{"id":"https://openalex.org/W4413973014","doi":"https://doi.org/10.1126/sciadv.adu2796","title":"Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma","display_name":"Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma","publication_year":2025,"publication_date":"2025-09-03","ids":{"openalex":"https://openalex.org/W4413973014","doi":"https://doi.org/10.1126/sciadv.adu2796","pmid":"https://pubmed.ncbi.nlm.nih.gov/40901948","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12407079"},"language":"en","primary_location":{"id":"doi:10.1126/sciadv.adu2796","doi":"https://doi.org/10.1126/sciadv.adu2796","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.adu2796","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.adu2796?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.science.org/doi/pdf/10.1126/sciadv.adu2796?download=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107475262","display_name":"Charles S. Umbaugh","orcid":"https://orcid.org/0000-0002-9241-2971","observed_orcids":["https://orcid.org/0000-0002-9241-2971"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Charles S. Umbaugh","raw_affiliation_strings":["Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany","National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9241-2971","affiliations":[{"raw_affiliation_string":"Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021094126","display_name":"Marie Groth","orcid":"https://orcid.org/0009-0006-6992-7674","observed_orcids":["https://orcid.org/0009-0006-6992-7674"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Marie Groth","raw_affiliation_strings":["Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany","Faculty of Biosciences, Heidelberg University, Heidelberg, Germany","National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0009-0006-6992-7674","affiliations":[{"raw_affiliation_string":"Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Faculty of Biosciences, Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032150599","display_name":"Cihan Erkut","orcid":"https://orcid.org/0000-0003-4378-9075","observed_orcids":["https://orcid.org/0000-0003-4378-9075"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Cihan Erkut","raw_affiliation_strings":["Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany","German Cancer Consortium (DKTK), Heidelberg, Germany","National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-4378-9075","affiliations":[{"raw_affiliation_string":"Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112219089","display_name":"Kwang-Seok Lee","orcid":"https://orcid.org/0000-0001-7682-5736","observed_orcids":["https://orcid.org/0000-0001-7682-5736","https://orcid.org/0000-0003-4315-1258"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kwang-Seok Lee","raw_affiliation_strings":["Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany","National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7682-5736","affiliations":[{"raw_affiliation_string":"Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Joana Marinho","orcid":"https://orcid.org/0000-0001-9001-9378","observed_orcids":["https://orcid.org/0000-0001-9001-9378"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Joana Marinho","raw_affiliation_strings":["Department of Biochemistry, University of Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-9001-9378","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061546693","display_name":"Simon Linder","orcid":"https://orcid.org/0000-0002-3315-305X","observed_orcids":["https://orcid.org/0000-0002-3315-305X"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Simon Linder","raw_affiliation_strings":["Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany","National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3315-305X","affiliations":[{"raw_affiliation_string":"Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030848267","display_name":"Florian Iser","orcid":"https://orcid.org/0009-0003-6514-817X","observed_orcids":["https://orcid.org/0009-0003-6514-817X"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian Iser","raw_affiliation_strings":["Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany","Faculty of Biosciences, Heidelberg University, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0009-0003-6514-817X","affiliations":[{"raw_affiliation_string":"Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Faculty of Biosciences, Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079607124","display_name":"Jonas N. Kapp","orcid":"https://orcid.org/0000-0002-7308-559X","observed_orcids":["https://orcid.org/0000-0002-7308-559X"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["CH","DE"],"is_corresponding":false,"raw_author_name":"Jonas N. Kapp","raw_affiliation_strings":["Department of Biochemistry, University of Zurich, Zurich, Switzerland","Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany","Faculty of Biosciences, Heidelberg University, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Faculty of Biosciences, Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012414060","display_name":"Petra Schroeter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Petra Schroeter","raw_affiliation_strings":["Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082545100","display_name":"Simay Dolaner","orcid":"https://orcid.org/0000-0003-2411-8559","observed_orcids":["https://orcid.org/0000-0003-2411-8559"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Simay Dolaner","raw_affiliation_strings":["Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany","Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany","Faculty of Biosciences, Heidelberg University, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-2411-8559","affiliations":[{"raw_affiliation_string":"Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Faculty of Biosciences, Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107475263","display_name":"Asli Kayserili","orcid":"https://orcid.org/0009-0002-0737-0664","observed_orcids":["https://orcid.org/0009-0002-0737-0664"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Asli Kayserili","raw_affiliation_strings":["Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0009-0002-0737-0664","affiliations":[{"raw_affiliation_string":"Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031234897","display_name":"Dominic Helm","orcid":"https://orcid.org/0000-0001-9321-2069","observed_orcids":["https://orcid.org/0000-0001-9321-2069"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dominic Helm","raw_affiliation_strings":["Proteomics Core Facility, DKFZ, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9321-2069","affiliations":[{"raw_affiliation_string":"Proteomics Core Facility, DKFZ, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019906909","display_name":"Martin Schneider","orcid":"https://orcid.org/0000-0001-5907-3587","observed_orcids":["https://orcid.org/0000-0001-5907-3587"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Schneider","raw_affiliation_strings":["Proteomics Core Facility, DKFZ, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5907-3587","affiliations":[{"raw_affiliation_string":"Proteomics Core Facility, DKFZ, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107528208","display_name":"Julia Hartmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Hartmann","raw_affiliation_strings":["Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047002854","display_name":"Philipp Walch","orcid":"https://orcid.org/0000-0002-7978-5685","observed_orcids":["https://orcid.org/0000-0002-7978-5685"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp Walch","raw_affiliation_strings":["Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany","Faculty of Biosciences, Heidelberg University, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7978-5685","affiliations":[{"raw_affiliation_string":"Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"Faculty of Biosciences, Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101807408","display_name":"Thomas F.E. Barth","orcid":"https://orcid.org/0000-0002-3379-6311","observed_orcids":["https://orcid.org/0000-0002-3379-6311"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas F. E. Barth","raw_affiliation_strings":["Institute of Pathology, Ulm University, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, Ulm University, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078541338","display_name":"Kevin Mellert","orcid":"https://orcid.org/0000-0001-6338-1857","observed_orcids":["https://orcid.org/0000-0001-6338-1857"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kevin Mellert","raw_affiliation_strings":["Institute of Pathology, Ulm University, Ulm, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6338-1857","affiliations":[{"raw_affiliation_string":"Institute of Pathology, Ulm University, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016483675","display_name":"Birgit Dreier","orcid":"https://orcid.org/0000-0002-5124-9346","observed_orcids":["https://orcid.org/0000-0002-5124-9346"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Birgit Dreier","raw_affiliation_strings":["Department of Biochemistry, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000486272","display_name":"Jonas V. Schaefer","orcid":"https://orcid.org/0000-0002-8332-4371","observed_orcids":["https://orcid.org/0000-0002-8332-4371"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jonas V. Schaefer","raw_affiliation_strings":["Department of Biochemistry, University of Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-8332-4371","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083658123","display_name":"Andreas Pl\u00fcckthun","orcid":"https://orcid.org/0000-0003-4191-5306","observed_orcids":["https://orcid.org/0000-0003-4191-5306"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andreas Pl\u00fcckthun","raw_affiliation_strings":["Department of