{"id":"https://openalex.org/W4413708346","doi":"https://doi.org/10.21037/tlcr-2025-800","title":"Enhancing the sensitivity of lung adenocarcinoma to immune therapeutic agents through SPRED1","display_name":"Enhancing the sensitivity of lung adenocarcinoma to immune therapeutic agents through SPRED1","publication_year":2025,"publication_date":"2025-08-01","ids":{"openalex":"https://openalex.org/W4413708346","doi":"https://doi.org/10.21037/tlcr-2025-800","pmid":"https://pubmed.ncbi.nlm.nih.gov/40948827","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12432670"},"language":"en","primary_location":{"id":"doi:10.21037/tlcr-2025-800","doi":"https://doi.org/10.21037/tlcr-2025-800","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tlcr-2025-800","pdf_url":null,"source":{"id":"https://openalex.org/S2764539079","display_name":"Translational Lung Cancer Research","issn_l":"2218-6751","issn":["2218-6751","2226-4477"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Lung Cancer Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4413708346"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21037/tlcr-2025-800","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051822072","display_name":"Chen\u2010Tu Wu","orcid":"https://orcid.org/0000-0001-8458-4119","observed_orcids":["https://orcid.org/0000-0001-8458-4119"]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210085873","display_name":"Nantong Maternity and Child Health Hospital","ror":"https://ror.org/0016atv87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210085873"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Wu","raw_affiliation_strings":["Department of Science and Education, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Science and Education, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, China","institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210085873"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102865579","display_name":"Lingling Ma","orcid":"https://orcid.org/0000-0002-5784-2503","observed_orcids":["https://orcid.org/0000-0002-5784-2503"]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210085873","display_name":"Nantong Maternity and Child Health Hospital","ror":"https://ror.org/0016atv87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210085873"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingling Ma","raw_affiliation_strings":["Department of Science and Education, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Science and Education, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, China","institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210085873"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yi Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210085873","display_name":"Nantong Maternity and Child Health Hospital","ror":"https://ror.org/0016atv87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210085873"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi Wang","raw_affiliation_strings":["Department of Science and Education, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Science and Education, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, China","institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210085873"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076799395","display_name":"Joanna Bidzi\u0144ska","orcid":"https://orcid.org/0000-0003-3890-5473","observed_orcids":["https://orcid.org/0000-0003-3890-5473"]},"institutions":[{"id":"https://openalex.org/I75124487","display_name":"Gda\u0144sk Medical University","ror":"https://ror.org/019sbgd69","country_code":"PL","type":"education","lineage":["https://openalex.org/I75124487"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Joanna Bidzi\u0144ska","raw_affiliation_strings":["2nd Department of Radiology, Medical University of Gdansk, Gdansk, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Radiology, Medical University of Gdansk, Gdansk, Poland","institution_ids":["https://openalex.org/I75124487"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025954006","display_name":"Yilang Wang","orcid":"https://orcid.org/0000-0003-1295-4808","observed_orcids":["https://orcid.org/0000-0003-1295-4808"]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210085873","display_name":"Nantong Maternity and Child Health Hospital","ror":"https://ror.org/0016atv87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210085873"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yilang Wang","raw_affiliation_strings":["Department of Science and Education, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Science and Education, Affiliated Maternity and Child Health Care Hospital of Nantong University, Nantong, China","institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210085873"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025954006"],"corresponding_institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210085873"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"8","first_page":"3076","last_page":"3089"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spred1","display_name":"SPRED1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.8659999966621399},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.843999981880188},{"id":"https://openalex.org/keywords/immunotherapy-sensitivity","display_name":"immunotherapy sensitivity","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9449999928474426},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8429999947547913},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8349525928497314},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6315159797668457},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5985072255134583},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5699424147605896},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.5486817359924316},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47422313690185547},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2557431757450104},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.24053776264190674},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2051667869091034},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13456496596336365},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.21037/tlcr-2025-800","doi":"https://doi.org/10.21037/tlcr-2025-800","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tlcr-2025-800","pdf_url":null,"source":{"id":"https://openalex.org/S2764539079","display_name":"Translational