{"id":"https://openalex.org/W4414101561","doi":"https://doi.org/10.36106/paripex/4800595","title":"DEXOMETOMIDINE (50 MCG) FOR SAFE AND SEAMLESS EXTUBATION RESPONSE","display_name":"DEXOMETOMIDINE (50 MCG) FOR SAFE AND SEAMLESS EXTUBATION RESPONSE","publication_year":2025,"publication_date":"2025-08-15","ids":{"openalex":"https://openalex.org/W4414101561","doi":"https://doi.org/10.36106/paripex/4800595"},"language":"en","primary_location":{"id":"doi:10.36106/paripex/4800595","doi":"https://doi.org/10.36106/paripex/4800595","is_oa":true,"landing_page_url":"https://doi.org/10.36106/paripex/4800595","pdf_url":"https://doi.org/10.36106/paripex/4800595","source":{"id":"https://openalex.org/S2765053643","display_name":"PARIPEX-INDIAN JOURNAL OF RESEARCH","issn_l":"2250-1991","issn":["2250-1991"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320570","host_organization_name":"World Wide Journals","host_organization_lineage":["https://openalex.org/P4310320570"],"host_organization_lineage_names":["World Wide Journals"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PARIPEX INDIAN JOURNAL OF RESEARCH","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.36106/paripex/4800595","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114306633","display_name":"J. Vennela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157458207","display_name":"Al-Ameen Medical College","ror":"https://ror.org/03gd6ja31","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I157458207"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"J. Vennela","raw_affiliation_strings":["MD Anesthesiology,Department of Anesthesiology,Critical Care and Pain medicine,Al-Ameen Medical College Hospital,Vijayapura"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anesthesiology,Department of Anesthesiology,Critical Care and Pain medicine,Al-Ameen Medical College Hospital,Vijayapura","institution_ids":["https://openalex.org/I157458207"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Meenal Agarwal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157458207","display_name":"Al-Ameen Medical College","ror":"https://ror.org/03gd6ja31","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I157458207"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Meenal Agarwal","raw_affiliation_strings":["Professor,Department of Anesthesiology,Critical Care and Pain medicine,AlAmeen Medical College Hospital,Vijayapura"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor,Department of Anesthesiology,Critical Care and Pain medicine,AlAmeen Medical College Hospital,Vijayapura","institution_ids":["https://openalex.org/I157458207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119583687","display_name":"Safura. Sultana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157458207","display_name":"Al-Ameen Medical College","ror":"https://ror.org/03gd6ja31","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I157458207"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Safura. Sultana","raw_affiliation_strings":["MD Anesthesiology,Department of Anesthesiology,Critical Care and Pain medicine,Al Ameen medical college and hospital, Vijayapura"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anesthesiology,Department of Anesthesiology,Critical Care and Pain medicine,Al Ameen medical college and hospital, Vijayapura","institution_ids":["https://openalex.org/I157458207"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5119583688","display_name":"Akbar. C.M","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157458207","display_name":"Al-Ameen Medical College","ror":"https://ror.org/03gd6ja31","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I157458207"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Akbar. C.M","raw_affiliation_strings":["MD Anesthesiology,Department of Anesthesiology,Critical Care and Pain medicine,Al Ameen medical college and hospital, Vijayapura"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MD Anesthesiology,Department of Anesthesiology,Critical Care and Pain medicine,Al Ameen medical college and hospital, Vijayapura","institution_ids":["https://openalex.org/I157458207"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I157458207"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31887801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"13","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10830","display_name":"Airway Management and Intubation Techniques","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexmedetomidine","display_name":"dexmedetomidine","score":1.0},{"id":"https://openalex.org/keywords/extubation","display_name":"extubation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/emergence-from-general-anesthesia","display_name":"emergence from general anesthesia","score":0.8209999799728394},{"id":"https://openalex.org/keywords/sympathoadrenal-response","display_name":"sympathoadrenal response","score":0.8019999861717224},{"id":"https://openalex.org/keywords/hemodynamic-stability","display_name":"hemodynamic stability","score":0.8289999961853027},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.7400000095367432},{"id":"https://openalex.org/keywords/bradycardia","display_name":"bradycardia","score":0.8920000195503235}],"concepts":[{"id":"https://openalex.org/C2781302539","wikidata":"https://www.wikidata.org/wiki/Q412133","display_name":"Dexmedetomidine","level":3,"score":0.9609000086784363},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8894000053405762},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.8357999920845032},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.6687999963760376},{"id":"https://openalex.org/C2777495988","wikidata":"https://www.wikidata.org/wiki/Q217111","display_name":"Bradycardia","level":4,"score":0.6391000151634216},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.5961999893188477},{"id":"https://openalex.org/C2778716859","wikidata":"https://www.wikidata.org/wiki/Q939018","display_name":"Intubation","level":2,"score":0.5482000112533569},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.46950000524520874},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.46619999408721924},{"id":"https://openalex.org/C2778029997","wikidata":"https://www.wikidata.org/wiki/Q750195","display_name":"Tracheal