Biochemistry, University of Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-4191-5306","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006404204","display_name":"Stefan Fr\u00f6hling","orcid":"https://orcid.org/0000-0001-7907-4595","observed_orcids":["https://orcid.org/0000-0001-7907-4595"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stefan Fr\u00f6hling","raw_affiliation_strings":["Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany","German Cancer Consortium (DKTK), Heidelberg, Germany","Institute of Human Genetics, Heidelberg University, Heidelberg, Germany","National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7907-4595","affiliations":[{"raw_affiliation_string":"Division of Translational Medical Oncology, DKFZ, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Institute of Human Genetics, Heidelberg University, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045032568","display_name":"Claudia Scholl","orcid":"https://orcid.org/0000-0001-6768-322X","observed_orcids":["https://orcid.org/0000-0001-6768-322X"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Claudia Scholl","raw_affiliation_strings":["Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany","German Cancer Consortium (DKTK), Heidelberg, Germany","National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6768-322X","affiliations":[{"raw_affiliation_string":"Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), Heidelberg, Germany","institution_ids":["https://openalex.org/I4391767962"]},{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5006404204","https://openalex.org/A5021094126","https://openalex.org/A5045032568","https://openalex.org/A5107475262"],"corresponding_institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I2802164966","https://openalex.org/I4210111460","https://openalex.org/I4391767962"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":3.8058,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.93327409,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"11","issue":"36","first_page":"eadu2796","last_page":"eadu2796"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chordoma","display_name":"chordoma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/brachyury","display_name":"Brachyury","score":0.9950000047683716},{"id":"https://openalex.org/keywords/designed-ankyrin-repeat-proteins","display_name":"DARPin","score":0.9509999752044678},{"id":"https://openalex.org/keywords/transcription-factor-inhibition","display_name":"transcription factor inhibition","score":0.7799999713897705},{"id":"https://openalex.org/keywords/interferon-response","display_name":"interferon response","score":0.6990000009536743},{"id":"https://openalex.org/keywords/jak2-inhibitors","display_name":"JAK2 inhibitors","score":0.968999981880188},{"id":"https://openalex.org/keywords/igfbp-3","display_name":"IGFBP-3","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/dna-replication-and-repair","display_name":"DNA replication and repair","score":0.8209999799728394},{"id":"https://openalex.org/keywords/tumor-senescence","display_name":"tumor senescence","score":0.5659999847412109},{"id":"https://openalex.org/keywords/therapeutic-vulnerabilities","display_name":"therapeutic vulnerabilities","score":0.4339999854564667},{"id":"https://openalex.org/keywords/druggability","display_name":"druggability","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C46122727","wikidata":"https://www.wikidata.org/wiki/Q14885879","display_name":"Brachyury","level":5,"score":0.8559152483940125},{"id":"https://openalex.org/C113241181","wikidata":"https://www.wikidata.org/wiki/Q24784174","display_name":"Ankyrin repeat","level":3,"score":0.7539005875587463},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7063099145889282},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5754810571670532},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4852988123893738},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.48479145765304565},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39300093054771423},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39077550172805786},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35993343591690063},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34610432386398315},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.296939492225647},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23154142498970032},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16008973121643066},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002817","descriptor_name":"Chordoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002817","descriptor_name":"Chordoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002817","descriptor_name":"Chordoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002817","descriptor_name":"Chordoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1126/sciadv.adu2796","doi":"https://doi.org/10.1126/sciadv.adu2796","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.adu2796","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.adu2796?