{"id":"https://openalex.org/W4413910106","doi":"https://doi.org/10.32708/uutfd.1723791","title":"Investigation of Drug Resistant Mycobacterium tuberculosis Strains with Molecular Methods","display_name":"Investigation of Drug Resistant Mycobacterium tuberculosis Strains with Molecular Methods","publication_year":2025,"publication_date":"2025-08-28","ids":{"openalex":"https://openalex.org/W4413910106","doi":"https://doi.org/10.32708/uutfd.1723791"},"language":"en","primary_location":{"id":"doi:10.32708/uutfd.1723791","doi":"https://doi.org/10.32708/uutfd.1723791","is_oa":true,"landing_page_url":"https://doi.org/10.32708/uutfd.1723791","pdf_url":"https://dergipark.org.tr/en/download/article-file/4976742","source":{"id":"https://openalex.org/S4306533682","display_name":"Uluda\u011f \u00dcniversitesi T\u0131p Fak\u00fcltesi Dergisi","issn_l":"1300-414X","issn":["1300-414X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Uluda\u011f \u00dcniversitesi T\u0131p Fak\u00fcltesi Dergisi","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/download/article-file/4976742","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112722821","display_name":"Ay\u015fe Melda Payasl\u0131o\u011flu","orcid":"https://orcid.org/0009-0004-1725-0644","observed_orcids":["https://orcid.org/0009-0004-1725-0644"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ay\u015fe Melda Payasl\u0131o\u011flu","raw_affiliation_strings":["Bursa Uluda\u011f University, Faculty of Medicine, Department of Medical Microbiology, Bursa, Tu\u0308rkiye"],"raw_orcid":"https://orcid.org/0009-0004-1725-0644","affiliations":[{"raw_affiliation_string":"Bursa Uluda\u011f University, Faculty of Medicine, Department of Medical Microbiology, Bursa, Tu\u0308rkiye","institution_ids":["https://openalex.org/I131835042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006714037","display_name":"Sezcan Sa\u011flam","orcid":"https://orcid.org/0000-0002-7270-0167","observed_orcids":["https://orcid.org/0000-0002-7270-0167"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sezcan Sa\u011flam","raw_affiliation_strings":["Bursa Uluda\u011f University, Faculty of Medicine, Department of Medical Microbiology, Bursa, Tu\u0308rkiye"],"raw_orcid":"https://orcid.org/0000-0002-7270-0167","affiliations":[{"raw_affiliation_string":"Bursa Uluda\u011f University, Faculty of Medicine, Department of Medical Microbiology, Bursa, Tu\u0308rkiye","institution_ids":["https://openalex.org/I131835042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052593585","display_name":"Se\u00e7il Ak Aksoy","orcid":"https://orcid.org/0000-0002-3760-9755","observed_orcids":["https://orcid.org/0000-0002-3760-9755"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Se\u00e7il Ak Aksoy","raw_affiliation_strings":["Bursa Uluda\u011f University, Faculty of Medicine, Department of Medical Microbiology, Bursa, Tu\u0308rkiye"],"raw_orcid":"https://orcid.org/0000-0002-3760-9755","affiliations":[{"raw_affiliation_string":"Bursa Uluda\u011f University, Faculty of Medicine, Department of Medical Microbiology, Bursa, Tu\u0308rkiye","institution_ids":["https://openalex.org/I131835042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052373133","display_name":"C\u00fcneyt \u00d6zak\u0131n","orcid":"https://orcid.org/0000-0001-5428-3630","observed_orcids":["https://orcid.org/0000-0001-5428-3630"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"C\u00fcneyt \u00d6zak\u0131n","raw_affiliation_strings":["Bursa Uluda\u011f University, Faculty of Medicine, Department of Medical Microbiology, Bursa, Tu\u0308rkiye"],"raw_orcid":"https://orcid.org/0000-0001-5428-3630","affiliations":[{"raw_affiliation_string":"Bursa Uluda\u011f University, Faculty of Medicine, Department of Medical Microbiology, Bursa, Tu\u0308rkiye","institution_ids":["https://openalex.org/I131835042"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I131835042"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2490586,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"51","issue":"2","first_page":"291","last_page":"294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.949999988079071},{"id":"https://openalex.org/keywords/drug-resistant-tuberculosis","display_name":"drug-resistant tuberculosis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/rifampicin-resistance","display_name":"rifampicin resistance","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ethambutol-resistance","display_name":"ethambutol resistance","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rpob-mutations","display_name":"rpoB mutations","score":0.9440000057220459},{"id":"https://openalex.org/keywords/embb-mutations","display_name":"embB mutations","score":0.9919999837875366},{"id":"https://openalex.org/keywords/molecular-detection-of-drug-resistance","display_name":"molecular detection of drug