{"id":"https://openalex.org/W4414003151","doi":"https://doi.org/10.19540/j.cnki.cjcmm.20250507.702","title":"[Mechanism of Cyanotis arachnoidea Gel in improving melasma based on network pharmacology and transcriptomics].","display_name":"[Mechanism of Cyanotis arachnoidea Gel in improving melasma based on network pharmacology and transcriptomics].","publication_year":2025,"publication_date":"2025-07-01","ids":{"openalex":"https://openalex.org/W4414003151","doi":"https://doi.org/10.19540/j.cnki.cjcmm.20250507.702","pmid":"https://pubmed.ncbi.nlm.nih.gov/40904158"},"language":"zh","primary_location":{"id":"pmid:40904158","doi":"https://doi.org/10.19540/j.cnki.cjcmm.20250507.702","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40904158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119545106","display_name":"Mamattursun Marziya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6645349","display_name":"Southwest Minzu University","ror":"https://ror.org/04gaexw88","country_code":"CN","type":"education","lineage":["https://openalex.org/I6645349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mamattursun Marziya","raw_affiliation_strings":["College of Pharmacy and Food, Southwest Minzu University Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Food, Southwest Minzu University Chengdu 610041, China","institution_ids":["https://openalex.org/I6645349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101005607","display_name":"Liying Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6645349","display_name":"Southwest Minzu University","ror":"https://ror.org/04gaexw88","country_code":"CN","type":"education","lineage":["https://openalex.org/I6645349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Ying Qiu","raw_affiliation_strings":["College of Pharmacy and Food, Southwest Minzu University Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Food, Southwest Minzu University Chengdu 610041, China","institution_ids":["https://openalex.org/I6645349"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wan-Quan Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6645349","display_name":"Southwest Minzu University","ror":"https://ror.org/04gaexw88","country_code":"CN","type":"education","lineage":["https://openalex.org/I6645349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wan-Quan Bai","raw_affiliation_strings":["College of Pharmacy and Food, Southwest Minzu University Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Food, Southwest Minzu University Chengdu 610041, China","institution_ids":["https://openalex.org/I6645349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119545107","display_name":"Amar Dlraba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6645349","display_name":"Southwest Minzu University","ror":"https://ror.org/04gaexw88","country_code":"CN","type":"education","lineage":["https://openalex.org/I6645349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Amar Dlraba","raw_affiliation_strings":["College of Pharmacy and Food, Southwest Minzu University Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Food, Southwest Minzu University Chengdu 610041, China","institution_ids":["https://openalex.org/I6645349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100652421","display_name":"Man Chen","orcid":"https://orcid.org/0009-0006-4599-7328","observed_orcids":["https://orcid.org/0009-0006-4599-7328"]},"institutions":[{"id":"https://openalex.org/I6645349","display_name":"Southwest Minzu University","ror":"https://ror.org/04gaexw88","country_code":"CN","type":"education","lineage":["https://openalex.org/I6645349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Ma","raw_affiliation_strings":["College of Pharmacy and Food, Southwest Minzu University Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Food, Southwest Minzu University Chengdu 610041, China","institution_ids":["https://openalex.org/I6645349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100350651","display_name":"Le Zhang","orcid":"https://orcid.org/0000-0003-4787-0524","observed_orcids":["https://orcid.org/0000-0003-4787-0524"]},"institutions":[{"id":"https://openalex.org/I6645349","display_name":"Southwest Minzu University","ror":"https://ror.org/04gaexw88","country_code":"CN","type":"education","lineage":["https://openalex.org/I6645349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Zhang","raw_affiliation_strings":["College of Pharmacy and Food, Southwest Minzu University Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Food, Southwest Minzu University Chengdu 610041, China","institution_ids":["https://openalex.org/I6645349"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101924998","display_name":"Jian Gu","orcid":"https://orcid.org/0000-0002-5834-5867","observed_orcids":["https://orcid.org/0000-0002-5834-5867"]},"institutions":[{"id":"https://openalex.org/I6645349","display_name":"Southwest Minzu University","ror":"https://ror.org/04gaexw88","country_code":"CN","type":"education","lineage":["https://openalex.org/I6645349"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Gu","raw_affiliation_strings":["College of Pharmacy and Food, Southwest Minzu University Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Food, Southwest Minzu University Chengdu 610041, China","institution_ids":["https://openalex.org/I6645349"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I6645349"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"50","issue":"13","first_page":"3775","last_page":"3790"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.7979000210762024,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.1965000033378601,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyanotis-arachnoidea","display_name":"Cyanotis arachnoidea","score":0.9750000238418579},{"id":"https://openalex.org/keywords/melasma","display_name":"melasma","score":0.9290000200271606},{"id":"https://openalex.org/keywords/arbutin","display_name":"arbutin","score":0.6259999871253967},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.671999990940094},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/il-17-signaling","display_name":"IL-17 