{"id":"https://openalex.org/W4414114652","doi":"https://doi.org/10.1101/2025.09.06.674651","title":"Development of an EMT-related exosomal miRNA signature that can predict prognosis in hepatocellular carcinoma","display_name":"Development of an EMT-related exosomal miRNA signature that can predict prognosis in hepatocellular carcinoma","publication_year":2025,"publication_date":"2025-09-11","ids":{"openalex":"https://openalex.org/W4414114652","doi":"https://doi.org/10.1101/2025.09.06.674651"},"language":"en","primary_location":{"id":"doi:10.1101/2025.09.06.674651","doi":"https://doi.org/10.1101/2025.09.06.674651","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.09.06.674651","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/09/11/2025.09.06.674651.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/09/11/2025.09.06.674651.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119588270","display_name":"Olka Missaghimamaghani","orcid":"https://orcid.org/0009-0005-2805-4515","observed_orcids":["https://orcid.org/0009-0005-2805-4515"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I201799495","display_name":"Middle East Technical University","ror":"https://ror.org/014weej12","country_code":"TR","type":"education","lineage":["https://openalex.org/I201799495"]},{"id":"https://openalex.org/I4405261103","display_name":"Vancouver Prostate Centre","ror":"https://ror.org/04skhpe58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405261103"]}],"countries":["CA","TR"],"is_corresponding":false,"raw_author_name":"Olka Missaghi","raw_affiliation_strings":["Current address: Vancouver Prostate Centre , University of British Columbia , Vancouver , British Columbia , V6H 3Z6 Canada","Middle East Technical University"],"raw_orcid":"https://orcid.org/0009-0005-2805-4515","affiliations":[{"raw_affiliation_string":"Current address: Vancouver Prostate Centre , University of British Columbia , Vancouver , British Columbia , V6H 3Z6 Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405261103"]},{"raw_affiliation_string":"Middle East Technical University","institution_ids":["https://openalex.org/I201799495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093766435","display_name":"Leman Nur Nehri","orcid":"https://orcid.org/0000-0003-3396-399X","observed_orcids":["https://orcid.org/0000-0003-3396-399X"]},"institutions":[{"id":"https://openalex.org/I201799495","display_name":"Middle East Technical University","ror":"https://ror.org/014weej12","country_code":"TR","type":"education","lineage":["https://openalex.org/I201799495"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Leman Nur Nehri","raw_affiliation_strings":["Middle East Technical University"],"raw_orcid":"https://orcid.org/0000-0003-3396-399X","affiliations":[{"raw_affiliation_string":"Middle East Technical University","institution_ids":["https://openalex.org/I201799495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019378819","display_name":"Sepehr Bakhshi","orcid":"https://orcid.org/0000-0003-2292-6130","observed_orcids":["https://orcid.org/0000-0003-2292-6130"]},"institutions":[{"id":"https://openalex.org/I168864056","display_name":"Bilkent University","ror":"https://ror.org/02vh8a032","country_code":"TR","type":"education","lineage":["https://openalex.org/I168864056"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sepehr Bakhshi","raw_affiliation_strings":["Bilkent University"],"raw_orcid":"https://orcid.org/0000-0003-2292-6130","affiliations":[{"raw_affiliation_string":"Bilkent University","institution_ids":["https://openalex.org/I168864056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015679316","display_name":"O\u011fuzhan Karaosmano\u011flu","orcid":"https://orcid.org/0000-0003-2028-7339","observed_orcids":["https://orcid.org/0000-0003-2028-7339"]},"institutions":[{"id":"https://openalex.org/I46464968","display_name":"Karamano\u011flu Mehmetbey University","ror":"https://ror.org/037vvf096","country_code":"TR","type":"education","lineage":["https://openalex.org/I46464968"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"O\u011fuzhan Karaosmano\u011flu","raw_affiliation_strings":["Karamanoglu Mehmetbey University"],"raw_orcid":"https://orcid.org/0000-0003-2028-7339","affiliations":[{"raw_affiliation_string":"Karamanoglu Mehmetbey University","institution_ids":["https://openalex.org/I46464968"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051223501","display_name":"H\u00fclya Sivas","orcid":"https://orcid.org/0000-0002-8570-8328","observed_orcids":["https://orcid.org/0000-0002-8570-8328"]},"institutions":[{"id":"https://openalex.org/I4210091955","display_name":"Eskisehir Technical University","ror":"https://ror.org/00gcgqv39","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210091955"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H\u00fclya Sivas","raw_affiliation_strings":["Eskisehir Technical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eskisehir Technical University","institution_ids":["https://openalex.org/I4210091955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037079774","display_name":"Aybar C. Acar","orcid":"https://orcid.org/0000-0001-5694-8675","observed_orcids":["https://orcid.org/0000-0001-5694-8675"]},"institutions":[{"id":"https://openalex.org/I201799495","display_name":"Middle