{"id":"https://openalex.org/W4413865205","doi":"https://doi.org/10.1038/s41392-025-02346-0","title":"Arterial stiffness and vascular aging: mechanisms, prevention, and therapy","display_name":"Arterial stiffness and vascular aging: mechanisms, prevention, and therapy","publication_year":2025,"publication_date":"2025-08-31","ids":{"openalex":"https://openalex.org/W4413865205","doi":"https://doi.org/10.1038/s41392-025-02346-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/40887468","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12399776"},"language":"en","primary_location":{"id":"doi:10.1038/s41392-025-02346-0","doi":"https://doi.org/10.1038/s41392-025-02346-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41392-025-02346-0","pdf_url":"https://www.nature.com/articles/s41392-025-02346-0.pdf","source":{"id":"https://openalex.org/S2739142469","display_name":"Signal Transduction and Targeted Therapy","issn_l":"2059-3635","issn":["2059-3635","2095-9907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduction and Targeted Therapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41392-025-02346-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109014889","display_name":"Maximilian Jonathan Herzog","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I4210107249","display_name":"Klinikum Magdeburg","ror":"https://ror.org/01trdns33","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210107249"]},{"id":"https://openalex.org/I4210138551","display_name":"University Hospital Magdeburg","ror":"https://ror.org/03m04df46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138551"]}],"countries":["DE","HU"],"is_corresponding":false,"raw_author_name":"Maximilian Jonathan Herzog","raw_affiliation_strings":["Division of Cardiology and Angiology, University Hospital Magdeburg, Magdeburg, Germany","Semmelweis University Budapest, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology and Angiology, University Hospital Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210107249","https://openalex.org/I4210138551"]},{"raw_affiliation_string":"Semmelweis University Budapest, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111236120","display_name":"Patrick M\u00fcller","orcid":"https://orcid.org/0000-0001-7458-2208","observed_orcids":["https://orcid.org/0000-0001-7458-2208"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210107249","display_name":"Klinikum Magdeburg","ror":"https://ror.org/01trdns33","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210107249"]},{"id":"https://openalex.org/I4210138551","display_name":"University Hospital Magdeburg","ror":"https://ror.org/03m04df46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138551"]},{"id":"https://openalex.org/I4405258522","display_name":"Deutsches Zentrum f\u00fcr Psychische Gesundheit","ror":"https://ror.org/00tkfw097","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4405256427","https://openalex.org/I4405258522"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Patrick M\u00fcller","raw_affiliation_strings":["Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C-I-R-C), Magdeburg, Germany","Division of Cardiology and Angiology, University Hospital Magdeburg, Magdeburg, Germany","German Center for Mental Health (DZPG), Magdeburg, Germany","German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C-I-R-C), Magdeburg, Germany","institution_ids":[]},{"raw_affiliation_string":"Division of Cardiology and Angiology, University Hospital Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210107249","https://openalex.org/I4210138551"]},{"raw_affiliation_string":"German Center for Mental Health (DZPG), Magdeburg, Germany","institution_ids":["https://openalex.org/I4405258522"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076521943","display_name":"Katharina Lechner","orcid":"https://orcid.org/0000-0002-3582-3512","observed_orcids":["https://orcid.org/0000-0002-3582-3512"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210127591","display_name":"German Centre for Cardiovascular Research","ror":"https://ror.org/031t5w623","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127591","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina Lechner","raw_affiliation_strings":["DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany","Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany","institution_ids":["https://openalex.org/I4210127591"]},{"raw_affiliation_string":"Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Neuherberg, Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083604246","display_name":"Marvin Stiebler","orcid":"https://orcid.org/0000-0002-3654-7265","observed_orcids":["https://orcid.org/0000-0002-3654-7265"]},"institutions":[{"id":"https://openalex.org/I4210107249","display_name":"Klinikum Magdeburg","ror":"https://ror.org/01trdns33","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210107249"]},{"id":"https://openalex.org/I4210138551","display_name":"University Hospital Magdeburg","ror":"https://ror.org/03m04df46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138551"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marvin Stiebler","raw_affiliation_strings":["Division of Cardiology and Angiology, University Hospital Magdeburg, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology and Angiology, University Hospital Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210107249","https://openalex.org/I4210138551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068907567","display_name":"Philipp Arndt","orcid":"https://orcid.org/0000-0002-0517-6473","observed_orcids":["https://orcid.org/0000-0002-0517-6473"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210138551","display_name":"University Hospital Magdeburg","ror":"https://ror.org/03m04df46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138551"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp Arndt","raw_affiliation_strings":["Division of Neurology, University Hospital Magdeburg, Magdeburg, Germany","German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurology, University Hospital Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210138551"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038608292","display_name":"Matthias Kunz","orcid":"https://orcid.org/0000-0002-0439-2254","observed_orcids":["https://orcid.org/0000-0002-0439-2254"]},"institutions":[{"id":"https://openalex.org/I4210107249","display_name":"Klinikum Magdeburg","ror":"https://ror.org/01trdns33","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210107249"]},{"id":"https://openalex.org/I4210138551","display_name":"University Hospital Magdeburg","ror":"https://ror.org/03m04df46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138551"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Kunz","raw_affiliation_strings":["Division of Cardiology and Angiology, University Hospital Magdeburg, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology and Angiology, University Hospital Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210107249","https://openalex.org/I4210138551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047125161","display_name":"D\u00f6rte Ahrens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107249","display_name":"Klinikum Magdeburg","ror":"https://ror.org/01trdns33","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210107249"]},{"id":"https://openalex.org/I4210138551","display_name":"University Hospital Magdeburg","ror":"https://ror.org/03m04df46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138551"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D\u00f6rte Ahrens","raw_affiliation_strings":["Division of Cardiology and Angiology, University Hospital Magdeburg, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology and Angiology, University Hospital Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210107249","https://openalex.org/I4210138551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102146236","display_name":"Alexander Schmei\u00dfer","orcid":"https://orcid.org/0000-0002-4075-6713","observed_orcids":["https://orcid.org/0000-0002-4075-6713"]},"institutions":[{"id":"https://openalex.org/I4210107249","display_name":"Klinikum Magdeburg","ror":"https://ror.org/01trdns33","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210107249"]},{"id":"https://openalex.org/I4210138551","display_name":"University Hospital Magdeburg","ror":"https://ror.org/03m04df46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138551"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Schmei\u00dfer","raw_affiliation_strings":["Division of Cardiology and Angiology, University Hospital Magdeburg, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology and Angiology, University