intubation","level":3,"score":0.4334000051021576},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.43299999833106995},{"id":"https://openalex.org/C2779520467","wikidata":"https://www.wikidata.org/wiki/Q427179","display_name":"Medetomidine","level":4,"score":0.41339999437332153},{"id":"https://openalex.org/C26170363","wikidata":"https://www.wikidata.org/wiki/Q1981408","display_name":"Haemodynamic response","level":4,"score":0.4117000102996826},{"id":"https://openalex.org/C2781312054","wikidata":"https://www.wikidata.org/wiki/Q5354947","display_name":"Elective surgery","level":2,"score":0.3215999901294708},{"id":"https://openalex.org/C2780978852","wikidata":"https://www.wikidata.org/wiki/Q286949","display_name":"Airway management","level":3,"score":0.311599999666214},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.30000001192092896},{"id":"https://openalex.org/C2780457178","wikidata":"https://www.wikidata.org/wiki/Q3774744","display_name":"Respiratory arrest","level":2,"score":0.2930999994277954},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.29179999232292175},{"id":"https://openalex.org/C2991710064","wikidata":"https://www.wikidata.org/wiki/Q750195","display_name":"Endotracheal intubation","level":3,"score":0.2904999852180481}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.36106/paripex/4800595","doi":"https://doi.org/10.36106/paripex/4800595","is_oa":true,"landing_page_url":"https://doi.org/10.36106/paripex/4800595","pdf_url":"https://doi.org/10.36106/paripex/4800595","source":{"id":"https://openalex.org/S2765053643","display_name":"PARIPEX-INDIAN JOURNAL OF RESEARCH","issn_l":"2250-1991","issn":["2250-1991"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320570","host_organization_name":"World Wide Journals","host_organization_lineage":["https://openalex.org/P4310320570"],"host_organization_lineage_names":["World Wide Journals"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PARIPEX INDIAN JOURNAL OF RESEARCH","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.36106/paripex/4800595","doi":"https://doi.org/10.36106/paripex/4800595","is_oa":true,"landing_page_url":"https://doi.org/10.36106/paripex/4800595","pdf_url":"https://doi.org/10.36106/paripex/4800595","source":{"id":"https://openalex.org/S2765053643","display_name":"PARIPEX-INDIAN JOURNAL OF RESEARCH","issn_l":"2250-1991","issn":["2250-1991"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320570","host_organization_name":"World Wide Journals","host_organization_lineage":["https://openalex.org/P4310320570"],"host_organization_lineage_names":["World Wide Journals"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PARIPEX INDIAN JOURNAL OF RESEARCH","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414101561.pdf","grobid_xml":"https://content.openalex.org/works/W4414101561.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":{"Emergence":[0],"from":[1],"general":[2],"anesthesia":[3],"and":[4,19,100,118,136,169,188],"tracheal":[5],"extubation":[6,94,138],"provoke":[7],"profound":[8],"sympathoadrenal":[9],"activation,":[10],"manifesting":[11],"as":[12],"tachycardia,":[13],"hypertension,":[14],"arrhythmogenesis,":[15],"elevated":[16],"intracranial/intraocular":[17],"pressures,":[18],"airway":[20,189],"hyperreactivity":[21],"(Reel":[22],"&":[23],"Maani,":[24],"2023).":[25],"This":[26],"investigation":[27],"evaluates":[28],"the":[29],"efficacy":[30],"of":[31,155],"a":[32,178],"single":[33],"pre-emptive":[34],"50":[35,76],"mcg":[36,77],"intravenous":[37],"dexmedetomidine":[38,75,156,175],"bolus,":[39],"administered":[40,82],"10":[41],"minutes":[42],"pre-extubation,":[43],"in":[44,153],"attenuating":[45],"this":[46],"high-stress":[47],"response":[48],"(Gertler":[49],"et":[50,147],"al.,":[51,148],"2001).":[52],"A":[53],"prospective,":[54],"randomized,":[55],"double-blind,":[56],"controlled":[57],"trial":[58],"enrolled":[59],"ASA":[60],"PS":[61],"I-III":[62],"adults":[63],"undergoing":[64],"elective":[65],"surgery":[66],"with":[67],"endotracheal":[68],"intubation":[69],">60":[70],"minutes.":[71],"Participants":[72],"received":[73],"either":[74],"IV":[78],"(n=10)":[79],"or":[80],"weren't":[81],"anything":[83],"(n=10).":[84],"Primary":[85],"endpoints":[86],"included":[87],"hemodynamic":[88,124,159,187],"stability":[89,190],"(heart":[90],"rate,":[91,113],"systolic/diastolic":[92],"pressures),":[93],"quality":[95,139],"(4-point":[96],"Extubation":[97],"Quality":[98],"Scale),":[99],"cough":[101,128],"suppression":[102],"(Cough":[103],"Severity":[104],"Score).":[105],"Secondary":[106],"metrics":[107],"encompassed":[108],"respiratory":[109,112,167],"parameters":[110],"(SpO\u2082,":[111],"rapid":[114],"shallow":[115],"breathing":[116],"index)":[117],"adverse":[119],"events.":[120],"Dexmedetomidine":[121],"significantly":[122],"blunted":[123],"perturbations":[125],"(p<0.05),":[126],"reduced":[127,170],"severity":[129],"(median":[130,140],"CSS":[131],"1":[132,142],"vs.":[133,143],"3,":[134,144],"p<0.01),":[135],"optimized":[137],"EQS":[141],"p<0.01)":[145],"(Wang":[146],"2019).":[149],"Transient":[150],"bradycardia":[151],"occurred":[152],"20%":[154],"recipients":[157],"without":[158],"compromise.":[160],"The":[161],"intervention":[162],"conferred":[163],"cooperative":[164],"sedation,":[165],"negligible":[166],"depression,":[168],"postextubation":[171],"analgesic":[172],"requirements.":[173],"Pre-extubation":[174],"bolus":[176],"is":[177],"potent":[179],"pharmacologic":[180],"strategy":[181],"for":[182],"mitigating":[183],"sympathetic":[184],"hyperactivation,":[185],"enhancing":[186],"during":[191],"emergence.":[192]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}