{"id":"https://openalex.org/W4414147752","doi":"https://doi.org/10.7554/elife.108061.2","title":"The lipocone superfamily, a unifying theme in metabolism of lipids, peptidoglycan and exopolysaccharides, inter-organismal conflicts and immunity","display_name":"The lipocone superfamily, a unifying theme in metabolism of lipids, peptidoglycan and exopolysaccharides, inter-organismal conflicts and immunity","publication_year":2025,"publication_date":"2025-07-22","ids":{"openalex":"https://openalex.org/W4414147752","doi":"https://doi.org/10.7554/elife.108061.2","pmid":"https://pubmed.ncbi.nlm.nih.gov/40236132","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11996534"},"language":"en","primary_location":{"id":"doi:10.7554/elife.108061.2","doi":"https://doi.org/10.7554/elife.108061.2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.108061.2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.108061.2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004461127","display_name":"Alexander Maxwell Burroughs","orcid":"https://orcid.org/0000-0002-2229-8771","observed_orcids":["https://orcid.org/0000-0002-2229-8771"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I2800548410","display_name":"United States National Library of Medicine","ror":"https://ror.org/0060t0j89","country_code":"US","type":"archive","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Maxwell Burroughs","raw_affiliation_strings":["Division of Intramural Research, National Library of Medicine, National Institutes of Health, USA","Division of Intramural Research, National Library of Medicine, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Intramural Research, National Library of Medicine, National Institutes of Health, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I2800548410"]},{"raw_affiliation_string":"Division of Intramural Research, National Library of Medicine, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I2800548410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080422008","display_name":"Gianlucca Gon\u00e7alves Nicastro","orcid":"https://orcid.org/0000-0002-3133-2441","observed_orcids":["https://orcid.org/0000-0002-3133-2441"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I2800548410","display_name":"United States National Library of Medicine","ror":"https://ror.org/0060t0j89","country_code":"US","type":"archive","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gianlucca G. Nicastro","raw_affiliation_strings":["Division of Intramural Research, National Library of Medicine, National Institutes of Health, USA","Division of Intramural Research, National Library of Medicine, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Intramural Research, National Library of Medicine, National Institutes of Health, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I2800548410"]},{"raw_affiliation_string":"Division of Intramural Research, National Library of Medicine, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I2800548410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026932356","display_name":"L. Aravind","orcid":"https://orcid.org/0000-0003-0771-253X","observed_orcids":["https://orcid.org/0000-0003-0771-253X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I2800548410","display_name":"United States National Library of Medicine","ror":"https://ror.org/0060t0j89","country_code":"US","type":"archive","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"L Aravind","raw_affiliation_strings":["Division of Intramural Research, National Library of Medicine, National Institutes of Health, USA","Division of Intramural Research, National Library of Medicine, National Institutes of Health"],"raw_orcid":"https://orcid.org/0000-0003-0771-253X","affiliations":[{"raw_affiliation_string":"Division of Intramural Research, National Library of Medicine, National Institutes of Health, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I2800548410"]},{"raw_affiliation_string":"Division of Intramural Research, National Library of Medicine, National Institutes of Health","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I2800548410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026932356"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I2800548410"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":0.9586,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.7205266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.4146000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.4146000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.1525000035762787,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.14970000088214874,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-proteins","display_name":"Wnt