{"id":"https://openalex.org/W4413778392","doi":"https://doi.org/10.1080/17460913.2026.2753047","title":"A different approach to vaginal-derived probiotics: anti\u2011quorum sensing and anti\u2011biofilm activities of exopolysaccharides","display_name":"A different approach to vaginal-derived probiotics: anti\u2011quorum sensing and anti\u2011biofilm activities of exopolysaccharides","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W4413778392","doi":"https://doi.org/10.1080/17460913.2026.2753047","pmid":"https://pubmed.ncbi.nlm.nih.gov/42968551"},"language":"en","primary_location":{"id":"doi:10.1080/17460913.2026.2753047","doi":"https://doi.org/10.1080/17460913.2026.2753047","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17460913.2026.2753047","pdf_url":null,"source":{"id":"https://openalex.org/S129524704","display_name":"Future Microbiology","issn_l":"1746-0913","issn":["1746-0913","1746-0921"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.5403013","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012641182","display_name":"Esin K\u0131ray","orcid":"https://orcid.org/0000-0002-6908-5909","observed_orcids":["https://orcid.org/0000-0002-6908-5909"]},"institutions":[{"id":"https://openalex.org/I204483917","display_name":"Ahi Evran University","ror":"https://ror.org/05rrfpt58","country_code":"TR","type":"education","lineage":["https://openalex.org/I204483917"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Esin K\u0131ray","raw_affiliation_strings":["Kirsehir Ahi Evran University Vocational School of Health Services"],"raw_orcid":"https://orcid.org/0000-0002-6908-5909","affiliations":[{"raw_affiliation_string":"Kirsehir Ahi Evran University Vocational School of Health Services","institution_ids":["https://openalex.org/I204483917"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5092095894","display_name":"Nadia Masser Raheel","orcid":"https://orcid.org/0000-0003-0741-5690","observed_orcids":["https://orcid.org/0000-0003-0741-5690"]},"institutions":[{"id":"https://openalex.org/I204483917","display_name":"Ahi Evran University","ror":"https://ror.org/05rrfpt58","country_code":"TR","type":"education","lineage":["https://openalex.org/I204483917"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nadia Masser Raheel","raw_affiliation_strings":["Kirsehir Ahi Evran University Graduate School of Natural and Applied Sciences"],"raw_orcid":"https://orcid.org/0000-0003-0741-5690","affiliations":[{"raw_affiliation_string":"Kirsehir Ahi Evran University Graduate School of Natural and Applied Sciences","institution_ids":["https://openalex.org/I204483917"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012641182"],"corresponding_institution_ids":["https://openalex.org/I204483917"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00506874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.5400000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.5400000214576721,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.2741999924182892,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.17139999568462372,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exopolysaccharides","display_name":"exopolysaccharides","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lactobacillus","display_name":"Lactobacillus","score":0.8880000114440918},{"id":"https://openalex.org/keywords/vaginal-microbiota","display_name":"vaginal microbiota","score":0.7149999737739563},{"id":"https://openalex.org/keywords/anti-quorum-sensing","display_name":"anti-quorum sensing","score":0.7440000176429749},{"id":"https://openalex.org/keywords/antibiofilm-activity","display_name":"antibiofilm activity","score":0.8669999837875366},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.8560000061988831},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.9779999852180481},{"id":"https://openalex.org/keywords/breast-cancer-cells","display_name":"breast cancer cells","score":0.7319999933242798},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8379999995231628},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.8840000033378601},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":1.0},{"id":"https://openalex.org/keywords/chromobacterium-violaceum","display_name":"Chromobacterium violaceum","score":0.9599999785423279},{"id":"https://openalex.org/keywords/lacticaseibacillus-casei","display_name":"Lactobacillus casei","score":0.9200000166893005},{"id":"https://openalex.org/keywords/lactiplantibacillus-plantarum","display_name":"Lactobacillus plantarum","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lactobacillus-crispatus","display_name":"Lactobacillus crispatus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lacticaseibacillus-rhamnosus","display_name":"Lactobacillus rhamnosus","score":0.996999979019165},{"id":"https://openalex.org/keywords/physicochemical-characterization","display_name":"physicochemical characterization","score":0.7670000195503235},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.8314554691314697},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.8163591623306274},{"id":"https://openalex.org/C2777454759","wikidata":"https://www.wikidata.org/wiki/Q676191","display_name":"Vaginal