{"id":"https://openalex.org/W4414168596","doi":"https://doi.org/10.31557/apjcp.2025.26.9.3495","title":"Doxorubicin Effects Breast Cancer Proliferation via the NEAT1/miR-410-3p Axis","display_name":"Doxorubicin Effects Breast Cancer Proliferation via the NEAT1/miR-410-3p Axis","publication_year":2025,"publication_date":"2025-09-01","ids":{"openalex":"https://openalex.org/W4414168596","doi":"https://doi.org/10.31557/apjcp.2025.26.9.3495","pmid":"https://pubmed.ncbi.nlm.nih.gov/40952308","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12882779"},"language":"en","primary_location":{"id":"doi:10.31557/apjcp.2025.26.9.3495","doi":"https://doi.org/10.31557/apjcp.2025.26.9.3495","is_oa":true,"landing_page_url":"https://doi.org/10.31557/apjcp.2025.26.9.3495","pdf_url":"https://journal.waocp.org/article_91858_701d4f011c1b07f2177cbde69d480c9b.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journal.waocp.org/article_91858_701d4f011c1b07f2177cbde69d480c9b.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014967832","display_name":"Zahra Azizi","orcid":"https://orcid.org/0000-0002-5456-6881","observed_orcids":["https://orcid.org/0000-0002-5456-6881","https://orcid.org/0009-0007-7234-432X"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Zahra Azizi","raw_affiliation_strings":["Department of Medical Biology, Faculty of Medicine, Pamukkale University, Denizli, Turkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Faculty of Medicine, Pamukkale University, Denizli, Turkiye","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022271451","display_name":"\u0130brahim A\u00e7\u0131kba\u015f","orcid":"https://orcid.org/0000-0001-7483-1147","observed_orcids":["https://orcid.org/0000-0001-7483-1147"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ibrahim Acikbas","raw_affiliation_strings":["Department of Medical Biology, Faculty of Medicine, Pamukkale University, Denizli, Turkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Faculty of Medicine, Pamukkale University, Denizli, Turkiye","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048334300","display_name":"Buket Er Urganc\u0131","orcid":"https://orcid.org/0000-0002-5339-3835","observed_orcids":["https://orcid.org/0000-0002-5339-3835"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Buket Er Urganci","raw_affiliation_strings":["Department of Medical Biology, Faculty of Medicine, Pamukkale University, Denizli, Turkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Faculty of Medicine, Pamukkale University, Denizli, Turkiye","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087737910","display_name":"Pervin Elvan Tokg\u00fcn","orcid":"https://orcid.org/0000-0001-9025-4140","observed_orcids":["https://orcid.org/0000-0001-9025-4140"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Pervin Elvan Tokgun","raw_affiliation_strings":["Department of Medical Genetic, Faculty of Medicine, Pamukkale University, Denizli, Turkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetic, Faculty of Medicine, Pamukkale University, Denizli, Turkiye","institution_ids":["https://openalex.org/I48843708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023250835","display_name":"Cihangir Do\u011fan","orcid":"https://orcid.org/0000-0001-9422-5996","observed_orcids":["https://orcid.org/0000-0001-9422-5996"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Cihangir Dogan","raw_affiliation_strings":["Department of Medical Biology, Faculty of Medicine, Pamukkale University, Denizli, Turkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Faculty of Medicine, Pamukkale University, Denizli, Turkiye","institution_ids":["https://openalex.org/I48843708"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014967832"],"corresponding_institution_ids":["https://openalex.org/I48843708"],"apc_list":{"value":200,"currency":"USD","value_usd":200},"apc_paid":{"value":200,"currency":"USD","value_usd":200},"fwci":0.561,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.56500419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"26","issue":"9","first_page":"3495","last_page":"3502"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":1.0},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9620000123977661},{"id":"https://openalex.org/keywords/neat1","display_name":"NEAT1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.8370000123977661},{"id":"https://openalex.org/keywords/mir-410-3p","display_name":"miR-410-3p","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.5759999752044678},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/anthracycline-based-chemotherapy","display_name":"anthracycline chemotherapy","score":0.8679999709129333},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/therapeutic-biomarkers","display_name":"therapeutic biomarkers","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.8084999918937683},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6194000244140625},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6158000230789185},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6071000099182129},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5267000198364258},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3691999912261963},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3472999930381775},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.31439998745918274},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28029999136924744},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.2637999951839447}],"mesh":[{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.31557/apjcp.2025.26.9.3495","doi":"https://doi.org/10.31557/apjcp.2025.26.9.3495","is_oa":true,"landing_page_url":"https://doi.org/10.31557/apjcp.2025.26.9.3495","pdf_url":"https://journal.waocp.org/article_91858_701d4f011c1b07f2177cbde69d480c9b.