proteins","score":0.902999997138977},{"id":"https://openalex.org/keywords/phosphatidylserine-synthase","display_name":"phosphatidylserine synthase","score":0.8669999837875366},{"id":"https://openalex.org/keywords/serum-amyloid-a","display_name":"serum amyloid A","score":0.8690000176429749},{"id":"https://openalex.org/keywords/transesterification","display_name":"transesterification","score":0.8240000009536743},{"id":"https://openalex.org/keywords/membrane-lipid-composition","display_name":"membrane lipid composition","score":0.5640000104904175},{"id":"https://openalex.org/keywords/exopolysaccharide-biosynthesis","display_name":"exopolysaccharide biosynthesis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/bacterial-outer-membrane","display_name":"bacterial outer membrane","score":0.5759999752044678},{"id":"https://openalex.org/keywords/antiviral-immunity","display_name":"antiviral immunity","score":0.9200000166893005},{"id":"https://openalex.org/keywords/peptidoglycan-metabolism","display_name":"peptidoglycan metabolism","score":0.7910000085830688},{"id":"https://openalex.org/keywords/exopolysaccharides","display_name":"exopolysaccharides","score":0.878000020980835},{"id":"https://openalex.org/keywords/protein-domain-evolution","display_name":"protein domain evolution","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7990000247955322},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.730400025844574},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.555899977684021},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.5231999754905701},{"id":"https://openalex.org/C2776634448","wikidata":"https://www.wikidata.org/wiki/Q206920","display_name":"Peptidoglycan","level":3,"score":0.48420000076293945},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.45100000500679016},{"id":"https://openalex.org/C197583594","wikidata":"https://www.wikidata.org/wiki/Q1052390","display_name":"Most recent common ancestor","level":4,"score":0.446399986743927},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.44589999318122864},{"id":"https://openalex.org/C188880781","wikidata":"https://www.wikidata.org/wiki/Q2430501","display_name":"Three-domain system","level":4,"score":0.4235999882221222},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40939998626708984},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.3732999861240387},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.3686000108718872},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.32010000944137573},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.3167000114917755},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.31619998812675476},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31310001015663147},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.31119999289512634},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2985999882221222},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.2985000014305115},{"id":"https://openalex.org/C178180057","wikidata":"https://www.wikidata.org/wiki/Q7251477","display_name":"Protein superfamily","level":3,"score":0.2962999939918518},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.29589998722076416},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.29260000586509705},{"id":"https://openalex.org/C107300179","wikidata":"https://www.wikidata.org/wiki/Q41797887","display_name":"Frizzled","level":4,"score":0.2921999990940094},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.29019999504089355},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.289000004529953},{"id":"https://openalex.org/C92028520","wikidata":"https://www.wikidata.org/wiki/Q7395025","display_name":"SUPERFAMILY","level":3,"score":0.2874000072479248},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.2840999960899353},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C191120209","wikidata":"https://www.wikidata.org/wiki/Q908902","display_name":"Structural biology","level":2,"score":0.26409998536109924},{"id":"https://openalex.org/C92938381","wikidata":"https://www.wikidata.org/wiki/Q83185","display_name":"Horizontal gene