{"id":"https://openalex.org/W4414044326","doi":"https://doi.org/10.1016/j.isci.2026.118049","title":"Axonal transcriptome remodeling during PGE2 induced sensitization identifies Tnfrsf12a/FN14 as a regulator of sensory neuron excitability","display_name":"Axonal transcriptome remodeling during PGE2 induced sensitization identifies Tnfrsf12a/FN14 as a regulator of sensory neuron excitability","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W4414044326","doi":"https://doi.org/10.1016/j.isci.2026.118049"},"language":"en","primary_location":{"id":"doi:10.1016/j.isci.2026.118049","doi":"https://doi.org/10.1016/j.isci.2026.118049","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2026.118049","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.isci.2026.118049","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075742214","display_name":"Asta Arendt-Tranholm","orcid":"https://orcid.org/0000-0002-6997-0959","observed_orcids":["https://orcid.org/0000-0002-6997-0959"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Asta Arendt-Tranholm","raw_affiliation_strings":["School of Life Sciences, Physiology, Pharmacology and Neuroscience Division, University of Nottingham, Nottingham, UK"],"raw_orcid":"https://orcid.org/0000-0002-6997-0959","affiliations":[{"raw_affiliation_string":"School of Life Sciences, Physiology, Pharmacology and Neuroscience Division, University of Nottingham, Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046664823","display_name":"Rafael Sebasti\u00e1n Fort","orcid":"https://orcid.org/0000-0002-0161-8860","observed_orcids":["https://orcid.org/0000-0002-0161-8860"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]},{"id":"https://openalex.org/I4210157419","display_name":"Instituto de Investigaciones Biol\u00f3gicas Clemente Estable","ror":"https://ror.org/05b50ej63","country_code":"UY","type":"nonprofit","lineage":["https://openalex.org/I4210098830","https://openalex.org/I4210157419"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Rafael Sebasti\u00e1n Fort","raw_affiliation_strings":["Departamento de Gen\u00f3mica, IIBCE, Montevideo, Uruguay","Secci\u00f3n Gen\u00f3mica Funcional, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo, Uruguay"],"raw_orcid":"https://orcid.org/0000-0002-0161-8860","affiliations":[{"raw_affiliation_string":"Departamento de Gen\u00f3mica, IIBCE, Montevideo, Uruguay","institution_ids":["https://openalex.org/I4210157419"]},{"raw_affiliation_string":"Secci\u00f3n Gen\u00f3mica Funcional, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110337287","display_name":"Robert K. Pope","orcid":"https://orcid.org/0000-0001-8598-494X","observed_orcids":["https://orcid.org/0000-0001-8598-494X"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rebecca Pope","raw_affiliation_strings":["School of Life Sciences, Physiology, Pharmacology and Neuroscience Division, University of Nottingham, Nottingham, UK"],"raw_orcid":"https://orcid.org/0000-0001-8598-494X","affiliations":[{"raw_affiliation_string":"School of Life Sciences, Physiology, Pharmacology and Neuroscience Division, University of Nottingham, Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086144872","display_name":"Alex Rathbone","orcid":"https://orcid.org/0000-0003-1871-7686","observed_orcids":["https://orcid.org/0000-0003-1871-7686"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alex Rathbone","raw_affiliation_strings":["School of Life Sciences, Physiology, Pharmacology and Neuroscience Division, University of Nottingham, Nottingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Physiology, Pharmacology and Neuroscience Division, University of Nottingham, Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160096883","display_name":"Paul Millns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Millns","raw_affiliation_strings":["School of Life Sciences, Physiology, Pharmacology and Neuroscience Division, University of Nottingham, Nottingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences, Physiology, Pharmacology and Neuroscience Division, University of Nottingham, Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002957093","display_name":"Gareth J. Hathway","orcid":"https://orcid.org/0000-0003-4347-9667","observed_orcids":["https://orcid.org/0000-0003-4347-9667"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4210117448","display_name":"Arthritis