{"id":"https://openalex.org/W4413826331","doi":"https://doi.org/10.1227/neu.0000000000003709","title":"Systematic Cavernous Sinus Exploration Combined With Early Hormonal Assessment in Cushing Disease","display_name":"Systematic Cavernous Sinus Exploration Combined With Early Hormonal Assessment in Cushing Disease","publication_year":2025,"publication_date":"2025-08-29","ids":{"openalex":"https://openalex.org/W4413826331","doi":"https://doi.org/10.1227/neu.0000000000003709","pmid":"https://pubmed.ncbi.nlm.nih.gov/40879393"},"language":"en","primary_location":{"id":"doi:10.1227/neu.0000000000003709","doi":"https://doi.org/10.1227/neu.0000000000003709","is_oa":false,"landing_page_url":"https://doi.org/10.1227/neu.0000000000003709","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074148177","display_name":"Maxwell Thomas Laws","orcid":"https://orcid.org/0000-0002-6820-3846","observed_orcids":["https://orcid.org/0000-0002-6820-3846"]},"institutions":[{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maxwell T. Laws","raw_affiliation_strings":["Department of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA;","Neurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;","Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;"],"raw_orcid":"https://orcid.org/0000-0002-6820-3846","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA;","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Neurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;","institution_ids":["https://openalex.org/I4210110767"]},{"raw_affiliation_string":"Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;","institution_ids":["https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039118331","display_name":"Ihika Rampalli","orcid":"https://orcid.org/0000-0002-9734-1391","observed_orcids":["https://orcid.org/0000-0002-9734-1391"]},"institutions":[{"id":"https://openalex.org/I1337852284","display_name":"Texas Medical Center","ror":"https://ror.org/00dqsbj20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1337852284"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ihika Rampalli","raw_affiliation_strings":["Baylor College of Medicine, Texas Medical Center, Houston, Texas, USA;","Neurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, Texas Medical Center, Houston, Texas, USA;","institution_ids":["https://openalex.org/I1337852284","https://openalex.org/I181547552"]},{"raw_affiliation_string":"Neurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;","institution_ids":["https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059066824","display_name":"David T. Asuzu","orcid":"https://orcid.org/0000-0001-7011-479X","observed_orcids":["https://orcid.org/0000-0001-7011-479X","https://orcid.org/0000-0002-6229-3190"]},"institutions":[{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David T. Asuzu","raw_affiliation_strings":["Department of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA;","Neurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;","Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA;","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Neurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;","institution_ids":["https://openalex.org/I4210110767"]},{"raw_affiliation_string":"Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;","institution_ids":["https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040062869","display_name":"Reinier Alvarez","orcid":"https://orcid.org/0000-0003-0694-5526","observed_orcids":["https://orcid.org/0000-0003-0694-5526"]},"institutions":[{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Reinier Alvarez","raw_affiliation_strings":["Department of Neurosurgery, University of Colorado, Denver, Colorado, USA;","Neurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Colorado, Denver, Colorado, USA;","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"Neurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;","institution_ids":["https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005199661","display_name":"Christina Piper Hayes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Hayes","raw_affiliation_strings":["Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;","institution_ids":["https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018706527","display_name":"Christina Tatsi","orcid":"https://orcid.org/0000-0002-2882-4584","observed_orcids":["https://orcid.org/0000-0002-2882-4584"]},"institutions":[{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Tatsi","raw_affiliation_strings":["Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Development, Bethesda, Maryland, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Development, Bethesda, Maryland, USA;","institution_ids":["https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043403667","display_name":"Lynnette K. Nieman","orcid":"https://orcid.org/0000-0003-0534-8025","observed_orcids":["https://orcid.org/0000-0003-0534-8025"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lynnette Nieman","raw_affiliation_strings":["Section on Reproductive Endocrinology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Reproductive Endocrinology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091098904","display_name":"Prashant