{"id":"https://openalex.org/W4413856431","doi":"https://doi.org/10.1371/journal.pcbi.1013463","title":"A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition","display_name":"A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition","publication_year":2026,"publication_date":"2026-05-13","ids":{"openalex":"https://openalex.org/W4413856431","doi":"https://doi.org/10.1371/journal.pcbi.1013463","pmid":"https://pubmed.ncbi.nlm.nih.gov/40909627","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12407971"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013463","doi":"https://doi.org/10.1371/journal.pcbi.1013463","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013463","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013463&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013463&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004551398","display_name":"Carlos Coronel\u2010Oliveros","orcid":"https://orcid.org/0000-0002-9428-2410","observed_orcids":["https://orcid.org/0000-0002-9428-2410"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I21067949","display_name":"Adolfo Ib\u00e1\u00f1ez University","ror":"https://ror.org/0326knt82","country_code":"CL","type":"education","lineage":["https://openalex.org/I21067949"]},{"id":"https://openalex.org/I4210156041","display_name":"Global Brain Health Institute","ror":"https://ror.org/058pagg05","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210156041"]}],"countries":["CL","IE","US"],"is_corresponding":false,"raw_author_name":"Carlos Coronel-Oliveros","raw_affiliation_strings":["Global Brain Health Institute (GBHI), University of California, San Francisco, US and Trinity College Dublin, Dublin, Ireland","Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago, Chile","Trinity College Dublin, The University of Dublin, Dublin, Ireland","Adolfo Ibanez University: Universidad Adolfo Ibanez"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Brain Health Institute (GBHI), University of California, San Francisco, US and Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I205274468","https://openalex.org/I4210156041"]},{"raw_affiliation_string":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago, Chile","institution_ids":["https://openalex.org/I21067949"]},{"raw_affiliation_string":"Trinity College Dublin, The University of Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Adolfo Ibanez University: Universidad Adolfo Ibanez","institution_ids":["https://openalex.org/I21067949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092675436","display_name":"Fernando Lehue","orcid":"https://orcid.org/0000-0002-6502-3487","observed_orcids":["https://orcid.org/0000-0002-6502-3487"]},"institutions":[{"id":"https://openalex.org/I21067949","display_name":"Adolfo Ib\u00e1\u00f1ez University","ror":"https://ror.org/0326knt82","country_code":"CL","type":"education","lineage":["https://openalex.org/I21067949"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Fernando Lehue","raw_affiliation_strings":["Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago, Chile","Adolfo Ibanez University: Universidad Adolfo Ibanez"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago, Chile","institution_ids":["https://openalex.org/I21067949"]},{"raw_affiliation_string":"Adolfo Ibanez University: Universidad Adolfo Ibanez","institution_ids":["https://openalex.org/I21067949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009142296","display_name":"Ruben A Herzog","orcid":"https://orcid.org/0000-0002-3498-5819","observed_orcids":["https://orcid.org/0000-0002-3498-5819"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210095952","display_name":"Institute for Cross-Disciplinary Physics and Complex Systems","ror":"https://ror.org/00pfxsh56","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210095952","https://openalex.org/I50441567"]},{"id":"https://openalex.org/I50441567","display_name":"Universitat de les Illes Balears","ror":"https://ror.org/03e10x626","country_code":"ES","type":"education","lineage":["https://openalex.org/I50441567"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rub\u00e9n Herzog","raw_affiliation_strings":["Instituto de F\u00edsica Interdisciplinar y Sistemas Complejos (IFISC, UIB-CSIC), Campus UIB, Palma de Mallorca, Spain","Instituto de F\u00edsica Interdisciplinar y Sistemas Complejos: Instituto de Fisica Interdisciplinar y Sistemas Complejos"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de F\u00edsica Interdisciplinar y Sistemas Complejos (IFISC, UIB-CSIC), Campus UIB, Palma de Mallorca, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210095952","https://openalex.org/I50441567"]},{"raw_affiliation_string":"Instituto