UK","ror":"https://ror.org/02jkpm469","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210117448"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gareth Hathway","raw_affiliation_strings":["Arthritis UK Pain Centre, University of Nottingham, Nottingham, UK","RNA Interdisciplinary Cluster (RIC@N), Nottingham, UK","School of Life Sciences, Physiology, Pharmacology and Neuroscience Division, University of Nottingham, Nottingham, UK"],"raw_orcid":"https://orcid.org/0000-0003-4347-9667","affiliations":[{"raw_affiliation_string":"Arthritis UK Pain Centre, University of Nottingham, Nottingham, UK","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4210117448"]},{"raw_affiliation_string":"RNA Interdisciplinary Cluster (RIC@N), Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]},{"raw_affiliation_string":"School of Life Sciences, Physiology, Pharmacology and Neuroscience Division, University of Nottingham, Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075294163","display_name":"Jos\u00e9 Roberto Sotelo-Silveira","orcid":"https://orcid.org/0000-0002-4758-8556","observed_orcids":["https://orcid.org/0000-0002-4758-8556"]},"institutions":[{"id":"https://openalex.org/I180910786","display_name":"Universidad de la Rep\u00fablica de Uruguay","ror":"https://ror.org/030bbe882","country_code":"UY","type":"education","lineage":["https://openalex.org/I180910786"]},{"id":"https://openalex.org/I4210157419","display_name":"Instituto de Investigaciones Biol\u00f3gicas Clemente Estable","ror":"https://ror.org/05b50ej63","country_code":"UY","type":"nonprofit","lineage":["https://openalex.org/I4210098830","https://openalex.org/I4210157419"]}],"countries":["UY"],"is_corresponding":false,"raw_author_name":"Jose Sotelo-Silveira","raw_affiliation_strings":["Departamento de Biolog\u00eda Celular, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo, Uruguay","Departamento de Gen\u00f3mica, IIBCE, Montevideo, Uruguay"],"raw_orcid":"https://orcid.org/0000-0002-4758-8556","affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular, Facultad de Ciencias, Universidad de la Rep\u00fablica, Montevideo, Uruguay","institution_ids":["https://openalex.org/I180910786"]},{"raw_affiliation_string":"Departamento de Gen\u00f3mica, IIBCE, Montevideo, Uruguay","institution_ids":["https://openalex.org/I4210157419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024563142","display_name":"Victoria Chapman","orcid":"https://orcid.org/0000-0002-7969-2788","observed_orcids":["https://orcid.org/0000-0002-7969-2788"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4210117448","display_name":"Arthritis UK","ror":"https://ror.org/02jkpm469","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210117448"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Victoria Chapman","raw_affiliation_strings":["Arthritis UK Pain Centre, University of Nottingham, Nottingham, UK","RNA Interdisciplinary Cluster (RIC@N), Nottingham, UK","School of Life Sciences, Physiology, Pharmacology and Neuroscience Division, University of Nottingham, Nottingham, UK"],"raw_orcid":"https://orcid.org/0000-0002-7969-2788","affiliations":[{"raw_affiliation_string":"Arthritis UK Pain Centre, University of Nottingham, Nottingham, UK","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4210117448"]},{"raw_affiliation_string":"RNA Interdisciplinary Cluster (RIC@N), Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]},{"raw_affiliation_string":"School of Life Sciences, Physiology, Pharmacology and Neuroscience Division, University of Nottingham, Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049453277","display_name":"Cornelia H. de Moor","orcid":"https://orcid.org/0000-0001-8776-0085","observed_orcids":["https://orcid.org/0000-0001-8776-0085"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4210117448","display_name":"Arthritis UK","ror":"https://ror.org/02jkpm469","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210117448"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cornelia H. de Moor","raw_affiliation_strings":["Arthritis UK Pain Centre, University of Nottingham, Nottingham, UK","RNA Interdisciplinary Cluster (RIC@N), Nottingham, UK","School of Pharmacy, University of Nottingham, Nottingham, UK"],"raw_orcid":"https://orcid.org/0000-0001-8776-0085","affiliations":[{"raw_affiliation_string":"Arthritis UK Pain Centre, University of Nottingham, Nottingham, UK","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4210117448"]},{"raw_affiliation_string":"RNA