{"id":"https://openalex.org/W4414106932","doi":"https://doi.org/10.1016/j.celrep.2025.116260","title":"TELS1 stabilizes t-loops independently of TRF2 and controls telomere length in pluripotent cells","display_name":"TELS1 stabilizes t-loops independently of TRF2 and controls telomere length in pluripotent cells","publication_year":2025,"publication_date":"2025-09-01","ids":{"openalex":"https://openalex.org/W4414106932","doi":"https://doi.org/10.1016/j.celrep.2025.116260","pmid":"https://pubmed.ncbi.nlm.nih.gov/40934081"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2025.116260","doi":"https://doi.org/10.1016/j.celrep.2025.116260","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2025.116260","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.celrep.2025.116260","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119585868","display_name":"Joey Dufourd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Joey Dufourd","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique Humaine, CNRS UMR9002, INSERM, Universit\u00e9 de Montpellier, Equipe Labellis\u00e9e la Ligue contre le cancer, 141 rue de la Cardonille, 34000 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Humaine, CNRS UMR9002, INSERM, Universit\u00e9 de Montpellier, Equipe Labellis\u00e9e la Ligue contre le cancer, 141 rue de la Cardonille, 34000 Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210163339"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thi Hai Yen Huynh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thi Hai Yen Huynh","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique Humaine, CNRS UMR9002, INSERM, Universit\u00e9 de Montpellier, Equipe Labellis\u00e9e la Ligue contre le cancer, 141 rue de la Cardonille, 34000 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Humaine, CNRS UMR9002, INSERM, Universit\u00e9 de Montpellier, Equipe Labellis\u00e9e la Ligue contre le cancer, 141 rue de la Cardonille, 34000 Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210163339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110724502","display_name":"Sandrine Sauzet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sandrine Sauzet","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique Humaine, CNRS UMR9002, INSERM, Universit\u00e9 de Montpellier, Equipe Labellis\u00e9e la Ligue contre le cancer, 141 rue de la Cardonille, 34000 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Humaine, CNRS UMR9002, INSERM, Universit\u00e9 de Montpellier, Equipe Labellis\u00e9e la Ligue contre le cancer, 141 rue de la Cardonille, 34000 Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210163339"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Quynh Huong Lai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210119200","display_name":"Institut de Recherche sur le Cancer et le Vieillissement de Nice","ror":"https://ror.org/01td3kv81","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210119200"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Quynh Huong Lai","raw_affiliation_strings":["University C\u00f4te d'Azur, CNRS UMR7284/INSERM U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Faculty of Medicine, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University C\u00f4te d'Azur, CNRS UMR7284/INSERM U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Faculty of Medicine, Nice, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210119200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119585869","display_name":"Francesco Abagnale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210119200","display_name":"Institut de Recherche sur le Cancer et le Vieillissement de Nice","ror":"https://ror.org/01td3kv81","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210119200"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Francesco Abagnale","raw_affiliation_strings":["University C\u00f4te d'Azur, CNRS UMR7284/INSERM U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Faculty of Medicine, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University C\u00f4te d'Azur, CNRS UMR7284/INSERM U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Faculty of Medicine, Nice, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210119200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058228444","display_name":"Sihem Zitouni","orcid":"https://orcid.org/0000-0003-3590-3931","observed_orcids":["https://orcid.org/0000-0003-3590-3931"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sihem Zitouni","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique Humaine, CNRS UMR9002, INSERM, Universit\u00e9 de Montpellier, Equipe Labellis\u00e9e la Ligue contre le cancer, 141 rue de la Cardonille, 34000 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Humaine, CNRS UMR9002, INSERM, Universit\u00e9 de Montpellier, Equipe Labellis\u00e9e la Ligue contre le cancer, 141 rue de la Cardonille, 34000 Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210163339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050665658","display_name":"Marie-Jos\u00e8phe