transfer","level":4,"score":0.2556000053882599}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.7554/elife.108061.2","doi":"https://doi.org/10.7554/elife.108061.2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.108061.2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"doi:10.7554/elife.108061","doi":"https://doi.org/10.7554/elife.108061","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.108061","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"doi:10.1101/2025.01.14.632903","doi":"https://doi.org/10.1101/2025.01.14.632903","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.01.14.632903","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40236132","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40236132","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:40923594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40923594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12419801","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12419801/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:11996534","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11996534","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ba5169baedb3447eabe90287be237673","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ba5169baedb3447eabe90287be237673","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 14 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7554/elife.108061.2","doi":"https://doi.org/10.7554/elife.108061.2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.108061.2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332382","display_name":"Oak Ridge Institute for Science and Education","ror":"https://ror.org/0526p1y61"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":271,"referenced_works":["https://openalex.org/W10876090","https://openalex.org/W116152577","https://openalex.org/W153102558","https://openalex.org/W176507988","https://openalex.org/W228765527","https://openalex.org/W229097380","https://openalex.org/W1498122156","https://openalex.org/W1507817378","https://openalex.org/W1508202631","https://openalex.org/W1546670038","https://openalex.org/W1558404732","https://openalex.org/W1564922487","https://openalex.org/W1573220291","https://openalex.org/W1579752539","https://openalex.org/W1588149841","https://openalex.org/W1602952910","https://openalex.org/W1671614471","https://openalex.org/W1864021403","https://openalex.org/W1885768087","https://openalex.org/W1891655862","https://openalex.org/W1934550690","https://openalex.org/W1956262850","https://openalex.org/W1963728028","https://openalex.org/W1963867445","https://openalex.org/W1967449074","https://openalex.org/W1967589406","https://openalex.org/W1967663492","https://openalex.org/W1969677431","https://openalex.org/W1970051672","https://openalex.org/W1970407894","https://openalex.org/W1970710213","https://openalex.org/W1971388047","https://openalex.org/W1971530027","https://openalex.org/W1972384393","https://openalex.org/W1972470306","https://openalex.org/W1972998645","https://openalex.org/W1974059817","https://openalex.org/W1974094726","https://openalex.org/W1974447011","https://openalex.org/W1976620611","https://openalex.org/W1977172528","https://openalex.org/W1978825157","https://openalex.org/W1978845112","https://openalex.org/W1979171058","https://openalex.org/W1980192812","https://openalex.org/W1980315021","https://openalex.org/W1982187338","https://openalex.org/W1982516699","https://openalex.org/W1982583457","https://openalex.org/W1983100843","https://openalex.org/W1985541198","https://openalex.org/W1987325953","https://openalex.org/W1988966516","https://openalex.org/W1991461487","https://openalex.org/W1995513207","https://openalex.org/W1996902433","https://openalex.org/W2001437131","https://openalex.org/W2003546293","https://openalex.org/W2005019603","https://openalex.org/W2005440429","https://openalex.org/W2005935812","https://openalex.org/W2006928935","https://openalex.org/W2008815241","https://openalex.org/W2010589798","https://openalex.org/W2011006768","https://openalex.org/W2013701725","https://openalex.org/W2014101652","https://openalex.org/W2017668082","https://openalex.org/W2020278115","https://openalex.org/W2020580205","https://openalex.org/W2020858977","https://openalex.org/W2020942708","https://openalex.org/W2021743399","https://openalex.org/W2022073880","https://openalex.org/W2023101570","https://openalex.org/W2026978096","https://openalex.org/W2028622187","https://openalex.org/W2030036822","https://openalex.org/W2030915307","https://openalex.org/W2031209863","https://openalex.org/W2031611770","https://openalex.org/W2032293502","https://openalex.org/W2033370448","https://openalex.org/W2037913221","https://openalex.org/W2038057037","https://openalex.org/W2039247152","https://openalex.org/W2039465938","https://openalex.org/W2039722695","https://openalex.org/W2041905742","https://openalex.org/W2041935553","https://openalex.org/W2044834980","https://openalex.org/W2045404157","https://openalex.org/W2045915531","https://openalex.org/W2046733873","https://openalex.org/W2048988399","https://openalex.org/W2049516586","https://openalex.org/W2050608553","https://openalex.org/W2052343711","https://openalex.org/W2053325564","https://openalex.org/W2053970377","https://openalex.org/W2057830132","https://openalex.org/W2059672809","https://openalex.org/W2060062579","https://openalex.org/W2060107244","https://