{"id":"https://openalex.org/W4413808918","doi":"https://doi.org/10.1002/mdc3.70311","title":"Adaptive Deep Brain Stimulation Benefits: Younger Patients with Persistent Wearing\u2010off Symptoms","display_name":"Adaptive Deep Brain Stimulation Benefits: Younger Patients with Persistent Wearing\u2010off Symptoms","publication_year":2025,"publication_date":"2025-08-29","ids":{"openalex":"https://openalex.org/W4413808918","doi":"https://doi.org/10.1002/mdc3.70311","pmid":"https://pubmed.ncbi.nlm.nih.gov/40878904"},"language":"en","primary_location":{"id":"doi:10.1002/mdc3.70311","doi":"https://doi.org/10.1002/mdc3.70311","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mdc3.70311","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mdc3.70311","source":{"id":"https://openalex.org/S2764712647","display_name":"Movement Disorders Clinical Practice","issn_l":"2330-1619","issn":["2330-1619"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Movement Disorders Clinical Practice","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mdc3.70311","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064235412","display_name":"Takuto Emura","orcid":"https://orcid.org/0009-0001-7152-435X","observed_orcids":["https://orcid.org/0009-0001-7152-435X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuto Emura","raw_affiliation_strings":["Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan"],"raw_orcid":"https://orcid.org/0009-0001-7152-435X","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004748763","display_name":"Naoki Tani","orcid":"https://orcid.org/0000-0003-2169-135X","observed_orcids":["https://orcid.org/0000-0003-2169-135X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Naoki Tani","raw_affiliation_strings":["Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan"],"raw_orcid":"https://orcid.org/0000-0003-2169-135X","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064921196","display_name":"Koichi Hosomi","orcid":"https://orcid.org/0000-0001-7731-3302","observed_orcids":["https://orcid.org/0000-0001-7731-3302"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Hosomi","raw_affiliation_strings":["Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7731-3302","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073886010","display_name":"Yuki Kimoto","orcid":"https://orcid.org/0009-0003-2328-1108","observed_orcids":["https://orcid.org/0009-0003-2328-1108"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Kimoto","raw_affiliation_strings":["Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan"],"raw_orcid":"https://orcid.org/0009-0003-2328-1108","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065719997","display_name":"Takahiro Matsuhashi","orcid":"https://orcid.org/0000-0002-8630-478X","observed_orcids":["https://orcid.org/0000-0002-8630-478X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Matsuhashi","raw_affiliation_strings":["Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan"],"raw_orcid":"https://orcid.org/0000-0002-8630-478X","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007025397","display_name":"Takahiro Fujinaga","orcid":"https://orcid.org/0009-0001-1754-2063","observed_orcids":["https://orcid.org/0009-0001-1754-2063"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Fujinaga","raw_affiliation_strings":["Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan"],"raw_orcid":"https://orcid.org/0009-0001-1754-2063","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103939617","display_name":"Shimpei Miura","orcid":"https://orcid.org/0009-0007-3142-8455","observed_orcids":["https://orcid.org/0009-0007-3142-8455"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shimpei Miura","raw_affiliation_strings":["Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan"],"raw_orcid":"https://orcid.org/0009-0007-3142-8455","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuya Fujita","orcid":"https://orcid.org/0000-0001-8155-6040","observed_orcids":["https://orcid.org/0000-0001-8155-6040"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuya Fujita","raw_affiliation_strings":["Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan"],"raw_orcid":"https://orcid.org/0000-0001-8155-6040","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059423002","display_name":"Nobuhiko Mori","orcid":"https://orcid.org/0000-0001-6537-6322","observed_orcids":["https://orcid.org/0000-0001-6537-6322"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuhiko Mori","raw_affiliation_strings":["Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6537-6322","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015819100","display_name":"Hui Ming Khoo","orcid":"https://orcid.org/0000-0002-4039-0520","observed_orcids":["https://orcid.org/0000-0002-4039-0520"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hui Ming Khoo","raw_affiliation_strings":["Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4039-0520","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054045156","display_name":"Satoru