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},{"id":"doi:10.1101/2024.09.20.614025","doi":"https://doi.org/10.1101/2024.09.20.614025","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2024.09.20.614025","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40901948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40901948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science advances","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12407079","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12407079/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Adv","raw_type":"Text"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/237711","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/237711","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Umbaugh, C. S., Groth, M., Erkut, C., Lee, K.-S., Marinho, J., Linder, S., Iser, F., Kapp, J. N., Schroeter, P., Dolaner, S., Kayserili, A., Helm, D., Schneider, M., Hartmann, J., Walch, P., Barth, T. F. E., Mellert, K., Dreier, B., Schaefer, J. V., \u2026 Scholl, C. (2025). Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma. Science Advances, 11, eadu2796. https://doi.org/10.1126/sciadv.adu2796","raw_type":"Journal Article"},{"id":"doi:10.5167/uzh-280009","doi":"https://doi.org/10.5167/uzh-280009","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-280009","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1126/sciadv.adu2796","doi":"https://doi.org/10.1126/sciadv.adu2796","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.adu2796","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.adu2796?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413973014.pdf","grobid_xml":"https://content.openalex.org/works/W4413973014.grobid-xml"},"referenced_works_count":132,"referenced_works":["https://openalex.org/W75030932","https://openalex.org/W1503533733","https://openalex.org/W1524269393","https://openalex.org/W1840001167","https://openalex.org/W1969916031","https://openalex.org/W1970261747","https://openalex.org/W1973160387","https://openalex.org/W1975372065","https://openalex.org/W1988995169","https://openalex.org/W1991366673","https://openalex.org/W1995981641","https://openalex.org/W2017715430","https://openalex.org/W2027540830","https://openalex.org/W2037851792","https://openalex.org/W2044918998","https://openalex.org/W2053702504","https://openalex.org/W2054462619","https://openalex.org/W2055792279","https://openalex.org/W2069085337","https://openalex.org/W2072828079","https://openalex.org/W2083486480","https://openalex.org/W2089950216","https://openalex.org/W2092803887","https://openalex.org/W2105888864","https://openalex.org/W2107277218","https://openalex.org/W2107665951","https://openalex.org/W2108234281","https://openalex.org/W2108649822","https://openalex.org/W2114360920","https://openalex.org/W2122598723","https://openalex.org/W2123142428","https://openalex.org/W2126703870","https://openalex.org/W2128505445","https://openalex.org/W2128551987","https://openalex.org/W2138207763","https://openalex.org/W2143604401","https://openalex.org/W2146512944","https://openalex.org/W2146903266","https://openalex.org/W2151444534","https://openalex.org/W2152390135","https://openalex.org/W2152599849","https://openalex.org/W2159707944","https://openalex.org/W2160443244","https://openalex.org/W2165238581","https://openalex.org/W2169456326","https://openalex.org/W2176714462","https://openalex.org/W2179438025","https://openalex.org/W2214074259","https://openalex.org/W2257573908","https://openalex.org/W2287840388","https://openalex.org/W2318646606","https://openalex.org/W2344714812","https://openalex.org/W2409872354","https://openalex.org/W2418024629","https://openalex.org/W2521500918","https://openalex.org/W2544360569","https://openalex.org/W2558945204","https://openalex.org/W2593037083","https://openalex.org/W2606715885","https://openalex.org/W2731998311","https://openalex.org/W2739158170","https://openalex.org/W2750682736","https://openalex.org/W2753754215","https://openalex.org/W2760852017","https://openalex.org/W2763732767","https://openalex.org/W2764274701","https://openalex.org/W2775466935","https://openalex.org/W2782477516","https://openalex.org/W2786472578","https://openalex.org/W2787897791","https://openalex.org/W2811218393","https://openalex.org/W2898479332","https://openalex.org/W2905212259","https://openalex.org/W2906123001","https://openalex.org/W2909188408","https://openalex.org/W2921625233","https://openalex.org/W2923615778","https://openalex.org/W2939212185","https://openalex.org/W2943456337","https://openalex.org/W2944377244","https://openalex.org/W2945867085","https://openalex.org/W2949830473","https://openalex.org/W2950908936","https://openalex.org/W2953067954","https://openalex.org/W2959449984","https://openalex.org/W2973216672","https://openalex.org/W2988310131","https://openalex.org