{"id":"https://openalex.org/W4413650714","doi":"https://doi.org/10.1002/alz.70627","title":"Linkage and association of preserved cognitive function in the midwestern Amish at a higher genetic risk of Alzheimer's disease","display_name":"Linkage and association of preserved cognitive function in the midwestern Amish at a higher genetic risk of Alzheimer's disease","publication_year":2025,"publication_date":"2025-08-01","ids":{"openalex":"https://openalex.org/W4413650714","doi":"https://doi.org/10.1002/alz.70627","pmid":"https://pubmed.ncbi.nlm.nih.gov/40855969","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12378373"},"language":"en","primary_location":{"id":"doi:10.1002/alz.70627","doi":"https://doi.org/10.1002/alz.70627","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.70627","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.70627","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.70627","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001834580","display_name":"Daniel A. Dorfsman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210131692","display_name":"Dr. John T. Macdonald Foundation","ror":"https://ror.org/02vawgn43","country_code":"US","type":"other","lineage":["https://openalex.org/I4210131692"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel A. Dorfsman","raw_affiliation_strings":["Dr. John T. Macdonald Foundation of Human Genetics University of Miami Miller School of Medicine  Miami Florida USA","John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. John T. Macdonald Foundation of Human Genetics University of Miami Miller School of Medicine  Miami Florida USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210131692"]},{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062996292","display_name":"Michael B. Prough","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael B. Prough","raw_affiliation_strings":["John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115699400","display_name":"Alex V. Gulyayev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex V. Gulyayev","raw_affiliation_strings":["John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071820702","display_name":"Laura J. Caywood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura J. Caywood","raw_affiliation_strings":["John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034664934","display_name":"Jason E. Clouse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason E. Clouse","raw_affiliation_strings":["John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038676225","display_name":"Sharlene D. Herington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharlene D. Herington","raw_affiliation_strings":["John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106725810","display_name":"Susan H. Slifer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan H. Slifer","raw_affiliation_strings":["John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109439277","display_name":"Larry Deon Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry D. Adams","raw_affiliation_strings":["John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066783581","display_name":"Rene\u00e9 A. Laux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renee A. Laux","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071977840","display_name":"Yeunjoo E. Song","orcid":"https://orcid.org/0000-0002-7452-3731","observed_orcids":["https://orcid.org/0000-0002-7452-3731"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yeunjoo E. Song","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111846941","display_name":"Audrey Lynn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Audrey Lynn","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089289757","display_name":"Sarada L. Fuzzell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarada L. Fuzzell","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047337415","display_name":"Sherri D. Hochstetler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherri D. Hochstetler","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007357271","display_name":"Kristy L. S. Miskimen","orcid":"https://orcid.org/0000-0003-0376-9053","observed_orcids":["https://orcid.org/0000-0003-0376-9053"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristy Miskimen","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025328133","display_name":"Leighanne R. Main","orcid":"https://orcid.org/0000-0002-8828-8066","observed_orcids":["https://orcid.org/0000-0002-8828-8066"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leighanne R. Main","raw_affiliation_strings":["Cleveland Institute for Computational Biology School of Medicine Case Western Reserve University  Cleveland Ohio USA","Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Institute for Computational Biology School of Medicine Case Western Reserve University  Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079990761","display_name":"Ping Wang","orcid":"https://orcid.org/0009-0005-8478-466X","observed_orcids":["https://orcid.org/0009-0005-8478-466X"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping Wang","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040839835","display_name":"Yining Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yining Liu","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Noel Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noel Moore","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071060728","display_name":"Paula