Chittiboina","orcid":"https://orcid.org/0000-0001-9349-4756","observed_orcids":["https://orcid.org/0000-0001-9349-4756"]},"institutions":[{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Prashant Chittiboina","raw_affiliation_strings":["Neurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;","Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;"],"raw_orcid":"https://orcid.org/0000-0001-9349-4756","affiliations":[{"raw_affiliation_string":"Neurosurgery Unit for Pituitary and Inheritable Diseases, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;","institution_ids":["https://openalex.org/I4210110767"]},{"raw_affiliation_string":"Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, USA;","institution_ids":["https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5039118331","https://openalex.org/A5040062869","https://openalex.org/A5043403667","https://openalex.org/A5059066824","https://openalex.org/A5074148177","https://openalex.org/A5091098904"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I1337852284","https://openalex.org/I181547552","https://openalex.org/I4210090567","https://openalex.org/I4210110767","https://openalex.org/I51556381","https://openalex.org/I921990950"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24861379,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"98","issue":"3","first_page":"632","last_page":"642"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11669","display_name":"Head and Neck Surgical Oncology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cushing-disease","display_name":"Cushing's disease","score":1.0},{"id":"https://openalex.org/keywords/cavernous-sinus-invasion","display_name":"cavernous sinus invasion","score":0.8759999871253967},{"id":"https://openalex.org/keywords/transsphenoidal-surgery","display_name":"transsphenoidal surgery","score":0.8190000057220459},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.8669999837875366},{"id":"https://openalex.org/keywords/adjuvant-radiotherapy","display_name":"adjuvant radiotherapy","score":0.765999972820282},{"id":"https://openalex.org/keywords/pituitary-adenoma","display_name":"pituitary adenoma","score":0.7559999823570251},{"id":"https://openalex.org/keywords/hypercortisolism","display_name":"hypercortisolism","score":0.7749999761581421},{"id":"https://openalex.org/keywords/sublabial-approach","display_name":"sublabial approach","score":0.6430000066757202},{"id":"https://openalex.org/keywords/cranial-neuropathy","display_name":"cranial neuropathy","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.960135817527771},{"id":"https://openalex.org/C2776741419","wikidata":"https://www.wikidata.org/wiki/Q1457751","display_name":"Cavernous sinus","level":2,"score":0.7720624208450317},{"id":"https://openalex.org/C2910616045","wikidata":"https://www.wikidata.org/wiki/Q219102","display_name":"Hypercortisolemia","level":3,"score":0.613274097442627},{"id":"https://openalex.org/C2910559741","wikidata":"https://www.wikidata.org/wiki/Q219102","display_name":"Cushing Disease","level":3,"score":0.6080287098884583},{"id":"https://openalex.org/C520017518","wikidata":"https://www.wikidata.org/wiki/Q178934","display_name":"Occult","level":3,"score":0.5790322422981262},{"id":"https://openalex.org/C2779318953","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary adenoma","level":3,"score":0.5396741628646851},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5086565613746643},{"id":"https://openalex.org/C2780546910","wikidata":"https://www.wikidata.org/wiki/Q185690","display_name":"Adrenocorticotropic hormone","level":3,"score":0.4888767600059509},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.4612201154232025},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4517773687839508},{"id":"https://openalex.org/C2776810848","wikidata":"https://www.wikidata.org/wiki/Q1947304","display_name":"Cushing's disease","level":3,"score":0.44090601801872253},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.42289280891418457},{"id":"https://openalex.org/C2779435821","wikidata":"https://www.wikidata.org/wiki/Q219102","display_name":"Cushing syndrome","level":2,"score":0.3211100101470947},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28903472423553467},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.23994037508964539},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13414126634597778},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002426","descriptor_name":"Cavernous Sinus","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002426","descriptor_name":"Cavernous Sinus","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019635","descriptor_name":"Neurosurgical Procedures","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D047748","descriptor_name":"Pituitary ACTH Hypersecretion","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D047748","descriptor_name":"Pituitary ACTH Hypersecretion","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D047748","descriptor_name":"Pituitary ACTH Hypersecretion","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1227/neu.0000000000003709","doi":"https://doi.org/10.1227/neu.0000000000003709","is_oa":false,"landing_page_url":"https://doi.org/10.1227/neu.0000000000003709","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},{"id":"pmid:40879393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40879393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G9000354216","display_name":null,"funder_award_id":"ZIA