Oshino","orcid":"https://orcid.org/0000-0002-4248-2322","observed_orcids":["https://orcid.org/0000-0002-4248-2322"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Oshino","raw_affiliation_strings":["Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4248-2322","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046288905","display_name":"Haruhiko Kishima","orcid":"https://orcid.org/0000-0002-9041-2337","observed_orcids":["https://orcid.org/0000-0002-9041-2337"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruhiko Kishima","raw_affiliation_strings":["Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan"],"raw_orcid":"https://orcid.org/0000-0002-9041-2337","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Osaka University Graduate School of Medicine  Suita Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004748763"],"corresponding_institution_ids":["https://openalex.org/I98285908"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":{"value":3400,"currency":"USD","value_usd":3400},"fwci":1.6913,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.84523621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"13","issue":"2","first_page":"452","last_page":"463"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adaptive-deep-brain-stimulation","display_name":"adaptive deep brain stimulation","score":0.996999979019165},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9810000061988831},{"id":"https://openalex.org/keywords/wearing-off-phenomenon","display_name":"wearing-off phenomenon","score":0.7360000014305115},{"id":"https://openalex.org/keywords/motor-fluctuations","display_name":"motor fluctuations","score":0.9470000267028809},{"id":"https://openalex.org/keywords/young-patients","display_name":"young patients","score":0.6790000200271606},{"id":"https://openalex.org/keywords/stimulation-parameter-adjustment","display_name":"stimulation parameter adjustment","score":0.5920000076293945},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.6949999928474426},{"id":"https://openalex.org/keywords/motor-function","display_name":"motor function","score":0.5619999766349792},{"id":"https://openalex.org/keywords/dyskinesia","display_name":"dyskinesia","score":0.7710000276565552},{"id":"https://openalex.org/keywords/battery-life","display_name":"battery life","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.8048688173294067},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.7913813591003418},{"id":"https://openalex.org/C83849319","wikidata":"https://www.wikidata.org/wiki/Q7295720","display_name":"Rating scale","level":2,"score":0.6679043173789978},{"id":"https://openalex.org/C2780405171","wikidata":"https://www.wikidata.org/wiki/Q629444","display_name":"Dyskinesia","level":4,"score":0.6647775173187256},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5737653970718384},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5661278963088989},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.5381705164909363},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.5035580992698669},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.49296092987060547},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4001506268978119},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3780952990055084},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3239145278930664},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22440317273139954},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1002/mdc3.70311","doi":"https://doi.org/10.1002/mdc3.70311","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mdc3.70311","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mdc3.70311","source":{"id":"https://openalex.org/S2764712647","display_name":"Movement Disorders Clinical Practice","issn_l":"2330-1619","issn":["2330-1619"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Movement Disorders Clinical Practice","raw_type":"journal-article"},{"id":"pmid:40878904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40878904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Movement disorders clinical practice","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01056:0006998072","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11094/102956","pdf_url":"https://ir.library.osaka-u.ac.jp/repo/ouka/all/102956/MovDisordClinPract.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Movement Disorders Clinical Practice","raw_type":"journal article"},{"id":"pmh:oai:ir.library.osaka-u.ac.jp:11094/102956","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.1002/mdc3.70311","pdf_url":null,"source":{"id":"https://openalex.org/S4306402540","display_name":"OUKA (Osaka University Knowledge Archive) (Osaka University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98285908","host_organization_name":"The University of Osaka","host_organization_lineage":["https://openalex.org/I98285908"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12911460","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12911460/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mov Disord Clin Pract","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/mdc3.70311","doi":"https://doi.org/10.1002/mdc3.70311","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mdc3.70311","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mdc3.70311","source":{"id":"https://openalex.org/S2764712647","display_name":"Movement Disorders Clinical Practice","issn_l":"2330-1619","issn":["2330-1619"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Movement Disorders Clinical Practice","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413808918.pdf","grobid_xml":"https://content.openalex.org/works/W4413808918.