K. Ogrocki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula Ogrocki","raw_affiliation_strings":["Department of Neurology School of Medicine Case Western Reserve University  Cleveland Ohio USA","University Hospitals Cleveland Medical Center  Cleveland Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology School of Medicine Case Western Reserve University  Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"University Hospitals Cleveland Medical Center  Cleveland Ohio USA","institution_ids":["https://openalex.org/I4210108791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062686238","display_name":"Alan Jay Lerner","orcid":"https://orcid.org/0000-0001-9447-6154","observed_orcids":["https://orcid.org/0000-0001-9447-6154"]},"institutions":[{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan J. Lerner","raw_affiliation_strings":["Department of Neurology School of Medicine Case Western Reserve University  Cleveland Ohio USA","University Hospitals Cleveland Medical Center  Cleveland Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology School of Medicine Case Western Reserve University  Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"University Hospitals Cleveland Medical Center  Cleveland Ohio USA","institution_ids":["https://openalex.org/I4210108791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039717261","display_name":"Jeffery M. Vance","orcid":"https://orcid.org/0000-0003-3815-8199","observed_orcids":["https://orcid.org/0000-0003-3815-8199"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210131692","display_name":"Dr. John T. Macdonald Foundation","ror":"https://ror.org/02vawgn43","country_code":"US","type":"other","lineage":["https://openalex.org/I4210131692"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffery M. Vance","raw_affiliation_strings":["Dr. John T. Macdonald Foundation of Human Genetics University of Miami Miller School of Medicine  Miami Florida USA","John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. John T. Macdonald Foundation of Human Genetics University of Miami Miller School of Medicine  Miami Florida USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210131692"]},{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039221620","display_name":"Michael L. Cuccaro","orcid":"https://orcid.org/0000-0003-4769-0785","observed_orcids":["https://orcid.org/0000-0003-4769-0785"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210131692","display_name":"Dr. John T. Macdonald Foundation","ror":"https://ror.org/02vawgn43","country_code":"US","type":"other","lineage":["https://openalex.org/I4210131692"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Cuccaro","raw_affiliation_strings":["Dr. John T. Macdonald Foundation of Human Genetics University of Miami Miller School of Medicine  Miami Florida USA","John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. John T. Macdonald Foundation of Human Genetics University of Miami Miller School of Medicine  Miami Florida USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210131692"]},{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020266650","display_name":"Jonathan L. Haines","orcid":"https://orcid.org/0000-0002-4351-4728","observed_orcids":["https://orcid.org/0000-0002-4351-4728"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan L. Haines","raw_affiliation_strings":["Cleveland Institute for Computational Biology School of Medicine Case Western Reserve University  Cleveland Ohio USA","Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Institute for Computational Biology School of Medicine Case Western Reserve University  Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences School of Medicine Case Western Reserve University  Cleveland Ohio USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069324665","display_name":"Margaret Ann Pericak\u2010Vance","orcid":"https://orcid.org/0000-0001-7283-8804","observed_orcids":["https://orcid.org/0000-0001-7283-8804","https://orcid.org/0000-0002-3309-1303"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210131692","display_name":"Dr. John T. Macdonald Foundation","ror":"https://ror.org/02vawgn43","country_code":"US","type":"other","lineage":["https://openalex.org/I4210131692"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret A. Pericak\u2010Vance","raw_affiliation_strings":["Dr. John T. Macdonald Foundation of Human Genetics University of Miami Miller School of Medicine  Miami Florida USA","John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. John T. Macdonald Foundation of Human Genetics University of Miami Miller School of Medicine  Miami Florida USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210131692"]},{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088628502","display_name":"William K. Scott","orcid":"https://orcid.org/0000-0001-9336-6404","observed_orcids":["https://orcid.org/0000-0001-9336-6404"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210131692","display_name":"Dr. John T. Macdonald Foundation","ror":"https://ror.org/02vawgn43","country_code":"US","type":"other","lineage":["https://openalex.org/I4210131692"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William K. Scott","raw_affiliation_strings":["Dr. John T. Macdonald Foundation of Human Genetics University of Miami Miller School of Medicine  Miami Florida USA","John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. John T. Macdonald Foundation of Human Genetics University of Miami