{"id":"https://openalex.org/W4414036237","doi":"https://doi.org/10.1080/03007995.2025.2558140","title":"Patient-reported efficacy of adjunctive brexpiprazole in major depressive disorder in a phase 4, open-label, interventional study","display_name":"Patient-reported efficacy of adjunctive brexpiprazole in major depressive disorder in a phase 4, open-label, interventional study","publication_year":2025,"publication_date":"2025-08-03","ids":{"openalex":"https://openalex.org/W4414036237","doi":"https://doi.org/10.1080/03007995.2025.2558140","pmid":"https://pubmed.ncbi.nlm.nih.gov/40913583"},"language":"en","primary_location":{"id":"doi:10.1080/03007995.2025.2558140","doi":"https://doi.org/10.1080/03007995.2025.2558140","is_oa":true,"landing_page_url":"https://doi.org/10.1080/03007995.2025.2558140","pdf_url":null,"source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1080/03007995.2025.2558140","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002387457","display_name":"Fran\u00e7ois Therrien","orcid":"https://orcid.org/0000-0002-6512-4333","observed_orcids":["https://orcid.org/0000-0002-6512-4333"]},"institutions":[{"id":"https://openalex.org/I4405272422","display_name":"Otsuka Canada Pharmaceutical Inc. (Canada)","ror":"https://ror.org/0453abt59","country_code":"CA","type":"company","lineage":["https://openalex.org/I4405272422"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Fran\u00e7ois Therrien","raw_affiliation_strings":["Medical Affairs Division, Otsuka Canada Pharmaceutical Inc","Otsuka Canada Pharmaceutical Inc","Otsuka Canada Pharmaceutical Inc., Saint-Laurent, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs Division, Otsuka Canada Pharmaceutical Inc","institution_ids":["https://openalex.org/I4405272422"]},{"raw_affiliation_string":"Otsuka Canada Pharmaceutical Inc","institution_ids":["https://openalex.org/I4405272422"]},{"raw_affiliation_string":"Otsuka Canada Pharmaceutical Inc., Saint-Laurent, Quebec, Canada","institution_ids":["https://openalex.org/I4405272422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085599086","display_name":"Pratap Rao Chokka","orcid":"https://orcid.org/0000-0002-1043-8554","observed_orcids":["https://orcid.org/0000-0002-1043-8554"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Pratap Chokka","raw_affiliation_strings":["Chokka Center for Integrative Health","Department of Psychiatry, University of Alberta","Chokka Center for Integrative Health, Edmonton, AB, Canada","Department of Psychiatry, University of Alberta, Edmonton, AB, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chokka Center for Integrative Health","institution_ids":[]},{"raw_affiliation_string":"Department of Psychiatry, University of Alberta","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Chokka Center for Integrative Health, Edmonton, AB, Canada","institution_ids":[]},{"raw_affiliation_string":"Department of Psychiatry, University of Alberta, Edmonton, AB, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021611399","display_name":"Jeffrey Habert","orcid":"https://orcid.org/0000-0003-0009-3182","observed_orcids":["https://orcid.org/0000-0003-0009-3182"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jeffrey Habert","raw_affiliation_strings":["Department of Family and Community Medicine, University of Toronto","Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family and Community Medicine, University of Toronto","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006781690","display_name":"Zahinoor Ismail","orcid":"https://orcid.org/0000-0002-5529-3731","observed_orcids":["https://orcid.org/0000-0002-5529-3731"]},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]},{"id":"https://openalex.org/I4405260330","display_name":"Hotchkiss Brain Institute","ror":"https://ror.org/03k51z204","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309","https://openalex.org/I4405260330"]},{"id":"https://openalex.org/I4405268522","display_name":"O'Brien Institute for Public Health","ror":"https://ror.org/017659471","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405268522"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Zahinoor Ismail","raw_affiliation_strings":["Departments of Psychiatry, Clinical Neurosciences, and Community Health Sciences, Hotchkiss Brain Institute and O\u2019Brien Institute for Public Health, University of Calgary","Departments of Psychiatry, Clinical Neurosciences, and Community Health Sciences, Hotchkiss Brain Institute and O'Brien Institute for Public Health, University of Calgary, Calgary, AB, Canada"],"raw_orcid":"https://orcid.org/0000-0002-5529-3731","affiliations":[{"raw_affiliation_string":"Departments of Psychiatry, Clinical Neurosciences, and Community Health Sciences, Hotchkiss Brain Institute and O\u2019Brien Institute for Public Health, University of