de F\u00edsica Interdisciplinar y Sistemas Complejos: Instituto de Fisica Interdisciplinar y Sistemas Complejos","institution_ids":["https://openalex.org/I4210095952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028820316","display_name":"Iv\u00e1n Mindlin","orcid":"https://orcid.org/0000-0001-6041-6081","observed_orcids":["https://orcid.org/0000-0001-6041-6081"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Iv\u00e1n Mindlin","raw_affiliation_strings":["Sorbonne Universit\u00e9, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, 75013, Paris, France","Paris Brain Institute: Institut du Cerveau"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorbonne Universit\u00e9, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, 75013, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210152724"]},{"raw_affiliation_string":"Paris Brain Institute: Institut du Cerveau","institution_ids":["https://openalex.org/I4210152724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015878492","display_name":"Marilyn Gatica","orcid":"https://orcid.org/0000-0001-5783-8283","observed_orcids":["https://orcid.org/0000-0001-5783-8283"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I2800917498","display_name":"Northeastern University London","ror":"https://ror.org/03hdf3w38","country_code":"GB","type":"education","lineage":["https://openalex.org/I12912129","https://openalex.org/I2800917498"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marilyn Gatica","raw_affiliation_strings":["Network Science Institute, Northeastern University London, School of Medicine","Precision Imaging, School of Medicine, University of Nottingham, United Kingdom","NU London: Northeastern University London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Network Science Institute, Northeastern University London, School of Medicine","institution_ids":["https://openalex.org/I2800917498"]},{"raw_affiliation_string":"Precision Imaging, School of Medicine, University of Nottingham, United Kingdom","institution_ids":["https://openalex.org/I142263535"]},{"raw_affiliation_string":"NU London: Northeastern University London","institution_ids":["https://openalex.org/I2800917498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014496503","display_name":"Natalia Kowalczyk\u2010Gr\u0119bska","orcid":"https://orcid.org/0000-0002-2294-5529","observed_orcids":["https://orcid.org/0000-0002-2294-5529"]},"institutions":[{"id":"https://openalex.org/I36685595","display_name":"Uniwersytet SWPS","ror":"https://ror.org/0407f1r36","country_code":"PL","type":"education","lineage":["https://openalex.org/I36685595"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Natalia Kowalczyk-Gr\u0119bska","raw_affiliation_strings":["Faculty of Psychology, SWPS University of Social Sciences and Humanities, Chodakowska 19/31, Warsaw, 03-815, Poland","SWPS: SWPS Uniwersytet Humanistycznospoleczny"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Psychology, SWPS University of Social Sciences and Humanities, Chodakowska 19/31, Warsaw, 03-815, Poland","institution_ids":["https://openalex.org/I36685595"]},{"raw_affiliation_string":"SWPS: SWPS Uniwersytet Humanistycznospoleczny","institution_ids":["https://openalex.org/I36685595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021928342","display_name":"Vicente Medel","orcid":"https://orcid.org/0000-0003-2443-8683","observed_orcids":["https://orcid.org/0000-0003-2443-8683"]},"institutions":[{"id":"https://openalex.org/I21067949","display_name":"Adolfo Ib\u00e1\u00f1ez University","ror":"https://ror.org/0326knt82","country_code":"CL","type":"education","lineage":["https://openalex.org/I21067949"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Vicente Medel","raw_affiliation_strings":["Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago, Chile","Universidad Adolfo Ib\u00e1\u00f1ez: Universidad Adolfo Ibanez"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago, Chile","institution_ids":["https://openalex.org/I21067949"]},{"raw_affiliation_string":"Universidad Adolfo Ib\u00e1\u00f1ez: Universidad Adolfo Ibanez","institution_ids":["https://openalex.org/I21067949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074754048","display_name":"Josephine Cruzat","orcid":"https://orcid.org/0000-0002-3252-8657","observed_orcids":["https://orcid.org/0000-0002-3252-8657","https://orcid.org/0009-0009-5521-259X"]},"institutions":[{"id":"https://openalex.org/I21067949","display_name":"Adolfo Ib\u00e1\u00f1ez University","ror":"https://ror.org/0326knt82","country_code":"CL","type":"education","lineage":["https://openalex.org/I21067949"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Josephine