Interdisciplinary Cluster (RIC@N), Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]},{"raw_affiliation_string":"School of Pharmacy, University of Nottingham, Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034444170","display_name":"Federico Dajas\u2010Bailador","orcid":"https://orcid.org/0000-0002-2212-1482","observed_orcids":["https://orcid.org/0000-0002-2212-1482"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I4210117448","display_name":"Arthritis UK","ror":"https://ror.org/02jkpm469","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210117448"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Federico Dajas-Bailador","raw_affiliation_strings":["Arthritis UK Pain Centre, University of Nottingham, Nottingham, UK","RNA Interdisciplinary Cluster (RIC@N), Nottingham, UK","School of Life Sciences, Physiology, Pharmacology and Neuroscience Division, University of Nottingham, Nottingham, UK"],"raw_orcid":"https://orcid.org/0000-0002-2212-1482","affiliations":[{"raw_affiliation_string":"Arthritis UK Pain Centre, University of Nottingham, Nottingham, UK","institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4210117448"]},{"raw_affiliation_string":"RNA Interdisciplinary Cluster (RIC@N), Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]},{"raw_affiliation_string":"School of Life Sciences, Physiology, Pharmacology and Neuroscience Division, University of Nottingham, Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5034444170"],"corresponding_institution_ids":["https://openalex.org/I142263535","https://openalex.org/I4210117448"],"apc_list":{"value":3240,"currency":"USD","value_usd":3240},"apc_paid":{"value":3240,"currency":"USD","value_usd":3240},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00203333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"11","first_page":"118049","last_page":"118049"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.8840000033378601},{"id":"https://openalex.org/keywords/dorsal-root-ganglion-neurons","display_name":"dorsal root ganglion neurons","score":0.8659999966621399},{"id":"https://openalex.org/keywords/tnfrsf12a","display_name":"TNFRSF12A","score":0.8460000157356262},{"id":"https://openalex.org/keywords/fn14","display_name":"Fn14","score":0.9660000205039978},{"id":"https://openalex.org/keywords/peripheral-sensitization","display_name":"peripheral sensitization","score":0.7269999980926514},{"id":"https://openalex.org/keywords/inflammatory-pain","display_name":"inflammatory pain","score":0.9290000200271606},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.9070000052452087}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.8493000268936157},{"id":"https://openalex.org/C2776281502","wikidata":"https://www.wikidata.org/wiki/Q1395415","display_name":"Dorsal root ganglion","level":3,"score":0.7376999855041504},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6337000131607056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5873000025749207},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.572700023651123},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5389999747276306},{"id":"https://openalex.org/C172659308","wikidata":"https://www.wikidata.org/wiki/Q412542","display_name":"Nociceptor","level":4,"score":0.5206000208854675},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.47920000553131104},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.40230000019073486},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.38499999046325684},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.37049999833106995},{"id":"https://openalex.org/C2775991916","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Nerve injury","level":2,"score":0.367900013923645},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.32910001277923584},{"id":"https://openalex.org/C2779683492","wikidata":"https://www.wikidata.org/wiki/Q792615","display_name":"Axotomy","level":3,"score":0.3246999979019165},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.3109000027179718},{"id":"https://openalex.org/C2776880756","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Peripheral nerve injury","level":3,"score":0.30390000343322754},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.30000001192092896},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.28290000557899475},{"id":"https://openalex.org/C2775908076","wikidata":"https://www.wikidata.org/wiki/Q3142126","display_name":"Sensory