E. Giraud-Panis","orcid":"https://orcid.org/0000-0001-7941-2873","observed_orcids":["https://orcid.org/0000-0001-7941-2873"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210119200","display_name":"Institut de Recherche sur le Cancer et le Vieillissement de Nice","ror":"https://ror.org/01td3kv81","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210119200"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Jos\u00e8phe Giraud-Panis","raw_affiliation_strings":["University C\u00f4te d'Azur, CNRS UMR7284/INSERM U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Faculty of Medicine, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University C\u00f4te d'Azur, CNRS UMR7284/INSERM U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Faculty of Medicine, Nice, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210119200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009888760","display_name":"Serge Urbach","orcid":"https://orcid.org/0000-0001-8663-2006","observed_orcids":["https://orcid.org/0000-0001-8663-2006"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210156758","display_name":"Institut de G\u00e9nomique Fonctionnelle","ror":"https://ror.org/043wmc583","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210156758"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Serge Urbach","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique Fonctionnelle, Universit\u00e9 de Montpellier, CNRS, INSERM, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Fonctionnelle, Universit\u00e9 de Montpellier, CNRS, INSERM, Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210156758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101455337","display_name":"\u00c9ric Gilson","orcid":"https://orcid.org/0000-0001-5738-6723","observed_orcids":["https://orcid.org/0000-0001-5738-6723","https://orcid.org/0000-0001-6820-9132"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]},{"id":"https://openalex.org/I4210119200","display_name":"Institut de Recherche sur le Cancer et le Vieillissement de Nice","ror":"https://ror.org/01td3kv81","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210119200"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Eric Gilson","raw_affiliation_strings":["University C\u00f4te d'Azur, CNRS UMR7284/INSERM U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Faculty of Medicine, Nice, France; Department of Medical Genetics, IHU RespirERA, CHU, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University C\u00f4te d'Azur, CNRS UMR7284/INSERM U1081, Institute for Research on Cancer and Aging, Nice (IRCAN), Faculty of Medicine, Nice, France; Department of Medical Genetics, IHU RespirERA, CHU, Nice, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210119200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007365367","display_name":"Mathieu Tardat","orcid":"https://orcid.org/0000-0001-6689-7373","observed_orcids":["https://orcid.org/0000-0001-6689-7373"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Mathieu Tardat","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique Humaine, CNRS UMR9002, INSERM, Universit\u00e9 de Montpellier, Equipe Labellis\u00e9e la Ligue contre le cancer, 141 rue de la Cardonille, 34000 Montpellier, France. Electronic address: mathieu.tardat@igh.cnrs.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Humaine, CNRS UMR9002, INSERM, Universit\u00e9 de Montpellier, Equipe Labellis\u00e9e la Ligue contre le cancer, 141 rue de la Cardonille, 34000 Montpellier, France. Electronic address: mathieu.tardat@igh.cnrs.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210163339"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017662368","display_name":"J\u00e9r\u00f4me D\u00e9jardin","orcid":"https://orcid.org/0000-0003-0151-1104","observed_orcids":["https://orcid.org/0000-0003-0151-1104"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"J\u00e9r\u00f4me D\u00e9jardin","raw_affiliation_strings":["Institut de G\u00e9n\u00e9tique Humaine, CNRS UMR9002, INSERM, Universit\u00e9 de Montpellier, Equipe Labellis\u00e9e la Ligue contre le cancer, 141 rue de la Cardonille, 34000 Montpellier, France. Electronic address: jerome.dejardin@igh.cnrs.fr"],"raw_orcid":"https://orcid.org/0000-0003-0151-1104","affiliations":[{"raw_affiliation_string":"Institut de G\u00e9n\u00e9tique Humaine, CNRS UMR9002, INSERM, Universit\u00e9 de Montpellier, Equipe Labellis\u00e9e la Ligue contre le cancer, 141 rue de la Cardonille, 34000 Montpellier, France. Electronic address: jerome.dejardin@igh.cnrs.