Cruzat","raw_affiliation_strings":["Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago, Chile","Adolfo Ibanez University: Universidad Adolfo Ibanez"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago, Chile","institution_ids":["https://openalex.org/I21067949"]},{"raw_affiliation_string":"Adolfo Ibanez University: Universidad Adolfo Ibanez","institution_ids":["https://openalex.org/I21067949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051520533","display_name":"Ra\u00fal Gonz\u00e1lez-G\u00f3mez","orcid":"https://orcid.org/0000-0003-2341-011X","observed_orcids":["https://orcid.org/0000-0003-2341-011X"]},"institutions":[{"id":"https://openalex.org/I21067949","display_name":"Adolfo Ib\u00e1\u00f1ez University","ror":"https://ror.org/0326knt82","country_code":"CL","type":"education","lineage":["https://openalex.org/I21067949"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Raul Gonzalez-Gomez","raw_affiliation_strings":["Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago, Chile","Universidad Adolfo Ib\u00e1\u00f1ez: Universidad Adolfo Ibanez"],"raw_orcid":"https://orcid.org/0000-0003-2341-011X","affiliations":[{"raw_affiliation_string":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago, Chile","institution_ids":["https://openalex.org/I21067949"]},{"raw_affiliation_string":"Universidad Adolfo Ib\u00e1\u00f1ez: Universidad Adolfo Ibanez","institution_ids":["https://openalex.org/I21067949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066840941","display_name":"Hern\u00e1n Hernandez","orcid":"https://orcid.org/0000-0002-0597-6059","observed_orcids":["https://orcid.org/0000-0002-0597-6059"]},"institutions":[{"id":"https://openalex.org/I21067949","display_name":"Adolfo Ib\u00e1\u00f1ez University","ror":"https://ror.org/0326knt82","country_code":"CL","type":"education","lineage":["https://openalex.org/I21067949"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Hern\u00e1n Hernandez","raw_affiliation_strings":["Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago, Chile","Adolfo Ibanez University: Universidad Adolfo Ibanez"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago, Chile","institution_ids":["https://openalex.org/I21067949"]},{"raw_affiliation_string":"Adolfo Ibanez University: Universidad Adolfo Ibanez","institution_ids":["https://openalex.org/I21067949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058986420","display_name":"Enzo Tagliazucchi","orcid":"https://orcid.org/0000-0003-0421-9993","observed_orcids":["https://orcid.org/0000-0003-0421-9993"]},"institutions":[{"id":"https://openalex.org/I21067949","display_name":"Adolfo Ib\u00e1\u00f1ez University","ror":"https://ror.org/0326knt82","country_code":"CL","type":"education","lineage":["https://openalex.org/I21067949"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Enzo Tagliazucchi","raw_affiliation_strings":["Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago, Chile","Universidad Adolfo Ib\u00e1\u00f1ez: Universidad Adolfo Ibanez"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago, Chile","institution_ids":["https://openalex.org/I21067949"]},{"raw_affiliation_string":"Universidad Adolfo Ib\u00e1\u00f1ez: Universidad Adolfo Ibanez","institution_ids":["https://openalex.org/I21067949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044999896","display_name":"Pavel Prado","orcid":"https://orcid.org/0000-0002-1324-6400","observed_orcids":["https://orcid.org/0000-0002-1324-6400"]},"institutions":[{"id":"https://openalex.org/I21067949","display_name":"Adolfo Ib\u00e1\u00f1ez University","ror":"https://ror.org/0326knt82","country_code":"CL","type":"education","lineage":["https://openalex.org/I21067949"]},{"id":"https://openalex.org/I3124150290","display_name":"Universidad San Sebasti\u00e1n","ror":"https://ror.org/04jrwm652","country_code":"CL","type":"education","lineage":["https://openalex.org/I3124150290"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Pavel Prado","raw_affiliation_strings":["Escuela de Fonoaudiolog\u00eda, Facultad de Ciencias de la Rehabilitaci\u00f3n y Calidad de Vida, Universidad San Sebasti\u00e1n, Regi\u00f3n Metropolitana, Santiago, Chile","Universidad Adolfo Ib\u00e1\u00f1ez: Universidad Adolfo Ibanez"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Escuela de Fonoaudiolog\u00eda, Facultad de Ciencias de la Rehabilitaci\u00f3n y Calidad de Vida, Universidad San Sebasti\u00e1n, Regi\u00f3n Metropolitana, Santiago, Chile","institution_ids":["https://openalex.org/I3124150290"]},{"raw_affiliation_string":"Universidad Adolfo Ib\u00e1\u00f1ez: Universidad Adolfo Ibanez","institution_ids":["https://openalex.org/I21067949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042230025","display_name":"Patricio