Hospital Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210107249","https://openalex.org/I4210138551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086875951","display_name":"Stefanie Schreiber","orcid":"https://orcid.org/0000-0003-4439-4374","observed_orcids":["https://orcid.org/0000-0003-4439-4374"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210138551","display_name":"University Hospital Magdeburg","ror":"https://ror.org/03m04df46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138551"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefanie Schreiber","raw_affiliation_strings":["Division of Neurology, University Hospital Magdeburg, Magdeburg, Germany","German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurology, University Hospital Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210138551"]},{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047217066","display_name":"Ruediger Christian Braun-Dullaeus","orcid":"https://orcid.org/0000-0003-3888-6532","observed_orcids":["https://orcid.org/0000-0003-3888-6532"]},"institutions":[{"id":"https://openalex.org/I4210107249","display_name":"Klinikum Magdeburg","ror":"https://ror.org/01trdns33","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210107249"]},{"id":"https://openalex.org/I4210138551","display_name":"University Hospital Magdeburg","ror":"https://ror.org/03m04df46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138551"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ruediger C. Braun-Dullaeus","raw_affiliation_strings":["Division of Cardiology and Angiology, University Hospital Magdeburg, Magdeburg, Germany. r.braun-dullaeus@med.ovgu.de","Division of Cardiology and Angiology, University Hospital Magdeburg, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology and Angiology, University Hospital Magdeburg, Magdeburg, Germany. r.braun-dullaeus@med.ovgu.de","institution_ids":["https://openalex.org/I4210138551"]},{"raw_affiliation_string":"Division of Cardiology and Angiology, University Hospital Magdeburg, Magdeburg, Germany","institution_ids":["https://openalex.org/I4210107249","https://openalex.org/I4210138551"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5047217066"],"corresponding_institution_ids":["https://openalex.org/I4210107249","https://openalex.org/I4210138551"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":37.3711,"has_fulltext":true,"cited_by_count":207,"citation_normalized_percentile":{"value":0.99983241,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"10","issue":"1","first_page":"282","last_page":"282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arterial-stiffness","display_name":"arterial stiffness","score":1.0},{"id":"https://openalex.org/keywords/vascular-aging","display_name":"vascular aging","score":1.0},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.6439999938011169},{"id":"https://openalex.org/keywords/vascular-calcification","display_name":"vascular calcification","score":0.878000020980835},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/vascular-fibrosis","display_name":"vascular fibrosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/windkessel-function","display_name":"Windkessel function","score":0.9589999914169312},{"id":"https://openalex.org/keywords/pulse-pressure","display_name":"pulse pressure","score":0.9800000190734863},{"id":"https://openalex.org/keywords/isolated-systolic-hypertension","display_name":"isolated systolic hypertension","score":0.9980000257492065},{"id":"https://openalex.org/keywords/target-organ-damage","display_name":"target organ damage","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.7350000143051147},{"id":"https://openalex.org/keywords/prevention","display_name":"prevention","score":0.5709999799728394},{"id":"https://openalex.org/keywords/treatment","display_name":"treatment","score":0.9070000052452087},{"id":"https://openalex.org/keywords/perivascular-adipose-tissue","display_name":"perivascular adipose tissue","score":0.9959999918937683},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":1.0}],"concepts":[{"id":"https://openalex.org/C2775850156","wikidata":"https://www.wikidata.org/wiki/Q4797538","display_name":"Arterial