openalex.org/W2060470202","https://openalex.org/W2060934682","https://openalex.org/W2061118289","https://openalex.org/W2066080177","https://openalex.org/W2066281446","https://openalex.org/W2066600235","https://openalex.org/W2069458148","https://openalex.org/W2070620540","https://openalex.org/W2071483973","https://openalex.org/W2073255491","https://openalex.org/W2075229513","https://openalex.org/W2078516832","https://openalex.org/W2079826979","https://openalex.org/W2081294871","https://openalex.org/W2081717721","https://openalex.org/W2082667898","https://openalex.org/W2084172135","https://openalex.org/W2084771679","https://openalex.org/W2084887960","https://openalex.org/W2086044927","https://openalex.org/W2086109291","https://openalex.org/W2086213641","https://openalex.org/W2087421551","https://openalex.org/W2088166296","https://openalex.org/W2088385175","https://openalex.org/W2091404655","https://openalex.org/W2092981956","https://openalex.org/W2094341069","https://openalex.org/W2095162524","https://openalex.org/W2095402347","https://openalex.org/W2095529535","https://openalex.org/W2096664751","https://openalex.org/W2099670333","https://openalex.org/W2100262865","https://openalex.org/W2104437034","https://openalex.org/W2105795902","https://openalex.org/W2107282650","https://openalex.org/W2108327348","https://openalex.org/W2108490599","https://openalex.org/W2109872885","https://openalex.org/W2110966981","https://openalex.org/W2112313101","https://openalex.org/W2113130311","https://openalex.org/W2113183492","https://openalex.org/W2113600446","https://openalex.org/W2114355635","https://openalex.org/W2114739684","https://openalex.org/W2115890711","https://openalex.org/W2119284420","https://openalex.org/W2120133190","https://openalex.org/W2120280700","https://openalex.org/W2120688918","https://openalex.org/W2122940553","https://openalex.org/W2124934990","https://openalex.org/W2125616853","https://openalex.org/W2125842439","https://openalex.org/W2126747339","https://openalex.org/W2127177253","https://openalex.org/W2127693554","https://openalex.org/W2128508997","https://openalex.org/W2128692287","https://openalex.org/W2132022337","https://openalex.org/W2134460557","https://openalex.org/W2134952381","https://openalex.org/W2135835127","https://openalex.org/W2136385105","https://openalex.org/W2138122982","https://openalex.org/W2139101379","https://openalex.org/W2139621307","https://openalex.org/W2139739677","https://openalex.org/W2142204601","https://openalex.org/W2143014493","https://openalex.org/W2146228523","https://openalex.org/W2147516452","https://openalex.org/W2148945900","https://openalex.org/W2154311082","https://openalex.org/W2154802584","https://openalex.org/W2156721231","https://openalex.org/W2157082535","https://openalex.org/W2158691001","https://openalex.org/W2158714788","https://openalex.org/W2160378127","https://openalex.org/W2162407342","https://openalex.org/W2162515800","https://openalex.org/W2163759087","https://openalex.org/W2165781463","https://openalex.org/W2166251364","https://openalex.org/W2169715845","https://openalex.org/W2170000318","https://openalex.org/W2171697552","https://openalex.org/W2218510053","https://openalex.org/W2222258085","https://openalex.org/W2224056471","https://openalex.org/W2234306941","https://openalex.org/W2288795997","https://openalex.org/W2303521084","https://openalex.org/W2311234333","https://openalex.org/W2336014825","https://openalex.org/W2407160000","https://openalex.org/W2497461506","https://openalex.org/W2517638694","https://openalex.org/W2531513855","https://openalex.org/W2566990048","https://openalex.org/W2598084456","https://openalex.org/W2601574496","https://openalex.org/W2619431296","https://openalex.org/W2736014558","https://openalex.org/W2748591042","https://openalex.org/W2752595878","https://openalex.org/W2776965845","https://openalex.org/W2791234962","https://openalex.org/W2792543387","https://openalex.org/W2800216095","https://openalex.org/W2803584042","https://openalex.org/W2809218575","https://openalex.org/W2884748086","https://openalex.org/W2889145334","https://openalex.org/W2891642385","https://openalex.org/W2896319452","https://openalex.org/W2897249806","https://openalex.org/W2903344343","https://openalex.org/W2910496356","https://openalex.org/W2912290813","https://openalex.org/W2914997547","https://openalex.org/W2947042688","https://openalex.org/W2951097224","https://openalex.org/W2954851300","https://openalex.org/W2972411752","https://openalex.org/W2980309067","https://openalex.org/W2998110188","https://openalex.org/W3005235420","https://openalex.org/W3007480931","https://openalex.org/W3024551994","https://openalex.org/W3043584664","https://openalex.org/W3048517330","https://openalex.org/W3082970947