Orio","orcid":"https://orcid.org/0000-0003-0332-8098","observed_orcids":["https://orcid.org/0000-0003-0332-8098"]},"institutions":[{"id":"https://openalex.org/I149744451","display_name":"Valparaiso University","ror":"https://ror.org/01pp0fx48","country_code":"US","type":"education","lineage":["https://openalex.org/I149744451"]},{"id":"https://openalex.org/I79274474","display_name":"University of Valpara\u00edso","ror":"https://ror.org/00h9jrb69","country_code":"CL","type":"education","lineage":["https://openalex.org/I79274474"]}],"countries":["CL","US"],"is_corresponding":false,"raw_author_name":"Patricio Orio","raw_affiliation_strings":["Centro Interdisciplinario de Neurociencia de Valpara\u00edso (CINV), Universidad de Valpara\u00edso, Valpara\u00edso, Chile","Instituto de Neurociencia, Facultad de Ciencias, Universidad de Valpara\u00edso, Playa Ancha, Valpara\u00edso, Chile","Valparaiso University: Universidad de Valparaiso"],"raw_orcid":"https://orcid.org/0000-0003-0332-8098","affiliations":[{"raw_affiliation_string":"Centro Interdisciplinario de Neurociencia de Valpara\u00edso (CINV), Universidad de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]},{"raw_affiliation_string":"Instituto de Neurociencia, Facultad de Ciencias, Universidad de Valpara\u00edso, Playa Ancha, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]},{"raw_affiliation_string":"Valparaiso University: Universidad de Valparaiso","institution_ids":["https://openalex.org/I149744451","https://openalex.org/I79274474"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014213472","display_name":"Agust\u00edn M. Ib\u00e1\u00f1ez","orcid":"https://orcid.org/0000-0001-6758-5101","observed_orcids":["https://orcid.org/0000-0001-6758-5101"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I21067949","display_name":"Adolfo Ib\u00e1\u00f1ez University","ror":"https://ror.org/0326knt82","country_code":"CL","type":"education","lineage":["https://openalex.org/I21067949"]},{"id":"https://openalex.org/I4210156041","display_name":"Global Brain Health Institute","ror":"https://ror.org/058pagg05","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210156041"]}],"countries":["CL","IE","US"],"is_corresponding":true,"raw_author_name":"Agust\u00edn Ib\u00e1\u00f1ez","raw_affiliation_strings":["Global Brain Health Institute (GBHI), University of California, San Francisco, US and Trinity College Dublin, Dublin, Ireland","Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago, Chile","Trinity College Dublin, The University of Dublin, Dublin, Ireland","Institute of Cognitive Neurology"],"raw_orcid":"https://orcid.org/0000-0001-6758-5101","affiliations":[{"raw_affiliation_string":"Global Brain Health Institute (GBHI), University of California, San Francisco, US and Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I205274468","https://openalex.org/I4210156041"]},{"raw_affiliation_string":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Iba\u00f1ez, Santiago, Chile","institution_ids":["https://openalex.org/I21067949"]},{"raw_affiliation_string":"Trinity College Dublin, The University of Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Institute of Cognitive Neurology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5014213472"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I205274468","https://openalex.org/I21067949","https://openalex.org/I4210156041"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":7.6338,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.96135972,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"22","issue":"5","first_page":"e1013463","last_page":"e1013463"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11187","display_name":"Nonlinear Dynamics and Pattern Formation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neural-mass-model","display_name":"neural mass model","score":0.875},{"id":"https://openalex.org/keywords/jansen-rit-model","display_name":"Jansen-Rit model","score":0.9959999918937683},{"id":"https://openalex.org/keywords/inhibitory-synaptic-plasticity","display_name":"inhibitory plasticity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/excitation-inhibition-balance","display_name":"excitation-inhibition balance","score":0.8019999861717224},{"id":"https://openalex.org/keywords/hyperexcitation","display_name":"hyperexcitation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/alpha-oscillations","display_name":"alpha oscillations","score":0.7110000252723694},{"id":"https://openalex.org/keywords/gamma-oscillations","display_name":"gamma oscillations","score":1.0},{"id":"https://openalex.org/keywords/eeg-spectral-power","display_name":"EEG spectral