East Technical University","ror":"https://ror.org/014weej12","country_code":"TR","type":"education","lineage":["https://openalex.org/I201799495"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Aybar Can Acar","raw_affiliation_strings":["Middle East Technical University"],"raw_orcid":"https://orcid.org/0000-0001-5694-8675","affiliations":[{"raw_affiliation_string":"Middle East Technical University","institution_ids":["https://openalex.org/I201799495"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064414624","display_name":"Sreeparna Banerjee","orcid":"https://orcid.org/0000-0003-4596-6768","observed_orcids":["https://orcid.org/0000-0003-4596-6768"]},"institutions":[{"id":"https://openalex.org/I201799495","display_name":"Middle East Technical University","ror":"https://ror.org/014weej12","country_code":"TR","type":"education","lineage":["https://openalex.org/I201799495"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Sreeparna Banerjee","raw_affiliation_strings":["Middle East Technical University"],"raw_orcid":"https://orcid.org/0000-0003-4596-6768","affiliations":[{"raw_affiliation_string":"Middle East Technical University","institution_ids":["https://openalex.org/I201799495"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5064414624"],"corresponding_institution_ids":["https://openalex.org/I201799495"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.6151999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.3783999979496002,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9279999732971191},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9779999852180481},{"id":"https://openalex.org/keywords/exosomal-mirna","display_name":"exosomal microRNAs","score":0.8880000114440918},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8450000286102295},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.722000002861023},{"id":"https://openalex.org/keywords/serum-exosomes","display_name":"serum exosomes","score":0.8119999766349792},{"id":"https://openalex.org/keywords/huh7-cells","display_name":"Huh7 cells","score":0.8450000286102295},{"id":"https://openalex.org/keywords/mir-215-5p","display_name":"miR-215-5p","score":0.847000002861023},{"id":"https://openalex.org/keywords/mir-340-5p","display_name":"miR-340-5p","score":0.9700000286102295},{"id":"https://openalex.org/keywords/mir-210-3p","display_name":"miR-210-3p","score":0.9679999947547913},{"id":"https://openalex.org/keywords/mir-19a-3p","display_name":"miR-19a-3p","score":0.949999988079071},{"id":"https://openalex.org/keywords/mir-19b-3p","display_name":"miR-19b-3p","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mir-25-3p","display_name":"miR-25-3p","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bayesian-networks","display_name":"Bayesian networks","score":0.5640000104904175},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/stemness","display_name":"stemness","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.794700026512146},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.7764000296592712},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6302000284194946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5593000054359436},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5365999937057495},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5214999914169312},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4691999852657318},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4361000061035156},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42640000581741333},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4083000123500824},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4025999903678894},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.38019999861717224},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.36469998955726624},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.36169999837875366},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.3280999958515167},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.3273000121116638},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.32120001316070557},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3154999911785126},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3037000000476837},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3034999966621399},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.2847999930381775},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.2833000123500824},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.27219998836517334},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.25540000200271606}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2025.09.06.674651","doi":"https://doi.org/10.1101/2025.09.06.674651","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.09.06.674651","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/09/11/2025.09.06.674651.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2025.09.06.674651","doi":"https://doi.org/10.1101/2025.09.06.674651","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.09.06.674651","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/09/11/2025.09.06.674651.