{"id":"https://openalex.org/W4413670345","doi":"https://doi.org/10.3390/cancers17172769","title":"Ribosomal RNA Degradation (RNA Disruption) in Tumour Cells: Mechanistic Insights and Potential Clinical Utility","display_name":"Ribosomal RNA Degradation (RNA Disruption) in Tumour Cells: Mechanistic Insights and Potential Clinical Utility","publication_year":2025,"publication_date":"2025-08-25","ids":{"openalex":"https://openalex.org/W4413670345","doi":"https://doi.org/10.3390/cancers17172769","pmid":"https://pubmed.ncbi.nlm.nih.gov/40940865","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12427290"},"language":"en","primary_location":{"id":"doi:10.3390/cancers17172769","doi":"https://doi.org/10.3390/cancers17172769","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers17172769","pdf_url":"https://www.mdpi.com/2072-6694/17/17/2769/pdf?version=1756186083","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/17/17/2769/pdf?version=1756186083","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052673141","display_name":"Amadeo Mark Parissenti","orcid":"https://orcid.org/0000-0003-1447-658X","observed_orcids":["https://orcid.org/0000-0003-1447-658X"]},"institutions":[{"id":"https://openalex.org/I2802851750","display_name":"Health Sciences North","ror":"https://ror.org/04br0rs05","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802851750"]},{"id":"https://openalex.org/I52353378","display_name":"Laurentian University","ror":"https://ror.org/03rcwtr18","country_code":"CA","type":"education","lineage":["https://openalex.org/I52353378"]},{"id":"https://openalex.org/I7899908","display_name":"NOSM University","ror":"https://ror.org/05yb43k62","country_code":"CA","type":"education","lineage":["https://openalex.org/I7899908"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Amadeo M. Parissenti","raw_affiliation_strings":["Division of Medical Sciences, Northern Ontario School of Medicine, Sudbury, ON P3E 2C6, Canada","Health Sciences North Research Institute, Sudbury, ON P3E 2H3, Canada","Rna Diagnostics, Inc., Toronto, ON M4T 1L9, Canada","School of Natural Sciences, Laurentian University, Sudbury, ON P3E 2C6, Canada"],"raw_orcid":"https://orcid.org/0000-0003-1447-658X","affiliations":[{"raw_affiliation_string":"Division of Medical Sciences, Northern Ontario School of Medicine, Sudbury, ON P3E 2C6, Canada","institution_ids":["https://openalex.org/I7899908"]},{"raw_affiliation_string":"Health Sciences North Research Institute, Sudbury, ON P3E 2H3, Canada","institution_ids":["https://openalex.org/I2802851750"]},{"raw_affiliation_string":"Rna Diagnostics, Inc., Toronto, ON M4T 1L9, Canada","institution_ids":[]},{"raw_affiliation_string":"School of Natural Sciences, Laurentian University, Sudbury, ON P3E 2C6, Canada","institution_ids":["https://openalex.org/I52353378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093528260","display_name":"Sanaa Noubir","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanaa Noubir","raw_affiliation_strings":["Rna Diagnostics, Inc., Toronto, ON M4T 1L9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rna Diagnostics, Inc., Toronto, ON M4T 1L9, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016056296","display_name":"Laura B. Pritzker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura B. Pritzker","raw_affiliation_strings":["Rna Diagnostics, Inc., Toronto, ON M4T 1L9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rna Diagnostics, Inc., Toronto, ON M4T 1L9, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078585735","display_name":"A. Thomas Kovala","orcid":"https://orcid.org/0000-0002-2908-5613","observed_orcids":["https://orcid.org/0000-0002-2908-5613"]},"institutions":[{"id":"https://openalex.org/I2802851750","display_name":"Health Sciences North","ror":"https://ror.org/04br0rs05","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2802851750"]},{"id":"https://openalex.org/I52353378","display_name":"Laurentian University","ror":"https://ror.org/03rcwtr18","country_code":"CA","type":"education","lineage":["https://openalex.org/I52353378"]},{"id":"https://openalex.org/I7899908","display_name":"NOSM University","ror":"https://ror.org/05yb43k62","country_code":"CA","type":"education","lineage":["https://openalex.org/I7899908"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Thomas