{"id":"https://openalex.org/W4413801239","doi":"https://doi.org/10.1016/j.redox.2025.103851","title":"Enhancing microglial antioxidant capacity via the ascorbate transporter SVCT2 delays onset and modifies disease progression in mouse models of Alzheimer's disease","display_name":"Enhancing microglial antioxidant capacity via the ascorbate transporter SVCT2 delays onset and modifies disease progression in mouse models of Alzheimer's disease","publication_year":2025,"publication_date":"2025-08-29","ids":{"openalex":"https://openalex.org/W4413801239","doi":"https://doi.org/10.1016/j.redox.2025.103851","pmid":"https://pubmed.ncbi.nlm.nih.gov/40907096"},"language":"en","primary_location":{"id":"doi:10.1016/j.redox.2025.103851","doi":"https://doi.org/10.1016/j.redox.2025.103851","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2025.103851","pdf_url":null,"source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.redox.2025.103851","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089925939","display_name":"Camila Cabral Portugal","orcid":"https://orcid.org/0000-0002-1093-6545","observed_orcids":["https://orcid.org/0000-0002-1093-6545"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]},{"id":"https://openalex.org/I4387153674","display_name":"Instituto de Biologia Molecular e Celular","ror":"https://ror.org/005dkht93","country_code":null,"type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Camila C. Portugal","raw_affiliation_strings":["i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal. Electronic address: camila.portugal@i3s.up.pt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal. Electronic address: camila.portugal@i3s.up.pt","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210158732","https://openalex.org/I4387153674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087259132","display_name":"Evelyn Cristina da Silva Santos","orcid":"https://orcid.org/0000-0001-5040-7966","observed_orcids":["https://orcid.org/0000-0001-5040-7966"]},"institutions":[{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Evelyn C.S. Santos","raw_affiliation_strings":["i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal","institution_ids":["https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119466642","display_name":"Ana Monteiro-Pacheco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana Monteiro-Pacheco","raw_affiliation_strings":["i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; Departamento de Biomedicina - Unidade de Biologia Experimental, Faculdade de Medicina da Universidade do Porto, Porto, Portugal; ICVS - Instituto de Investiga\u00e7\u00e3o em Ci\u00eancias da Vida e Sa\u00fade, Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; Departamento de Biomedicina - Unidade de Biologia Experimental, Faculdade de Medicina da Universidade do Porto, Porto, Portugal; ICVS - Instituto de Investiga\u00e7\u00e3o em Ci\u00eancias da Vida e Sa\u00fade, Braga, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025498024","display_name":"Sara Pinto","orcid":"https://orcid.org/0000-0002-9785-8956","observed_orcids":["https://orcid.org/0000-0002-9785-8956"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4405252434","display_name":"Centro Cardiovascular da Universidade de Lisboa","ror":"https://ror.org/015dy5p63","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405252434"]},{"id":"https://openalex.org/I4405252639","display_name":"Gulbenkian Institute for Molecular Medicine","ror":"https://ror.org/0346k0491","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sara Costa-Pinto","raw_affiliation_strings":["Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; GIMM - Gulbenkian Institute for Molecular Medicine, Lisboa, Portugal; CCUL - Centro Cardiovascular da Universidade de Lisboa, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; GIMM - Gulbenkian Institute for Molecular Medicine, Lisboa, Portugal; CCUL - Centro Cardiovascular da Universidade de Lisboa, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4405252434","https://openalex.org/I4405252639"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062960537","display_name":"Tiago O. Almeida","orcid":"https://orcid.org/0000-0003-3825-7111","observed_orcids":["https://orcid.org/0000-0003-3825-7111"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]},{"id":"https://openalex.org/I4405263123","display_name":"Instituto de Ci\u00eancias Biom\u00e9dicas Albel Salazar","ror":"https://ror.org/02trb6b02","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Tiago O. Almeida","raw_affiliation_strings":["i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; ICBAS - Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar da Universidade do Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; ICBAS - Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar da Universidade do Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210158732","https://openalex.org/I4405263123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051989526","display_name":"Joana