{"id":"https://openalex.org/W4413873797","doi":"https://doi.org/10.2147/ijgm.s530523","title":"The Role of Sirtuins in Bone Repair From the Perspective of Glucose Metabolism","display_name":"The Role of Sirtuins in Bone Repair From the Perspective of Glucose Metabolism","publication_year":2025,"publication_date":"2025-09-01","ids":{"openalex":"https://openalex.org/W4413873797","doi":"https://doi.org/10.2147/ijgm.s530523","pmid":"https://pubmed.ncbi.nlm.nih.gov/40919109","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12412762"},"language":"en","primary_location":{"id":"doi:10.2147/ijgm.s530523","doi":"https://doi.org/10.2147/ijgm.s530523","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijgm.s530523","pdf_url":"https://www.dovepress.com/article/download/106424","source":{"id":"https://openalex.org/S123199335","display_name":"International Journal of General Medicine","issn_l":"1178-7074","issn":["1178-7074"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of General Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/106424","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yun Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Ding","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Naval Medical Center, Naval Medical University (Second Military Medical University), Shanghai, 200052, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Naval Medical Center, Naval Medical University (Second Military Medical University), Shanghai, 200052, People's Republic of China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yu Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Gao","raw_affiliation_strings":["Department of Gastroenterology, Naval Medical Center, Naval Medical University (Second Military Medical University), Shanghai, 200052, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Naval Medical Center, Naval Medical University (Second Military Medical University), Shanghai, 200052, People's Republic of China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jianjun Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianjun Sun","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Naval Medical Center, Naval Medical University (Second Military Medical University), Shanghai, 200052, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Naval Medical Center, Naval Medical University (Second Military Medical University), Shanghai, 200052, People's Republic of China","institution_ids":["https://openalex.org/I177933477"]}]},{"author_position":"last","author":{"id":null,"display_name":"Zhigang Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhigang Cai","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Naval Medical Center, Naval Medical University (Second Military Medical University), Shanghai, 200052, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Naval Medical Center, Naval Medical University (Second Military Medical University), Shanghai, 200052, People's Republic of China","institution_ids":["https://openalex.org/I177933477"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I177933477"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04577823,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 18","issue":null,"first_page":"5013","last_page":"5031"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.031099999323487282,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirtuins","display_name":"sirtuins","score":0.9819999933242798},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.7630000114440918},{"id":"https://openalex.org/keywords/fracture-healing","display_name":"fracture healing","score":0.9940000176429749},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nad-dependent-deacetylase","display_name":"NAD+-dependent deacetylase","score":0.8799999952316284},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9190000295639038},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":1.0},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.9589999914169312},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9679999947547913},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.8939999938011169},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.921999990940094},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7680000066757202},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8747110366821289},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.6490841507911682},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.6387271881103516},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.514517068862915},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.45776963233947754},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18691623210906982},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/ijgm.s530523","doi":"https://doi.org/10.2147/ijgm.s530523","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijgm.s530523","pdf_url":"https://www.dovepress.com/article/download/106424","source":{"id":"https://openalex.org/S123199335","display_name":"International Journal of General Medicine","issn_l":"1178-7074","issn":["1178-7074"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of General Medicine","raw_type":"journal-article"},{"id":"pmid:40919109","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40919109","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of general medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12412762","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12412762/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Gen Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:219e502ece944eb4808d18aa8be57aff","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/219e502ece944eb4808d18aa8be57aff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of General Medicine, Vol Volume 18, Iss Issue 1, Pp 5013-5031 (2025)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/106424","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/the-role-of-sirtuins-in-bone-repair-from-the-perspective-of-glucose-me-peer-reviewed-fulltext-article-IJGM","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Review"}],"best_oa_location":{"id":"doi:10.2147/ijgm.s530523","doi":"https://doi.org/10.2147/ijgm.s530523","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijgm.s530523","pdf_url":"https://www.dovepress.com/article/download/106424","source":{"id":"https://openalex.org/S123199335","display_name":"International Journal of General Medicine","issn_l":"1178-7074","issn":["1178-7074"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of General Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413873797.pdf","grobid_xml":"https://content.openalex.org/works/W4413873797.