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414114652.pdf","grobid_xml":"https://content.openalex.org/works/W4414114652.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1590412095","https://openalex.org/W1609044025","https://openalex.org/W1867260472","https://openalex.org/W1884243320","https://openalex.org/W1965127442","https://openalex.org/W1987525605","https://openalex.org/W2026546029","https://openalex.org/W2072079749","https://openalex.org/W2085648696","https://openalex.org/W2103126984","https://openalex.org/W2112543725","https://openalex.org/W2146512944","https://openalex.org/W2163366734","https://openalex.org/W2166646088","https://openalex.org/W2179438025","https://openalex.org/W2313936981","https://openalex.org/W2407848977","https://openalex.org/W2414333934","https://openalex.org/W2487275113","https://openalex.org/W2586830130","https://openalex.org/W2752950559","https://openalex.org/W2759480666","https://openalex.org/W2767109827","https://openalex.org/W2790559177","https://openalex.org/W2799898775","https://openalex.org/W2806189561","https://openalex.org/W2807334922","https://openalex.org/W2808423871","https://openalex.org/W2809156896","https://openalex.org/W2897825874","https://openalex.org/W2899510892","https://openalex.org/W2908514932","https://openalex.org/W2954932673","https://openalex.org/W2969146776","https://openalex.org/W2972967307","https://openalex.org/W2983078243","https://openalex.org/W2987179243","https://openalex.org/W2987567173","https://openalex.org/W2995930867","https://openalex.org/W2999635612","https://openalex.org/W3000522739","https://openalex.org/W3011299571","https://openalex.org/W3085616253","https://openalex.org/W3106035297","https://openalex.org/W3112366990","https://openalex.org/W3124226459","https://openalex.org/W3135222784","https://openalex.org/W3138027348","https://openalex.org/W3210953958","https://openalex.org/W4206160123","https://openalex.org/W4221080824","https://openalex.org/W4282974526","https://openalex.org/W4283258591","https://openalex.org/W4294193220","https://openalex.org/W4296161463","https://openalex.org/W4306722800","https://openalex.org/W4318929327","https://openalex.org/W4323036511","https://openalex.org/W4361297397","https://openalex.org/W4382344618","https://openalex.org/W4387703029","https://openalex.org/W4387734333"],"related_works":["https://openalex.org/W3019635545","https://openalex.org/W3119425801","https://openalex.org/W2797863673","https://openalex.org/W3112145902","https://openalex.org/W3085616253","https://openalex.org/W4288692438","https://openalex.org/W4408280270","https://openalex.org/W2898769102","https://openalex.org/W4386273963","https://openalex.org/W3004296379"],"abstract_inverted_index":{"Abstract":[0],"Chemoresistance":[1],"and":[2,13,24,40,59,117,157,179,187],"epithelial-mesenchymal":[3],"transition":[4],"(EMT)":[5],"are":[6,48],"associated":[7,109,129],"with":[8,110,130,167,175,185],"failure":[9],"of":[10,16,36,44,74,100],"cancer":[11],"chemotherapy":[12],"poor":[14],"survival":[15,188],"patients.":[17,102],"We":[18],"have":[19],"previously":[20],"shown":[21],"that":[22,47,78,107,125,143,193,200],"chemoresistance":[23],"stemness":[25],"in":[26,81,93,164,213],"hepatocellular":[27],"carcinoma":[28],"(HCC)":[29],"cells":[30,70,86,206,214],"was":[31,197],"accompanied":[32],"by":[33],"the":[34,61,75,82,94,98,176,190,194,201],"development":[35],"partial":[37],"EMT":[38,186],"(p-EMT)":[39],"identified":[41,92],"a":[42],"number":[43],"EMT-associated":[45],"proteins":[46],"released":[49,204],"from":[50,67,84,97,205],"exosomes.":[51],"In":[52],"this":[53],"study,":[54],"we":[55],"aimed":[56],"to":[57,88],"identify":[58],"classify":[60],"differentially":[62],"expressed":[63],"(DE)":[64],"exosomal":[65,202],"miRNAs":[66,77,104,127,145,178,203],"chemoresistant":[68],"HuH7":[69],"undergoing":[71,207],"p-EMT.":[72],"Out":[73],"fifty-four":[76],"were":[79,91,108,128],"enriched":[80],"exosomes":[83,95],"these":[85],"compared":[87],"controls,":[89],"thirteen":[90,177],"isolated":[96],"serum":[99],"HCC":[101],"These":[103],"targeted":[105],"genes":[106],"cell-cell":[111],"junctions,":[112],"extracellular":[113],"matrix,":[114],"cytoskeleton,":[115],"transcription":[116],"signal":[118],"transduction.":[119],"Univariate":[120],"Cox":[121],"regression":[122],"analysis":[123,174],"indicated":[124,142,192],"11/13":[126],"either":[131],"favorable":[132],"(n=4)":[133],"or":[134],"worse":[135,162],"(n=7)":[136],"prognosis.":[137],"A":[138,170],"machine":[139],"learning":[140],"algorithm":[141],"seven":[144],"(miR":[146],"215-5p,":[147],"miR":[148,150,152,155,158],"340-5p,":[149],"210-3p,":[151],"19a-3p,":[153],"miR19b-3p,":[154],"1266-5p":[156],"25-3p)":[159],"could":[160],"predict":[161],"prognosis":[163],"multiple":[165],"datasets":[166],"64-68%":[168],"accuracy.":[169],"Bayesian":[171],"Inference":[172],"network":[173],"their":[180],"key":[181],"target":[182],"proteins,":[183],"along":[184],"as":[189],"nodes":[191],"common":[195],"denominator":[196],"transcription,":[198],"suggesting":[199],"p-EMT":[208],"can":[209],"mediate":[210],"phenotypic":[211],"changes":[212],"through":[215],"transcriptional":[216],"regulation.":[217]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2025-09-12T00:00:00"}