{"id":"https://openalex.org/W4413639716","doi":"https://doi.org/10.1055/s-0045-1811561","title":"Treatment-Related Toxicity Profile in Children with Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma during Induction Chemotherapy: Prospective Insights from a South Indian Cohort","display_name":"Treatment-Related Toxicity Profile in Children with Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma during Induction Chemotherapy: Prospective Insights from a South Indian Cohort","publication_year":2025,"publication_date":"2025-08-26","ids":{"openalex":"https://openalex.org/W4413639716","doi":"https://doi.org/10.1055/s-0045-1811561"},"language":"en","primary_location":{"id":"doi:10.1055/s-0045-1811561","doi":"https://doi.org/10.1055/s-0045-1811561","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0045-1811561","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0045-1811561.pdf","source":{"id":"https://openalex.org/S112025928","display_name":"Indian Journal of Medical and Paediatric Oncology","issn_l":"0971-5851","issn":["0971-5851","0975-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Medical and Paediatric Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0045-1811561.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113877838","display_name":"Monica Selvan","orcid":"https://orcid.org/0009-0005-4076-3963","observed_orcids":["https://orcid.org/0009-0005-4076-3963"]},"institutions":[{"id":"https://openalex.org/I61923386","display_name":"Jawaharlal Institute of Post Graduate Medical Education and Research","ror":"https://ror.org/02fq2px14","country_code":"IN","type":"education","lineage":["https://openalex.org/I61923386"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Monica Selvan","raw_affiliation_strings":["Departments of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"],"raw_orcid":"https://orcid.org/0009-0005-4076-3963","affiliations":[{"raw_affiliation_string":"Departments of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India","institution_ids":["https://openalex.org/I61923386"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052438565","display_name":"Jaikumar Govindaswamy Ramamoorthy","orcid":"https://orcid.org/0000-0002-0446-7260","observed_orcids":["https://orcid.org/0000-0002-0446-7260"]},"institutions":[{"id":"https://openalex.org/I61923386","display_name":"Jawaharlal Institute of Post Graduate Medical Education and Research","ror":"https://ror.org/02fq2px14","country_code":"IN","type":"education","lineage":["https://openalex.org/I61923386"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jaikumar Govindaswamy Ramamoorthy","raw_affiliation_strings":["Departments of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"],"raw_orcid":"https://orcid.org/0000-0002-0446-7260","affiliations":[{"raw_affiliation_string":"Departments of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India","institution_ids":["https://openalex.org/I61923386"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113877838"],"corresponding_institution_ids":["https://openalex.org/I61923386"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24010383,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":"02","first_page":"133","last_page":"142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/t-lymphoblastic-lymphoma","display_name":"T-cell lymphoblastic lymphoma","score":0.9300000071525574},{"id":"https://openalex.org/keywords/induction-chemotherapy","display_name":"induction chemotherapy","score":0.8629999756813049},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.9340000152587891},{"id":"https://openalex.org/keywords/treatment-delay","display_name":"treatment delay","score":0.6990000009536743},{"id":"https://openalex.org/keywords/protocol-amendments","display_name":"protocol modification","score":0.7540000081062317},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/infection-related-mortality","display_name":"infection-related mortality","score":0.9290000200271606},{"id":"https://openalex.org/keywords/risk-groups","display_name":"risk groups","score":0.7170000076293945},{"id":"https://openalex.org/keywords/pediatric-oncology","display_name":"pediatric oncology","score":0.6779999732971191},{"id":"https://openalex.org/keywords/resource-limited-settings","display_name":"resource-limited settings","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9552415609359741},{"id":"https://openalex.org/C2777478502","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic lymphoma","level":4,"score":0.7803390026092529},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.7779209613800049},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5922808647155762},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5876882076263428},{"id":"https://openalex.org/C2776611710","wikidata":"https://www.wikidata.org/wiki/Q16888295","display_name":"Induction