Tedim-Moreira","orcid":"https://orcid.org/0000-0002-2766-2595","observed_orcids":["https://orcid.org/0000-0002-2766-2595"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joana Tedim-Moreira","raw_affiliation_strings":["i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; Departamento de Biomedicina - Unidade de Biologia Experimental, Faculdade de Medicina da Universidade do Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; Departamento de Biomedicina - Unidade de Biologia Experimental, Faculdade de Medicina da Universidade do Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113132425","display_name":"Dora Gavin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Dora Gavin","raw_affiliation_strings":["i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal","institution_ids":["https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010004104","display_name":"Teresa Canedo","orcid":"https://orcid.org/0000-0002-4000-153X","observed_orcids":["https://orcid.org/0000-0002-4000-153X"]},"institutions":[{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Teresa Canedo","raw_affiliation_strings":["i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; ICVS - Instituto de Investiga\u00e7\u00e3o em Ci\u00eancias da Vida e Sa\u00fade, Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; ICVS - Instituto de Investiga\u00e7\u00e3o em Ci\u00eancias da Vida e Sa\u00fade, Braga, Portugal","institution_ids":["https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103045573","display_name":"Fabiana Sodr\u00e9 de Oliveira","orcid":"https://orcid.org/0000-0003-2154-6523","observed_orcids":["https://orcid.org/0000-0003-2154-6523"]},"institutions":[{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Fabiana Oliveira","raw_affiliation_strings":["i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal","institution_ids":["https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084034441","display_name":"Isabel Cardoso","orcid":"https://orcid.org/0000-0003-2472-7055","observed_orcids":["https://orcid.org/0000-0003-2472-7055"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]},{"id":"https://openalex.org/I4387153674","display_name":"Instituto de Biologia Molecular e Celular","ror":"https://ror.org/005dkht93","country_code":null,"type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]},{"id":"https://openalex.org/I4405263123","display_name":"Instituto de Ci\u00eancias Biom\u00e9dicas Albel Salazar","ror":"https://ror.org/02trb6b02","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4405263123"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Isabel Cardoso","raw_affiliation_strings":["i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal; ICBAS - Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar da Universidade do Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal; ICBAS - Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar da Universidade do Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210158732","https://openalex.org/I4387153674","https://openalex.org/I4405263123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027758024","display_name":"Teresa Summavielle","orcid":"https://orcid.org/0000-0003-2548-6281","observed_orcids":["https://orcid.org/0000-0003-2548-6281"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]},{"id":"https://openalex.org/I4387153674","display_name":"Instituto de Biologia Molecular e Celular","ror":"https://ror.org/005dkht93","country_code":null,"type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Teresa Summavielle","raw_affiliation_strings":["i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210158732","https://openalex.org/I4387153674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027568151","display_name":"Sandra Henriques Vaz","orcid":"https://orcid.org/0000-0003-4258-9397","observed_orcids":["https://orcid.org/0000-0003-4258-9397"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4405252434","display_name":"Centro Cardiovascular da Universidade de Lisboa","ror":"https://ror.org/015dy5p63","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4405252434"]},{"id":"https://openalex.org/I4405252639","display_name":"Gulbenkian Institute for Molecular Medicine","ror":"https://ror.org/0346k0491","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sandra H. Vaz","raw_affiliation_strings":["Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; GIMM - Gulbenkian Institute for Molecular Medicine, Lisboa, Portugal; CCUL - Centro Cardiovascular da Universidade de Lisboa, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Farmacologia e Neuroci\u00eancias, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; GIMM - Gulbenkian Institute for Molecular Medicine, Lisboa, Portugal; CCUL - Centro Cardiovascular da Universidade de Lisboa, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4405252434","https://openalex.org/I4405252639"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065157625","display_name":"Renato Socodato","orcid":"https://orcid.org/0000-0002-6882-5020","observed_orcids":["https://orcid.org/0000-0002-6882-5020"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]},{"id":"https://openalex.org/I4387153674","display_name":"Instituto