{"id":"https://openalex.org/W4414136151","doi":"https://doi.org/10.36347/sjmcr.2025.v13i09.018","title":"Atypical Digestive Disorders under Clozapine","display_name":"Atypical Digestive Disorders under Clozapine","publication_year":2025,"publication_date":"2025-09-10","ids":{"openalex":"https://openalex.org/W4414136151","doi":"https://doi.org/10.36347/sjmcr.2025.v13i09.018"},"language":"en","primary_location":{"id":"doi:10.36347/sjmcr.2025.v13i09.018","doi":"https://doi.org/10.36347/sjmcr.2025.v13i09.018","is_oa":true,"landing_page_url":"https://doi.org/10.36347/sjmcr.2025.v13i09.018","pdf_url":"https://saspublishers.com/article/22878/download/","source":{"id":"https://openalex.org/S4210178611","display_name":"Scholars Journal of Medical Case Reports","issn_l":"2347-6559","issn":["2347-6559","2347-9507"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scholars Journal of Medical Case Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://saspublishers.com/article/22878/download/","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019646446","display_name":"A. Korchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"A. Korchi","raw_affiliation_strings":["Faculty of Medicine and Pharmacy of Rabat , Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Pharmacy of Rabat , Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092080525","display_name":"Nihad Ait Bensaid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Ait Benssaid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064405055","display_name":"Hesham Nafia","orcid":"https://orcid.org/0000-0003-0182-889X","observed_orcids":["https://orcid.org/0000-0003-0182-889X"]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"H Nafia","raw_affiliation_strings":["Faculty of Medicine and Pharmacy of Rabat , Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Pharmacy of Rabat , Morocco","institution_ids":["https://openalex.org/I126477371"]}]},{"author_position":"last","author":{"id":null,"display_name":"M Sabir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126477371","display_name":"Mohammed V University","ror":"https://ror.org/00r8w8f84","country_code":"MA","type":"education","lineage":["https://openalex.org/I126477371"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"M Sabir","raw_affiliation_strings":["Faculty of Medicine and Pharmacy of Rabat , Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Pharmacy of Rabat , Morocco","institution_ids":["https://openalex.org/I126477371"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2224792,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"09","first_page":"2033","last_page":"2034"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-induced-diarrhea","display_name":"drug-induced diarrhea","score":0.9309999942779541},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.9319999814033508},{"id":"https://openalex.org/keywords/treatment-resistant-schizophrenia","display_name":"treatment-resistant schizophrenia","score":0.9710000157356262},{"id":"https://openalex.org/keywords/gastrointestinal-side-effects","display_name":"gastrointestinal adverse effects","score":0.9190000295639038},{"id":"https://openalex.org/keywords/leukocytosis","display_name":"leukocytosis","score":0.859000027179718},{"id":"https://openalex.org/keywords/drug-withdrawal","display_name":"drug withdrawal","score":0.6470000147819519},{"id":"https://openalex.org/keywords/immune-mediated-toxicity","display_name":"immune-mediated toxicity","score":0.734000027179718},{"id":"https://openalex.org/keywords/mucosal-toxicity","display_name":"mucosal toxicity","score":0.9639999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8723999857902527},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.8589000105857849},{"id":"https://openalex.org/C2780864610","wikidata":"https://www.wikidata.org/wiki/Q221361","display_name":"Clozapine","level":3,"score":0.8313999772071838},{"id":"https://openalex.org/C2780955771","wikidata":"https://www.wikidata.org/wiki/Q183425","display_name":"Abdominal pain","level":2,"score":0.6384999752044678},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5611000061035156},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.48339998722076416},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4584999978542328},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.39399999380111694},{"id":"https://openalex.org/C2776921671","wikidata":"https://www.wikidata.org/wiki/Q758295","display_name":"Atypical