neuron","level":3,"score":0.28139999508857727},{"id":"https://openalex.org/C70192387","wikidata":"https://www.wikidata.org/wiki/Q792602","display_name":"Axoplasmic transport","level":2,"score":0.28049999475479126},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.2721000015735626},{"id":"https://openalex.org/C2777198256","wikidata":"https://www.wikidata.org/wiki/Q4860325","display_name":"Prostaglandin E","level":2,"score":0.2678000032901764},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.26460000872612},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.26100000739097595},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.2596000134944916},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.2540000081062317},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.2515999972820282}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.isci.2026.118049","doi":"https://doi.org/10.1016/j.isci.2026.118049","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2026.118049","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},{"id":"doi:10.1101/2025.09.02.673723","doi":"https://doi.org/10.1101/2025.09.02.673723","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.09.02.673723","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:doaj.org/article:382642b996444194a837ff30643d88df","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/382642b996444194a837ff30643d88df","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"iScience, Vol 29, Iss 11, Pp 118049- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.isci.2026.118049","doi":"https://doi.org/10.1016/j.isci.2026.118049","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2026.118049","pdf_url":null,"source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3035200603","display_name":"Pain Centre Arthritis UK","funder_award_id":"20777","funder_id":"https://openalex.org/F4320327444","funder_display_name":"Versus Arthritis"},{"id":"https://openalex.org/G755716364","display_name":null,"funder_award_id":"21586","funder_id":"https://openalex.org/F4320327444","funder_display_name":"Versus Arthritis"}],"funders":[{"id":"https://openalex.org/F4320314731","display_name":"UK Research and Innovation","ror":"https://ror.org/001aqnf71"},{"id":"https://openalex.org/F4320327444","display_name":"Versus Arthritis","ror":"https://ror.org/02jkpm469"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W105474233","https://openalex.org/W193867833","https://openalex.org/W1484641059","https://openalex.org/W1532048115","https://openalex.org/W1569294608","https://openalex.org/W1731795725","https://openalex.org/W1831892029","https://openalex.org/W1942930266","https://openalex.org/W1952903895","https://openalex.org/W1964628656","https://openalex.org/W1967011263","https://openalex.org/W1969137460","https://openalex.org/W1980360785","https://openalex.org/W1983159021","https://openalex.org/W1992863847","https://openalex.org/W2002567538","https://openalex.org/W2006213039","https://openalex.org/W2010289572","https://openalex.org/W2021044001","https://openalex.org/W2027895544","https://openalex.org/W2028997371","https://openalex.org/W2033072655","https://openalex.org/W2038338205","https://openalex.org/W2054414357","https://openalex.org/W2056701849","https://openalex.org/W2073197172","https://openalex.org/W2075715972","https://openalex.org/W2076938724","https://openalex.org/W2077358692","https://openalex.org/W2080383365","https://openalex.org/W2089626913","https://openalex.org/W2090661905","https://openalex.org/W2098829275","https://openalex.org/W2101460836","https://openalex.org/W2114570899","https://openalex.org/W2117169037","https://openalex.org/W2124150189","https://openalex.org/W2127279968","https://openalex.org/W2129563086","https://openalex.org/W2129935236","https://openalex.org/W2130410032","https://openalex.org/W2133948974","https://openalex.org/W2145192310","https://openalex.org/W2148281583","https://openalex.org/W2155524482","https://openalex.org/W2156933957","https://openalex.org/W2158021569","https://openalex.org/W2165775274","https://openalex.org/W2195049256","https://openalex.org/W2416334331","https://openalex.org/W2440302195","https://openalex.org/W2468478263","https://openalex.org/W2540401908","https://openalex.org/W2591515373","https://openalex.org/W2605892792","https://openalex