Miller School of Medicine  Miami Florida USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210131692"]},{"raw_affiliation_string":"John P. Hussman Institute for Human Genomics University of Miami Miller School of Medicine  Miami Florida USA","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001834580"],"corresponding_institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210131692"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":{"value":4200,"currency":"USD","value_usd":4200},"fwci":1.703,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.84390109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"21","issue":"8","first_page":"e70627","last_page":"e70627"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.7832000255584717,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.7832000255584717,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.19359999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cognitive-function-preservation","display_name":"cognitive preservation","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5303246378898621},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.5234591364860535},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49770525097846985},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.48227718472480774},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4171105623245239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41654422879219055},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.3214290142059326},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3213909864425659},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2631792426109314},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.2627345025539398},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.1505039632320404},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.10615238547325134}],"mesh":[{"descriptor_ui":"D000073216","descriptor_name":"Mental Status and Dementia Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002881","descriptor_name":"Chromosomes, Human, Pair 12","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002889","descriptor_name":"Chromosomes, Human, Pair 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015146","descriptor_name":"Midwestern United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D061365","descriptor_name":"Amish","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/alz.70627","doi":"https://doi.org/10.1002/alz.70627","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.70627","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.70627","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},{"id":"doi:10.1101/2025.01.06.25320073","doi":"https://doi.org/10.1101/2025.01.06.25320073","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.01.06.25320073","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/01/07/2025.01.06.25320073.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:11187062","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12378373","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12378373","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12378373","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimers Dement","raw_type":"Text"},{"id":"pmid:40855969","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40855969","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & dementia : the journal of the Alzheimer's Association","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/alz.70627","doi":"https://doi.org/10.1002/alz.70627","is_oa":true,"landing_page_url":"https://doi.org/10.1002/alz.70627","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.70627","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G6550912826","display_name":"Protective Genetic Variants for Alzheimer Disease in the Amish","funder_award_id":"RF1AG058066","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7654779916","display_name":null,"funder_award_id":"AG058066","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000860728","display_name":"Protective Genetic Variants for Alzheimer Disease in the Amish - RENEWAL","funder_award_id":"R01AG058066","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320309249","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92"},{"id":"https://openalex.org/F4320310281","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413650714.pdf","grobid_xml":"https://content.openalex.org/works/W4413650714.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W38490725","https://openalex.org/W1488336305","https://openalex.org/W1585895556","https://openalex.org/W1767653793","https://openalex.org/W1847168837","https://openalex.org/W1969055690","https://openalex.org/W1974157095","https://openalex.org/W1980316292","https://openalex.org/W2008854521","https://openalex.org/W2036362108","https://openalex.org/W2043247687","https://openalex.org/W2047487074","https://openalex.org/W2051672359","https://openalex.org/W2054287151","https://openalex.org/W2070345960","https://openalex.org/W2070674867","https://openalex.org/W2088708872","https://openalex.org/W2090271811","https://openalex.org/W2105306382","https://openalex.org/W2115386352","https://openalex.org/W2132831532","https://openalex.org/W2148080316","https://openalex.org/W2154755614","https://openalex.org/W2161633633","https://openalex.org/W2167311298","https://openalex.org/W2214787545","https://openalex.org/W2507733249","https://openalex.org/W2529241974","https://openalex.org/W2574