{"id":"https://openalex.org/W4413818405","doi":"https://doi.org/10.1097/md.0000000000044224","title":"Multisystem fatal metastasis of large cell lung carcinoma (LCLC) masquerading as acute cerebral infarction: A case report","display_name":"Multisystem fatal metastasis of large cell lung carcinoma (LCLC) masquerading as acute cerebral infarction: A case report","publication_year":2025,"publication_date":"2025-08-29","ids":{"openalex":"https://openalex.org/W4413818405","doi":"https://doi.org/10.1097/md.0000000000044224","pmid":"https://pubmed.ncbi.nlm.nih.gov/40898486"},"language":"en","primary_location":{"id":"doi:10.1097/md.0000000000044224","doi":"https://doi.org/10.1097/md.0000000000044224","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000044224","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/md.0000000000044224","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054106547","display_name":"Tian-Shui Yu","orcid":"https://orcid.org/0009-0001-5216-4600","observed_orcids":["https://orcid.org/0009-0001-5216-4600"]},"institutions":[{"id":"https://openalex.org/I177955009","display_name":"China University of Political Science and Law","ror":"https://ror.org/00e49gy82","country_code":"CN","type":"education","lineage":["https://openalex.org/I177955009"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tian-Shui Yu","raw_affiliation_strings":["Key Laboratory of Evidence Science, China University of Political Science and Law, Ministry of Education, Beijing, China","Tian-Shui Yu, No. 26, Houtun South Road, Haidian District, Beijing 100192, China (e-mail"],"raw_orcid":"https://orcid.org/0009-0001-5216-4600","affiliations":[{"raw_affiliation_string":"Key Laboratory of Evidence Science, China University of Political Science and Law, Ministry of Education, Beijing, China","institution_ids":["https://openalex.org/I177955009"]},{"raw_affiliation_string":"Tian-Shui Yu, No. 26, Houtun South Road, Haidian District, Beijing 100192, China (e-mail","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080094789","display_name":"Baoqing Pei","orcid":"https://orcid.org/0000-0002-6929-2430","observed_orcids":["https://orcid.org/0000-0002-6929-2430"]},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bao-Qing Pei","raw_affiliation_strings":["School of Biological Science and Medical Engineering, Beihang University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Science and Medical Engineering, Beihang University, Beijing, China","institution_ids":["https://openalex.org/I82880672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059927593","display_name":"Dong Hui Zhao","orcid":"https://orcid.org/0000-0002-3239-3449","observed_orcids":["https://orcid.org/0000-0002-3239-3449"]},"institutions":[{"id":"https://openalex.org/I177955009","display_name":"China University of Political Science and Law","ror":"https://ror.org/00e49gy82","country_code":"CN","type":"education","lineage":["https://openalex.org/I177955009"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Zhao","raw_affiliation_strings":["Key Laboratory of Evidence Science, China University of Political Science and Law, Ministry of Education, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Evidence Science, China University of Political Science and Law, Ministry of Education, Beijing, China","institution_ids":["https://openalex.org/I177955009"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054106547"],"corresponding_institution_ids":["https://openalex.org/I177955009"],"apc_list":{"value":1950,"currency":"USD","value_usd":1950},"apc_paid":{"value":1950,"currency":"USD","value_usd":1950},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26268085,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"35","first_page":"e44224","last_page":"e44224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.8237000107765198,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.8237000107765198,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.07479999959468842,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.056299999356269836,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/large-cell-lung-carcinoma","display_name":"large cell lung carcinoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.7860000133514404},{"id":"https://openalex.org/keywords/acute-cerebral-infarction","display_name":"acute cerebral infarction","score":0.8119999766349792},{"id":"https://openalex.org/keywords/misdiagnosis","display_name":"misdiagnosis","score":0.6129999756813049},{"id":"https://openalex.org/keywords/extrapulmonary-metastasis","display_name":"extrapulmonary metastasis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/edaravone","display_name":"edaravone","score":0.8220000267028809},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8659999966621399},{"id":"https://openalex.org/keywords/occult-malignancy","display_name":"occult malignancy","score":0.5170000195503235},{"id":"https://openalex.org/keywords/stroke-mimics","display_name":"stroke mimics","score":0.3449999988079071},{"id":"https://openalex.org/keywords/multimodal-imaging","display_name":"multimodal imaging","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9581546783447266},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4705260992050171},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4673633575439453},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.434734046459198},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.406720906496048},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33607566356658936},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23754915595054626}],"mesh":[{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D002544","descriptor_name":"Cerebral Infarction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002544","descriptor_name":"Cerebral Infarction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002544","descriptor_name":"Cerebral Infarction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002544","descriptor_name":"Cerebral Infarction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002544","descriptor_name":"Cerebral