stiffness","level":3,"score":0.9097039699554443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.778651237487793},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.5534977316856384},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5255685448646545},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.5098882913589478},{"id":"https://openalex.org/C2778319312","wikidata":"https://www.wikidata.org/wiki/Q2118022","display_name":"Pulse wave velocity","level":3,"score":0.46679598093032837},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4475303292274475},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4184546172618866},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.40847307443618774},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3702165186405182},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.334469735622406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07801657915115356}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D059289","descriptor_name":"Vascular Stiffness","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41392-025-02346-0","doi":"https://doi.org/10.1038/s41392-025-02346-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41392-025-02346-0","pdf_url":"https://www.nature.com/articles/s41392-025-02346-0.pdf","source":{"id":"https://openalex.org/S2739142469","display_name":"Signal Transduction and Targeted Therapy","issn_l":"2059-3635","issn":["2059-3635","2095-9907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduction and Targeted Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11210462","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12399776","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40887468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40887468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal transduction and targeted therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12399776","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12399776/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduct Target Ther","raw_type":"Text"},{"id":"pmh:oai:pub.dzne.de:280942","doi":null,"is_oa":true,"landing_page_url":"https://pub.dzne.de/record/280942","pdf_url":"https://pub.dzne.de/record/280942/files/DZNE-2025-01025.pdf","source":{"id":"https://openalex.org/S7407051172","display_name":"DZNE Pub","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801533059","host_organization_name":"German Center for Neurodegenerative Diseases","host_organization_lineage":["https://openalex.org/I2801533059"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Signal transduction and targeted therapy 10(1), 282 (2025). doi:10.1038/s41392-025-02346-0","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:c041d4af2afc469b976f4e8283189a3c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c041d4af2afc469b976f4e8283189a3c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Signal Transduction and Targeted Therapy, Vol 10, Iss 1, Pp 1-33 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41392-025-02346-0","doi":"https://doi.org/10.1038/s41392-025-02346-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41392-025-02346-0","pdf_url":"https://www.nature.com/articles/s41392-025-02346-0.pdf","source":{"id":"https://openalex.org/S2739142469","display_name":"Signal Transduction and Targeted Therapy","issn_l":"2059-3635","issn":["2059-3635","2095-9907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduction and Targeted Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5442811035","display_name":null,"funder_award_id":"ZS/2024/02/184014","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5470838123","display_name":null,"funder_award_id":"ZS/2024/05/187256 to PM","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G627360304","display_name":null,"funder_award_id":"ZS/2024/02/184014","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G8831343317","display_name":null,"funder_award_id":"ZS/2024/05/187256 to PM","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322884","display_name":"Novartis Stiftung\u00a0f\u00fcr\u00a0Medizinisch-Biologische