{"id":"https://openalex.org/W4413810299","doi":"https://doi.org/10.1016/j.ctrv.2025.103016","title":"Interpreting immunogenicity in oncology clinical trials","display_name":"Interpreting immunogenicity in oncology clinical trials","publication_year":2025,"publication_date":"2025-08-25","ids":{"openalex":"https://openalex.org/W4413810299","doi":"https://doi.org/10.1016/j.ctrv.2025.103016","pmid":"https://pubmed.ncbi.nlm.nih.gov/40886486"},"language":"en","primary_location":{"id":"doi:10.1016/j.ctrv.2025.103016","doi":"https://doi.org/10.1016/j.ctrv.2025.103016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctrv.2025.103016","pdf_url":"https://www.cancertreatmentreviews.com/article/S0305-7372(25)00138-0/pdf","source":{"id":"https://openalex.org/S49831067","display_name":"Cancer Treatment Reviews","issn_l":"0305-7372","issn":["0305-7372","1532-1967"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment Reviews","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.cancertreatmentreviews.com/article/S0305-7372(25)00138-0/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069151214","display_name":"Peter R. Galle","orcid":"https://orcid.org/0000-0001-8294-0992","observed_orcids":["https://orcid.org/0000-0001-8294-0992","https://orcid.org/0000-0003-1967-0621"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter R. Galle","raw_affiliation_strings":["Director of the I. Medical Department at the University Medical Center, Johannes Gutenberg University, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Director of the I. Medical Department at the University Medical Center, Johannes Gutenberg University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543","https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046728958","display_name":"Martin Reck","orcid":"https://orcid.org/0000-0002-5348-4462","observed_orcids":["https://orcid.org/0000-0002-5348-4462"]},"institutions":[{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210140903","display_name":"LungenClinic Grosshansdorf","ror":"https://ror.org/041wfjw90","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210140903"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Reck","raw_affiliation_strings":["Department of Thoracic Oncology, Lung Clinic Grosshansdorf, Airway Research Censer North, German Center of Lung Research, Grosshansdorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, Lung Clinic Grosshansdorf, Airway Research Censer North, German Center of Lung Research, Grosshansdorf, Germany","institution_ids":["https://openalex.org/I4210129183","https://openalex.org/I4210140903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001343667","display_name":"David James Pinato","orcid":"https://orcid.org/0000-0002-3529-0103","observed_orcids":["https://orcid.org/0000-0002-3529-0103"]},"institutions":[{"id":"https://openalex.org/I2801748203","display_name":"Hammersmith Hospital","ror":"https://ror.org/05jg8yp15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I2801748203"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J. Pinato","raw_affiliation_strings":["Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK, and Division of Oncology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK, and Division of Oncology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy","institution_ids":["https://openalex.org/I2801748203","https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040173904","display_name":"Rosario Garc\u00eda\u2010Campelo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140856","display_name":"Complexo Hospitalario Universitario A Coru\u00f1a","ror":"https://ror.org/044knj408","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210140856"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rosario Garcia-Campelo","raw_affiliation_strings":["Department of Medical Oncology, Complejo Hospitalario Universitario A Coru\u00f1a, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Complejo Hospitalario Universitario A Coru\u00f1a, Spain","institution_ids":["https://openalex.org/I4210140856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073989429","display_name":"Richard S. Finn","orcid":"https://orcid.org/0000-0003-2494-2126","observed_orcids":["https://orcid.org/0000-0003-2494-2126"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard S. Finn","raw_affiliation_strings":["Department of Hematology/Oncology, University of California Los Angeles, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology/Oncology, University of California Los Angeles, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102750304","display_name":"Sophie Cousin","orcid":"https://orcid.org/0000-0002-4847-6329","observed_orcids":["https://orcid.org/0000-0002-4847-6329"]},"institutions":[{"id":"https://openalex.org/I4210134409","display_name":"Institut Bergoni\u00e9","ror":"https://ror.org/02yw1f353","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210134409"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sophie Cousin","raw_affiliation_strings":["Department of Medical Oncology, Institut Bergoni\u00e9, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Institut Bergoni\u00e9, Bordeaux, France","institution_ids":["https://openalex.org/I4210134409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109182709","display_name":"Jim Zanghi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jim Zanghi","raw_affiliation_strings":["BioAnalytical Sciences Department, Genentech, Inc. South San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioAnalytical Sciences Department, Genentech, Inc. South San Francisco, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083434070","display_name":"Coen A. Bernaards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Coen A. Bernaards","raw_affiliation_strings":["Department of Data Sciences, Genentech, Inc. South San Francisco, USA. Electronic address: bernaards.coen@gene.