de Biologia Molecular e Celular","ror":"https://ror.org/005dkht93","country_code":null,"type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Renato Socodato","raw_affiliation_strings":["i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal. Electronic address: renato.socodato@ibmc.up.pt"],"raw_orcid":"https://orcid.org/0000-0002-6882-5020","affiliations":[{"raw_affiliation_string":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal. Electronic address: renato.socodato@ibmc.up.pt","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210158732","https://openalex.org/I4387153674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071169141","display_name":"Jo\u00e3o Bettencourt Relvas","orcid":"https://orcid.org/0000-0001-7636-0924","observed_orcids":["https://orcid.org/0000-0001-7636-0924"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]},{"id":"https://openalex.org/I4387153674","display_name":"Instituto de Biologia Molecular e Celular","ror":"https://ror.org/005dkht93","country_code":null,"type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Jo\u00e3o B. Relvas","raw_affiliation_strings":["i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal; Departamento de Biomedicina - Unidade de Biologia Experimental, Faculdade de Medicina da Universidade do Porto, Porto, Portugal. Electronic address: jrelvas@i3s.up.pt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto, Porto, Portugal; IBMC - Instituto de Biologia Molecular e Celular, Porto, Portugal; Departamento de Biomedicina - Unidade de Biologia Experimental, Faculdade de Medicina da Universidade do Porto, Porto, Portugal. Electronic address: jrelvas@i3s.up.pt","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210158732","https://openalex.org/I4387153674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5065157625","https://openalex.org/A5071169141","https://openalex.org/A5089925939"],"corresponding_institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210158732","https://openalex.org/I4387153674"],"apc_list":{"value":4310,"currency":"USD","value_usd":4310},"apc_paid":{"value":4310,"currency":"USD","value_usd":4310},"fwci":1.0706,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.77955507,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"86","issue":null,"first_page":"103851","last_page":"103851"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0640999972820282,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9950000047683716},{"id":"https://openalex.org/keywords/svct2","display_name":"SVCT2","score":0.8479999899864197},{"id":"https://openalex.org/keywords/slc23a2","display_name":"SLC23A2","score":0.9459999799728394},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8679999709129333},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.703000009059906},{"id":"https://openalex.org/keywords/antioxidant-capacity","display_name":"antioxidant capacity","score":0.7279999852180481},{"id":"https://openalex.org/keywords/5xfad-mice","display_name":"5xFAD mice","score":0.8320000171661377},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.8640000224113464},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.847000002861023},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.9649999737739563},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8840000033378601},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7295517325401306},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.599635124206543},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5548346638679504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48146381974220276},{"id":"https://openalex.org/C2993539680","wikidata":"https://www.wikidata.org/wiki/Q902552","display_name":"Antioxidant capacity","level":3,"score":0.4437021017074585},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4426713287830353},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4247962236404419},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3338889479637146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30612075328826904},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25486940145492554},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2183886170387268},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19057244062423706},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14753863215446472}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060347","descriptor_name":"Sodium-Coupled Vitamin C Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060347","descriptor_name":"Sodium-Coupled Vitamin C Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060347","descriptor_name":"Sodium-Coupled Vitamin C Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060347","descriptor_name":"Sodium-Coupled Vitamin C Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060347","descriptor_name":"Sodium-Coupled Vitamin C Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060347","descriptor_name":"Sodium-Coupled Vitamin C Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.redox.2025.103851","doi":"https://doi.org/10.1016/j.redox.2025.103851","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2025.103851","pdf_url":null,"source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},{"id":"pmid:40907096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40907096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11255089","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12445587","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e64020ae0e3840a7a2333fdfc4a0aafa","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e64020ae0e3840a7a2333fdfc4a0aafa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Redox Biology, Vol 86, Iss , Pp 103851- (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12445587","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12445587/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Redox Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.redox.2025.103851","doi":"https://doi.org/10.1016/j.redox.2025.103851","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2025.103851","pdf_url":null,"source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5600000023841858,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1181749155","display_name":null,"funder_award_id":"2024.05324","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G1555396074","display_name":null,"funder_award_id":"2023.06380","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G1690109813","display_name":null,"funder_award_id":"57/2016","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G1949695853","display_name":"Astrossomas: Astr\u00f3citos Artificiais como reguladores da comunica\u00e7\u00e3o neuronal","funder_award_id":"PTDC/BTM-SAL/32147/2017","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G253812421","display_name":null,"funder_award_id":"57/2017","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G2798107709","display_name":null,"funder_award_id":"LISBOA\u201001\u20100145\u2010FEDER\u2010022125","funder_id":"https://openalex.org/F4853140727","funder_display_name":"Rede Nacional de Espectrometria de Massa"},{"id":"https://openalex.org/G5192854944","display_name":"Role of cdc42 in microglia function","funder_award_id":"UI/BD/151552/2021","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G6192083375","display_name":null,"funder_award_id":"952455","funder_id":"https://openalex.org/F4320330836","funder_display_name":"Institut Sukan Negara"},{"id":"https://openalex.org/G7690294753","display_name":"Astrosomes: Artificial Astrocytes as a Novel Therapeutic to Amyotrophic Lateral Sclerosis (ALS)","funder_award_id":"SFRH/BD/147277/2019","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G7693272048","display_name":"Unveiling the roles of small Rho GTPase Rac1 in microglia homeostasis and activation during neuroinflammation","funder_award_id":"SFRH/BD/147981/2019","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G854259893","display_name":"Aumentando a capta\u00e7\u00e3o de Vitamina C pela microglia para melhorar a Doen\u00e7a de Alzheimer","funder_award_id":"EXPL/MED-NEU/0588/2021","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G910018558","display_name":null,"funder_award_id":"ROTEIRO/0028/2013","funder_id":"https://openalex.org/F4853140727","funder_display_name":"Rede Nacional de Espectrometria de Massa"}],"funders":[{"id":"https://openalex.org/F4320325543","display_name":"International Society for Neurochemistry","ror":"https://ror.org/050qa2043"},{"id":"https://openalex.org/F4320330836","display_name":"Institut Sukan Negara","ror":"https://ror.org/043544h31"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320337709","display_name":"Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases","ror":"https://ror.org/03z258t47"},{"id":"https://openalex.org/F4853140727","display_name":"Rede Nacional de Espectrometria de Massa","ror":"https://ror.org/00fem8f23"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W159669330","https://openalex.org/W1531083195","https://openalex.org/W1542215809","https://openalex.org/W1599323322","https://openalex.org/W1973533307","https://openalex.org/W1976921928","https://openalex.org/W1982462963","https://openalex.org/W1986760345","https://openalex.org/W1993383247","https://openalex.org/W1998293871","https://openalex.org/W2003685223","https://openalex.org/W2015741711","https://openalex.org/W2023765801","https://openalex.org/W2038561595","https://openalex.org/W2054628503","https://openalex.org/W2055175037","https://openalex.org/W2062214806","https://openalex.org/W2069932077","https://openalex.org/W2071610467","https://openalex.org/W2096500024","https://openalex.org/W2103450794","https://openalex.org/W2106877484","https://openalex.org/W2120862638","https://openalex.org/W2123619340","https://openalex.org/W2128987869","https://openalex.org/W2133584350","https://openalex.org/W2135743634","https://openalex.org/W2141930618","https://openalex.org/W2142350129","https://openalex.org/W2159099334","https://openalex.org/W2160504750