Forschung","ror":"https://ror.org/02f9zrr09"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413865205.pdf","grobid_xml":"https://content.openalex.org/works/W4413865205.grobid-xml"},"referenced_works_count":431,"referenced_works":["https://openalex.org/W23747989","https://openalex.org/W56623326","https://openalex.org/W114856138","https://openalex.org/W122349615","https://openalex.org/W154416618","https://openalex.org/W164205712","https://openalex.org/W171259044","https://openalex.org/W182334367","https://openalex.org/W211905087","https://openalex.org/W335296136","https://openalex.org/W353261369","https://openalex.org/W1447158976","https://openalex.org/W1483149074","https://openalex.org/W1498903464","https://openalex.org/W1502716447","https://openalex.org/W1517137443","https://openalex.org/W1605866597","https://openalex.org/W1827217512","https://openalex.org/W1876174007","https://openalex.org/W1891981104","https://openalex.org/W1935304841","https://openalex.org/W1952293023","https://openalex.org/W1965575508","https://openalex.org/W1967129860","https://openalex.org/W1967862319","https://openalex.org/W1969654155","https://openalex.org/W1970265839","https://openalex.org/W1975837142","https://openalex.org/W1978927205","https://openalex.org/W1979049477","https://openalex.org/W1990532201","https://openalex.org/W1994169449","https://openalex.org/W1995586381","https://openalex.org/W1995696649","https://openalex.org/W1997158886","https://openalex.org/W2000496619","https://openalex.org/W2000881220","https://openalex.org/W2002839242","https://openalex.org/W2004882448","https://openalex.org/W2005385258","https://openalex.org/W2006496068","https://openalex.org/W2012177783","https://openalex.org/W2014188073","https://openalex.org/W2016695697","https://openalex.org/W2020804368","https://openalex.org/W2024264687","https://openalex.org/W2024379532","https://openalex.org/W2024955728","https://openalex.org/W2024990134","https://openalex.org/W2029774571","https://openalex.org/W2034147064","https://openalex.org/W2034349743","https://openalex.org/W2036794681","https://openalex.org/W2039273105","https://openalex.org/W2039391975","https://openalex.org/W2039420330","https://openalex.org/W2039438951","https://openalex.org/W2040570483","https://openalex.org/W2041077485","https://openalex.org/W2042972403","https://openalex.org/W2043618136","https://openalex.org/W2044004122","https://openalex.org/W2047367002","https://openalex.org/W2048903244","https://openalex.org/W2049878269","https://openalex.org/W2050612188","https://openalex.org/W2053079769","https://openalex.org/W2054129325","https://openalex.org/W2057710992","https://openalex.org/W2057742297","https://openalex.org/W2058579856","https://openalex.org/W2059982400","https://openalex.org/W2060923587","https://openalex.org/W2061609963","https://openalex.org/W2061755142","https://openalex.org/W2064239411","https://openalex.org/W2064941558","https://openalex.org/W2073019915","https://openalex.org/W2073614919","https://openalex.org/W2075394493","https://openalex.org/W2076383107","https://openalex.org/W2077612517","https://openalex.org/W2078800845","https://openalex.org/W2080094749","https://openalex.org/W2081463266","https://openalex.org/W2084043378","https://openalex.org/W2085051977","https://openalex.org/W2085076776","https://openalex.org/W2090873886","https://openalex.org/W2092784951","https://openalex.org/W2094550322","https://openalex.org/W2094632509","https://openalex.org/W2096237016","https://openalex.org/W2099003584","https://openalex.org/W2099259194","https://openalex.org/W2101833366","https://openalex.org/W2102015915","https://openalex.org/W2102730289","https://openalex.org/W2104842795","https://openalex.org/W2104920673","https://openalex.org/W2105456870","https://openalex.org/W2109734267","https://openalex.org/W2111644571","https://openalex.org/W2112856272","https://openalex.org/W2114140274","https://openalex.org/W2115233614","https://openalex.org/W2115692972","https://openalex.org/W2119846536","https://openalex.org/W2120437689","https://openalex.org/W2122091522","https://openalex.org/W2122649866","https://openalex.org/W2128621051","https://openalex.org/W2130700163","https://openalex.org/W2131184340","https://openalex.org/W2131599914","https://openalex.org/W2132588562","https://openalex.org/W2135046139","https://openalex.org/W2136815651","https://openalex.org/W2138209376","https://openalex.org/W2140106465","https://openalex.org/W2140615065","https://openalex.org/W2141276198","https://openalex.org/W2143691602","https://openalex.org/W2144261101","https://openalex.org/W2146609951","https://openalex.org/W2149144582","https://openalex.org/W2151380782","https://openalex.org/W2154401382","https://openalex.org/W2156002770","https://openalex.org/W2157137240","https://openalex.org/W2157744388","https://openalex