Kovala","raw_affiliation_strings":["Division of Medical Sciences, Northern Ontario School of Medicine, Sudbury, ON P3E 2C6, Canada","Health Sciences North Research Institute, Sudbury, ON P3E 2H3, Canada","School of Natural Sciences, Laurentian University, Sudbury, ON P3E 2C6, Canada"],"raw_orcid":"https://orcid.org/0000-0002-2908-5613","affiliations":[{"raw_affiliation_string":"Division of Medical Sciences, Northern Ontario School of Medicine, Sudbury, ON P3E 2C6, Canada","institution_ids":["https://openalex.org/I7899908"]},{"raw_affiliation_string":"Health Sciences North Research Institute, Sudbury, ON P3E 2H3, Canada","institution_ids":["https://openalex.org/I2802851750"]},{"raw_affiliation_string":"School of Natural Sciences, Laurentian University, Sudbury, ON P3E 2C6, Canada","institution_ids":["https://openalex.org/I52353378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025558872","display_name":"Carita Lann\u00e9r","orcid":"https://orcid.org/0000-0002-7442-0142","observed_orcids":["https://orcid.org/0000-0002-7442-0142"]},"institutions":[{"id":"https://openalex.org/I7899908","display_name":"NOSM University","ror":"https://ror.org/05yb43k62","country_code":"CA","type":"education","lineage":["https://openalex.org/I7899908"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Carita Lann\u00e9r","raw_affiliation_strings":["Division of Medical Sciences, Northern Ontario School of Medicine, Sudbury, ON P3E 2C6, Canada"],"raw_orcid":"https://orcid.org/0000-0002-7442-0142","affiliations":[{"raw_affiliation_string":"Division of Medical Sciences, Northern Ontario School of Medicine, Sudbury, ON P3E 2C6, Canada","institution_ids":["https://openalex.org/I7899908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029998964","display_name":"Jennifer A. Lemon","orcid":"https://orcid.org/0000-0002-3910-5438","observed_orcids":["https://orcid.org/0000-0002-3910-5438"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer Lemon","raw_affiliation_strings":["Rna Diagnostics, Inc., Toronto, ON M4T 1L9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rna Diagnostics, Inc., Toronto, ON M4T 1L9, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119436327","display_name":"Tunde Onayemi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tunde Onayemi","raw_affiliation_strings":["Rna Diagnostics, Inc., Toronto, ON M4T 1L9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rna Diagnostics, Inc., Toronto, ON M4T 1L9, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119436328","display_name":"Sreepriya Pk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52353378","display_name":"Laurentian University","ror":"https://ror.org/03rcwtr18","country_code":"CA","type":"education","lineage":["https://openalex.org/I52353378"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sreepriya Pk","raw_affiliation_strings":["School of Natural Sciences, Laurentian University, Sudbury, ON P3E 2C6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Natural Sciences, Laurentian University, Sudbury, ON P3E 2C6, Canada","institution_ids":["https://openalex.org/I52353378"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005781686","display_name":"Gabriel Th\u00e9riault","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel Th\u00e9riault","raw_affiliation_strings":["Rna Diagnostics, Inc., Toronto, ON M4T 1L9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rna Diagnostics, Inc., Toronto, ON M4T 1L9, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047113165","display_name":"Maureen Trudeau","orcid":"https://orcid.org/0000-0002-0938-4499","observed_orcids":["https://orcid.org/0000-0002-0938-4499"]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I4405271711","display_name":"Odette Cancer Centre","ror":"https://ror.org/02ww1s787","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004","https://openalex.org/I4405271711"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Maureen E. Trudeau","raw_affiliation_strings":["Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada"],"raw_orcid":"https://orcid.org/0000-0002-0938-4499","affiliations":[{"raw_affiliation_string":"Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I4405271711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003405177","display_name":"Michael