{"id":"https://openalex.org/W4413835889","doi":"https://doi.org/10.1101/2025.08.27.25334497","title":"Mapping heterogeneity in the neuroanatomical correlates of depression","display_name":"Mapping heterogeneity in the neuroanatomical correlates of depression","publication_year":2025,"publication_date":"2025-08-29","ids":{"openalex":"https://openalex.org/W4413835889","doi":"https://doi.org/10.1101/2025.08.27.25334497"},"language":"en","primary_location":{"id":"doi:10.1101/2025.08.27.25334497","doi":"https://doi.org/10.1101/2025.08.27.25334497","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.08.27.25334497","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/08/29/2025.08.27.25334497.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2025/08/29/2025.08.27.25334497.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047375749","display_name":"Devon Watts","orcid":"https://orcid.org/0000-0002-8789-0266","observed_orcids":["https://orcid.org/0000-0002-8789-0266"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Devon Watts","raw_affiliation_strings":["Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital. Boston, MA, USA","Massachusetts General Hospital"],"raw_orcid":"https://orcid.org/0000-0002-8789-0266","affiliations":[{"raw_affiliation_string":"Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital. Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045978673","display_name":"Travis T. Mallard","orcid":"https://orcid.org/0000-0002-3265-3001","observed_orcids":["https://orcid.org/0000-0002-3265-3001"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Travis T Mallard","raw_affiliation_strings":["Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital. Boston, MA, USA","Department of Psychiatry, Harvard Medical School, Boston, MA, USA","Massachusetts General Hospital"],"raw_orcid":"https://orcid.org/0000-0002-3265-3001","affiliations":[{"raw_affiliation_string":"Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital. Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lorenza Dall\u2019 Aglio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorenza Dall\u2019 Aglio","raw_affiliation_strings":["Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital. Boston, MA, USA","Massachusetts General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital. Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041471149","display_name":"Evan Jeffrey Giangrande","orcid":"https://orcid.org/0000-0002-8023-0062","observed_orcids":["https://orcid.org/0000-0002-8023-0062"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evan Giangrande","raw_affiliation_strings":["Center for Genomic Medicine, Mass General Brigham, Boston, MA, USA","Massachusetts General Hospital"],"raw_orcid":"https://orcid.org/0000-0002-8023-0062","affiliations":[{"raw_affiliation_string":"Center for Genomic Medicine, Mass General Brigham, Boston, MA, USA","institution_ids":["https://openalex.org/I48633490"]},{"raw_affiliation_string":"Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101484083","display_name":"Chris J. Kennedy","orcid":"https://orcid.org/0000-0001-7444-2766","observed_orcids":["https://orcid.org/0000-0001-7444-2766"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Kennedy","raw_affiliation_strings":["Center for Genomic Medicine, Mass General Brigham, Boston, MA, USA","Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital. Boston, MA, USA","Department of Psychiatry, Harvard Medical School, Boston, MA, USA","Massachusetts General Hospital"],"raw_orcid":"https://orcid.org/0000-0001-7444-2766","affiliations":[{"raw_affiliation_string":"Center for Genomic Medicine, Mass General Brigham, Boston, MA, USA","institution_ids":["https://openalex.org/I48633490"]},{"raw_affiliation_string":"Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital. Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044285300","display_name":"Na Cai","orcid":"https://orcid.org/0000-0001-7496-2075","observed_orcids":["https://orcid.org/0000-0001-7496-2075"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Na Cai","raw_affiliation_strings":["Department of Biosystems and Engineering, ETH Zurich, Basel, Switzerland","ETH Zurich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"ETH Zurich","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032674001","display_name":"Karmel W. Choi","orcid":"https://orcid.org/0000-0002-3914-2431","observed_orcids":["https://orcid.org/0000-0002-3914-2431"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karmel Choi","raw_affiliation_strings":["Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital. Boston, MA, USA","Department of Psychiatry, Harvard Medical School, Boston, MA, USA","Massachusetts General Hospital"],"raw_orcid":"https://orcid.org/0000-0002-3914-2431","affiliations":[{"raw_affiliation_string":"Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital. Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032711494","display_name":"Tian Ge","orcid":"https://orcid.org/0000-0003-4785-4444","observed_orcids":["https://orcid.org/0000-0003-4785-4444","https://orcid.org/0000-0003-4738-0314"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tian Ge","raw_affiliation_strings":["Center for Genomic Medicine, Mass General Brigham, Boston, MA, USA","Department of Psychiatry, Harvard Medical School, Boston, MA, USA","Massachusetts General Hospital"],"raw_orcid":"https://orcid.org/0000-0003-4785-4444","affiliations":[{"raw_affiliation_string":"Center for Genomic Medicine, Mass General Brigham, Boston, MA, USA","institution_ids":["https://openalex.org/I48633490"]},{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044998046","display_name":"Jordan W. Smoller","orcid":"https://orcid.org/0000-0002-0381-6334","observed_orcids":["https://orcid.org/0000-0002-0381-6334"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan W. Smoller","raw_affiliation_strings":["Center for Genomic Medicine, Mass General Brigham, Boston, MA, USA","Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital. Boston, MA, USA","Department of Psychiatry, Harvard Medical School, Boston, MA, USA","Massachusetts General Hospital"],"raw_orcid":"https://orcid.org/0000-0002-0381-6334","affiliations":[{"raw_affiliation_string":"Center for Genomic Medicine, Mass General Brigham, Boston, MA, USA","institution_ids":["https://openalex.org/I48633490"]},{"raw_affiliation_string":"Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital. Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5047375749"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.39579999446868896,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.39579999446868896,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.37299999594688416,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.04830000177025795,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9990000128746033},{"id":"https://openalex.org/keywords/white-matter-microstructure","display_name":"white matter microstructure","score":0.8579999804496765},{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"fractional anisotropy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mean-diffusivity","display_name":"mean diffusivity","score":0.984000027179718},{"id":"https://openalex.org/keywords/cortical-thickness","display_name":"cortical thickness","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cortical-surface-area","display_name":"cortical surface area","score":0.949999988079071},{"id":"https://openalex.org/keywords/depression-classification","display_name":"depression classification","score":0.5519999861717224},{"id":"https://openalex.org/keywords/sample-size","display_name":"sample size","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6319811940193176},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4708927273750305},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.46238651871681213},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.35041943192481995},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.220316082239151},{"id":"https://openalex.org/C165556158","wikidata":"https://www.wikidata.org/wiki/Q83937","display_name":"Keynesian economics","level":1,"score":0.11476969718933105}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2025.08.27.25334497","doi":"https://doi.org/10.1101/2025.08.27.25334497","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.08.27.25334497","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/08/29/2025.08.27.25334497.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/793863","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/793863","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"info:eu-repo/semantics/workingPaper"},{"id":"doi:10.3929/ethz-c-000793863","doi":"https://doi.org/10.3929/ethz-c-000793863","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-c-000793863","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1101/2025.08.27.25334497","doi":"https://doi.org/10.1101/2025.08.27.25334497","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.08.27.25334497","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/08/29/2025.08.27.25334497.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.979200005531311,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413835889.pdf","grobid_xml":"https://content.openalex.org/works/W4413835889.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1524375783","https://openalex.org/W1566415063","https://openalex.org/W1597482516","https://openalex.org/W1964940342","https://openalex.org/W2003896853","https://openalex.org/W2031550338","https://openalex.org/W2049785594","https://openalex.org/W2095647587","https://openalex.org/W2101135654","https://openalex.org/W2110065044","https://openalex.org/W2122825543","https://openalex.org/W2124833832","https://openalex.org/W2131241448","https://openalex.org/W2146272590","https://openalex.org/W2148143831","https://openalex.org/W2149308034","https://openalex.org/W2153150899","https://openalex.org/W2157395790","https://openalex.org/W2167277498","https://openalex.org/W2169353679","https://openalex.org/W2261084462","https://openalex.org/W2300422661","https://openalex.org/W2342603028","https://openalex.org/W2342969114","https://openalex.org/W2346576232","https