.org/W2158711047","https://openalex.org/W2158821980","https://openalex.org/W2161431171","https://openalex.org/W2161924597","https://openalex.org/W2161958778","https://openalex.org/W2164706673","https://openalex.org/W2165853103","https://openalex.org/W2168228291","https://openalex.org/W2179003502","https://openalex.org/W2189534812","https://openalex.org/W2194304382","https://openalex.org/W2210524848","https://openalex.org/W2227813149","https://openalex.org/W2254262262","https://openalex.org/W2273568758","https://openalex.org/W2274924551","https://openalex.org/W2290846307","https://openalex.org/W2308720422","https://openalex.org/W2316426285","https://openalex.org/W2317934819","https://openalex.org/W2324170318","https://openalex.org/W2326801135","https://openalex.org/W2327226597","https://openalex.org/W2327867808","https://openalex.org/W2331322317","https://openalex.org/W2339083408","https://openalex.org/W2399674801","https://openalex.org/W2403676269","https://openalex.org/W2407425215","https://openalex.org/W2410052246","https://openalex.org/W2428264960","https://openalex.org/W2472191294","https://openalex.org/W2514251438","https://openalex.org/W2521666083","https://openalex.org/W2523502093","https://openalex.org/W2527412351","https://openalex.org/W2553580697","https://openalex.org/W2575389659","https://openalex.org/W2581121474","https://openalex.org/W2605983725","https://openalex.org/W2606418819","https://openalex.org/W2623319173","https://openalex.org/W2735363562","https://openalex.org/W2736390152","https://openalex.org/W2758054633","https://openalex.org/W2758433057","https://openalex.org/W2760879974","https://openalex.org/W2763204922","https://openalex.org/W2764288910","https://openalex.org/W2769457988","https://openalex.org/W2770837559","https://openalex.org/W2772902268","https://openalex.org/W2775826732","https://openalex.org/W2783006976","https://openalex.org/W2783897061","https://openalex.org/W2786919805","https://openalex.org/W2789452586","https://openalex.org/W2790427241","https://openalex.org/W2790436749","https://openalex.org/W2791434718","https://openalex.org/W2792237486","https://openalex.org/W2792914061","https://openalex.org/W2793920331","https://openalex.org/W2794944252","https://openalex.org/W2799381775","https://openalex.org/W2801464741","https://openalex.org/W2803282494","https://openalex.org/W2803815839","https://openalex.org/W2883376857","https://openalex.org/W2883840350","https://openalex.org/W2884292252","https://openalex.org/W2885454748","https://openalex.org/W2885972205","https://openalex.org/W2888388477","https://openalex.org/W2888452602","https://openalex.org/W2888671837","https://openalex.org/W2889539388","https://openalex.org/W2890272267","https://openalex.org/W2891919070","https://openalex.org/W2893184825","https://openalex.org/W2896151579","https://openalex.org/W2896989040","https://openalex.org/W2897217378","https://openalex.org/W2900392750","https://openalex.org/W2901166225","https://openalex.org/W2902358944","https://openalex.org/W2902444611","https://openalex.org/W2903302497","https://openalex.org/W2904573211","https://openalex.org/W2909267078","https://openalex.org/W2910456986","https://openalex.org/W2913976105","https://openalex.org/W2917957333","https://openalex.org/W2919947473","https://openalex.org/W2920951015","https://openalex.org/W2922510661","https://openalex.org/W2922842315","https://openalex.org/W2923862589","https://openalex.org/W2937033043","https://openalex.org/W2938540058","https://openalex.org/W2944883797","https://openalex.org/W2945932739","https://openalex.org/W2946679928","https://openalex.org/W2950933766","https://openalex.org/W2952584877","https://openalex.org/W2955058739","https://openalex.org/W2956001745","https://openalex.org/W2962176767","https://openalex.org/W2963655570","https://openalex.org/W2968241928","https://openalex.org/W2969026579","https://openalex.org/W2970280482","https://openalex.org/W2971164718","https://openalex.org/W2973061133","https://openalex.org/W2979971613","https://openalex.org/W2980513069","https://openalex.org/W2990278592","https://openalex.org/W2991072457","https://openalex.org/W2992890959","https://openalex.org/W2998385609","https://openalex.org/W2998467274","https://openalex.org/W3004896280","https://openalex.org/W3005310960","https://openalex.org/W3005887408","https://openalex.org/W3007062780","https://openalex.org/