Calgary","institution_ids":["https://openalex.org/I168635309","https://openalex.org/I4405260330","https://openalex.org/I4405268522"]},{"raw_affiliation_string":"Departments of Psychiatry, Clinical Neurosciences, and Community Health Sciences, Hotchkiss Brain Institute and O'Brien Institute for Public Health, University of Calgary, Calgary, AB, Canada","institution_ids":["https://openalex.org/I168635309","https://openalex.org/I4405260330","https://openalex.org/I4405268522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068850044","display_name":"Roger S. McIntyre","orcid":"https://orcid.org/0000-0003-4733-2523","observed_orcids":["https://orcid.org/0000-0003-4733-2523"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Roger S. McIntyre","raw_affiliation_strings":["Department of Psychiatry and Department of Pharmacology and Toxicology, University of Toronto","Department of Psychiatry and Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Department of Pharmacology and Toxicology, University of Toronto","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Psychiatry and Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032811220","display_name":"Jennifer L. Dine","orcid":"https://orcid.org/0000-0002-2121-9752","observed_orcids":["https://orcid.org/0000-0002-2121-9752"]},"institutions":[{"id":"https://openalex.org/I4210120329","display_name":"RTI Health Solutions","ror":"https://ror.org/032nh7f71","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670","https://openalex.org/I4210120329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Dine","raw_affiliation_strings":["Patient-Centered Outcomes Assessment, RTI Health Solutions","RTI Health Solutions","RTI Health Solutions, Research Triangle Park, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Patient-Centered Outcomes Assessment, RTI Health Solutions","institution_ids":["https://openalex.org/I4210120329"]},{"raw_affiliation_string":"RTI Health Solutions","institution_ids":["https://openalex.org/I4210120329"]},{"raw_affiliation_string":"RTI Health Solutions, Research Triangle Park, NC, USA","institution_ids":["https://openalex.org/I4210120329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086321001","display_name":"T. Michelle Brown","orcid":"https://orcid.org/0000-0002-4580-805X","observed_orcids":["https://orcid.org/0000-0002-4580-805X"]},"institutions":[{"id":"https://openalex.org/I4210120329","display_name":"RTI Health Solutions","ror":"https://ror.org/032nh7f71","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I137902535","https://openalex.org/I170897317","https://openalex.org/I180297670","https://openalex.org/I4210120329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Michelle Brown","raw_affiliation_strings":["Patient-Centered Outcomes Assessment, RTI Health Solutions","RTI Health Solutions","RTI Health Solutions, Research Triangle Park, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Patient-Centered Outcomes Assessment, RTI Health Solutions","institution_ids":["https://openalex.org/I4210120329"]},{"raw_affiliation_string":"RTI Health Solutions","institution_ids":["https://openalex.org/I4210120329"]},{"raw_affiliation_string":"RTI Health Solutions, Research Triangle Park, NC, USA","institution_ids":["https://openalex.org/I4210120329"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhen Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268153","display_name":"Otsuka Pharmaceutical Development & Commercialization, Inc. (United States)","ror":"https://ror.org/001nxvg84","country_code":"US","type":"company","lineage":["https://openalex.org/I4405268153"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhen Zhang","raw_affiliation_strings":["Medical and Real-World Data Analytics, Otsuka Pharmaceutical Development & Commercialization Inc","Otsuka Pharmaceutical Development & Commercialization Inc","Otsuka Pharmaceutical Development & Commercialization Inc., Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical and Real-World Data Analytics, Otsuka Pharmaceutical Development & Commercialization Inc","institution_ids":["https://openalex.org/I4405268153"]},{"raw_affiliation_string":"Otsuka Pharmaceutical Development & Commercialization Inc","institution_ids":["https://openalex.org/I4405268153"]},{"raw_affiliation_string":"Otsuka Pharmaceutical Development & Commercialization Inc., Princeton, NJ, USA","institution_ids":["https://openalex.org/I4405268153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046102409","display_name":"Erin M. MacKenzie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405271964","display_name":"Lundbeck Canada (Canada)","ror":"https://ror.org/03b7hs962","country_code":"CA","type":"company","lineage":["https://openalex.org/I4405271964"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Erin M. MacKenzie","raw_affiliation_strings":["Medical Affairs Division, Lundbeck Canada Inc","Lundbeck Canada Inc","Lundbeck Canada Inc., Saint-Laurent, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs Division, Lundbeck Canada Inc","institution_ids":["https://openalex.org/I4405271964"]},{"raw_affiliation_string":"Lundbeck Canada Inc","institution_ids":["https://openalex.org/I4405271964"]},{"raw_affiliation_string":"Lundbeck Canada Inc., Saint-Laurent, Quebec, Canada","institution_ids":["https://openalex.org/I4405271964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037282921","display_name":"Caroline Ward","orcid":"https://orcid.org/0000-0001-8362-4713","observed_orcids":["https://orcid.org/0000-0001-8362-4713"]},"institutions":[{"id":"https://openalex.org/I4405268153","display_name":"Otsuka Pharmaceutical Development & Commercialization, Inc. (United States)","ror":"https://ror.org/001nxvg84","country_code":"US","type":"company","lineage":["https://openalex.org/I4405268153"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline L. Ward","raw_affiliation_strings":["Clinical Development, Otsuka Pharmaceutical Development & Commercialization Inc","Otsuka Pharmaceutical Development & Commercialization Inc","Otsuka Pharmaceutical Development & Commercialization Inc., Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Development, Otsuka Pharmaceutical Development & Commercialization Inc","institution_ids":["https://openalex.org/I4405268153"]},{"raw_affiliation_string":"Otsuka Pharmaceutical Development & Commercialization Inc","institution_ids":["https://openalex.org/I4405268153"]},{"raw_affiliation_string":"Otsuka Pharmaceutical Development & Commercialization Inc., Princeton, NJ, USA","institution_ids":["https://openalex.org/I4405268153"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5002387457"],"corresponding_institution_ids":["https://openalex.org/I4405272422"],"apc_list":null,"apc_paid":null,"fwci":0.3949,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.5062707,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"41","issue":"8","first_page":"1511","last_page":"1522"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9869999885559082},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.8299999833106995},{"id":"https://openalex.org/keywords/inadequate-response-to-antidepressants","display_name":"inadequate response to antidepressants","score":0.7720000147819519},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.8709999918937683},{"id":"https://openalex.org/keywords/patient-global-impression-of-severity","display_name":"Patient Global Impression of Severity","score":0.8240000009536743},{"id":"https://openalex.org/keywords/patient-global-impression-of-improvement","display_name":"Patient Global Impression of Improvement","score":0.9729999899864197},{"id":"https://openalex.org/keywords/life-engagement","display_name":"life engagement","score":0.7269999980926514},{"id":"https://openalex.org/keywords/patient-diary","display_name":"patient diary","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9444057941436768},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.5424081087112427},{"id":"https://openalex.org/C3019800554","wikidata":"https://www.wikidata.org/wiki/Q3813242","display_name":"Open label","level":3,"score":0.44705596566200256},{"id":"https://openalex.org/C3018162438","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Adjunctive treatment","level":2,"score":0.41860663890838623},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4090435206890106},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3013325333595276},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.29522931575775146},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.1579725444316864}],"mesh":[{"descriptor_ui":"D000071066","descriptor_name":"Patient Reported Outcome Measures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015363","descriptor_name":"Quinolones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015363","descriptor_name":"Quinolones","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015363","descriptor_name":"Quinolones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/03007995.2025.2558140","doi":"https://doi.org/10.1080/03007995.2025.2558140","is_oa":true,"landing_page_url":"https://doi.org/10.1080/03007995.2025.2558140","pdf_url":null,"source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},{"id":"pmid:40913583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40913583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current medical research and opinion","raw_type":"Clinical Trial, Phase IV"}],"best_oa_location":{"id":"doi:10.1080/03007995.2025.2558140","doi":"https://doi.org/10.1080/03007995.2025.2558140","is_oa":true,"landing_page_url":"https://doi.org/10.1080/03007995.2025.2558140","pdf_url":null,"source":{"id":"https://openalex.org/S206643269","display_name":"Current Medical Research and Opinion","issn_l":"0300-7995","issn":["0300-7995","1473-4877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Research and