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1972879677","https://openalex.org/W2043719987","https://openalex.org/W2095270577","https://openalex.org/W2106956384","https://openalex.org/W2112455323","https://openalex.org/W2141405085","https://openalex.org/W2143685192","https://openalex.org/W2328435466","https://openalex.org/W2588429935","https://openalex.org/W2622294281","https://openalex.org/W2755620129","https://openalex.org/W2786828489","https://openalex.org/W2802450380","https://openalex.org/W2898165758","https://openalex.org/W2913766627","https://openalex.org/W3007197464","https://openalex.org/W3107060429","https://openalex.org/W3158498219","https://openalex.org/W4291982393","https://openalex.org/W4385650127"],"related_works":["https://openalex.org/W2318700213","https://openalex.org/W2107579380","https://openalex.org/W2142371639","https://openalex.org/W2609400243","https://openalex.org/W2051854229","https://openalex.org/W2914511819","https://openalex.org/W4386070499","https://openalex.org/W2414205034","https://openalex.org/W2037384627","https://openalex.org/W4407934295"],"abstract_inverted_index":{"BACKGROUND:":[0],"Parkinson's":[1,102,108],"disease":[2],"(PD)":[3],"often":[4],"involves":[5],"motor":[6,153,177,213],"fluctuations":[7],"and":[8,80,107,132,191,223,234],"dyskinesia,":[9],"which":[10,54],"are":[11,237],"difficult":[12],"to":[13,75,124,140,246],"manage":[14],"with":[15,86,169,220],"medication":[16],"alone.":[17],"Conventional":[18],"deep":[19],"brain":[20],"stimulation":[21,57,229],"(cDBS)":[22],"effectively":[23],"alleviates":[24],"symptoms":[25,214],"but":[26],"has":[27],"limitations,":[28],"including":[29],"the":[30,77,94,100,163,242],"challenge":[31],"of":[32,71,82,99,148,188,193,244],"balancing":[33],"therapeutic":[34],"effects":[35],"against":[36],"potential":[37,243],"side":[38],"effects,":[39],"as":[40,42,155],"well":[41],"limited":[43],"battery":[44],"life.":[45],"To":[46],"address":[47],"these":[48,239],"issues,":[49],"adaptive":[50],"DBS":[51],"(aDBS)":[52],"systems,":[53],"dynamically":[55,227],"adjust":[56],"parameters":[58],"based":[59],"on":[60],"real-time":[61],"physiological":[62],"feedback,":[63],"have":[64],"attracted":[65],"growing":[66],"interest.":[67],"OBJECTIVES:":[68],"The":[69],"aim":[70],"this":[72],"study":[73,116],"was":[74],"assess":[76],"efficacy,":[78],"tolerability,":[79],"safety":[81],"aDBS":[83,208,245],"in":[84,152,162,176,211,215,218],"patients":[85,119,133,144,184,219],"advanced":[87,252],"PD":[88],"over":[89],"a":[90],"1-year":[91],"period,":[92],"using":[93],"Movement":[95],"Disorder":[96],"Society-Sponsored":[97],"Revision":[98],"Unified":[101],"Disease":[103,109],"Rating":[104],"Scale":[105],"(MDS-UPDRS)":[106],"Questionnaire-39":[110],"(PDQ-39).":[111],"METHODS:":[112],"This":[113],"prospective,":[114],"single-arm":[115],"involved":[117],"19":[118],"who":[120],"transitioned":[121],"from":[122],"cDBS":[123],"aDBS.":[125,141,149],"Baseline":[126],"assessments":[127],"were":[128,134,166,203],"conducted":[129],"under":[130],"cDBS,":[131],"re-evaluated":[135],"1":[136,146],"year":[137,147],"after":[138],"switching":[139],"RESULTS:":[142],"Sixteen":[143],"completed":[145],"Significant":[150],"improvements":[151],"function,":[154],"measured":[156],"by":[157,226],"MDS-UPDRS":[158],"Part":[159,180,197],"III":[160],"scores":[161],"medication-off/stimulation-on":[164],"condition,":[165],"observed.":[167],"Patients":[168],"severe":[170],"baseline":[171],"wearing-off":[172,222],"showed":[173,185],"greater":[174],"reductions":[175],"fluctuation":[178],"(MDS-UPDRS":[179,196],"IV)":[181],"scores.":[182],"Younger":[183],"better":[186],"quality":[187],"life":[189],"(PDQ-39)":[190],"activity":[192],"daily":[194],"living":[195],"II)":[198],"scores,":[199],"though":[200],"overall":[201],"changes":[202],"not":[204],"statistically":[205],"significant.":[206],"CONCLUSIONS:":[207],"shows":[209],"promise":[210],"managing":[212],"PD,":[216],"particularly":[217],"pronounced":[221],"younger":[224],"patients,":[225],"adjusting":[228],"parameters.":[230],"Although":[231],"further":[232],"optimization":[233],"long-term":[235],"studies":[236],"necessary,":[238],"findings":[240],"underscore":[241],"offer":[247],"personalized":[248],"treatment":[249],"options":[250],"for":[251],"PD.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}