Lung Cancer Research","issn_l":"2218-6751","issn":["2218-6751","2226-4477"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Lung Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12432670","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12432670/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12432670/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Lung Cancer Res","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11242751","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12432670","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40948827","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40948827","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational lung cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/tlcr-2025-800","doi":"https://doi.org/10.21037/tlcr-2025-800","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tlcr-2025-800","pdf_url":null,"source":{"id":"https://openalex.org/S2764539079","display_name":"Translational Lung Cancer Research","issn_l":"2218-6751","issn":["2218-6751","2226-4477"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Lung Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413708346.pdf","grobid_xml":"https://content.openalex.org/works/W4413708346.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1666806163","https://openalex.org/W1978802056","https://openalex.org/W1978857579","https://openalex.org/W1982847089","https://openalex.org/W1999729166","https://openalex.org/W2000905326","https://openalex.org/W2018242772","https://openalex.org/W2024650265","https://openalex.org/W2031006128","https://openalex.org/W2034605371","https://openalex.org/W2044835625","https://openalex.org/W2046451544","https://openalex.org/W2047626038","https://openalex.org/W2047902191","https://openalex.org/W2048974336","https://openalex.org/W2121315227","https://openalex.org/W2123918574","https://openalex.org/W2140733229","https://openalex.org/W2142903622","https://openalex.org/W2153725546","https://openalex.org/W2155464214","https://openalex.org/W2160721372","https://openalex.org/W2166870762","https://openalex.org/W2168635759","https://openalex.org/W2279561773","https://openalex.org/W2340514591","https://openalex.org/W2407612352","https://openalex.org/W2578528809","https://openalex.org/W2586256440","https://openalex.org/W2728491028","https://openalex.org/W2783576981","https://openalex.org/W2790574591","https://openalex.org/W2805876954","https://openalex.org/W2888294115","https://openalex.org/W2895441403","https://openalex.org/W2921818100","https://openalex.org/W3096197482","https://openalex.org/W3112425888","https://openalex.org/W3128131226","https://openalex.org/W3134553072","https://openalex.org/W4315754639","https://openalex.org/W4410337265"],"related_works":["https://openalex.org/W4404504091","https://openalex.org/W3171473356","https://openalex.org/W4386959803","https://openalex.org/W4389628230","https://openalex.org/W7213872653","https://openalex.org/W4317721650","https://openalex.org/W4313368582","https://openalex.org/W4413275615","https://openalex.org/W2796978265","https://openalex.org/W7164644717"],"abstract_inverted_index":{"Background:":[0],"Programmed":[1],"death-ligand":[2],"1":[3,22],"(PD-L1),":[4],"a":[5,10,24,174],"classic":[6],"immune":[7],"checkpoint,":[8],"is":[9,252,259],"key":[11,97],"target":[12],"for":[13],"immunotherapy.":[14,166],"Research":[15],"has":[16],"demonstrated":[17,200],"that":[18,171,201,232,245],"Sprouty-related":[19],"EVH1":[20],"domain-containing":[21],"(SPRED1),":[23],"negative":[25],"regulator":[26],"of":[27,53,59,90,100,105,137,159],"the":[28,49,57,82,87,130,135,157,241],"mitogen-activated":[29],"protein":[30],"kinase":[31],"(MAPK)":[32],"pathway,":[33],"modulates":[34],"PD-L1":[35,266],"expression":[36,103,176,211],"and":[37,51,65,86,94,117,134,150,165,181,198,208,219,227,238,258],"exhibits":[38],"antitumor":[39],"activity":[40],"in":[41,55,107,177,192,205,254,272,276],"diverse":[42],"cancers.":[43],"This":[44],"study":[45],"aimed":[46],"to":[47,63,80,95,128,155],"investigate":[48,156],"role":[50,191,271],"mechanisms":[52],"SPRED1":[54,85,106,133,160,172,202,233,246,251,264],"enhancing":[56,273],"sensitivity":[58,275],"lung":[60],"adenocarcinoma":[61],"(LUAD)":[62],"immunotherapy":[64],"develop":[66],"novel":[67],"clinical":[68],"therapeutic":[69],"sensitization":[70],"strategies.":[71],"Methods:":[72],"In":[73],"this":[74],"study,":[75],"bioinformatics":[76],"technologies":[77],"were":[78,110,153],"employed":[79],"examine":[81],"interaction":[83],"between":[84,132],"survival":[88],"prognosis":[89,136,186],"patients":[91,138,178,255],"with":[92,139,179,184,215,256],"LUAD":[93,108,162,180,206,235,257],"identify":[96],"interacting":[98],"molecules":[99],"SPRED1.":[101],"The":[102],"levels":[104],"tissues":[109],"measured":[111],"by":[112],"tissue":[113],"staining,":[114,195],"Western":[115,196],"blotting,":[116,197],"quantitative":[118],"real-time":[119],"polymerase":[120],"chain":[121],"reaction":[122],"(qRT-PCR).":[123],"Kaplan-Meier":[124],"analysis":[125],"was":[126,182,203,212],"used":[127],"confirm":[129],"correlation":[131],"LUAD.":[140,193,277],"Moreover,":[141],"Cell":[142],"Counting":[143],"Kit-8":[144],"(CCK-8),":[145],"colony":[146,228],"formation,":[147],"wound":[148,225],"healing,":[149,226],"Transwell":[151],"assays":[152,230],"conducted":[154],"effects":[158],"on":[161],"cell":[163,236],"function":[164],"Results:":[167],"Bioinformatics":[168],"analyses":[169],"revealed":[170],"had":[173],"low":[175,210],"associated":[183],"poor":[185,216],"(P<0.05),":[187],"suggesting":[188],"its":[189,209,270],"prominent":[190],"Tissue":[194],"qRT-PCR":[199],"downregulated":[204,253],"tissues,":[207],"significantly":[213],"correlated":[214],"N":[217],"stage":[218,222],"advanced":[220],"pathological":[221],"(P<0.05).":[223],"Transwell,":[224],"formation":[229],"indicated":[231],"suppressed":[234],"migration":[237],"proliferation.":[239],"Furthermore,":[240],"CCK-8":[242],"assay":[243],"confirmed":[244],"increases":[247],"immunotherapeutic":[248,274],"sensitivity.":[249],"Conclusions:":[250],"an":[260],"independent":[261],"prognostic":[262],"factor.":[263],"enhances":[265],"expression,":[267],"thereby":[268],"mediating":[269]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2025-08-27T00:00:00"}