power","score":0.6940000057220459},{"id":"https://openalex.org/keywords/eeg-functional-connectivity","display_name":"EEG functional connectivity","score":0.7390000224113464},{"id":"https://openalex.org/keywords/nrem-sleep","display_name":"NREM sleep","score":0.9399999976158142},{"id":"https://openalex.org/keywords/slow-wave-activity","display_name":"slow-wave activity","score":0.9750000238418579},{"id":"https://openalex.org/keywords/bifurcation-analysis","display_name":"bifurcation analysis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/global-coupling","display_name":"global coupling","score":0.550000011920929},{"id":"https://openalex.org/keywords/whole-brain-simulation","display_name":"whole-brain simulation","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5110796689987183},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4980497360229492},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4236561954021454},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.3689395487308502},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.27242058515548706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2375771403312683},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.16135084629058838},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.09034931659698486},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.08556634187698364}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1013463","doi":"https://doi.org/10.1371/journal.pcbi.1013463","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013463","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013463&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"doi:10.1101/2025.08.26.672269","doi":"https://doi.org/10.1101/2025.08.26.672269","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.08.26.672269","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/08/31/2025.08.26.672269.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40909627","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40909627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42127149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42127149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12407971","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12407971/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:13183287","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13183287/pdf/pcbi.1013463.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11216202","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12407971","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:33dd01f71582496f96e0a5a0178399f7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/33dd01f71582496f96e0a5a0178399f7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 22, Iss 5, p e1013463 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013463","doi":"https://doi.org/10.1371/journal.pcbi.1013463","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013463","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013463&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","ccf-b","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G103627852","display_name":null,"funder_award_id":"15150012","funder_id":"https://openalex.org/F4320338206","funder_display_name":"Fondo de Financiamiento de Centros de Investigaci\u00f3n en \u00c1reas Prioritarias"},{"id":"https://openalex.org/G1581799926","display_name":null,"funder_award_id":"20-725707","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G1768777012","display_name":"NEUROVASCULAR PATHWAYS IN AGING AND NEURODEGENERATIVE DISEASES (ND): INTEGRATING CARDIOVASCULAR HEALTH AND BRAIN FUNCTION","funder_award_id":"13240170","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G1919018801","display_name":null,"funder_award_id":"ANID/PIA/ANILLOS ACT210096","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G2113303780","display_name":null,"funder_award_id":"R01 AG057234, R01 AG075775, R01 AG21051, R01 AG083799, CARDS-NIH, R01 AG057234","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G2118524674","display_name":null,"funder_award_id":"SG-20- 725707","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G2714391911","display_name":"MACHINE LEARNING FOR MENTAL HEALTH NEW DEVELOPMENTS AND APPLICATIONS USING MULTIMODAL DATA","funder_award_id":"ACT210096","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G2845774930","display_name":"BIOLOGIC EMBEDDING OF SOCIAL INEQUALITY AND LIFESTYLE IN AGING AND DEMENTIA","funder_award_id":"1250091","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G3481889345","display_name":null,"funder_award_id":"FONDAP-15150012","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G3628792472","display_name":null,"funder_award_id":"PIA/ANILLOS