Opinion","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1868790909","https://openalex.org/W2049571898","https://openalex.org/W2050394983","https://openalex.org/W2074874853","https://openalex.org/W2115905656","https://openalex.org/W2132322340","https://openalex.org/W2140725933","https://openalex.org/W2151839057","https://openalex.org/W2155959499","https://openalex.org/W2171672882","https://openalex.org/W2172973382","https://openalex.org/W2471382349","https://openalex.org/W2511590383","https://openalex.org/W2519531315","https://openalex.org/W2586571825","https://openalex.org/W2589370417","https://openalex.org/W2788181968","https://openalex.org/W2789214860","https://openalex.org/W2803445534","https://openalex.org/W2807035513","https://openalex.org/W2898124695","https://openalex.org/W2899320385","https://openalex.org/W2902154350","https://openalex.org/W2957698583","https://openalex.org/W4200621182","https://openalex.org/W4247665917","https://openalex.org/W4254230094","https://openalex.org/W4286220322","https://openalex.org/W4294199299","https://openalex.org/W4304807349","https://openalex.org/W4317567803","https://openalex.org/W4364355463","https://openalex.org/W4392366224","https://openalex.org/W4396699590","https://openalex.org/W4413040242"],"related_works":["https://openalex.org/W4392366224","https://openalex.org/W4364355463","https://openalex.org/W4200621182","https://openalex.org/W6977099797","https://openalex.org/W7213450966","https://openalex.org/W4327719835","https://openalex.org/W4414895110","https://openalex.org/W7119709666","https://openalex.org/W7223157071","https://openalex.org/W4392713822"],"abstract_inverted_index":{"OBJECTIVES:":[0],"In":[1],"ENGAGE,":[2,40,55],"patients":[3,73,94,135],"with":[4,65,72,74,95],"major":[5],"depressive":[6,267],"disorder":[7],"(MDD)":[8],"demonstrated":[9],"improvements":[10,265],"in":[11,93,133,151,266],"patient-reported":[12],"depression":[13,66],"and":[14,41,62,97,126,166,175,214,227,241,250,263],"life":[15],"engagement":[16],"while":[17],"taking":[18],"adjunctive":[19,33,89,274],"brexpiprazole.":[20],"This":[21,146],"analysis":[22,147],"aimed":[23],"to":[24,54,100,139,196,247],"further":[25],"characterize":[26],"patient":[27,36],"perspectives":[28],"on":[29],"the":[30,43,49,111,130,178,235,237,251,279],"effects":[31],"of":[32,45,48,88,117,129,177,208,234,239,253,273,278],"brexpiprazole,":[34],"using":[35],"diary":[37,259],"data":[38,260],"from":[39,69,245],"describe":[42,140],"development":[44],"a":[46,59,127],"'word":[47,128,176,233],"day'":[50,131,179,280],"activity.":[51],"METHODS:":[52],"Prior":[53],"word":[56,138],"lists":[57],"describing":[58],"'good,'":[60],"'average,'":[61],"'bad'":[63],"day":[64],"were":[67,105,217],"generated":[68],"semi-structured":[70],"interviews":[71],"MDD.":[75],"ENGAGE":[76],"(ClinicalTrials.gov":[77],"identifier:":[78],"NCT04830215)":[79],"was":[80],"an":[81,283],"8-week,":[82],"phase":[83],"4,":[84],"single-arm,":[85],"open-label":[86],"study":[87],"brexpiprazole":[90,275],"0.5-2":[91],"mg/day":[92],"MDD":[96],"inadequate":[98],"response":[99,165,169,172,216],"antidepressant":[101],"treatment.":[102,276],"Patient":[103,112,120],"diaries":[104],"completed":[106],"periodically":[107],"at":[108,190],"home,":[109],"comprising":[110],"Global":[113,121],"Impression":[114,122],"-":[115,123],"Severity":[116],"illness":[118],"(PGI-S),":[119],"Improvement":[124],"(PGI-I),":[125],"activity":[132],"which":[134],"selected":[136],"one":[137],"how":[141],"they":[142],"felt":[143],"that":[144],"day.":[145],"evaluated":[148],"mean":[149,159],"change":[150],"PGI-S":[152,164,167,209,212],"scores":[153,161,189],"(mixed":[154],"model":[155],"for":[156,287],"repeated":[157],"measures),":[158],"PGI-I":[160,171,188,215],"(descriptive":[162,180],"statistics),":[163],"sustained":[168,211,264],"(Kaplan-Meier),":[170],"(normal":[173],"approximation),":[174],"statistics).":[181],"RESULTS:":[182],"<":[183],"0.001;":[184],"effect":[185],"size:":[186],"1.04).":[187],"week":[191,205,248],"8":[192,271],"indicated":[193],"'minimal":[194],"improvement'":[195,198],"'much":[197],"(mean":[199],"[standard":[200],"deviation]:":[201],"2.6":[202],"[1.1]).":[203],"At":[204],"8,":[206,249],"rates":[207],"response,":[210,213],"86.0%":[218],"(95%":[219],"confidence":[220],"interval:":[221],"77.1,":[222],"92.8),":[223],"67.9%":[224],"(54.5,":[225],"80.6),":[226],"47.1%":[228],"(38.1,":[229],"56.0),":[230],"respectively.":[231],"On":[232],"day,'":[236],"proportion":[238,252],"positive":[240],"neutral":[242],"words":[243,255],"increased":[244],"baseline":[246],"negative":[254],"decreased.":[256],"CONCLUSIONS:":[257],"Patient-reported":[258],"revealed":[261],"early":[262],"symptom":[268],"severity":[269],"during":[270],"weeks":[272],"'Word":[277],"may":[281],"be":[282],"effective":[284],"qualitative":[285],"tool":[286],"future":[288],"trials.":[289]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}