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},{"id":"doi:10.22541/au.171902943.39615857/v1","doi":"https://doi.org/10.22541/au.171902943.39615857/v1","is_oa":true,"landing_page_url":"https://doi.org/10.22541/au.171902943.39615857/v1","pdf_url":"https://www.authorea.com/doi/pdf/10.22541/au.171902943.39615857/v1","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"doi:10.21203/rs.3.rs-3854343/v1","doi":"https://doi.org/10.21203/rs.3.rs-3854343/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3854343/v1","pdf_url":"https://www.researchsquare.com/article/rs-3854343/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:11690258","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12882779","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40952308","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40952308","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12882779","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12882779/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pac J Cancer Prev","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.31557/apjcp.2025.26.9.3495","doi":"https://doi.org/10.31557/apjcp.2025.26.9.3495","is_oa":true,"landing_page_url":"https://doi.org/10.31557/apjcp.2025.26.9.3495","pdf_url":"https://journal.waocp.org/article_91858_701d4f011c1b07f2177cbde69d480c9b.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414168596.pdf","grobid_xml":"https://content.openalex.org/works/W4414168596.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1879996757","https://openalex.org/W2011429579","https://openalex.org/W2087351768","https://openalex.org/W2102897174","https://openalex.org/W2125548623","https://openalex.org/W2317055602","https://openalex.org/W2344774066","https://openalex.org/W2419036647","https://openalex.org/W2507628504","https://openalex.org/W2611582655","https://openalex.org/W2782369838","https://openalex.org/W2783386765","https://openalex.org/W2786294422","https://openalex.org/W2891494400","https://openalex.org/W2897891164","https://openalex.org/W2900490748","https://openalex.org/W2902481242","https://openalex.org/W2923321984","https://openalex.org/W2979438587","https://openalex.org/W3011087857","https://openalex.org/W3022833757","https://openalex.org/W3042287582","https://openalex.org/W3128646645","https://openalex.org/W3138666308","https://openalex.org/W3186487971","https://openalex.org/W4391581491","https://openalex.org/W4408084079"],"related_works":["https://openalex.org/W4399922279","https://openalex.org/W2601729618","https://openalex.org/W3096514992","https://openalex.org/W4378574269","https://openalex.org/W3042287582","https://openalex.org/W2114993186","https://openalex.org/W3034980736","https://openalex.org/W3150672388","https://openalex.org/W3114687810","https://openalex.org/W4231702733"],"abstract_inverted_index":{"BACKGROUND:":[0],"Doxorubicin":[1],"(DOX)":[2],"is":[3,219],"an":[4,180],"anthracycline":[5],"derivative,":[6],"a":[7,24,200,242],"conversant":[8],"chemotherapeutic":[9,17],"agent,":[10],"and":[11,40,43,48,59,105,154,216,231,247],"one":[12],"of":[13,62,67,229,249],"the":[14,53,60,65,79,93,135,168,227,245],"most":[15],"influential":[16],"drugs.":[18],"Long":[19],"noncoding":[20],"RNAs":[21],"(lncRNAs)":[22],"play":[23],"vital":[25],"role":[26],"in":[27,113,117,146,161,167,182,193,221],"this":[28,222],"process.":[29],"The":[30,83],"current":[31],"review":[32],"demonstrates":[33],"that":[34,188,208,217],"lncRNAs":[35,106],"can":[36,238],"function":[37],"as":[38,241],"oncogenic":[39],"tumor":[41],"suppressors":[42],"contribute":[44],"to":[45,77,107,110,233],"cancer":[46,149,162,194],"development":[47],"progression.":[49],"Our":[50,185,224],"study":[51],"addressed":[52],"nuclear-enriched":[54],"abundant":[55],"transcript":[56],"1":[57],"(NEAT1)":[58],"effect":[61],"DOX":[63,140,209,234],"on":[64],"regulation":[66],"miR410-3p":[68,176,218,232],"by":[69,122],"NEAT1.":[70],"METHODS:":[71],"An":[72],"MTT":[73],"assay":[74],"was":[75,86,90,99,132,165,191],"conducted":[76],"determine":[78],"half-maximal":[80],"inhibitory":[81],"concentration.":[82],"initial":[84],"step":[85],"RNA":[87,114],"isolation,":[88],"which":[89],"performed":[91,133],"after":[92],"cell":[94,163,172],"culture.":[95],"Then,":[96],"cDNA":[97],"synthesis":[98],"carried":[100],"out":[101],"for":[102,244],"both":[103],"miRNAs":[104],"use":[108],"RT-PCR":[109],"identify":[111],"changes":[112],"expression.":[115],"Alterations":[116],"expression":[118,143,159,177,190],"levels":[119,144,178],"were":[120],"measured":[121],"quantitative":[123],"real-time":[124],"polymerase":[125],"chain":[126],"reaction":[127],"analyses.":[128],"This":[129],"web-based":[130],"analysis":[131],"using":[134],"Student's":[136],"t-test.":[137],"RESULTS:":[138],"After":[139],"treatment,":[141],"NEAT1":[142,189,230],"decreased":[145],"human":[147],"breast":[148],"(BC)":[150],"cells,":[151],"including":[152],"MDA-MB231":[153],"MCF-7.":[155],"As":[156],"expected,":[157],"further":[158],"than":[160],"lines":[164,213],"detected":[166],"normal":[169],"mammary":[170],"epithelial":[171],"line":[173],"MCF-10A.":[174],"Simultaneously,":[175],"exhibited":[179],"increase":[181],"BC":[183,212],"cells.":[184],"data":[186,206,225],"demonstrated":[187],"suppressed":[192],"cells":[195],"treated":[196],"with":[197],"doxorubicin,":[198],"suggesting":[199],"potential":[201],"therapeutic":[202],"effect.":[203],"CONCLUSION:":[204],"These":[205],"indicate":[207],"may":[210],"affect":[211],"via":[214],"NEAT1,":[215],"effective":[220],"pathway.":[223],"confirm":[226],"contribution":[228],"treatment.":[235],"Therefore,":[236],"they":[237],"be":[239],"used":[240],"biomarker":[243],"diagnosis":[246],"treatment":[248],"BC.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2025-10-10T00:00:00"}