resistance","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7864529490470886},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7003980875015259},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5568620562553406},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5005452632904053},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4852854907512665},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4198474884033203},{"id":"https://openalex.org/C3018107894","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multi drug resistant","level":3,"score":0.4162665903568268},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3682798743247986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29243093729019165},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1324940323829651},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06271940469741821}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.32708/uutfd.1723791","doi":"https://doi.org/10.32708/uutfd.1723791","is_oa":true,"landing_page_url":"https://doi.org/10.32708/uutfd.1723791","pdf_url":"https://dergipark.org.tr/en/download/article-file/4976742","source":{"id":"https://openalex.org/S4306533682","display_name":"Uluda\u011f \u00dcniversitesi T\u0131p Fak\u00fcltesi Dergisi","issn_l":"1300-414X","issn":["1300-414X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Uluda\u011f \u00dcniversitesi T\u0131p Fak\u00fcltesi Dergisi","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:05ff1b2376c54035a72b2180002e4de6","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/05ff1b2376c54035a72b2180002e4de6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Uluda\u011f \u00dcniversitesi T\u0131p Fak\u00fcltesi Dergisi, Vol 51, Iss 2, Pp 291-294 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.32708/uutfd.1723791","doi":"https://doi.org/10.32708/uutfd.1723791","is_oa":true,"landing_page_url":"https://doi.org/10.32708/uutfd.1723791","pdf_url":"https://dergipark.org.tr/en/download/article-file/4976742","source":{"id":"https://openalex.org/S4306533682","display_name":"Uluda\u011f \u00dcniversitesi T\u0131p Fak\u00fcltesi Dergisi","issn_l":"1300-414X","issn":["1300-414X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Uluda\u011f \u00dcniversitesi T\u0131p Fak\u00fcltesi Dergisi","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413910106.pdf","grobid_xml":"https://content.openalex.org/works/W4413910106.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1856192699","https://openalex.org/W2049345312","https://openalex.org/W2052433541","https://openalex.org/W2075150929","https://openalex.org/W2137502223","https://openalex.org/W2154326381","https://openalex.org/W2468795462","https://openalex.org/W2607463220","https://openalex.org/W2619164896","https://openalex.org/W2788327314","https://openalex.org/W2793529266","https://openalex.org/W2925872345","https://openalex.org/W2949473602","https://openalex.org/W2969916825","https://openalex.org/W3047260679","https://openalex.org/W3133202375","https://openalex.org/W4200509774","https://openalex.org/W4210627381","https://openalex.org/W4281719214","https://openalex.org/W4367313540"],"related_works":["https://openalex.org/W2972094210","https://openalex.org/W4308058527","https://openalex.org/W2110949356","https://openalex.org/W4210506554","https://openalex.org/W1538374398","https://openalex.org/W2050407936","https://openalex.org/W2042252940","https://openalex.org/W2411061500","https://openalex.org/W3160640465","https://openalex.org/W1983144055"],"abstract_inverted_index":{"The":[0,77],"aim":[1],"of":[2,31,73,102,108],"this":[3],"study":[4],"was":[5,41,51,81],"to":[6,24],"investigate":[7],"mutations":[8,96,110],"in":[9,18,35,85],"the":[10,44,65,74],"rpoB":[11,75],"and":[12,39,115],"embB":[13],"genes":[14],"using":[15,43],"molecular":[16,100,106],"methods":[17],"Mycobacterium":[19],"tuberculosis":[20,117],"isolates":[21,33],"phenotypically":[22],"resistant":[23],"rifampicin":[25,103],"and/or":[26],"ethambutol.":[27],"Drug":[28],"susceptibility":[29],"testing":[30],"110":[32],"collected":[34],"Turkey":[36],"between":[37,70],"2005":[38],"2014":[40],"performed":[42],"modified":[45],"agar":[46],"proportion":[47],"method.":[48],"Molecular":[49],"analysis":[50],"conducted":[52],"on":[53],"28":[54],"selected":[55],"isolates,":[56],"including":[57],"7":[58],"rifampicin-resistant":[59],"strains.":[60],"Mutations":[61],"were":[62,97],"detected":[63],"within":[64],"Rifampicin":[66],"Resistance-Determining":[67],"Region":[68],"(RRDR)":[69],"codons":[71],"507\u2013533":[72],"gene.":[76],"most":[78],"common":[79],"mutation":[80],"Ser531Leu":[82],"(TCG\u2192TTG),":[83],"found":[84],"10":[86],"strains;":[87],"one":[88],"strain":[89],"had":[90],"a":[91],"His526Asn":[92],"(CAC\u2192AAC)":[93],"mutation.":[94],"These":[95],"considered":[98],"important":[99,112],"markers":[101],"resistance.":[104],"Rapid":[105],"detection":[107],"these":[109],"is":[111],"for":[113],"early":[114],"effective":[116],"treatment":[118],"planning.":[119]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