infections","level":2,"score":0.7225440144538879},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.7107527852058411},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6604788899421692},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4369145929813385},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.23319676518440247},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.2297762930393219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22368445992469788},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.04079735279083252},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.03667581081390381},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1080/17460913.2026.2753047","doi":"https://doi.org/10.1080/17460913.2026.2753047","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17460913.2026.2753047","pdf_url":null,"source":{"id":"https://openalex.org/S129524704","display_name":"Future Microbiology","issn_l":"1746-0913","issn":["1746-0913","1746-0921"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Microbiology","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.5403013","doi":"https://doi.org/10.2139/ssrn.5403013","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5403013","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:42968551","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42968551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future microbiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2139/ssrn.5403013","doi":"https://doi.org/10.2139/ssrn.5403013","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5403013","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W878845476","https://openalex.org/W1968834637","https://openalex.org/W1979764437","https://openalex.org/W2023227836","https://openalex.org/W2031406182","https://openalex.org/W2058568791","https://openalex.org/W2064633474","https://openalex.org/W2067569075","https://openalex.org/W2074276269","https://openalex.org/W2076708643","https://openalex.org/W2077324390","https://openalex.org/W2081612731","https://openalex.org/W2082863981","https://openalex.org/W2089054156","https://openalex.org/W2099116903","https://openalex.org/W2104018395","https://openalex.org/W2109434556","https://openalex.org/W2120978086","https://openalex.org/W2324539492","https://openalex.org/W2465401953","https://openalex.org/W2506447066","https://openalex.org/W2529227495","https://openalex.org/W2734740963","https://openalex.org/W2757810368","https://openalex.org/W2769991380","https://openalex.org/W2903758424","https://openalex.org/W2982299340","https://openalex.org/W2985443916","https://openalex.org/W3008557842","https://openalex.org/W3012106863","https://openalex.org/W3026381448","https://openalex.org/W3035535272","https://openalex.org/W3100597859","https://openalex.org/W3154048614","https://openalex.org/W4210430650","https://openalex.org/W4379054545","https://openalex.org/W4402559069","https://openalex.org/W6960225571"],"related_works":["https://openalex.org/W4379507942","https://openalex.org/W4323544593","https://openalex.org/W2784389625","https://openalex.org/W2327146875","https://openalex.org/W3016443649","https://openalex.org/W4385638411","https://openalex.org/W2438379771","https://openalex.org/W2734740963","https://openalex.org/W4231636185","https://openalex.org/W3046139519"],"abstract_inverted_index":{"Aims":[0],"This":[1],"study":[2],"aimed":[3],"to":[4,30,200],"characterize":[5],"the":[6,50,107,127,145],"physicochemical":[7],"properties":[8],"of":[9,119,190],"exopolysaccharides":[10],"(EPS)":[11],"produced":[12],"by":[13,73],"vaginal":[14],"Lactobacillus":[15,18,21,25,177],"casei":[16],"L2,":[17],"plantarum":[19],"L4,":[20],"crispatus":[22],"L5,":[23],"and":[24,29,38,66,76,84,121,135,152,188,195],"rhamnosus":[26],"L17":[27,125,136,153],"strains":[28,137],"evaluate":[31],"their":[32,202],"antimicrobial,":[33],"antibiofilm,":[34],"anti-quorum":[35],"sensing":[36,141],"(anti-QS),":[37],"antiproliferative":[39],"activities":[40],"under":[41],"in":[42,106,157,185],"vitro":[43],"conditions.Methods":[44],"EPS":[45,114,131,149,172],"production":[46],"was":[47,61,71,91],"quantified":[48],"using":[49,78,93],"phenol\u2013sulfuric":[51],"acid":[52],"method,":[53],"with":[54,124,161],"glucose":[55],"as":[56,98],"a":[57,158],"standard.":[58],"Antimicrobial":[59],"activity":[60,70,90],"assessed":[62],"against":[63],"selected":[64],"Gram-positive":[65],"Gram-negative":[67],"bacteria.":[68],"Antibiofilm":[69],"evaluated":[72],"quantitative":[74],"assays":[75],"visualized":[77],"confocal":[79],"laser":[80],"scanning":[81,85],"microscopy":[82,87],"(CLSM)":[83],"electron":[86],"(SEM).":[88],"Anti-QS":[89],"determined":[92],"Chromobacterium":[94],"violaceum":[95],"ATCC":[96],"12,472":[97],"an":[99],"indicator":[100],"strain.":[101],"Antiproliferative":[102],"effects":[103],"were":[104],"analyzed":[105],"MDA-MB-231":[108,146],"breast":[109],"cancer":[110],"cell":[111,147,155],"line.Results":[112],"All":[113],"preparations":[115],"exhibited":[116],"varying":[117],"degrees":[118],"antimicrobial":[120],"antibiofilm":[122,186],"activity,":[123],"demonstrating":[126],"strongest":[128],"biofilm":[129],"inhibition.":[130],"derived":[132,173,176],"from":[133,150,174],"L2":[134,151],"showed":[138],"marked":[139],"quorum":[140,191],"inhibitory":[142],"effects.":[143],"In":[144],"line,":[148],"reduced":[154],"viability":[156],"dose-dependent":[159],"manner,":[160],"maximal":[162],"inhibition":[163],"observed":[164],"at":[165],"85":[166],"\u00b5g/mL.Conclusions":[167],"These":[168],"findings":[169],"demonstrate":[170],"that":[171],"vaginally":[175],"spp.":[178],"species":[179],"possess":[180],"strain-dependent":[181],"biological":[182],"activities,":[183],"particularly":[184],"effect":[187],"regulation":[189],"sensing.":[192],"Further":[193],"structural":[194],"mechanistic":[196],"studies":[197],"are":[198],"needed":[199],"elucidate":[201],"functional":[203],"potential.":[204]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}