Infarction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002544","descriptor_name":"Cerebral Infarction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017809","descriptor_name":"Fatal Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017809","descriptor_name":"Fatal Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017809","descriptor_name":"Fatal Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017809","descriptor_name":"Fatal Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017809","descriptor_name":"Fatal Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017809","descriptor_name":"Fatal Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D018287","descriptor_name":"Carcinoma, Large Cell","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1097/md.0000000000044224","doi":"https://doi.org/10.1097/md.0000000000044224","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000044224","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},{"id":"pmid:40898486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40898486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11211990","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12401423","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12401423","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12401423/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicine (Baltimore)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1097/md.0000000000044224","doi":"https://doi.org/10.1097/md.0000000000044224","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000044224","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1544876451","https://openalex.org/W1972412321","https://openalex.org/W1995034267","https://openalex.org/W2042846677","https://openalex.org/W2057788056","https://openalex.org/W2066537787","https://openalex.org/W2070183939","https://openalex.org/W2084753218","https://openalex.org/W2102307346","https://openalex.org/W2115061904","https://openalex.org/W2119883857","https://openalex.org/W2936056011","https://openalex.org/W2951022109","https://openalex.org/W3027029079","https://openalex.org/W3215921195"],"related_works":["https://openalex.org/W1966504330","https://openalex.org/W1979139803","https://openalex.org/W2037631372","https://openalex.org/W4252436151","https://openalex.org/W2030889776","https://openalex.org/W2159000141","https://openalex.org/W1978297557","https://openalex.org/W1974041167","https://openalex.org/W2391409986","https://openalex.org/W1966775726"],"abstract_inverted_index":{"RATIONALE:":[0],"Large":[1],"cell":[2],"lung":[3],"carcinoma":[4],"(LCLC)":[5],"is":[6],"a":[7,94,222],"rare":[8],"undifferentiated":[9,110],"malignant":[10],"epithelial":[11],"tumor":[12,96],"of":[13,19,86,143,187,200,203,250],"the":[14,36,65,72,101,125,134,140,144,146,173,178,231],"lung.":[15],"The":[16,60,218],"diagnostic":[17,240],"complexity":[18],"LCLC":[20],"stems":[21],"from":[22],"its":[23],"pronounced":[24],"histological":[25],"heterogeneity":[26],"and":[27,53,76,105,122,153,177,195,212,244,255],"diverse":[28],"clinical":[29],"presentation,":[30,39],"particularly":[31],"when":[32],"extrapulmonary":[33],"manifestations":[34,249],"constitute":[35],"initial":[37,141,248],"disease":[38],"complicating":[40],"early":[41],"detection.":[42],"PATIENT":[43],"CONCERNS:":[44],"A":[45],"58-year-old":[46],"smoker":[47],"presented":[48],"with":[49,97],"acute-onset":[50],"dizziness,":[51],"lethargy,":[52],"communication":[54],"difficulties":[55],"lasting":[56],"1":[57],"day.":[58],"DIAGNOSES:":[59],"patient":[61,147,219],"was":[62,230],"admitted":[63],"to":[64,260],"hospital,":[66],"where":[67],"extensive":[68],"hypodense":[69],"lesions":[70],"in":[71,100,264],"right":[73,179],"temporal,":[74],"parietal,":[75],"occipital":[77],"lobes":[78,176],"were":[79,114],"detected":[80],"via":[81],"cranial":[82],"computed":[83],"tomography,":[84],"indicative":[85],"acute":[87,135,169,227],"massive":[88],"cerebral":[89,131,228],"infarction.":[90],"Histopathological":[91],"examination":[92],"revealed":[93,168],"pulmonary":[95],"systemic":[98],"metastases":[99,132],"brain,":[102],"heart,":[103],"liver,":[104],"pancreas.":[106],"Immunohistochemical":[107],"staining":[108],"showed":[109],"pleomorphic":[111],"cells":[112],"that":[113],"negative":[115],"for":[116,246],"thyroid":[117],"transcription":[118],"factor-1,":[119],"p40,":[120],"synaptophysin,":[121],"CD56,":[123],"confirming":[124],"WHO-defined":[126],"null":[127],"immunophenotype":[128],"LCLC.":[129,251],"Extensive":[130],"explained":[133],"neurological":[136],"presentation.":[137],"INTERVENTIONS:":[138],"During":[139],"phase":[142],"illness,":[145],"received":[148],"intravenous":[149],"edaravone":[150,190],"(30":[151],"mg/d)":[152],"enteric-coated":[154],"oral":[155],"aspirin":[156],"tablets":[157],"(100":[158],"mg":[159],"daily).":[160],"On":[161],"May":[162],"15,":[163],"follow-up":[164],"magnetic":[165],"resonance":[166],"imaging":[167,254],"multifocal":[170],"infarcts":[171],"involving":[172],"bilateral":[174],"frontal-parietal":[175],"temporo-occipital":[180],"regions.":[181],"This":[182,236],"radiographic":[183],"progression":[184],"prompted":[185],"escalation":[186],"therapy,":[188],"including":[189],"intensification,":[191],"neuroprotection":[192],"(cerebroprotein":[193],"hydrolysate),":[194],"supportive":[196],"care":[197],"(intravenous":[198],"infusion":[199],"250":[201],"mL":[202],"5%":[204],"glucose":[205],"solution":[206],"containing":[207],"2":[208],"g":[209,214],"calcium":[210],"gluconate":[211],"3":[213],"vitamin":[215],"C).":[216],"OUTCOMES:":[217],"succumbed":[220],"following":[221],"2-month":[223],"hospitalization":[224],"during":[225],"which":[226],"infarction":[229],"primary":[232],"treatment":[233],"focus.":[234],"LESSONS:":[235],"case":[237],"highlights":[238],"LCLC's":[239],"complexity,":[241],"aggressive":[242],"metastasis,":[243],"potential":[245],"non-respiratory":[247],"Early":[252],"whole-body":[253],"multidisciplinary":[256],"evaluation":[257],"are":[258],"imperative":[259],"detect":[261],"occult":[262],"malignancies":[263],"unexplained":[265],"stroke":[266],"cases.":[267]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}