W3007173220","https://openalex.org/W3008421441","https://openalex.org/W3009362929","https://openalex.org/W3010751848","https://openalex.org/W3015394081","https://openalex.org/W3021399606","https://openalex.org/W3023060903","https://openalex.org/W3023529892","https://openalex.org/W3026408597","https://openalex.org/W3029107529","https://openalex.org/W3033277959","https://openalex.org/W3036255021","https://openalex.org/W3040316441","https://openalex.org/W3044804316","https://openalex.org/W3048475313","https://openalex.org/W3080995607","https://openalex.org/W3083719627","https://openalex.org/W3084434894","https://openalex.org/W3089198705","https://openalex.org/W3089351001","https://openalex.org/W3089407290","https://openalex.org/W3093056287","https://openalex.org/W3105601043","https://openalex.org/W3109216560","https://openalex.org/W3109946873","https://openalex.org/W3110282950","https://openalex.org/W3112039773","https://openalex.org/W3119479703","https://openalex.org/W3127175217","https://openalex.org/W3127902394","https://openalex.org/W3131835902","https://openalex.org/W3137139446","https://openalex.org/W3143484431","https://openalex.org/W3144235332","https://openalex.org/W3145407809","https://openalex.org/W3148534145","https://openalex.org/W3149979760","https://openalex.org/W3154456345","https://openalex.org/W3155052439","https://openalex.org/W3155340699","https://openalex.org/W3157291651","https://openalex.org/W3160282231","https://openalex.org/W3160522418","https://openalex.org/W3166921190","https://openalex.org/W3167395595","https://openalex.org/W3171833894","https://openalex.org/W3173996236","https://openalex.org/W3177117624","https://openalex.org/W3181183321","https://openalex.org/W3190451162","https://openalex.org/W3195296682","https://openalex.org/W3197258213","https://openalex.org/W3197632843","https://openalex.org/W3198931253","https://openalex.org/W3199131033","https://openalex.org/W3204051651","https://openalex.org/W3209726214","https://openalex.org/W3211567717","https://openalex.org/W3212571933","https://openalex.org/W4206332077","https://openalex.org/W4206333356","https://openalex.org/W4206359940","https://openalex.org/W4206598062","https://openalex.org/W4207073778","https://openalex.org/W4210304742","https://openalex.org/W4210887725","https://openalex.org/W4211109295","https://openalex.org/W4212859921","https://openalex.org/W4214581189","https://openalex.org/W4220828826","https://openalex.org/W4220970096","https://openalex.org/W4226117775","https://openalex.org/W4233469193","https://openalex.org/W4234756224","https://openalex.org/W4237171581","https://openalex.org/W4240571538","https://openalex.org/W4249033657","https://openalex.org/W4255540893","https://openalex.org/W4280514264","https://openalex.org/W4281723484","https://openalex.org/W4281839906","https://openalex.org/W4281994339","https://openalex.org/W4282035660","https://openalex.org/W4283012993","https://openalex.org/W4283695295","https://openalex.org/W4288074479","https://openalex.org/W4288078039","https://openalex.org/W4289754840","https://openalex.org/W4289856872","https://openalex.org/W4292590580","https://openalex.org/W4293514956","https://openalex.org/W4294877948","https://openalex.org/W4296285833","https://openalex.org/W4300772619","https://openalex.org/W4303415616","https://openalex.org/W4307583650","https://openalex.org/W4310297334","https://openalex.org/W4311001935","https://openalex.org/W4312194597","https://openalex.org/W4313417278","https://openalex.org/W4313435188","https://openalex.org/W4313588640","https://openalex.org/W4313827579","https://openalex.org/W4317382090","https://openalex.org/W4317692589","https://openalex.org/W4319216374","https://openalex.org/W4321098235","https://openalex.org/W4322504443","https://openalex.org/W4322761896","https://openalex.org/W4323352189","https://openalex.org/W4327922506","https://openalex.org/W4353094256","https://openalex.org/W4360993774","https://openalex.org/W4362674168","https://openalex.org/W4365511500","https://openalex.org/W4366251469","https://openalex.org/W4366251482","https://openalex.org/W4366371744","https://openalex.org/W4367182956","https://openalex.org/W4367187790","https://openalex.org/W4377286955","https://openalex.org/W4379053660","https://openalex.org/W4379232387","https://openalex.org/W4381598483","https://openalex.org/W4382359318","https://openalex.org/W4382