ACT210096","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G3897583310","display_name":"CENTRO DE GEROCIENCIA SALUD MENTAL Y METABOLISMO (GERO)","funder_award_id":"15150012","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G3949186969","display_name":null,"funder_award_id":"2013/11/N/HS6/01335","funder_id":"https://openalex.org/F4320322650","funder_display_name":"Narodowym Centrum Nauki"},{"id":"https://openalex.org/G4319372948","display_name":null,"funder_award_id":"RYC2022-035106-I","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G4724273204","display_name":"NEXT GENERATION OF WHOLE-BRAIN COMPUTATIONAL MODELS FOR UNDERSTANDING AND MODULATING NEURODEGENERATIVE DISEASES.","funder_award_id":"3240042","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G5654823996","display_name":"MACHINE LEARNING PARA EL DIAGNOSTICO PRECOZ Y PERFIL MULTIMODAL DE LA ENFERMEDAD DE ALZHEIMER BASADO EN MIRNA DE EXOSOMAS CIRCULANTES.","funder_award_id":"ID20I10152","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G6510480520","display_name":"SENSITIVE NEUROCOGNITIVE MARKERS OF NEURODEGENERATION A MULTI-FEATURE FRAMEWORK","funder_award_id":"1210195","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G7616641907","display_name":null,"funder_award_id":"ID20I10152","funder_id":"https://openalex.org/F4320338106","funder_display_name":"Fondo de Fomento al Desarrollo Cient\u00edfico y Tecnol\u00f3gico"},{"id":"https://openalex.org/G7664693860","display_name":"NATURAL SPEECH MARKERS OF NEURODEGENERATION AN INTERDISCIPLINARY APPROACH FOR DISEASE DISCRIMINATION AND SYMPTOM TRACKING","funder_award_id":"1210176","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G7924038339","display_name":null,"funder_award_id":"1250091 and 1210176 and 1220995, ANID/PIA/ANILLOS ACT210096, FONDEF ID20I10152, and ANID/FONDAP 15150012","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G8575553299","display_name":"MAPPING AND MODELING THE HEALTHY AND PATHOLOGICAL AGING TRAJECTORIES OF THE HUMAN BRAIN","funder_award_id":"1220995","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G883642430","display_name":null,"funder_award_id":"15150012","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8878188802","display_name":"US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative Research","funder_award_id":"R01AG057234","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000869108","display_name":"Social epigenetics of Alzheimer's disease and related dementias in Latin American countries","funder_award_id":"R01AG082056","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000897022","display_name":"An automated machine learning approach to language changes in Alzheimer\u2019s disease and frontotemporal dementia across Latino and English-speaking populations","funder_award_id":"R01AG075775","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000899378","display_name":"Circadian Disturbance and Dementia in Latin America","funder_award_id":"R01AG083799","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9001312614","display_name":"BRAIN-CLIMA: Investigating the Combined Impact of Heat and Air Pollution on Blood-Brain Barrier Integrity and Brain Aging in Latin America","funder_award_id":"335293/Z/25/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G906244395","display_name":null,"funder_award_id":"101236426","funder_id":"https://openalex.org/F4320334322","funder_display_name":"HORIZON EUROPE Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320316719","display_name":"Rainwater Charitable Foundation","ror":"https://ror.org/003q4qk22"},{"id":"https://openalex.org/F4320322650","display_name":"Narodowym Centrum Nauki","ror":"https://ror.org/03ha2q922"},{"id":"https://openalex.org/F4320331146","display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","ror":"https://ror.org/05btm5233"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"},{"id":"https://openalex.org/F4320338106","display_name":"Fondo de Fomento al Desarrollo Cient\u00edfico y Tecnol\u00f3gico","ror":null},{"id":"https://openalex.org/F4320338206","display_name":"Fondo de Financiamiento de Centros de Investigaci\u00f3n en \u00c1reas Prioritarias","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413856431.pdf","grobid_xml":"https://content.openalex.org/works/W4413856431.