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W1504707262","https://openalex.org/W1515922000","https://openalex.org/W1543384246","https://openalex.org/W1901404250","https://openalex.org/W1976265795","https://openalex.org/W1983877946","https://openalex.org/W1985716862","https://openalex.org/W2000077738","https://openalex.org/W2003509125","https://openalex.org/W2007928508","https://openalex.org/W2018576241","https://openalex.org/W2026387061","https://openalex.org/W2044515633","https://openalex.org/W2049751449","https://openalex.org/W2054738820","https://openalex.org/W2055962024","https://openalex.org/W2057294869","https://openalex.org/W2060424229","https://openalex.org/W2072392441","https://openalex.org/W2074500132","https://openalex.org/W2078719918","https://openalex.org/W2097948853","https://openalex.org/W2098546374","https://openalex.org/W2103190171","https://openalex.org/W2107498856","https://openalex.org/W2115516793","https://openalex.org/W2120989136","https://openalex.org/W2138062757","https://openalex.org/W2139116328","https://openalex.org/W2149788186","https://openalex.org/W2302276122","https://openalex.org/W2341833580","https://openalex.org/W2366576414","https://openalex.org/W2510770156","https://openalex.org/W2514979671","https://openalex.org/W2520485443","https://openalex.org/W2522309832","https://openalex.org/W2524323837","https://openalex.org/W2527109745","https://openalex.org/W2554535625","https://openalex.org/W2586409573","https://openalex.org/W2589610914","https://openalex.org/W2615896933","https://openalex.org/W2750746460","https://openalex.org/W2757874772","https://openalex.org/W2769632036","https://openalex.org/W2777566449","https://openalex.org/W2791470310","https://openalex.org/W2794329260","https://openalex.org/W2794401640","https://openalex.org/W2799579025","https://openalex.org/W2810150743","https://openalex.org/W2810241167","https://openalex.org/W2894968693","https://openalex.org/W2898700653","https://openalex.org/W2900547589","https://openalex.org/W2903596877","https://openalex.org/W2911940519","https://openalex.org/W2923964382","https://openalex.org/W2944596344","https://openalex.org/W2963301415","https://openalex.org/W2970822705","https://openalex.org/W2975004131","https://openalex.org/W2980839322","https://openalex.org/W2995236678","https://openalex.org/W2998625724","https://openalex.org/W3009532162","https://openalex.org/W3016298098","https://openalex.org/W3037052478","https://openalex.org/W3039321675","https://openalex.org/W3083915579","https://openalex.org/W3084130987","https://openalex.org/W3113847529","https://openalex.org/W3119018627","https://openalex.org/W3135724518","https://openalex.org/W3152505230","https://openalex.org/W3156776868","https://openalex.org/W3181805284","https://openalex.org/W4210285985","https://openalex.org/W4210528245","https://openalex.org/W4211160959","https://openalex.org/W4220743033","https://openalex.org/W4281480181","https://openalex.org/W4308510433","https://openalex.org/W4309531159","https://openalex.org/W4390036068","https://openalex.org/W4391130353","https://openalex.org/W4406255018"],"related_works":["https://openalex.org/W7140762087","https://openalex.org/W4401442368","https://openalex.org/W7144274419","https://openalex.org/W4401150529","https://openalex.org/W2964694932","https://openalex.org/W7162643031","https://openalex.org/W7134194738","https://openalex.org/W3039167676","https://openalex.org/W3134172121","https://openalex.org/W7167334382"],"abstract_inverted_index":{"Impaired":[0],"clinical":[1],"fracture":[2,79],"healing":[3],"remains":[4],"a":[5],"major":[6],"challenge,":[7],"with":[8,15,59],"surgical":[9],"treatment":[10],"often":[11],"insufficient":[12],"in":[13,27,52,89,103],"patients":[14],"metabolic":[16,105],"disorders":[17],"or":[18],"comorbidities":[19],"such":[20,66],"as":[21,67,100],"diabetes":[22],"and":[23,48,54,70],"osteoporosis.":[24],"Recent":[25],"advances":[26],"metabolomics":[28],"have":[29],"brought":[30],"the":[31,36,76,95,104],"Sirtuin":[32],"protein":[33],"family":[34],"to":[35],"forefront":[37],"of":[38,78,97,107],"bone":[39,60,108],"regeneration":[40],"research.":[41],"These":[42],"NAD\u207a-dependent":[43],"deacetylases":[44],"exhibit":[45],"cell-specific":[46],"expression":[47],"regulate":[49],"critical":[50],"processes":[51],"osteoblasts":[53],"osteoclasts,":[55],"linking":[56],"glucose":[57],"metabolism":[58],"remodeling.":[61],"Sirtuins":[62,85],"influence":[63],"key":[64],"pathways":[65],"Wnt/\u03b2-catenin,":[68],"AMPK,":[69],"mTOR,":[71],"offering":[72],"novel":[73],"insights":[74],"into":[75],"mechanisms":[77],"healing.":[80],"Emerging":[81],"pharmacological":[82],"strategies":[83],"targeting":[84],"show":[86],"promising":[87],"results":[88],"preclinical":[90],"models.":[91],"This":[92],"review":[93],"highlights":[94],"potential":[96],"Sirtuin-based":[98],"interventions":[99],"therapeutic":[101],"targets":[102],"regulation":[106],"repair.":[109]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