432813","https://openalex.org/W2606536226","https://openalex.org/W2794454775","https://openalex.org/W2892134688","https://openalex.org/W2907768682","https://openalex.org/W2916749909","https://openalex.org/W2958615822","https://openalex.org/W2962685339","https://openalex.org/W3049297159","https://openalex.org/W3083437588","https://openalex.org/W3144154321","https://openalex.org/W3159386190","https://openalex.org/W4206038508","https://openalex.org/W4223591189","https://openalex.org/W4300942465","https://openalex.org/W4324309277","https://openalex.org/W4387607559","https://openalex.org/W4396560090","https://openalex.org/W4403231613"],"related_works":["https://openalex.org/W4406140585","https://openalex.org/W4312087417","https://openalex.org/W3112018008","https://openalex.org/W4403231613","https://openalex.org/W4390196010","https://openalex.org/W4210588525","https://openalex.org/W7141592407","https://openalex.org/W1977084972","https://openalex.org/W7117120204","https://openalex.org/W2040291192"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Genetic":[2],"studies":[3],"of":[4,20,62,91,97,197,235,245,304,365,376,393],"Alzheimer\u2019s":[5],"disease":[6],"(AD)":[7],"have":[8],"made":[9],"remarkable":[10],"progress":[11],"in":[12,100,116,217,232,276,308,318,354,383],"identifying":[13,107],"genetic":[14,24,60,70,89,98,179,193,271,331,347,359,403],"factors":[15,71],"that":[16,26,36,83],"increase":[17],"the":[18,23,44,126,190,218,262,296,309,319,373,391],"risk":[19,61,90,194,209,360],"AD.":[21,63,362],"However,":[22],"determinants":[25],"contribute":[27,389],"to":[28,67,186,350,390],"preserved":[29,102,274,351],"cognition":[30,275],"at":[31,104,255,289,357],"older":[32,49],"ages,":[33],"particularly":[34],"those":[35,149],"mitigate":[37],"AD":[38,92,192,208],"risk,":[39,106,180],"are":[40],"less":[41],"understood.":[42],"In":[43],"Midwestern":[45],"Amish":[46,74,118],"community,":[47],"certain":[48],"adults":[50],"maintain":[51],"normal":[52],"cognitive":[53,352,385,394,406],"abilities":[54],"despite":[55],"carrying":[56],"a":[57,233,269,280,326],"relatively":[58],"high":[59,358],"Our":[64,334],"goal":[65],"was":[66,123,165,184,250,284],"identify":[68],"shared":[69,270],"among":[72],"\u2018high-risk\u2019":[73],"sibships":[75,85,103,169],"enriched":[76],"with":[77,137,150,170,330],"cognitively":[78,101,145,158,306],"unimpaired":[79,146,307],"individuals.":[80,278],"We":[81],"hypothesized":[82],"ranking":[84],"by":[86,189],"their":[87,198],"mean":[88,191],"would":[93],"provide":[94],"greater":[95],"evidence":[96,244],"linkage":[99,163,246],"higher":[105],"genomic":[108,338],"regions":[109],"containing":[110],"protective":[111,402],"loci.":[112,210],"Methods":[113],"Cognitive":[114],"status":[115],"adult":[117],"participants":[119],"(n":[120],"=":[121,266,313,323],"1,855)":[122],"evaluated":[124,225],"using":[125,201,226],"Modified":[127],"Mini":[128],"Mental":[129],"Status":[130],"Exam":[131],"(3MS).":[132],"Those":[133],"aged":[134,355],"\u2265":[135,140,171],"75":[136],"education-adjusted":[138,151],"3MS":[139,152],"87":[141,154],"were":[142,155,223],"classified":[143,156],"as":[144,157,369],"(CU),":[147],"while":[148],"<":[153],"impaired":[159],"(CI).":[160],"Genome-wide":[161],"non-parametric":[162],"analysis":[164,182],"performed":[166],"on":[167,252,286,340,401],"143":[168],"2":[172,254,342],"CU":[173,199,237],"members.":[174],"To":[175],"account":[176],"for":[177,204,361],"known":[178],"ordered-subsets":[181],"(OSA)":[183],"used":[185],"rank":[187],"families":[188],"score":[195,220],"(GRS)":[196],"members":[200],"effect":[202,283,329],"sizes":[203],"25":[205],"established":[206],"European":[207],"Regions":[211],"exhibiting":[212],"significant":[213,281],"or":[214],"suggestive":[215],"increases":[216],"LOD*":[219],"during":[221],"OSA":[222,248],"further":[224],"single-variant":[227],"and":[228,238,315,343,367,379,396],"interaction":[229,282],"association":[230],"tests":[231],"sample":[234],"715":[236],"460":[239],"CI":[240],"participants.":[241],"Results":[242],"Significant":[243],"following":[247],"adjustment":[249],"detected":[251],"chromosome":[253,287],"SNP":[256,290],"rs6719884":[257],"(\u223c":[258,292],"59.0":[259],"Mb)":[260,294],"within":[261],"lincRNA":[263],"LINC01122":[264,366],"(LOD*":[265],"3.08),":[267],"suggesting":[268],"factor":[272],"influencing":[273],"high-risk":[277],"Additionally,":[279],"observed":[285],"12":[288],"rs11063479":[291],"5.1":[293],"near":[295],"KCNA5":[297,368],"gene.":[298],"The":[299,363],"variant":[300],"showed":[301],"increased":[302],"odds":[303,317],"being":[305],"high-GRS":[310],"stratum":[311,321],"(OR":[312,322],"2.07)":[314],"decreased":[316],"low-GRS":[320],"0.70),":[324],"indicating":[325],"potential":[327,374],"synergistic":[328],"risk.":[332],"Conclusions":[333],"findings":[335],"highlight":[336],"specific":[337],"regions\u2014particularly":[339],"chromosomes":[341],"12\u2014that":[344],"may":[345,397],"harbor":[346],"loci":[348],"contributing":[349],"function":[353],"individuals":[356],"identification":[364],"candidate":[370],"genes":[371,382],"underscores":[372],"role":[375],"brain-expressed":[377],"lincRNAs":[378],"potassium":[380],"channel":[381],"preserving":[384],"function.":[386],"These":[387],"results":[388],"understanding":[392],"preservation":[395],"inform":[398],"future":[399],"research":[400],"mechanisms":[404],"against":[405],"decline.":[407]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2025-10-10T00:00:00"}