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210163339"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5007365367","https://openalex.org/A5017662368"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210163339"],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":5620,"currency":"USD","value_usd":5620},"fwci":1.6059,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.84123106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"44","issue":"9","first_page":"116260","last_page":"116260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trf2","display_name":"TRF2","score":0.7789999842643738},{"id":"https://openalex.org/keywords/shelterin","display_name":"shelterin","score":0.9100000262260437},{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.8109999895095825},{"id":"https://openalex.org/keywords/pluripotent-cells","display_name":"pluripotent cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/telomere-protection","display_name":"telomere protection","score":0.871999979019165},{"id":"https://openalex.org/keywords/strand-invasion","display_name":"strand invasion","score":0.9190000295639038},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.6940000057220459},{"id":"https://openalex.org/keywords/telomere-elongation","display_name":"telomere elongation","score":0.902999997138977},{"id":"https://openalex.org/keywords/atm-activation","display_name":"ATM activation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/ubr5","display_name":"UBR5","score":0.9700000286102295},{"id":"https://openalex.org/keywords/crispr-screening","display_name":"CRISPR screen","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2776879488","wikidata":"https://www.wikidata.org/wiki/Q3959366","display_name":"Shelterin","level":5,"score":0.964900016784668},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.9078999757766724},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.8622999787330627},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6837999820709229},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.6309999823570251},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5771999955177307},{"id":"https://openalex.org/C202265312","wikidata":"https://www.wikidata.org/wiki/Q7697810","display_name":"Telomere-binding protein","level":5,"score":0.4404999911785126},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.40610000491142273},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.35920000076293945},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32179999351501465},{"id":"https://openalex.org/C99611785","wikidata":"https://www.wikidata.org/wiki/Q6453233","display_name":"Duplex (building)","level":3,"score":0.2971000075340271},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.28940001130104065},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.28679999709129333},{"id":"https://openalex.org/C132455925","wikidata":"https://www.wikidata.org/wiki/Q16965677","display_name":"Cas9","level":4,"score":0.259799987077713},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.25940001010894775},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25619998574256897},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.25099998712539673},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25049999356269836}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034501","descriptor_name":"Telomere-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034501","descriptor_name":"Telomere-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034501","descriptor_name":"Telomere-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035341","descriptor_name":"Telomeric Repeat Binding Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035341","descriptor_name":"Telomeric Repeat Binding Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035341","descriptor_name":"Telomeric Repeat Binding Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D039904","descriptor_name":"Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059505","descriptor_name":"Telomere Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059505","descriptor_name":"Telomere Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059505","descriptor_name":"Telomere Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064007","descriptor_name":"Ataxia Telangiectasia Mutated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.celrep.2025.116260","doi":"https://doi.org/10.1016/j.celrep.2025.116260","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2025.116260","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:40934081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40934081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05360233v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05360233","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, 2025, 44 (9), pp.116260. ⟨10.1016/j.celrep.2025.116260⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2025.116260","doi":"https://doi.org/10.1016/j.celrep.2025.116260","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2025.116260","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G120131529","display_name":null,"funder_award_id":"ANR-10\u2013INSB\u201304","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G1921057727","display_name":"Alternative telomere protection","funder_award_id":"ANR-22-CE12-0026","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G793941223","display_name":"From