","https://openalex.org/W2164633741","https://openalex.org/W2170644095","https://openalex.org/W2292730121","https://openalex.org/W2311668744","https://openalex.org/W2336296004","https://openalex.org/W2346578806","https://openalex.org/W2409306902","https://openalex.org/W2569452645","https://openalex.org/W2601099346","https://openalex.org/W2602373342","https://openalex.org/W2617693460","https://openalex.org/W2618794795","https://openalex.org/W2622807556","https://openalex.org/W2630041514","https://openalex.org/W2724874603","https://openalex.org/W2732599352","https://openalex.org/W2752339005","https://openalex.org/W2754890392","https://openalex.org/W2769659544","https://openalex.org/W2790854317","https://openalex.org/W2792576326","https://openalex.org/W2804685648","https://openalex.org/W2805185070","https://openalex.org/W2900569176","https://openalex.org/W2912680348","https://openalex.org/W2941510527","https://openalex.org/W2997046468","https://openalex.org/W3016463102","https://openalex.org/W3036007944","https://openalex.org/W3047740470","https://openalex.org/W3088525341","https://openalex.org/W3119403831","https://openalex.org/W3120786363","https://openalex.org/W3124864544","https://openalex.org/W3184504351","https://openalex.org/W3191296436","https://openalex.org/W3193715446","https://openalex.org/W3196827409","https://openalex.org/W3207056385","https://openalex.org/W4213455879","https://openalex.org/W4291134812","https://openalex.org/W4294930497","https://openalex.org/W4316193639","https://openalex.org/W4378714758","https://openalex.org/W4380886625","https://openalex.org/W4383823386","https://openalex.org/W4386593517","https://openalex.org/W4387618633","https://openalex.org/W4388789578","https://openalex.org/W4389478603","https://openalex.org/W4390532128","https://openalex.org/W4391351539","https://openalex.org/W4391617126","https://openalex.org/W4398231688"],"related_works":["https://openalex.org/W2373652477","https://openalex.org/W2376852207","https://openalex.org/W2369476199","https://openalex.org/W2368069639","https://openalex.org/W1996120835","https://openalex.org/W2056758965","https://openalex.org/W2135556645","https://openalex.org/W2379991655","https://openalex.org/W4320006096","https://openalex.org/W4389003236"],"abstract_inverted_index":{"Despite":[0],"clear":[1],"evidence":[2],"that":[3,63,110,183],"vitamin":[4,189],"C":[5,190],"levels":[6],"are":[7],"depleted":[8],"in":[9,22,30,34,58,72,89,94,103,168,210,224],"the":[10,50,77,127,134,158,169,194,205,221],"brains":[11],"of":[12,49,79,136,207],"Alzheimer's":[13],"disease":[14,92,145],"(AD)":[15],"patients,":[16],"dietary":[17,208],"supplementation":[18,209],"has":[19],"consistently":[20],"failed":[21],"clinical":[23,179],"trials,":[24],"suggesting":[25],"a":[26,46,98,104,177,201,216],"critical":[27],"bottleneck":[28,44],"not":[29,156,186],"systemic":[31,188],"supply,":[32],"but":[33,192],"its":[35],"transport":[36],"into":[37],"brain":[38],"cells.":[39],"Here,":[40],"we":[41,61],"identify":[42],"this":[43,65,118],"as":[45,56,215],"progressive":[47],"downregulation":[48],"ascorbate":[51],"transporter,":[52],"Slc23a2,":[53],"also":[54],"known":[55],"SVCT2,":[57],"microglia.":[59],"Then":[60],"hypothesized":[62],"bypassing":[64],"cellular":[66,196],"deficiency":[67],"via":[68],"targeted":[69],"SVCT2":[70,88,147,214],"overexpression":[71,148],"microglia":[73,90],"could":[74],"either":[75],"prevent":[76],"onset":[78,93],"pathology":[80],"or":[81],"rescue":[82,163],"established":[83],"functional":[84],"deficits.":[85,140],"Indeed,":[86],"overexpressing":[87],"before":[91],"5xFAD":[95],"mice":[96],"triggered":[97],"profound":[99],"redox":[100],"reprogramming,":[101],"resulting":[102],"unique":[105],"\"hybrid\"":[106],"neuroprotective":[107],"microglial":[108,170],"phenotype":[109],"co-expressed":[111],"both":[112],"homeostatic":[113],"and":[114,125,138,152,212],"disease-associated":[115],"markers.":[116],"Functionally,":[117],"leads":[119],"to":[120],"decreased":[121],"amyloid":[122,160],"plaque":[123],"burden":[124],"strengthens":[126],"synaptic":[128,137,150],"bioenergetic":[129],"capacity,":[130],"which":[131],"consequently":[132],"prevents":[133],"development":[135],"memory":[139,153],"Strikingly,":[141],"when":[142],"employed":[143],"after":[144],"establishment,":[146],"rescued":[149],"plasticity":[151],"performance":[154],"despite":[155],"affecting":[157],"existing":[159],"burden.":[161],"This":[162,199],"was":[164],"driven":[165],"by":[166,181],"changes":[167],"secretory":[171],"pathways.":[172],"Collectively,":[173],"these":[174],"findings":[175],"resolve":[176],"long-standing":[178],"paradox":[180],"establishing":[182],"neuroprotection":[184],"depends":[185],"on":[187,193],"intake":[191],"brain's":[195],"uptake":[197],"machinery.":[198],"offers":[200],"mechanistic":[202],"explanation":[203],"for":[204],"failure":[206],"AD":[211],"identifies":[213],"promising":[217],"therapeutic":[218],"target":[219],"against":[220],"neurodegenerative":[222],"process":[223],"AD.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}