Untch","orcid":"https://orcid.org/0000-0002-1233-1267","observed_orcids":["https://orcid.org/0000-0002-1233-1267"]},"institutions":[{"id":"https://openalex.org/I4210138940","display_name":"Helios Kliniken","ror":"https://ror.org/04fjkxc67","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138940"]},{"id":"https://openalex.org/I4210156283","display_name":"Helios Hospital Berlin-Buch","ror":"https://ror.org/05hgh1g19","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210138940","https://openalex.org/I4210156283"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael M. Untch","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Interdisciplinary Breast Cancer Center, Medical School Berlin, Helios Kliniken Berlin-Buch, 13125 Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1233-1267","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Interdisciplinary Breast Cancer Center, Medical School Berlin, Helios Kliniken Berlin-Buch, 13125 Berlin, Germany","institution_ids":["https://openalex.org/I4210138940","https://openalex.org/I4210156283"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5052673141"],"corresponding_institution_ids":["https://openalex.org/I2802851750","https://openalex.org/I52353378","https://openalex.org/I7899908"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"17","first_page":"2769","last_page":"2769"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.7964000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.7964000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0364999994635582,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.029100000858306885,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribosomal-rna-degradation","display_name":"ribosomal RNA degradation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ribosome","display_name":"ribosome","score":0.8009999990463257},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9290000200271606},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.6819999814033508},{"id":"https://openalex.org/keywords/adaptive-clinical-trials","display_name":"adaptive clinical trials","score":0.593999981880188},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8130000233650208},{"id":"https://openalex.org/keywords/tumor-cell-death","display_name":"cancer cell death","score":0.6729999780654907},{"id":"https://openalex.org/keywords/drug-response-prediction","display_name":"drug response prediction","score":0.4690000116825104},{"id":"https://openalex.org/keywords/residual-disease","display_name":"residual disease","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7322410345077515},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.7041809558868408},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.4610506594181061},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44781047105789185},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3887147903442383},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3702987730503082},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.354644775390625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2011960744857788},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1943730115890503},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09554862976074219},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/cancers17172769","doi":"https://doi.org/10.3390/cancers17172769","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers17172769","pdf_url":"https://www.mdpi.com/2072-6694/17/17/2769/pdf?version=1756186083","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmid:40940865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40940865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12427290","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12427290/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/cancers17172769","doi":"https://doi.org/10.3390/cancers17172769","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers17172769","pdf_url":"https://www.mdpi.com/2072-6694/17/17/2769/pdf?version=1756186083","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4216049271","display