NS003150-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1493959924","https://openalex.org/W1528166189","https://openalex.org/W1969677811","https://openalex.org/W1990995386","https://openalex.org/W1995699280","https://openalex.org/W2006660990","https://openalex.org/W2042359463","https://openalex.org/W2045660710","https://openalex.org/W2057166117","https://openalex.org/W2061493396","https://openalex.org/W2097725132","https://openalex.org/W2109557147","https://openalex.org/W2138252613","https://openalex.org/W2158714583","https://openalex.org/W2301254821","https://openalex.org/W2324363396","https://openalex.org/W2730908775","https://openalex.org/W2746964212","https://openalex.org/W2778416629","https://openalex.org/W2782839485","https://openalex.org/W2857091052","https://openalex.org/W2889663600","https://openalex.org/W2890021121","https://openalex.org/W2919279406","https://openalex.org/W3108223593","https://openalex.org/W4318159690","https://openalex.org/W4319322111","https://openalex.org/W4379928255","https://openalex.org/W4388703964","https://openalex.org/W4406820473"],"related_works":["https://openalex.org/W4310574485","https://openalex.org/W2408925080","https://openalex.org/W2409553012","https://openalex.org/W4249068481","https://openalex.org/W2058897233","https://openalex.org/W4280539499","https://openalex.org/W4388919139","https://openalex.org/W4392292449","https://openalex.org/W4214852073","https://openalex.org/W4285492592"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"OBJECTIVES:":[2],"Unrecognized":[3],"cavernous":[4],"sinus":[5],"(CS)":[6],"invasion":[7,198],"by":[8,119],"adenomas":[9],"is":[10],"a":[11,103,120],"major":[12],"factor":[13],"in":[14,107,168,255,266,309],"surgical":[15],"failure":[16],"and":[17,23,34,66,84,100,132,145,152,283,289,300],"recurrence":[18,253],"of":[19,27,36,41,45,80,90,98,178,203,230],"Cushing":[20],"disease":[21],"(CD),":[22],"pituitary":[24],"adenomas.":[25],"Exploration":[26],"the":[28,37,46,74,204],"CS":[29,42,99,130,164,279,281],"during":[30],"trans-sphenoidal":[31],"surgery":[32],"(TSS)":[33],"resection":[35,135,213,286],"involved":[38],"medial":[39,133,205,284],"wall":[40,44,134,206,285],"(medial":[43],"CS)":[47],"can":[48],"achieve":[49],"apparent":[50],"gross":[51,222],"total":[52,223],"resection.":[53],"However,":[54],"novel":[55],"strategies":[56],"are":[57,287],"needed":[58],"to":[59,69],"identify":[60],"patients":[61,115,170,210,220],"with":[62,211,221,269],"occult":[63],"tumor":[64],"residuals":[65],"direct":[67],"them":[68],"early":[70,76,88],"radiotherapy.":[71],"We":[72,110],"developed":[73],"normalized":[75],"postoperative":[77,232,301],"value":[78],"(NEPV)":[79],"adrenocorticotropic":[81],"hormone":[82,233],"(ACTH)":[83],"cortisol":[85,144,248],"as":[86],"potential":[87],"predictors":[89],"remission.":[91,293],"In":[92],"this":[93],"study,":[94],"we":[95],"integrate":[96],"exploration":[97,165,282],"NEPV":[101,242],"into":[102],"clinical":[104],"decision-making":[105],"strategy":[106],"CD.":[108,124,310],"METHODS:":[109],"analyzed":[111],"data":[112],"from":[113],"315":[114],"(2012-2023)":[116],"undergoing":[117],"TSS":[118],"single":[121],"surgeon":[122],"for":[123,157,216,291],"Surgical":[125],"approaches":[126],"included":[127],"sublabial":[128],"TSS,":[129],"exploration,":[131],"based":[136],"on":[137],"preoperative":[138,179],"imaging":[139],"or":[140,185,197,247],"intraoperative":[141,186,298],"findings.":[142],"Postoperative":[143],"ACTH":[146,243],"levels":[147],"were":[148,214,264],"assessed":[149],"at":[150],"extubation":[151],"every":[153],"6":[154],"hours":[155,159],"postoperatively":[156],"72":[158],"before":[160],"corticosteroid":[161],"replacement.":[162],"RESULTS:":[163],"was":[166,207],"performed":[167],"50":[169],"(33":[171],"female;":[172],"median":[173],"age":[174],"26.5":[175],"years)":[176],"because":[177,229],"MRI":[180,276],"findings":[181,187,299],"(n":[182,188,193,199,238,244,249],"=":[183,189,194,200,239,245,250],"37)":[184],"13).":[190],"Adenoma":[191],"adherence":[192],"18,":[195],"36%)":[196],"32,":[201],"64%)":[202],"observed.":[208],"Thirteen":[209],"subtotal":[212],"recommended":[215],"radiation.":[217],"Among":[218],"37":[219],"resection,":[224],"12":[225,257],"(29.7%)":[226],"received":[227],"radiotherapy":[228],"elevated":[231,241],"levels,":[234],"including":[235],"persistent":[236],"hypercortisolemia":[237],"5),":[240,246],"5).":[251],"No":[252],"occurred":[254],"these":[256],"patients.":[258],"Transient":[259],"cranial":[260],"neuropathies":[261],"(<90":[262],"days)":[263],"observed":[265],"4":[267],"patients,":[268],"no":[270],"arterial":[271],"injuries":[272],"reported.":[273],"CONCLUSION:":[274],"Preoperative":[275],"often":[277],"underestimates":[278],"invasion.":[280],"safe":[288],"effective":[290,306],"durable":[292],"An":[294],"integrated":[295],"strategy,":[296],"using":[297],"biochemical":[302],"monitoring,":[303],"may":[304],"guide":[305],"adjuvant":[307],"therapy":[308]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}