{"id":"https://openalex.org/W4413944972","doi":"https://doi.org/10.3390/vaccines13090938","title":"Metabolic Regulation of Influenza Vaccine Responses in Racially Diverse Hispanics","display_name":"Metabolic Regulation of Influenza Vaccine Responses in Racially Diverse Hispanics","publication_year":2025,"publication_date":"2025-09-02","ids":{"openalex":"https://openalex.org/W4413944972","doi":"https://doi.org/10.3390/vaccines13090938","pmid":"https://pubmed.ncbi.nlm.nih.gov/41012141","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12474446"},"language":"en","primary_location":{"id":"doi:10.3390/vaccines13090938","doi":"https://doi.org/10.3390/vaccines13090938","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines13090938","pdf_url":"https://www.mdpi.com/2076-393X/13/9/938/pdf?version=1756798337","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-393X/13/9/938/pdf?version=1756798337","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030792723","display_name":"Daniela Frasca","orcid":"https://orcid.org/0000-0002-9816-6679","observed_orcids":["https://orcid.org/0000-0002-9816-6679"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniela Frasca","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA","Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029680736","display_name":"Maria Romero","orcid":"https://orcid.org/0000-0002-1992-070X","observed_orcids":["https://orcid.org/0000-0002-1992-070X"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Romero","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024777848","display_name":"Suresh Pallikkuth","orcid":"https://orcid.org/0000-0003-4451-8859","observed_orcids":["https://orcid.org/0000-0003-4451-8859"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Suresh Pallikkuth","raw_affiliation_strings":["Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA"],"raw_orcid":"https://orcid.org/0000-0003-4451-8859","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024777848","https://openalex.org/A5030792723"],"corresponding_institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":1.3861,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.81945435,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"13","issue":"9","first_page":"938","last_page":"938"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.2759000062942505,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-vaccination","display_name":"influenza vaccination","score":0.8240000009536743},{"id":"https://openalex.org/keywords/vaccine-response","display_name":"vaccine response","score":0.5220000147819519},{"id":"https://openalex.org/keywords/racial-disparities","display_name":"racial disparities","score":0.7279999852180481},{"id":"https://openalex.org/keywords/hispanic-population","display_name":"Hispanic population","score":0.8659999966621399},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.7160000205039978},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.8130000233650208},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.9769999980926514}],"concepts":[{"id":"https://openalex.org/C2780689484","wikidata":"https://www.wikidata.org/wiki/Q383260","display_name":"Influenza vaccine","level":3,"score":0.5854803323745728},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4567308723926544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4084368944168091},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40768593549728394},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39297112822532654},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.29433146119117737}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/vaccines13090938","doi":"https://doi.org/10.3390/vaccines13090938","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines13090938","pdf_url":"https://www.mdpi.com/2076-393X/13/9/938/pdf?version=1756798337","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11282798","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12474446","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41012141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41012141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12474446","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12474446/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ceb40a06308a4389ae6e92e2c7913f3b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ceb40a06308a4389ae6e92e2c7913f3b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vaccines, Vol 13, Iss 9, p 938 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/vaccines13090938","doi":"https://doi.org/10.3390/vaccines13090938","is_oa":true,"landing_page_url":"https://doi.org/10.3390/vaccines13090938","pdf_url":"https://www.mdpi.com/2076-393X/13/9/938/pdf?version=1756798337","source":{"id":"https://openalex.org/S4210226234","display_name":"Vaccines","issn_l":"2076-393X","issn":["2076-393X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vaccines","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Reduced inequalities","score":0.7578999996185303,"id":"https://metadata.un.org/sdg/10"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G305175183","display_name":null,"funder_award_id":"P30 CA 240139","funder_id":"https://openalex.org/F4320318541","funder_display_name":"Sylvester Comprehensive Cancer Center, University of Miami Health Systems"},{"id":"https://openalex.org/G6135005755","display_name":"Obesity accelerates age defects in human B cells and induces autoimmunity","funder_award_id":"1r56ag059719-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G694419616","display_name":null,"funder_award_id":"R56 