Three Gorges Hospital, Chongqing, China","institution_ids":["https://openalex.org/I158842170"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2000,"currency":"AUD","value_usd":1337},"apc_paid":{"value":2000,"currency":"AUD","value_usd":1337},"fwci":1.4899,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.84408357,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"16","issue":"13","first_page":"3899","last_page":"3906"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8460000157356262},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.9129999876022339},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.9350000023841858},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.921999990940094},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.9860000014305115},{"id":"https://openalex.org/keywords/immunosuppressive-cells","display_name":"immunosuppressive cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.8220000267028809},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6899999976158142},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6700000166893005},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4009999930858612},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.753000020980835},{"id":"https://openalex.org/C2781251061","wikidata":"https://www.wikidata.org/wiki/Q5416089","display_name":"Evasion (ethics)","level":3,"score":0.7037000060081482},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5674999952316284},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5425999760627747},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5422000288963318},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4124999940395355},{"id":"https://openalex.org/C2910239545","wikidata":"https://www.wikidata.org/wiki/Q3843811","display_name":"Immune Dysfunction","level":3,"score":0.40799999237060547},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4034000039100647},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.37599998712539673},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.36880001425743103},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3634999990463257},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.3549000024795532},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3463999927043915},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3181999921798706},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.3061999976634979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2840000092983246},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2628999948501587},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.25920000672340393},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.25760000944137573},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.25619998574256897},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.25589999556541443},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.2551000118255615},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25380000472068787}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.7150/jca.113576","doi":"https://doi.org/10.7150/jca.113576","is_oa":true,"landing_page_url":"https://doi.org/10.7150/jca.113576","pdf_url":"https://www.jcancer.org/v16p3899.pdf","source":{"id":"https://openalex.org/S200072998","display_name":"Journal of Cancer","issn_l":"1837-9664","issn":["1837-9664"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:41049014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41049014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11301517","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12491011","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12491011","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12491011/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Cancer","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7150/jca.113576","doi":"https://doi.org/10.7150/jca.113576","is_oa":true,"landing_page_url":"https://doi.org/10.7150/jca.113576","pdf_url":"https://www.jcancer.org/v16p3899.pdf","source":{"id":"https://openalex.org/S200072998","display_name":"Journal of Cancer","issn_l":"1837-9664","issn":["1837-9664"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321135","display_name":"Chongqing University","ror":"https://ror.org/023rhb549"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414205276.pdf","grobid_xml":"https://content.openalex.org/works/W4414205276.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"P53":[0,26,46,71,90],"is":[1],"a":[2],"crucial":[3],"tumor":[4,49],"suppressor":[5],"gene":[6],"that":[7],"plays":[8],"an":[9],"essential":[10],"role":[11,79],"in":[12,73,80],"maintaining":[13],"genomic":[14],"stability,":[15],"regulating":[16],"cell":[17],"cycle":[18],"progression,":[19],"and":[20,36,60,83],"inducing":[21],"apoptosis.":[22],"In":[23],"hematologic":[24,74,111],"malignancies,":[25,75],"mutations":[27,72],"are":[28],"frequently":[29],"associated":[30,94],"with":[31],"poor":[32],"prognosis,":[33],"treatment":[34],"resistance,":[35],"immune":[37,50,81],"evasion.":[38],"Recent":[39],"research":[40],"has":[41],"highlighted":[42],"the":[43,104],"impact":[44],"of":[45,62,106],"dysfunction":[47],"on":[48,70,77],"escape":[51],"mechanisms,":[52],"including":[53],"impaired":[54],"antigen":[55],"presentation,":[56],"altered":[57],"cytokine":[58],"signaling,":[59],"recruitment":[61],"immunosuppressive":[63],"cells.":[64],"This":[65],"review":[66],"integrates":[67],"recent":[68],"findings":[69],"focusing":[76],"their":[78],"evasion":[82],"potential":[84],"therapeutic":[85],"strategies":[86],"aimed":[87],"at":[88],"restoring":[89],"function":[91],"or":[92],"targeting":[93],"pathways.":[95],"Understanding":[96],"these":[97],"mechanisms":[98],"may":[99],"provide":[100],"new":[101],"insights":[102],"into":[103],"development":[105],"effective":[107],"immunotherapeutic":[108],"approaches":[109],"for":[110],"cancers.":[112]},"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2025-10-10T00:00:00"}