.org/W2755967204","https://openalex.org/W2762851710","https://openalex.org/W2772413986","https://openalex.org/W2784097477","https://openalex.org/W2789909579","https://openalex.org/W2797436565","https://openalex.org/W2896943750","https://openalex.org/W2905106210","https://openalex.org/W2937876776","https://openalex.org/W2946872736","https://openalex.org/W2949138297","https://openalex.org/W2949693884","https://openalex.org/W2950162000","https://openalex.org/W2979925777","https://openalex.org/W2995312562","https://openalex.org/W2999978880","https://openalex.org/W3001305827","https://openalex.org/W3005763256","https://openalex.org/W3010645005","https://openalex.org/W3016778275","https://openalex.org/W3018484291","https://openalex.org/W3037975981","https://openalex.org/W3040992385","https://openalex.org/W3078481672","https://openalex.org/W3099613440","https://openalex.org/W3112361215","https://openalex.org/W3120706667","https://openalex.org/W3172617217","https://openalex.org/W3174436335","https://openalex.org/W3214631367","https://openalex.org/W3215378256","https://openalex.org/W4280508982","https://openalex.org/W4304183624","https://openalex.org/W4319987484","https://openalex.org/W4402599413","https://openalex.org/W4403507449","https://openalex.org/W4412983880","https://openalex.org/W4416011824"],"related_works":["https://openalex.org/W7017562306","https://openalex.org/W7217587244","https://openalex.org/W2530881521","https://openalex.org/W4220990362","https://openalex.org/W7102405195","https://openalex.org/W4401101444","https://openalex.org/W2054240696","https://openalex.org/W3209492895","https://openalex.org/W3011189593","https://openalex.org/W2519025238"],"abstract_inverted_index":{"Abstract":[0],"Chronic":[1],"pain":[2,117],"arises":[3],"when":[4],"dorsal":[5],"root":[6],"ganglion":[7],"(DRG)":[8],"neurons":[9,71],"become":[10],"sensitised":[11],"to":[12,47,89,113,156,187],"noxious":[13],"inputs,":[14],"a":[15,35,82,152,162,206],"process":[16],"driven":[17],"by":[18],"inflammatory":[19,48,210],"mediators":[20],"such":[21],"as":[22,161,197,205],"prostaglandin":[23],"E":[24],"2":[25,27,78,107,130,164],"(PGE":[26],").":[28],"Local":[29],"translation":[30],"of":[31,38,140,172,199],"axonal":[32,43,60,85,128,166,170,194],"mRNAs":[33],"is":[34],"key":[36],"regulator":[37],"nociceptor":[39],"plasticity,":[40],"yet":[41],"how":[42],"transcriptome":[44,86,195],"dynamics":[45],"contribute":[46],"sensitisation":[49,139,201],"remains":[50],"unclear.":[51],"Using":[52],"compartmentalised":[53],"culture":[54],"systems":[55],"and":[56,61,67,72,96,103,116,136,158,202],"RNA-sequencing,":[57],"we":[58,148],"defined":[59],"somatic":[62],"transcriptomes":[63],"in":[64,120,124],"embryonic":[65,88],"(E16.5)":[66],"adult":[68,90],"(W8)":[69],"DRG":[70],"assessed":[73],"their":[74],"remodelling":[75],"after":[76],"PGE":[77,106,129,163],"exposure.":[79],"We":[80],"identify":[81],"conserved":[83,193],"core":[84],"spanning":[87],"stages,":[91],"prominently":[92],"enriched":[93,182],"for":[94,209],"ribosomal":[95],"mitochondrial":[97],"functions,":[98],"consistent":[99],"with":[100,145],"sustained":[101],"translational":[102],"metabolic":[104],"demands.":[105],"elicited":[108],"compartment-specific":[109],"reprogramming:":[110],"pathways":[111],"related":[112],"sensory":[114],"processing":[115],"were":[118],"upregulated":[119],"axons":[121],"but":[122],"downregulated":[123],"somata.":[125,142],"Functionally,":[126],"prolonged":[127],"exposure":[131],"enhanced":[132],"capsaicin-evoked":[133],"Ca\u00b2\u207a":[134],"responses":[135],"drove":[137],"retrograde":[138],"neuronal":[141,176],"Integrating":[143],"transcriptomics":[144],"functional":[146],"assays,":[147],"pinpointed":[149],"Tnfrsf12a":[150,173,204],"(Fn14),":[151],"cytokine":[153],"receptor":[154],"linked":[155],"regeneration":[157],"neuropathic":[159],"pain,":[160],"-induced":[165],"mRNA.":[167],"Crucially,":[168],"local":[169],"knockdown":[171],"significantly":[174],"reduced":[175],"excitability,":[177],"providing":[178],"proof-of-concept":[179],"that":[180],"axonally":[181],"transcripts":[183],"can":[184],"be":[185],"targeted":[186],"modulate":[188],"sensitisation.":[189],"These":[190],"findings":[191],"position":[192],"programmes":[196],"drivers":[198],"peripheral":[200],"establish":[203],"therapeutic":[207],"candidate":[208],"pain.":[211]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}