AG059719","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7865685837","display_name":null,"funder_award_id":"P30CA240139","funder_id":"https://openalex.org/F4320332699","funder_display_name":"Leonard M. Miller School of Medicine"},{"id":"https://openalex.org/G9000870205","display_name":"Metabolic deficits and immune dysfunction in aging people living with HIV","funder_award_id":"R01AG086071","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000898192","display_name":"The Sylvester Cancer Center Support Grant","funder_award_id":"P30CA240139","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309249","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92"},{"id":"https://openalex.org/F4320318541","display_name":"Sylvester Comprehensive Cancer Center, University of Miami Health Systems","ror":"https://ror.org/0552r4b12"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332699","display_name":"Leonard M. Miller School of Medicine","ror":"https://ror.org/02dgjyy92"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413944972.pdf","grobid_xml":"https://content.openalex.org/works/W4413944972.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1757383019","https://openalex.org/W1984573859","https://openalex.org/W2014532483","https://openalex.org/W2039765544","https://openalex.org/W2045118520","https://openalex.org/W2082402714","https://openalex.org/W2085396235","https://openalex.org/W2146195489","https://openalex.org/W2149814810","https://openalex.org/W2155892497","https://openalex.org/W2172020040","https://openalex.org/W2191745121","https://openalex.org/W2267132985","https://openalex.org/W2289876562","https://openalex.org/W2349078546","https://openalex.org/W2509106468","https://openalex.org/W2998900717","https://openalex.org/W3092006883","https://openalex.org/W3094401426","https://openalex.org/W3102850153","https://openalex.org/W3131333399","https://openalex.org/W3195075395","https://openalex.org/W3195277233","https://openalex.org/W3215589136","https://openalex.org/W4280632199","https://openalex.org/W4362557478","https://openalex.org/W4391991308","https://openalex.org/W4399223745","https://openalex.org/W4401828141","https://openalex.org/W4401982610","https://openalex.org/W4404024975","https://openalex.org/W4404083074","https://openalex.org/W4404528959","https://openalex.org/W4405016246","https://openalex.org/W4405556008","https://openalex.org/W4406087888","https://openalex.org/W4406316157","https://openalex.org/W4406437110","https://openalex.org/W4408149994"],"related_works":["https://openalex.org/W7214728600","https://openalex.org/W2998900717","https://openalex.org/W2790986194","https://openalex.org/W2509106468","https://openalex.org/W2068999770","https://openalex.org/W7171580796","https://openalex.org/W1976300054","https://openalex.org/W2979562298","https://openalex.org/W7009260337","https://openalex.org/W7049281523"],"abstract_inverted_index":{"Background:":[0],"Racial":[1],"and":[2,23,50,58,67,98,145,154,187,230],"ethnic":[3],"differences":[4],"in":[5,15,37,150,159,201,213,239],"vaccine":[6,203],"responses,":[7],"particularly":[8],"within":[9,205],"Hispanic":[10,42,112,178,207],"populations,":[11],"remain":[12],"underexplored.":[13],"Disparities":[14],"immune":[16,32],"function":[17],"may":[18,225],"be":[19],"influenced":[20],"by":[21,157],"metabolic":[22,68,79,160,166,185],"inflammatory":[24,66,84,148,171],"mechanisms.":[25],"Methods:":[26],"The":[27],"current":[28],"study":[29,193],"investigated":[30],"humoral":[31,131],"responses":[33,54,118,204],"to":[34,64,75,120,197,232,236],"influenza":[35,127,202],"vaccination":[36],"a":[38,181,206,227],"diverse":[39],"cohort":[40],"of":[41,86,165,173],"individuals":[43,113],"from":[44,176],"South":[45],"Florida,":[46],"encompassing":[47],"both":[48],"White":[49,121],"Black":[51,111,177,214],"Hispanics.":[52,215],"Antibody":[53],"were":[55,62,73,90],"assessed":[56],"post-vaccination,":[57],"B":[59,87,152,174,222],"cell":[60,223],"phenotypes":[61,149],"analyzed":[63,91],"evaluate":[65],"characteristics.":[69],"In":[70,162],"vitro":[71,163],"experiments":[72],"conducted":[74,102],"determine":[76],"whether":[77],"blocking":[78],"pathways":[80,167],"could":[81],"alter":[82],"the":[83,170,195],"phenotype":[85,172],"cells.":[88],"Data":[89],"using":[92],"an":[93],"unpaired":[94],"Student\u2019s":[95],"t-test":[96],"(two-tailed),":[97],"correlation":[99],"analysis":[100],"was":[101,155],"with":[103,134,136],"Pearson":[104],"correlation.":[105],"Results:":[106],"Our":[107],"findings":[108,217],"indicated":[109],"that":[110,219],"exhibited":[114],"significantly":[115],"reduced":[116,169,210],"antibody":[117,211],"compared":[119],"Hispanics":[122],"(p":[123],"<":[124],"0.01)":[125],"following":[126],"vaccination.":[128],"This":[129,192],"diminished":[130],"response":[132],"correlated":[133],"inversely":[135],"serum":[137],"LDH":[138],"(r":[139],"=":[140,143],"\u22120.58;":[141],"p":[142],"0.0005)":[144],"other":[146],"intrinsic":[147],"blood-derived":[151],"cells":[153,175],"supported":[156],"changes":[158],"activity.":[161],"blockade":[164],"effectively":[168],"individuals,":[179],"suggesting":[180],"mechanistic":[182],"link":[183],"between":[184],"dysfunction":[186],"impaired":[188],"vaccine-induced":[189,240],"immunity.":[190,241],"Conclusion:":[191],"is":[194],"first":[196],"reveal":[198],"racial":[199],"disparities":[200,238],"population,":[208],"highlighting":[209],"production":[212],"These":[216],"suggest":[218],"metabolically":[220],"driven":[221],"inflammation":[224],"play":[226],"critical":[228],"role":[229],"point":[231],"potential":[233],"therapeutic":[234],"strategies":[235],"address":[237]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-10-10T00:00:00"}