_name":null,"funder_award_id":"IT12731","funder_id":"https://openalex.org/F4320322675","funder_display_name":"Mitacs"},{"id":"https://openalex.org/G4461957051","display_name":null,"funder_award_id":"IT28469","funder_id":"https://openalex.org/F4320322675","funder_display_name":"Mitacs"}],"funders":[{"id":"https://openalex.org/F4320322675","display_name":"Mitacs","ror":"https://ror.org/00cjrc276"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413670345.pdf","grobid_xml":"https://content.openalex.org/works/W4413670345.grobid-xml"},"referenced_works_count":131,"referenced_works":["https://openalex.org/W979723212","https://openalex.org/W1546139069","https://openalex.org/W1574174694","https://openalex.org/W1811714417","https://openalex.org/W1862207111","https://openalex.org/W1972087054","https://openalex.org/W1973216203","https://openalex.org/W1981358981","https://openalex.org/W1985161570","https://openalex.org/W1986097563","https://openalex.org/W1999758530","https://openalex.org/W2004085522","https://openalex.org/W2006104941","https://openalex.org/W2012945939","https://openalex.org/W2017794382","https://openalex.org/W2022984399","https://openalex.org/W2028106708","https://openalex.org/W2035244376","https://openalex.org/W2040069945","https://openalex.org/W2050824673","https://openalex.org/W2050994990","https://openalex.org/W2051357882","https://openalex.org/W2054721498","https://openalex.org/W2055802714","https://openalex.org/W2057511360","https://openalex.org/W2059586921","https://openalex.org/W2063591664","https://openalex.org/W2065126270","https://openalex.org/W2068944453","https://openalex.org/W2076606535","https://openalex.org/W2080288264","https://openalex.org/W2088155226","https://openalex.org/W2093199938","https://openalex.org/W2099318494","https://openalex.org/W2103334789","https://openalex.org/W2103509661","https://openalex.org/W2106016335","https://openalex.org/W2109916911","https://openalex.org/W2110040614","https://openalex.org/W2114264989","https://openalex.org/W2114918609","https://openalex.org/W2123105952","https://openalex.org/W2140951322","https://openalex.org/W2145981915","https://openalex.org/W2149608137","https://openalex.org/W2152414109","https://openalex.org/W2152718020","https://openalex.org/W2155163967","https://openalex.org/W2157706516","https://openalex.org/W2163672244","https://openalex.org/W2172163368","https://openalex.org/W2264000214","https://openalex.org/W2275709532","https://openalex.org/W2284723470","https://openalex.org/W2434439994","https://openalex.org/W2469000447","https://openalex.org/W2581130118","https://openalex.org/W2749983621","https://openalex.org/W2752684570","https://openalex.org/W2768980003","https://openalex.org/W2777786283","https://openalex.org/W2781925472","https://openalex.org/W2796882023","https://openalex.org/W2801422021","https://openalex.org/W2802593879","https://openalex.org/W2884499324","https://openalex.org/W2893801711","https://openalex.org/W2898994124","https://openalex.org/W2899659781","https://openalex.org/W2900705752","https://openalex.org/W2940950898","https://openalex.org/W2942814044","https://openalex.org/W2944315478","https://openalex.org/W2945863457","https://openalex.org/W2963199063","https://openalex.org/W2969238458","https://openalex.org/W2969316012","https://openalex.org/W2971409314","https://openalex.org/W2985506230","https://openalex.org/W2986572941","https://openalex.org/W2991735809","https://openalex.org/W2993298108","https://openalex.org/W2994925586","https://openalex.org/W2995383111","https://openalex.org/W2996767918","https://openalex.org/W3006930853","https://openalex.org/W3023011061","https://openalex.org/W3029199196","https://openalex.org/W3030834164","https://openalex.org/W3031281461","https://openalex.org/W3032970906","https://openalex.org/W3041426930","https://openalex.org/W3087483314","https://openalex.org/W3108052922","https://openalex.org/W3122116150","https://openalex.org/W3153502267","https://openalex.org/W3157566098","https://openalex.org/W3160666703","https://openalex.org/W4200008602","https://openalex.org/W4200034848","https://openalex.org/W4210957314","https://openalex.org/W4213287704","https://openalex.org/W4220746304","https://openalex.org/W4223500161","https://