signaling","score":0.9509999752044678},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.7929999828338623},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.8619999885559082},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cyp17a1","display_name":"CYP17A1","score":0.9190000295639038},{"id":"https://openalex.org/keywords/thioredoxin-1","display_name":"thioredoxin-1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tyrosinase","display_name":"tyrosinase","score":0.8539999723434448},{"id":"https://openalex.org/keywords/skin-collagen","display_name":"skin collagen","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C2776677263","wikidata":"https://www.wikidata.org/wiki/Q305190","display_name":"Melasma","level":2,"score":0.9118877649307251},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6972726583480835},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4546036124229431},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39325007796287537},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3587011694908142},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32109254598617554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3008691668510437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2625505328178406},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.2228611409664154},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09953063726425171},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07448616623878479},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07282429933547974},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.04181629419326782},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000091484","descriptor_name":"Network Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008548","descriptor_name":"Melanosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008548","descriptor_name":"Melanosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008548","descriptor_name":"Melanosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:40904158","doi":"https://doi.org/10.19540/j.cnki.cjcmm.20250507.702","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40904158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4406344277","https://openalex.org/W4322616486","https://openalex.org/W4310680430","https://openalex.org/W4401769741","https://openalex.org/W4403695679","https://openalex.org/W2907033628","https://openalex.org/W2078933032","https://openalex.org/W4388751491","https://openalex.org/W4408142088","https://openalex.org/W7153550021"],"abstract_inverted_index":{"Through":[0],"a":[1,318],"comprehensive":[2],"analysis":[3,188,223],"combining":[4],"network":[5],"pharmacology":[6,126,187],"prediction":[7],"and":[8,66,76,99,105,112,136,138,159,162,169,183,200,209,211,218,248,275,284,313],"transcriptomics,":[9],"this":[10],"study":[11],"systematically":[12],"explained":[13],"the":[14,46,58,93,102,119,123,139,166,213,230,249,280,291,295,322],"multi-target":[15,305],"mechanism":[16,297],"of":[17,70,95,171,202,233,298,308,324],"Cyanotis":[18],"arachnoidea(CA)":[19],"Gel":[20,154,227,271,300],"in":[21,29,101,122,165,301],"improving":[22,302],"melasma.":[23],"A":[24,259],"melasma":[25,303],"model":[26,56,172],"was":[27,50,130,143],"induced":[28],"female":[30],"SD":[31],"rats":[32,59],"by":[33,145,278],"progesterone":[34],"injection":[35],"combined":[36,127],"with":[37,128,327],"ultraviolet":[38],"B(UVB)":[39],"irradiation":[40],"for":[41,88,290,321],"40":[42],"consecutive":[43,90],"days,":[44],"while":[45,262],"blank":[47],"control":[48],"group":[49],"only":[51],"fed":[52],"routinely.":[53],"After":[54],"successful":[55],"establishment,":[57],"were":[60,84,108,115],"randomly":[61],"divided":[62],"into":[63],"five":[64],"groups":[65],"administered":[67],"different":[68],"doses":[69],"CA":[71,153,191,226,270,299],"ethanol":[72],"extract":[73],"gel(high,":[74],"medium,":[75],"low":[77],"doses)":[78],"or":[79],"arbutin":[80],"Gel(positive":[81],"control),":[82],"which":[83],"applied":[85],"once":[86],"daily":[87],"28":[89],"days.":[91],"Subsequently,":[92],"levels":[94,164],"superoxide":[96],"dismutase(SOD),":[97],"malondialdehyde(MDA),":[98],"tyrosinase(TYR)":[100],"skin,":[103,167],"serum,":[104,168],"liver":[106,170],"tissues":[107],"measured.":[109],"Hematoxylin-eosin(HE)":[110],"staining":[111,114],"Masson-Fontana":[113],"used":[116],"to":[117,132],"observe":[118],"pathological":[120],"changes":[121],"tissues.":[124],"Network":[125,186],"transcriptomics":[129],"employed":[131],"identify":[133],"core":[134,194],"targets":[135,195],"pathways,":[137,316],"differential":[140],"gene":[141,231],"expression":[142,232],"validated":[144],"quantitative":[146],"real-time":[147],"PCR(qPCR).":[148],"Pharmacodynamic":[149],"experiments":[150],"showed":[151,189,224],"that":[152,190,225,269],"significantly":[155,228],"increased":[156],"SOD":[157],"activity":[158],"decreased":[160],"MDA":[161],"TYR":[163],"rats.":[173],"It":[174],"also":[175],"improved":[176],"epidermal":[177,205],"thickening,":[178],"inflammatory":[179,276,311],"infiltration,":[180],"collagen":[181],"loss,":[182],"melanin":[184],"deposition.":[185],"mainly":[192],"regulated":[193,272],"such":[196],"as":[197],"signal":[198],"transducer":[199],"activator":[201],"transcription":[203],"3(STAT3),":[204],"growth":[206],"factor":[207],"receptor(EGFR),":[208],"interleukin-6(IL-6),":[210],"modulated":[212],"phosphatidylinositol":[214],"3-kinase(PI3K)-protein":[215],"kinase":[216],"B(AKT)":[217],"interleukin-17(IL-17)":[219],"signaling":[220,282],"pathways.":[221],"Transcriptomic":[222],"downregulated":[229],"heat":[234,241],"shock":[235,242],"protein":[236,243],"90\u03b2":[237],"family":[238,245,256],"member":[239,246,260],"1(Hsp90b1),":[240],"90\u03b1":[244],"1(Hsp90aa1),":[247],"key":[250],"steroid":[251,285],"synthesis":[252],"enzyme":[253],"cytochrome":[254],"P450":[255],"17":[257],"subfamily":[258],"1(Cyp17a1),":[261],"upregulating":[263],"thioredoxin":[264],"1(Txn1).":[265],"qPCR":[266],"results":[267],"confirmed":[268],"oxidative":[273,309],"stress":[274],"response":[277],"inhibiting":[279],"IL-17":[281],"pathway":[283],"hormone":[286,314],"synthesis.":[287],"This":[288],"study,":[289],"first":[292],"time,":[293],"reveals":[294],"molecular":[296],"through":[304],"synergistic":[306],"regulation":[307],"stress,":[310],"response,":[312],"metabolism":[315],"providing":[317],"scientific":[319],"basis":[320],"treatment":[323],"pigmentation":[325],"diseases":[326],"traditional":[328],"Chinese":[329],"medicine.":[330]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2025-10-10T00:00:00"}