/W2990122700","https://openalex.org/W2999209745","https://openalex.org/W3003119869","https://openalex.org/W3016533027","https://openalex.org/W3019989145","https://openalex.org/W3042773856","https://openalex.org/W3046562558","https://openalex.org/W3048998868","https://openalex.org/W3081986849","https://openalex.org/W3085672394","https://openalex.org/W3099862724","https://openalex.org/W3121171432","https://openalex.org/W3129714075","https://openalex.org/W3144996175","https://openalex.org/W3165317954","https://openalex.org/W3171689169","https://openalex.org/W3171778992","https://openalex.org/W3177828909","https://openalex.org/W3193566355","https://openalex.org/W3200850145","https://openalex.org/W3211408310","https://openalex.org/W3212705536","https://openalex.org/W3216146155","https://openalex.org/W4210678863","https://openalex.org/W4214719698","https://openalex.org/W4220764623","https://openalex.org/W4281620292","https://openalex.org/W4283528509","https://openalex.org/W4286493109","https://openalex.org/W4292421148","https://openalex.org/W4298147465","https://openalex.org/W4300427210","https://openalex.org/W4306399839","https://openalex.org/W4308052526","https://openalex.org/W4308101956","https://openalex.org/W4308458365","https://openalex.org/W4308834893","https://openalex.org/W4321203748","https://openalex.org/W4362663848","https://openalex.org/W4390509141","https://openalex.org/W4391778044","https://openalex.org/W4399731408","https://openalex.org/W4400484189","https://openalex.org/W4402762525","https://openalex.org/W4407585709"],"related_works":["https://openalex.org/W4409633850","https://openalex.org/W2909188408","https://openalex.org/W3081986849","https://openalex.org/W2892851053","https://openalex.org/W2169049403","https://openalex.org/W4416825593","https://openalex.org/W4282964274","https://openalex.org/W4362663848","https://openalex.org/W4408111858","https://openalex.org/W3189828461"],"abstract_inverted_index":{"ABSTRACT":[0],"Aberrant":[1],"expression":[2],"of":[3,85,130,146,154,209,215,223],"the":[4,100,143,207,213,220],"embryonal":[5,120],"transcription":[6,228],"factor":[7,229],"TBXT":[8,29,91,101,132,149,162,193],"(also":[9],"known":[10],"as":[11,142],"brachyury)":[12],"drives":[13],"chordoma,":[14],"a":[15,165,170],"rare":[16],"spinal":[17],"neoplasm":[18],"with":[19,93,196],"no":[20],"effective":[21],"drug":[22],"therapies.":[23],"The":[24,128],"gene":[25],"network":[26],"regulated":[27],"by":[28,192,226],"is":[30],"poorly":[31],"understood,":[32],"and":[33,63,75,80,87,95,118,125,176,186,194],"strategies":[34],"to":[35,61,151,168,199,211,218],"disrupt":[36],"its":[37,59],"abnormal":[38],"activity":[39],"for":[40,172,235],"therapeutic":[41],"purposes":[42],"are":[43],"lacking.":[44],"Here,":[45],"we":[46,98,159],"developed":[47],"TBXT-targeted":[48],"designed":[49],"ankyrin":[50],"repeat":[51],"proteins":[52,217],"(T-DARPins)":[53],"that":[54,238],"selectively":[55],"bind":[56],"TBXT,":[57],"inhibiting":[58],"binding":[60],"DNA":[62,116],"expression.":[64],"In":[65],"chordoma":[66,104,139,183],"cells,":[67,105],"T-DARPins":[68],"reduced":[69],"cell":[70,113,121,184],"cycle":[71,114],"progression,":[72],"spheroid":[73],"formation,":[74],"tumor":[76],"growth":[77],"in":[78,103,108,112,182,241],"mice":[79],"induced":[81],"morphologic":[82],"changes":[83],"indicative":[84],"senescence":[86],"differentiation.":[88],"Combining":[89],"T-DARPin-mediated":[90],"inhibition":[92,150],"transcriptomic":[94],"proteomic":[96],"analyses,":[97],"determined":[99],"regulome":[102,133,163],"which":[106,189],"comprises":[107],"particular":[109],"networks":[110,222],"involved":[111],"regulation,":[115],"replication":[117],"repair,":[119],"identity,":[122],"metabolic":[123],"processes,":[124],"interferon":[126,179],"response.":[127],"analysis":[129],"selected":[131],"components":[134],"provided":[135],"new":[136],"insights":[137],"into":[138],"biology,":[140],"such":[141],"strong":[144,197],"upregulation":[145],"IGFBP3":[147],"upon":[148],"fine-tune":[152],"part":[153],"TBXT\u2019s":[155],"downstream":[156],"effectors.":[157],"Finally,":[158],"assigned":[160],"each":[161],"member":[164],"druggability":[166],"status":[167],"create":[169],"resource":[171],"future":[173],"translational":[174],"studies":[175],"found":[177],"high":[178],"response":[180],"signaling":[181],"lines":[185],"patient":[187],"tumors,":[188],"was":[190],"promoted":[191],"associated":[195],"sensitivity":[198],"clinically":[200],"approved":[201],"JAK2":[202],"inhibitors.":[203],"These":[204],"findings":[205],"demonstrate":[206],"potential":[208],"DARPins":[210],"investigate":[212],"function":[214],"nuclear":[216],"understand":[219],"regulatory":[221],"cancers":[224],"driven":[225],"aberrant":[227],"activity,":[230],"including":[231],"novel":[232],"entry":[233],"points":[234],"targeted":[236],"therapies":[237],"warrant":[239],"testing":[240],"patients.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2025-10-10T00:00:00"}