openalex.org/W4307793611","https://openalex.org/W4318617145","https://openalex.org/W4319922981","https://openalex.org/W4368373009","https://openalex.org/W4377019682","https://openalex.org/W4389163114","https://openalex.org/W4389934170","https://openalex.org/W4390706369","https://openalex.org/W4392058541","https://openalex.org/W4392773838","https://openalex.org/W4392977246","https://openalex.org/W4393858340","https://openalex.org/W4396780828","https://openalex.org/W4400466967","https://openalex.org/W4401499694","https://openalex.org/W4401627214","https://openalex.org/W4401728822","https://openalex.org/W4402551965","https://openalex.org/W4404468632","https://openalex.org/W4406924680","https://openalex.org/W4407230737","https://openalex.org/W4407391826","https://openalex.org/W4408890085","https://openalex.org/W4411016316","https://openalex.org/W4411027841","https://openalex.org/W4413106741","https://openalex.org/W7095682847"],"related_works":["https://openalex.org/W4318617145","https://openalex.org/W7024364892","https://openalex.org/W979723212","https://openalex.org/W3206092963","https://openalex.org/W2284723470","https://openalex.org/W4413106741","https://openalex.org/W3031281461","https://openalex.org/W99744418","https://openalex.org/W4389934170","https://openalex.org/W2275709532"],"abstract_inverted_index":{"The":[0],"ribosome":[1],"in":[2,23,31,57,60,63,75,166,184,189,204,220,236],"eukaryotic":[3],"cells":[4,59],"is":[5,28,126],"a":[6,36,138,157],"macromolecular":[7],"complex":[8],"composed":[9],"of":[10,38,155,213,234,240],"four":[11],"ribonucleic":[12],"acids":[13],"and":[14,25,41,44,62,79,100,113,132,188,223],"over":[15],"80":[16],"proteins.":[17],"This":[18,195],"organelle":[19],"facilitates":[20],"protein":[21],"synthesis":[22],"cells,":[24,35,103],"its":[26,182],"activity":[27],"strongly":[29,127],"upregulated":[30],"human":[32],"cancers.":[33],"Immune":[34],"variety":[37],"cellular":[39,201],"stressors":[40],"numerous":[42],"structurally":[43],"mechanistically":[45],"distinct":[46],"anti-cancer":[47,91,110],"agents":[48],"have":[49],"been":[50],"shown":[51],"to":[52,160,173],"induce":[53],"ribosomal":[54],"RNA":[55,70,84,117,145,206,218],"degradation":[56],"tumour":[58,102,116,217],"vitro":[61],"vivo-a":[64],"phenomenon":[65],"we":[66],"termed":[67],"\"RNA":[68],"disruption\".":[69],"disruption":[71,85,118,146,219],"can":[72,96],"be":[73,229],"quantified":[74],"cultured":[76],"cell":[77],"lines":[78],"patient":[80],"samples":[81],"using":[82,124],"the":[83,153,170,200,211,232,237],"assay":[86,108],"(RDA).":[87],"Unlike":[88],"well-known":[89],"high-throughput":[90],"drug":[92,111,190],"sensitivity":[93],"assays,":[94],"RDA":[95,151],"distinguish":[97],"between":[98],"dying":[99],"arrested":[101],"making":[104,136],"it":[105,137],"an":[106],"attractive":[107],"for":[109,231],"discovery":[112],"development.":[114],"Low":[115],"during":[119,177],"neoadjuvant":[120,164,178,246],"chemotherapy":[121,165,179,247],"(as":[122],"measured":[123],"RDA)":[125],"associated":[128],"with":[129],"residual":[130],"disease":[131],"reduced":[133],"disease-free":[134],"survival,":[135],"potentially":[139],"valuable":[140],"chemo-resistance":[141],"assessment":[142],"tool.":[143],"High":[144],"may":[147,180],"also":[148,209],"indicate":[149],"chemo-responsiveness.":[150],"holds":[152],"prospect":[154],"being":[156],"useful":[158],"tool":[159],"escalate":[161],"or":[162],"de-escalate":[163],"cancer":[167,221,242],"patients.":[168],"Moreover,":[169],"assay's":[171],"ability":[172],"predict":[174],"treatment":[175],"outcomes":[176],"permit":[181],"use":[183],"adaptive":[185],"clinical":[186,214,238],"trials":[187],"approval":[191],"by":[192],"regulatory":[193],"agencies.":[194],"review":[196],"provides":[197],"insight":[198],"into":[199],"processes":[202],"involved":[203],"chemotherapy-induced":[205],"disruption.":[207],"It":[208],"describes":[210],"results":[212],"studies":[215],"on":[216],"patients":[222,243],"suggests":[224],"possible":[225],"approaches":[226],"that":[227],"could":[228],"considered":[230],"utilization":[233],"RDAs":[235],"management":[239],"breast":[241],"undergoing":[244],"current":[245],"regimens.":[248]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