Genome and Epigenome to Molecular Medicine: turning new paradigms in biology into the therapeutic strategies of tomorrow","funder_award_id":"ANR-10-LABX-0012","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G8447172698","display_name":"D\u00e9veloppment d'une infrastructure fran\u00e7aise distribu\u00e9e coordonn\u00e9e","funder_award_id":"ANR-10-INBS-0004","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320322363","display_name":"Ligue Contre le Cancer","ror":"https://ror.org/00rkrv905"},{"id":"https://openalex.org/F4320330081","display_name":"Laboratoire d'Excellence EpiGenMed","ror":null},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1965019589","https://openalex.org/W1966149222","https://openalex.org/W1966346464","https://openalex.org/W1972655555","https://openalex.org/W1972984145","https://openalex.org/W1977709885","https://openalex.org/W1979609161","https://openalex.org/W1979794741","https://openalex.org/W1982199027","https://openalex.org/W1989635874","https://openalex.org/W2002255627","https://openalex.org/W2005083925","https://openalex.org/W2005631407","https://openalex.org/W2032407757","https://openalex.org/W2032640007","https://openalex.org/W2033731825","https://openalex.org/W2035389897","https://openalex.org/W2038661569","https://openalex.org/W2045526190","https://openalex.org/W2050674095","https://openalex.org/W2056625030","https://openalex.org/W2058815198","https://openalex.org/W2060209663","https://openalex.org/W2072744580","https://openalex.org/W2073204556","https://openalex.org/W2074429117","https://openalex.org/W2080032853","https://openalex.org/W2087011288","https://openalex.org/W2106996266","https://openalex.org/W2120438776","https://openalex.org/W2125724353","https://openalex.org/W2136856258","https://openalex.org/W2147137771","https://openalex.org/W2148197898","https://openalex.org/W2156930669","https://openalex.org/W2164580633","https://openalex.org/W2177542975","https://openalex.org/W2231683418","https://openalex.org/W2252568502","https://openalex.org/W2320876948","https://openalex.org/W2575544787","https://openalex.org/W2588449240","https://openalex.org/W2614103507","https://openalex.org/W2790795270","https://openalex.org/W2801872537","https://openalex.org/W2892224724","https://openalex.org/W2911986456","https://openalex.org/W2923937922","https://openalex.org/W2944481848","https://openalex.org/W2978935190","https://openalex.org/W2988232733","https://openalex.org/W3036575099","https://openalex.org/W3106796412","https://openalex.org/W3109939438","https://openalex.org/W3115175503","https://openalex.org/W3126960103","https://openalex.org/W4206969779","https://openalex.org/W4310668135","https://openalex.org/W4386332671","https://openalex.org/W4403513301"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2096760656","https://openalex.org/W2045637853","https://openalex.org/W2005903392","https://openalex.org/W2417511905","https://openalex.org/W4295073628","https://openalex.org/W2175325490","https://openalex.org/W2362612357","https://openalex.org/W2103156000","https://openalex.org/W2380378134"],"abstract_inverted_index":{"Telomeric":[0],"loops":[1],"(t-loops)":[2],"are":[3],"thought":[4],"to":[5,68,76,104,139,144],"protect":[6],"chromosome":[7],"ends,":[8],"with":[9,59],"their":[10],"stabilization":[11],"generally":[12],"requiring":[13],"the":[14,19,82,123],"shelterin":[15],"protein":[16],"TRF2.":[17],"However,":[18],"mechanisms":[20],"operating":[21],"in":[22,36,56,63,70,80,107],"pluripotent":[23,37,92,140],"cells":[24,141],"remain":[25,98],"unknown.":[26],"Here,":[27],"we":[28],"identify":[29],"TELS1":[30,39,73],"as":[31,115,125],"a":[32,60,134],"TRF2-independent":[33],"t-loop":[34,64,124],"stabilizer":[35],"cells.":[38],"binds":[40],"single-stranded,":[41],"G-rich":[42],"telomeric":[43,50],"DNA":[44],"tracts":[45],"likely":[46],"present":[47],"within":[48],"duplex":[49],"regions":[51],"and":[52,100,132],"promotes":[53],"strand":[54],"invasion":[55],"vitro,":[57],"consistent":[58],"direct":[61],"role":[62],"formation.":[65],"When":[66],"targeted":[67],"telomeres":[69,94],"differentiated":[71],"cells,":[72,93],"is":[74],"able":[75],"substitute":[77],"for":[78,117,129],"TRF2":[79],"making":[81],"t-loop,":[83],"which":[84],"partially":[85],"protects":[86],"from":[87],"ATM":[88],"activation.":[89],"In":[90],"TELS1-deficient":[91],"lack":[95],"t-loops":[96],"but":[97],"protected":[99],"become":[101],"more":[102],"accessible":[103],"telomerase,":[105],"resulting":[106],"elongation.":[108],"A":[109],"genome-wide":[110],"CRISPR":[111],"screen":[112],"identifies":[113],"Ubr5":[114],"essential":[116,127],"this":[118],"tolerance.":[119],"These":[120],"findings":[121],"validate":[122],"an":[126],"structure":[128],"end":[130],"protection":[131,136],"uncover":[133],"telomere":[135],"pathway":[137],"unique":[138],"that":[142],"appears":[143],"function":[145],"independently":[146],"of":[147],"shelterin.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}