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Data Sciences, Genentech, Inc. South San Francisco, USA. Electronic address: bernaards.coen@gene.com","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015264403","display_name":"Steven J. Swanson","orcid":"https://orcid.org/0009-0005-6320-1461","observed_orcids":["https://orcid.org/0009-0005-6320-1461"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven J. Swanson","raw_affiliation_strings":["Translational PKPD Department, Genentech, Inc. South San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational PKPD Department, Genentech, Inc. South San Francisco, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114210079","display_name":"Stefanie Morris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stefanie Morris","raw_affiliation_strings":["F. Hoffmann-La Roche Ltd, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffmann-La Roche Ltd, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100780320","display_name":"Yuan Song","orcid":"https://orcid.org/0000-0003-4233-1927","observed_orcids":["https://orcid.org/0000-0003-4233-1927"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuan Song","raw_affiliation_strings":["BioAnalytical Sciences Department, Genentech, Inc. South San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioAnalytical Sciences Department, Genentech, Inc. South San Francisco, USA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063300526","display_name":"Solange Peters","orcid":"https://orcid.org/0000-0002-0412-7143","observed_orcids":["https://orcid.org/0000-0002-0412-7143"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Solange Peters","raw_affiliation_strings":["Department of Oncology, University Hospital CHUV, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University Hospital CHUV, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5083434070"],"corresponding_institution_ids":["https://openalex.org/I183934855"],"apc_list":{"value":4910,"currency":"USD","value_usd":4910},"apc_paid":{"value":4910,"currency":"USD","value_usd":4910},"fwci":0.1788,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.22735724,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"140","issue":null,"first_page":"103016","last_page":"103016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.9760000109672546},{"id":"https://openalex.org/keywords/anti-drug-antibodies","display_name":"anti-drug antibodies","score":0.9929999709129333},{"id":"https://openalex.org/keywords/therapeutic-proteins","display_name":"therapeutic proteins","score":0.7950000166893005},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cancer-clinical-trials","display_name":"cancer clinical trials","score":0.8399999737739563},{"id":"https://openalex.org/keywords/assay-sensitivity","display_name":"assay sensitivity","score":0.6620000004768372},{"id":"https://openalex.org/keywords/drug-interference","display_name":"drug interference","score":0.8569999933242798},{"id":"https://openalex.org/keywords/sampling-rate","display_name":"sampling frequency","score":0.8379999995231628},{"id":"https://openalex.org/keywords/survivorship-bias","display_name":"survivorship bias","score":0.7080000042915344},{"id":"https://openalex.org/keywords/regulatory-guidance","display_name":"regulatory guidelines","score":0.6859999895095825},{"id":"https://openalex.org/keywords/pharmacokinetics-pharmacodynamics","display_name":"pharmacokinetics/pharmacodynamics","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9545955061912537},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.8518543839454651},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6002503633499146},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5830280780792236},{"id":"https://openalex.org/C2776598537","wikidata":"https://www.wikidata.org/wiki/Q1812651","display_name":"Clinical Oncology","level":3,"score":0.48454323410987854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46320831775665283},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.40291327238082886},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2703632116317749},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.203921377658844},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.10719770193099976}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ctrv.2025.103016","doi":"https://doi.org/10.1016/j.ctrv.2025.103016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctrv.2025.103016","pdf_url":"https://www.cancertreatmentreviews.com/article/S0305-7372(25)00138-0/pdf","source":{"id":"https://openalex.org/S49831067","display_name":"Cancer Treatment Reviews","issn_l":"0305-7372","issn":["0305-7372","1532-1967"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment Reviews","raw_type":"journal-article"},{"id":"pmid:40886486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40886486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer treatment reviews","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unil.ch:iris/275487","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/275487","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1016/j.ctrv.2025.103016","doi":"https://doi.org/10.1016/j.ctrv.2025.103016","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ctrv.2025.103016","pdf_url":"https://www.cancertreatmentreviews.com/article/S0305-7372(25)00138-0/pdf","source":{"id":"https://openalex.org/S49831067","display_name":"Cancer Treatment Reviews","issn_l":"0305-7372","issn":["0305-7372","1532-1967"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Treatment Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309432","display_name":"F. Hoffmann-La Roche","ror":"https://ror.org/00by1q217"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413810299.pdf","grobid_xml":"https://content.openalex.org/works/W4413810299.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1967295501","https://openalex.org/W1976821928","https://openalex.org/W2015730831","https://openalex.org/W2046974419","https://openalex.org/W2078110114","https://openalex.org/W2086437884","https://openalex.org/W2088629488","https://openalex.org/W2098254080","https://openalex.org/W2108233388","https://openalex.org/W2120312043","https://openalex.org/W2181230016","https://openalex.org/W2462428899","https://openalex.org/W2475781394","https://openalex.org/W2506318659","https://openalex.org/W2517194758","https://openalex.org/W2596676407","https://openalex.org/W2605493496","https://openalex.org/W2761154221","https://openalex.org/W2787084857","https://openalex.org/W2967423315","https://openalex.org/W3000573092","https://openalex.org/W3132884620","https://openalex.org/W3195137671","https://openalex.org/W3203155293","https://openalex.org/W4206608364","https://openalex.org/W4220774869","https://openalex.org/W4245552746","https://openalex.org/W4253850874","https://openalex.org/W4281645619","https://openalex.org/W4317863136","https://openalex.org/W4388042611","https://openalex.org/W4389740232","https://openalex.org/W4390988319","https://openalex.org/W4396828879","https://openalex.org/W4400644922","https://openalex.org/W4405414497","https://openalex.org/W4409798577"],"related_works":["https://openalex.org/W2181230016","https://openalex.org/W2046974419","https://openalex.org/W2054616299","https://openalex.org/W2475781394","https://openalex.org/W2325279369","https://openalex.org/W2774235371","https://openalex.org/W4407295944","https://openalex.org/W3087611698","https://openalex.org/W2794416752","https://openalex.org/W4400644922"],"abstract_inverted_index":{"Immunogenicity":[0],"of":[1,24,36,45,68,76,85,97,110,141,155,175,199],"a":[2,14],"therapeutic":[3,186],"protein":[4,187],"product":[5,135],"may":[6],"elicit":[7],"an":[8],"unintended":[9],"immune":[10],"response,":[11],"and":[12,34,43,51,64,122,150,163,178],"is":[13,92,99,115,166],"critical":[15],"aspect":[16],"evaluated":[17],"in":[18,48,55,82,113,147,189],"oncology":[19,49,114],"clinical":[20,95,173,197],"trials.":[21],"The":[22,74,191],"development":[23],"anti-drug":[25],"antibodies":[26],"(ADAs)":[27],"can":[28],"impact":[29,96],"the":[30,41,53,66,83,94,108,172,196],"pharmacokinetics,":[31],"pharmacodynamics,":[32],"efficacy,":[33],"safety":[35],"these":[37,129],"therapies.":[38],"We":[39],"review":[40],"background":[42],"nomenclature":[44],"immunogenicity":[46,111,156],"assessment":[47],"studies":[50],"emphasize":[52],"complexities":[54],"ADA":[56,72,98,142,176],"detection":[57],"arising":[58],"from":[59],"assay":[60,148,159],"sensitivity,":[61],"drug":[62],"interference,":[63],"notably,":[65],"frequency":[67],"patient":[69],"sampling":[70,151,164],"for":[71,90,168,183],"analysis.":[73],"applicability":[75],"common":[77],"nomenclature,":[78],"however,":[79],"has":[80],"limitations":[81],"context":[84],"oncology.":[86,190],"Of":[87],"prime":[88],"consideration":[89],"physicians":[91],"that":[93],"far":[100],"more":[101],"important":[102],"than":[103,202],"just":[104],"their":[105,204],"presence.":[106],"Furthermore,":[107],"interpretation":[109,154],"data":[112],"complicated":[116],"by":[117],"patient-specific":[118],"factors,":[119],"concomitant":[120],"treatments,":[121],"potential":[123],"survivorship":[124],"bias.":[125],"Regulatory":[126],"guidelines":[127],"acknowledge":[128],"complexities,":[130],"mandating":[131],"specific":[132],"statements":[133],"on":[134,195],"labels":[136],"cautioning":[137],"against":[138],"cross-trial":[139],"comparisons":[140],"incidence":[143],"due":[144],"to":[145,170],"variations":[146],"methods":[149],"schedules.":[152],"Accurate":[153],"data,":[157],"considering":[158],"methodologies,":[160],"study":[161],"design,":[162],"frequency,":[165],"crucial":[167],"clinicians":[169],"assess":[171],"relevance":[174,198],"findings":[177],"make":[179],"informed":[180],"treatment":[181],"decisions":[182],"patients":[184],"receiving":[185],"products":[188],"focus":[192],"should":[193],"be":[194],"ADAs":[200],"rather":[201],"simply":[203],"incidence.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-10T00:00:00"}