","https://openalex.org/W3131125337","https://openalex.org/W3159719254","https://openalex.org/W3164683859","https://openalex.org/W3177828909","https://openalex.org/W3199972932","https://openalex.org/W3200931213","https://openalex.org/W3214847601","https://openalex.org/W4200486799","https://openalex.org/W4211089574","https://openalex.org/W4214677910","https://openalex.org/W4221080428","https://openalex.org/W4223588022","https://openalex.org/W4224063546","https://openalex.org/W4255507877","https://openalex.org/W4281485691","https://openalex.org/W4289274885","https://openalex.org/W4289703894","https://openalex.org/W4306973421","https://openalex.org/W4313829222","https://openalex.org/W4328054256","https://openalex.org/W4360776418","https://openalex.org/W4375858802","https://openalex.org/W4377969101","https://openalex.org/W4386181543","https://openalex.org/W4391924050","https://openalex.org/W4392468583","https://openalex.org/W4396721167","https://openalex.org/W4399125216","https://openalex.org/W4402474075","https://openalex.org/W4406600162","https://openalex.org/W6608965179"],"related_works":["https://openalex.org/W4414334217","https://openalex.org/W1976668731","https://openalex.org/W2737016706","https://openalex.org/W1977462853","https://openalex.org/W6884734468","https://openalex.org/W1969370288","https://openalex.org/W2804761777","https://openalex.org/W1971388047","https://openalex.org/W2430421449","https://openalex.org/W4235494674"],"abstract_inverted_index":{"ABSTRACT":[0],"Wnt":[1,149,204,239],"proteins":[2,86],"are":[3,33,97,114],"critical":[4],"signaling":[5,240],"molecules":[6],"in":[7,87,171,212,221,232],"developmental":[8],"processes":[9],"across":[10,108,247],"animals.":[11],"Despite":[12],"intense":[13],"study,":[14],"their":[15],"evolutionary":[16],"roots":[17],"have":[18,207],"remained":[19],"enigmatic.":[20],"Using":[21],"sensitive":[22],"sequence":[23],"analysis":[24],"and":[25,61,80,130,150,184,205,218,224,241],"structure":[26],"modeling,":[27],"we":[28,100,166],"establish":[29,167,228],"that":[30,138,168],"the":[31,41,47,57,62,70,74,94,200,236,248],"Wnts":[32,96],"part":[34],"of":[35,39,84,90,112,122,177,186,196,203,238,250],"a":[36,81,88,104,229],"vast":[37],"assemblage":[38],"domains,":[40],"Lipocone":[42],"superfamily,":[43,110,198],"defined":[44],"here":[45],"for":[46,103],"first":[48],"time.":[49],"It":[50],"includes":[51],"previously":[52],"studied":[53],"enzymatic":[54],"domains":[55],"like":[56,190],"phosphatidylserine":[58],"synthases":[59],"(PTDSS1/2)":[60],"TelC":[63],"toxin":[64],"domain":[65],"from":[66,163],"Streptococcus":[67],"intermedius":[68],",":[69],"enigmatic":[71],"VanZ":[72],"proteins,":[73,144],"animal":[75],"Serum":[76],"Amyloid":[77],"A":[78],"(SAA)":[79],"further":[82],"host":[83],"uncharacterized":[85],"total":[89],"30":[91],"families.":[92],"Although":[93],"metazoan":[95],"catalytically":[98],"inactive,":[99],"present":[101],"evidence":[102],"conserved":[105],"active":[106],"site":[107],"this":[109,139,197],"versions":[111],"which":[113],"consistently":[115],"predicted":[116],"to":[117],"operate":[118],"on":[119],"head":[120,132],"groups":[121],"either":[123],"phospholipids":[124],"or":[125],"polyisoprenoid":[126],"lipids,":[127],"catalyzing":[128],"transesterification":[129],"phosphate-containing":[131],"group":[133],"cleavage":[134],"reactions.":[135],"We":[136],"argue":[137],"superfamily":[140],"originated":[141],"as":[142,210],"membrane":[143,178],"with":[145],"one":[146],"branch":[147],"(including":[148],"SAA)":[151],"evolving":[152],"into":[153],"diffusible":[154],"versions.":[155],"By":[156],"comprehensively":[157],"analyzing":[158],"contextual":[159],"information":[160],"networks":[161],"derived":[162],"comparative":[164],"genomics,":[165],"they":[169],"act":[170],"varied":[172],"functional":[173],"contexts,":[174],"including":[175,199],"regulation":[176],"lipid":[179,233],"composition,":[180],"extracellular":[181],"polysaccharide":[182],"biosynthesis,":[183],"biogenesis":[185],"bacterial":[187,201],"outer-membrane":[188],"components,":[189],"lipopolysaccharides.":[191],"On":[192],"multiple":[193],"occasions,":[194],"members":[195],"progenitors":[202],"SAA,":[206],"been":[208],"recruited":[209],"effectors":[211],"biological":[213],"conflicts":[214],"spanning":[215],"inter-organismal":[216],"interactions":[217],"anti-viral":[219],"immunity":[220,246],"both":[222],"prokaryotes":[223],"eukaryotes.":[225],"These":[226],"findings":[227],"unifying":[230],"theme":[231],"biochemistry,":[234],"explain":[235],"origins":[237],"provide":[242],"new":[243],"leads":[244],"regarding":[245],"tree":[249],"life.":[251],"Graphical":[252],"abstract":[253]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2025-10-10T00:00:00"}