795662","https://openalex.org/W4383302295","https://openalex.org/W4385421772","https://openalex.org/W4385857973","https://openalex.org/W4386001695","https://openalex.org/W4386019925","https://openalex.org/W4386101166","https://openalex.org/W4386660092","https://openalex.org/W4387773736","https://openalex.org/W4388019247","https://openalex.org/W4388074230","https://openalex.org/W4388599696","https://openalex.org/W4388774810","https://openalex.org/W4388816932","https://openalex.org/W4389163707","https://openalex.org/W4389208559","https://openalex.org/W4389474064","https://openalex.org/W4389569935","https://openalex.org/W4390631651","https://openalex.org/W4390793393","https://openalex.org/W4390794033","https://openalex.org/W4391108640","https://openalex.org/W4391446938","https://openalex.org/W4391566765","https://openalex.org/W4391756452","https://openalex.org/W4392096347","https://openalex.org/W4392653125","https://openalex.org/W4392752735","https://openalex.org/W4393061657","https://openalex.org/W4393346112","https://openalex.org/W4393898712","https://openalex.org/W4394874247","https://openalex.org/W4396596606","https://openalex.org/W4396703982","https://openalex.org/W4396869326","https://openalex.org/W4399576376","https://openalex.org/W4400691777","https://openalex.org/W4401418500","https://openalex.org/W4401429310","https://openalex.org/W4401500416","https://openalex.org/W4402066166","https://openalex.org/W4404197368","https://openalex.org/W4406633314","https://openalex.org/W4407110587","https://openalex.org/W4407695009","https://openalex.org/W4407760968","https://openalex.org/W4408657324","https://openalex.org/W4412033888","https://openalex.org/W6892536042","https://openalex.org/W6931726981"],"related_works":["https://openalex.org/W2024318601","https://openalex.org/W7073899380","https://openalex.org/W4303444541","https://openalex.org/W2901562065","https://openalex.org/W2971164718","https://openalex.org/W3204760012","https://openalex.org/W2587768467","https://openalex.org/W1994637482","https://openalex.org/W1987593551","https://openalex.org/W2097518393"],"abstract_inverted_index":{"Cardiovascular":[0],"diseases":[1,17,92],"are":[2,18],"the":[3,109,119,127,133],"leading":[4],"cause":[5,62],"of":[6,15,47,55,112,129,136,150],"morbidity":[7],"and":[8,21,41,43,53,65,75,93,101,115,138,140,159,177],"mortality":[9],"worldwide.":[10],"The":[11,148],"central":[12],"underlying":[13],"mechanisms":[14,111,168],"cardiovascular":[16,91],"vascular":[19,37,59,71,113],"aging":[20,114],"associated":[22],"arterial":[23,83,116,130,145,163],"stiffness.":[24],"Arterial":[25],"stiffness":[26,84,146],"is":[27,85,153],"characterized":[28],"by":[29],"structural":[30],"(e.g.,":[31,45,68,169],"tunica":[32],"media":[33],"calcification,":[34],"alterations":[35],"in":[36],"smooth":[38],"muscle":[39],"cells,":[40],"fibrosis)":[42],"functional":[44],"loss":[46],"Windkessel":[48],"function,":[49],"elevated":[50],"pulse":[51],"pressure,":[52],"development":[54],"isolated":[56],"systolic":[57],"hypertension)":[58],"changes":[60],"that":[61,82],"microvascular":[63],"dysfunction":[64],"end-organ":[66,121],"damage":[67],"heart":[69],"failure,":[70],"dementia,":[72],"hypertensive":[73],"retinopathy,":[74],"chronic":[76],"kidney":[77],"disease).":[78],"Current":[79],"research":[80],"indicates":[81],"an":[86],"independent":[87],"risk":[88],"factor":[89],"for":[90,98,126,144],"represents":[94],"a":[95,156],"potential":[96,134],"target":[97],"personalized":[99],"prevention":[100,137],"therapeutic":[102],"approaches.":[103],"In":[104],"this":[105,151],"review,":[106],"we":[107],"summarize":[108],"pathophysiological":[110,167],"stiffness,":[117,131,164],"outline":[118],"resulting":[120],"damage,":[122],"present":[123],"different":[124],"methods":[125],"measurement":[128],"highlight":[132],"role":[135],"therapy,":[139],"provide":[141,155],"future":[142,178],"perspectives":[143],"research.":[147],"purpose":[149],"review":[152],"to":[154,162],"state-of-the-art":[157],"interdisciplinary":[158],"translational":[160],"approach":[161],"highlighting":[165],"unique":[166],"perivascular":[170],"adipose":[171],"tissue,":[172],"extracellular":[173],"vesicles),":[174],"clinical":[175],"relevance,":[176],"directions.":[179]},"counts_by_year":[{"year":2026,"cited_by_count":194},{"year":2025,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-10T00:00:00"}