://openalex.org/W2596902563","https://openalex.org/W2723723801","https://openalex.org/W2748022024","https://openalex.org/W2767050687","https://openalex.org/W2804287612","https://openalex.org/W2873705236","https://openalex.org/W2888432148","https://openalex.org/W2891385203","https://openalex.org/W2941336008","https://openalex.org/W2968265130","https://openalex.org/W2969290450","https://openalex.org/W2969721658","https://openalex.org/W2970275262","https://openalex.org/W2989787606","https://openalex.org/W2990427812","https://openalex.org/W2990855036","https://openalex.org/W2996717911","https://openalex.org/W3004386287","https://openalex.org/W3007560027","https://openalex.org/W3013422836","https://openalex.org/W3013660197","https://openalex.org/W3021472336","https://openalex.org/W3108978982","https://openalex.org/W3157759037","https://openalex.org/W3200982191","https://openalex.org/W4200088695","https://openalex.org/W4223938893","https://openalex.org/W4233056867","https://openalex.org/W4239160510","https://openalex.org/W4241074797","https://openalex.org/W4288051001","https://openalex.org/W4360603970","https://openalex.org/W4376118242","https://openalex.org/W4379162608","https://openalex.org/W4382058162","https://openalex.org/W4386886562","https://openalex.org/W4387451401","https://openalex.org/W4388824145","https://openalex.org/W4389753112","https://openalex.org/W4403412734","https://openalex.org/W4407731433"],"related_works":["https://openalex.org/W4223938893","https://openalex.org/W3036341959","https://openalex.org/W4366371553","https://openalex.org/W2972288994","https://openalex.org/W4407800927","https://openalex.org/W4288051001","https://openalex.org/W6890103818","https://openalex.org/W7217421155","https://openalex.org/W4390752108","https://openalex.org/W2555699120"],"abstract_inverted_index":{"Abstract":[0],"Major":[1],"depressive":[2],"disorder":[3],"(MDD)":[4],"affects":[5],"millions":[6],"worldwide,":[7],"yet":[8],"its":[9],"neurobiological":[10],"underpinnings":[11],"remain":[12],"elusive.":[13],"Neuroimaging":[14],"studies":[15],"have":[16],"yielded":[17],"inconsistent":[18],"results,":[19],"hindered":[20],"by":[21,35],"small":[22],"sample":[23,216],"sizes":[24],"and":[25,64,68,88,100,119,127,137,161],"heterogeneous":[26],"depression":[27,47,70,107,135,149],"definitions.":[28,108],"We":[29,55],"sought":[30],"to":[31,44,78,94,169,186,221],"address":[32],"these":[33,197],"limitations":[34],"leveraging":[36],"the":[37,101,215,227],"UK":[38],"Biobank\u2019s":[39],"extensive":[40],"neuroimaging":[41,233],"data":[42],"(n=30,122)":[43],"investigate":[45],"how":[46],"phenotyping":[48,208],"depth":[49],"influences":[50],"neuroanatomic":[51],"profiles":[52],"of":[53,103,218],"MDD.":[54],"examined":[56],"256":[57],"brain":[58,66],"structural":[59],"features,":[60],"obtained":[61],"from":[62,73,151],"T1-":[63],"diffusion-weighted":[65],"imaging,":[67],"nine":[69],"phenotypes,":[71],"ranging":[72],"self-reported":[74],"symptoms":[75],"(shallow":[76],"definitions)":[77],"clinical":[79],"diagnoses":[80],"(deep).":[81],"Multivariable":[82],"logistic":[83],"regression,":[84],"machine":[85],"learning":[86,142],"classifiers,":[87],"feature":[89],"transfer":[90],"approaches":[91],"were":[92,130,184],"used":[93],"explore":[95],"correlational":[96],"patterns,":[97],"predictive":[98,165],"accuracy":[99],"transferability":[102],"important":[104],"features":[105],"across":[106,134,207],"For":[109],"white":[110],"matter":[111],"microstructure,":[112],"we":[113],"observed":[114],"widespread":[115],"fractional":[116],"anisotropy":[117],"decreases":[118],"mean":[120],"diffusivity":[121],"increases.":[122],"In":[123],"contrast,":[124],"cortical":[125],"thickness":[126],"surface":[128],"area":[129],"less":[131],"consistently":[132],"associated":[133],"definitions,":[136],"demonstrated":[138],"weaker":[139],"associations.":[140],"Machine":[141],"classifiers":[143],"showed":[144],"varying":[145],"performance":[146,159,192],"in":[147,231],"distinguishing":[148],"cases":[150],"controls,":[152],"with":[153],"shallow":[154,182,210],"phenotypes":[155,171,183,211,220],"achieving":[156],"similar":[157],"discriminative":[158],"(AUC=0.807)":[160],"slightly":[162],"higher":[163],"positive":[164],"value":[166],"(PPV=0.655)":[167],"compared":[168],"deep":[170,188,219],"(AUC=0.831,":[172],"PPV=0.456),":[173],"when":[174,181],"sensitivity":[175],"was":[176],"standardized":[177],"at":[178],"80%.":[179],"However,":[180],"downsampled":[185],"match":[187],"phenotype":[189],"case/control":[190],"ratios,":[191],"degraded":[193],"substantially":[194],"(AUC=0.690).":[195],"Together,":[196],"results":[198],"suggest":[199],"that":[200],"while":[201],"core":[202],"white-matter":[203],"alterations":[204],"are":[205],"shared":[206],"strategies,":[209],"require":[212],"approximately":[213],"twice":[214],"size":[217],"achieve":[222],"comparable":[223],"classification":[224],"performance,":[225],"underscoring":[226],"fundamental":[228],"power-specificity":[229],"tradeoff":[230],"psychiatric":[232],"research.":[234]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