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W1973207880","https://openalex.org/W1974105735","https://openalex.org/W1977111281","https://openalex.org/W1988578489","https://openalex.org/W1993770350","https://openalex.org/W1996187129","https://openalex.org/W1999475362","https://openalex.org/W2000619457","https://openalex.org/W2005821483","https://openalex.org/W2005848700","https://openalex.org/W2017581687","https://openalex.org/W2027280942","https://openalex.org/W2036325410","https://openalex.org/W2052769522","https://openalex.org/W2053100455","https://openalex.org/W2058046532","https://openalex.org/W2070765152","https://openalex.org/W2096935768","https://openalex.org/W2100157657","https://openalex.org/W2106822551","https://openalex.org/W2111277581","https://openalex.org/W2117882336","https://openalex.org/W2119823590","https://openalex.org/W2127786259","https://openalex.org/W2128378732","https://openalex.org/W2130801245","https://openalex.org/W2133478841","https://openalex.org/W2146052710","https://openalex.org/W2162615325","https://openalex.org/W2162686834","https://openalex.org/W2290509746","https://openalex.org/W2525248522","https://openalex.org/W2580627162","https://openalex.org/W2615397937","https://openalex.org/W2728707994","https://openalex.org/W2752480938","https://openalex.org/W2788786700","https://openalex.org/W2801331459","https://openalex.org/W2808826367","https://openalex.org/W2890448436","https://openalex.org/W2893373014","https://openalex.org/W2952277065","https://openalex.org/W2953144044","https://openalex.org/W2958093451","https://openalex.org/W2963839688","https://openalex.org/W2969829800","https://openalex.org/W2998606888","https://openalex.org/W3015902292","https://openalex.org/W3016049614","https://openalex.org/W3047141578","https://openalex.org/W3110862467","https://openalex.org/W3129390720","https://openalex.org/W3138107600","https://openalex.org/W3165858085","https://openalex.org/W3180578469","https://openalex.org/W3185074371","https://openalex.org/W3186256997","https://openalex.org/W4200459750","https://openalex.org/W4220979393","https://openalex.org/W4224217494","https://openalex.org/W4254419114","https://openalex.org/W4281564634","https://openalex.org/W4307494802","https://openalex.org/W4309662767","https://openalex.org/W4311448611","https://openalex.org/W4315476314","https://openalex.org/W4316041278","https://openalex.org/W4361271275","https://openalex.org/W4386393675","https://openalex.org/W4387448082","https://openalex.org/W4389341518","https://openalex.org/W4390975871","https://openalex.org/W4391383096","https://openalex.org/W4392959201","https://openalex.org/W4394720570","https://openalex.org/W4396621969","https://openalex.org/W4401224237","https://openalex.org/W4401393240","https://openalex.org/W4404914125","https://openalex.org/W4409146807","https://openalex.org/W4415624380"],"related_works":["https://openalex.org/W2313034295","https://openalex.org/W2066004435","https://openalex.org/W2036789051","https://openalex.org/W3119997535","https://openalex.org/W1999475362","https://openalex.org/W2969339420","https://openalex.org/W7099426924","https://openalex.org/W1987602703","https://openalex.org/W7018561448","https://openalex.org/W3212517778"],"abstract_inverted_index":{"Abstract":[0],"Whole-brain":[1],"models":[2,36,52,360,412,433],"are":[3,337,380,560],"valuable":[4],"tools":[5],"for":[6,291,399],"understanding":[7],"brain":[8,271,293,302,367,370,458,535,558],"dynamics":[9,559],"in":[10,124,170,225,241,252,277,295,358,389,437,562,590],"health":[11,296],"and":[12,21,48,74,126,145,155,212,248,273,280,297,311,322,346,352,427,430,466,484,499,519,527,557,577,586],"disease":[13],"by":[14,449,489],"enabling":[15],"the":[16,65,80,114,167,172,177,187,190,226,245,249,264,314,330,364,390,416,439,464,478,485,523,538,541,544,591,598],"testing":[17],"of":[18,23,68,79,119,216,263,266,320,332,419,434,442,453,469,497,540,543,565,575],"causal":[19],"mechanisms":[20,379],"identification":[22],"therapeutic":[24],"targets":[25],"through":[26],"dynamic":[27],"simulations.":[28,405],"Among":[29],"these":[30,88,359],"models,":[31,334],"biophysically":[32],"inspired":[33],"neural":[34,69,82,120,323],"mass":[35,83],"have":[37],"been":[38],"widely":[39],"used":[40,552],"to":[41,57,63,104,129,199,229,397,414,501,514,520,553,593,597],"simulate":[42,344],"electrophysiological":[43,443],"recordings,":[44],"such":[45,567],"as":[46,182,275,568],"MEG":[47],"EEG.":[49,470],"However,":[50,313],"traditional":[51,432],"face":[53],"limitations,":[54,341],"including":[55],"susceptibility":[56],"hyperexcitation,":[58],"which":[59,97,171],"constrains":[60],"their":[61,106],"ability":[62],"capture":[64,516],"full":[66],"richness":[67,418],"dynamics.":[70,529],"Here,":[71,445],"we":[72,385,446,531],"developed":[73],"characterized":[75],"a":[76,110,131,149,183,213,289,387],"new":[77],"version":[78],"Jansen-Rit":[81],"model":[84,91,115,140,173,228,257,285,391,549,581],"aimed":[85],"at":[86],"overcoming":[87],"limitations.":[89],"Our":[90,580],"incorporates":[92],"inhibitory":[93,99],"synaptic":[94],"plasticity":[95],"(ISP),":[96],"adjusts":[98],"feedback":[100,395],"onto":[101],"pyramidal":[102],"neurons":[103,321],"clamp":[105],"firing":[107,179,210],"rates":[108],"around":[109],"target":[111,178],"value.":[112],"Further,":[113],"combined":[116,472],"two":[117,451],"subpopulations":[118,452],"cortical":[121,454],"columns":[122,455],"oscillating":[123,462],"\u03b1":[125,219,465],"\u03b3,":[127],"respectively,":[128],"generate":[130],"richer":[132],"EEG":[133,154,232,310,345,420,422,435,475,517,524,546],"power":[134,525],"spectrum.":[135],"We":[136,147,493,506],"analyzed":[137],"how":[138,555],"different":[139,194,495,563],"parameters":[141],"modulate":[142],"oscillatory":[143,195],"frequency":[144,202,236],"connectivity.":[146],"considered":[148],"model\u2019s":[150],"showcase,":[151],"simultaneously":[152,521],"fitting":[153],"fMRI":[156,347,528],"recordings":[157,348,423],"during":[158,482],"NREM":[159,253],"sleep.":[160,254],"Bifurcation":[161],"analysis":[162],"showed":[163,532],"that":[164,392,410,508,533],"ISP":[165,222,287],"increases":[166],"parameters\u2019":[168],"range":[169,441],"exhibited":[174],"sustained":[175],"oscillations;":[176],"rate":[180],"acts":[181],"bifurcation":[184,191],"parameter,":[185],"moving":[186],"system":[188,510],"across":[189,235],"point,":[192],"producing":[193],"regimes,":[196],"from":[197,205,340,349],"slower":[198,426,479],"faster.":[200],"High":[201],"activity":[203,247,303,319,473],"emerged":[204],"low":[206],"global":[207],"coupling,":[208],"high":[209,214],"rates,":[211],"proportion":[215],"\u03b3":[217,467],"versus":[218],"subpopulations.":[220],"Importantly,":[221],"was":[223],"necessary":[224,513],"multi-frequency":[227],"successfully":[230],"fit":[231],"functional":[233],"connectivity":[234,251,518,556],"bands.":[237],"Finally,":[238],"ISP-controlled":[239],"reductions":[240],"excitability":[242,401,511,536],"reproduced":[243],"both":[244],"slow-wave":[246],"reduced":[250],"Altogether,":[255],"our":[256,504],"is":[258,325,329,361,409,512,537,582],"compatible":[259],"with":[260,286,588],"biological":[261],"evidence":[262],"effects":[265],"E/I":[267],"balance":[268],"on":[269],"modulating":[270],"rhythms":[272,480],"connectivity,":[274],"observed":[276,481,507],"sleep,":[278,483],"neurodegeneration,":[279],"chemical":[281,569],"neuromodulation.":[282],"This":[283],"biophysical":[284],"provides":[288],"springboard":[290],"realistic":[292],"simulations":[294,498],"disease.":[298],"Author":[299],"Summary":[300],"Macroscale":[301],"can":[304,343,550],"be":[305,551],"captured":[306],"using":[307],"techniques":[308],"like":[309],"fMRI.":[312],"granular":[315],"or":[316],"more":[317],"detailed":[318],"masses":[324],"inaccessible.":[326],"A":[327,406],"solution":[328],"use":[331],"whole-brain":[333],"although":[335],"they":[336,342],"not":[338],"free":[339],"mathematical":[350],"equations":[351],"empirical":[353],"data.":[354],"One":[355],"first":[356],"limitation":[357,408],"hyperexcitation.":[362],"When":[363],"coupling":[365],"between":[366],"areas":[368,371],"increases,":[369],"might":[372],"become":[373],"aberrantly":[374],"hyperexcitable":[375],"if":[376],"no":[377],"compensatory":[378],"considered.":[381],"To":[382],"address":[383],"this,":[384],"introduce":[386],"mechanism":[388],"dynamically":[393],"modifies":[394],"inhibition":[396],"compensate":[398],"this":[400,448],"increase":[402],"when":[403],"running":[404],"second":[407],"many":[411],"fail":[413,436],"reproduce":[415,522],"spectral":[417,440],"signals.":[421],"reflect":[424],"interweaving":[425],"faster":[428,486],"rhythms,":[429],"some":[431],"capturing":[438],"recordings.":[444],"addressed":[447],"combining":[450],"within":[456,463],"single":[457],"areas,":[459],"each":[460],"one":[461],"bands":[468],"Their":[471],"generates":[474],"oscillations":[476],"resembling":[477],"ones":[487],"triggered":[488],"increased":[490],"attentional":[491],"load.":[492],"ran":[494],"types":[496,564],"analyses":[500],"fully":[502,515],"characterize":[503,554],"model.":[505],"controlling":[509],"spectrum":[526],"Moreover,":[530],"reduced/increased":[534],"cause":[539],"emergence":[542],"slowest/fastest":[545],"rhythms.":[547],"The":[548],"altered":[561,573],"conditions,":[566],"neuromodulation,":[570],"drug":[571],"delivery,":[572],"states":[574],"consciousness,":[576],"neurodegenerative":[578],"disorders.":[579],"open":[583],"access,":[584],"well-documented,":[585],"introduced":[587],"tutorials,":[589],"way":[592],"make":[594],"it":[595],"accessible":[596],"whole":[599],"neuroscience":[600],"community.":[601]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}