antipsychotic","level":4,"score":0.3856000006198883},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.34540000557899475},{"id":"https://openalex.org/C2994368867","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal system","level":2,"score":0.3077999949455261},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2784999907016754},{"id":"https://openalex.org/C2910545032","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Chronic diarrhea","level":3,"score":0.27149999141693115},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2540999948978424},{"id":"https://openalex.org/C3019834005","wikidata":"https://www.wikidata.org/wiki/Q156103","display_name":"Acute diarrhea","level":3,"score":0.25360000133514404},{"id":"https://openalex.org/C2910452277","wikidata":"https://www.wikidata.org/wiki/Q4736316","display_name":"Altered Mental Status","level":2,"score":0.2513999938964844}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.36347/sjmcr.2025.v13i09.018","doi":"https://doi.org/10.36347/sjmcr.2025.v13i09.018","is_oa":true,"landing_page_url":"https://doi.org/10.36347/sjmcr.2025.v13i09.018","pdf_url":"https://saspublishers.com/article/22878/download/","source":{"id":"https://openalex.org/S4210178611","display_name":"Scholars Journal of Medical Case Reports","issn_l":"2347-6559","issn":["2347-6559","2347-9507"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scholars Journal of Medical Case Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.36347/sjmcr.2025.v13i09.018","doi":"https://doi.org/10.36347/sjmcr.2025.v13i09.018","is_oa":true,"landing_page_url":"https://doi.org/10.36347/sjmcr.2025.v13i09.018","pdf_url":"https://saspublishers.com/article/22878/download/","source":{"id":"https://openalex.org/S4210178611","display_name":"Scholars Journal of Medical Case Reports","issn_l":"2347-6559","issn":["2347-6559","2347-9507"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scholars Journal of Medical Case Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414136151.pdf","grobid_xml":"https://content.openalex.org/works/W4414136151.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7162663397","https://openalex.org/W4303649385","https://openalex.org/W2731364068","https://openalex.org/W4403725919","https://openalex.org/W7160560741","https://openalex.org/W4391437393","https://openalex.org/W3018757344","https://openalex.org/W7125714465","https://openalex.org/W7008524769","https://openalex.org/W7212166001"],"abstract_inverted_index":{"Clozapine":[0],"is":[1],"a":[2,24,31,76,102],"key":[3],"atypical":[4],"antipsychotic":[5],"used":[6],"in":[7,30],"treatment-resistant":[8],"schizophrenia,":[9],"but":[10,57,68],"its":[11],"gastrointestinal":[12],"adverse":[13],"effects":[14],"are":[15],"most":[16],"often":[17],"limited":[18],"to":[19],"constipation.":[20],"This":[21],"report":[22],"describes":[23],"rare":[25],"case":[26,81],"of":[27,105],"clozapine-induced":[28],"diarrhea":[29,50,69,86],"44-year-old":[32],"male":[33],"hospitalized":[34],"for":[35,111],"resistant":[36],"schizophrenia.":[37],"Two":[38],"weeks":[39],"after":[40,72],"initiating":[41],"clozapine":[42,73,90],"(400":[43],"mg/day),":[44],"the":[45],"patient":[46],"developed":[47],"profuse":[48],"watery":[49],"with":[51,109],"mild":[52],"abdominal":[53],"pain":[54],"and":[55,63,107,120],"leukocytosis,":[56],"without":[58],"major":[59],"inflammatory":[60,64],"signs.":[61],"Infectious":[62],"causes":[65],"were":[66],"suspected,":[67],"resolved":[70],"quickly":[71],"withdrawal,":[74],"suggesting":[75],"probable":[77],"drug-related":[78],"effect.":[79],"The":[80],"emphasizes":[82],"that,":[83],"although":[84],"rare,":[85],"can":[87,116],"occur":[88],"under":[89],"treatment,":[91],"possibly":[92],"through":[93],"immune-mediated":[94],"or":[95],"mucosal":[96],"toxicity":[97],"mechanisms.":[98],"Clinicians":[99],"should":[100],"maintain":[101],"high":[103],"index":[104],"suspicion":[106],"collaborate":[108],"gastroenterology":[110],"diagnosis,":[112],"as":[113],"early":[114],"recognition":[115],"avoid":[117],"unnecessary":[118],"investigations":[119],"prolonged":[121],"treatment":[122],"interruption.":[123]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