chemotherapy","level":3,"score":0.5641341209411621},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5290592908859253},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5287606120109558},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4532930552959442},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.38630393147468567},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.360927551984787},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.23294192552566528},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1567600667476654},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0045-1811561","doi":"https://doi.org/10.1055/s-0045-1811561","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0045-1811561","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0045-1811561.pdf","source":{"id":"https://openalex.org/S112025928","display_name":"Indian Journal of Medical and Paediatric Oncology","issn_l":"0971-5851","issn":["0971-5851","0975-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Medical and Paediatric Oncology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:15b628366b7741248f10fa989a704821","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/15b628366b7741248f10fa989a704821","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Indian Journal of Medical and Paediatric Oncology, Vol 47, Iss 02, Pp 133-142 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1055/s-0045-1811561","doi":"https://doi.org/10.1055/s-0045-1811561","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0045-1811561","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0045-1811561.pdf","source":{"id":"https://openalex.org/S112025928","display_name":"Indian Journal of Medical and Paediatric Oncology","issn_l":"0971-5851","issn":["0971-5851","0975-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Medical and Paediatric Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413639716.pdf","grobid_xml":"https://content.openalex.org/works/W4413639716.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1021737805","https://openalex.org/W1569751617","https://openalex.org/W1857047053","https://openalex.org/W1988600429","https://openalex.org/W2007348709","https://openalex.org/W2057386641","https://openalex.org/W2068936243","https://openalex.org/W2082217912","https://openalex.org/W2118755887","https://openalex.org/W2125277492","https://openalex.org/W2144921015","https://openalex.org/W2154410907","https://openalex.org/W2203215848","https://openalex.org/W2284529928","https://openalex.org/W2534906573","https://openalex.org/W2596725530","https://openalex.org/W2604718291","https://openalex.org/W2750889638","https://openalex.org/W2765593029","https://openalex.org/W2772927421","https://openalex.org/W2781471255","https://openalex.org/W2782475041","https://openalex.org/W2794199605","https://openalex.org/W2953490199","https://openalex.org/W2955165098","https://openalex.org/W3097138268","https://openalex.org/W3192994525","https://openalex.org/W4210295748","https://openalex.org/W4221091419","https://openalex.org/W4289756512"],"related_works":["https://openalex.org/W2542651472","https://openalex.org/W4409054336","https://openalex.org/W4200474412","https://openalex.org/W4392772646","https://openalex.org/W4409054508","https://openalex.org/W2972976158","https://openalex.org/W4238608405","https://openalex.org/W4233683617","https://openalex.org/W2407840394","https://openalex.org/W2660330130"],"abstract_inverted_index":{"Abstract":[0],"There":[1],"is":[2,21],"limited":[3],"data":[4],"on":[5],"treatment-related":[6,44,273],"toxicity":[7,45],"and":[8,25,58,63,83,97,112,115,148,158,166,175,205,235,270,282,284],"mortality":[9,214,221],"in":[10,17,184,192,199,224],"children":[11,37,78,117,186],"with":[12,38,86,118,188,241,256,275,294],"acute":[13],"lymphoblastic":[14,40],"leukemia":[15],"(ALL)":[16],"resource-limited":[18],"settings,":[19],"which":[20,141,150,171,219],"important":[22],"for":[23,108],"anticipation":[24],"better":[26],"prophylactic":[27],"care.":[28],"This":[29],"study":[30,50,74,266],"aims":[31],"to":[32,49,203],"determine":[33],"the":[34,51,55,104,242,257,268,279,298],"proportion":[35,52],"of":[36,53,60,65,121,132,140,145,154,170,218,237,251,272,300],"ALL/T-":[39],"lymphoma":[41],"(T-LL)":[42],"developing":[43],"during":[46,94],"induction":[47,95,213],"chemotherapy,":[48],"mortality,":[54],"cumulative":[56],"duration":[57],"frequency":[59,64],"treatment":[61,66,180,285],"delays,":[62],"protocol":[67],"modifications.":[68],"It":[69],"was":[70,197,216,222,230,292],"a":[71],"prospective":[72],"cohort":[73],"where":[75],"all":[76],"consecutive":[77],"aged":[79],"between":[80,232],"1":[81],"month":[82],"15":[84],"years":[85,123],"ALL/T-LL":[87],"were":[88,91,99,128,135,144,151,161,173,177,182],"included.":[89],"They":[90],"followed":[92],"up":[93],"chemotherapy":[96],"toxicities":[98,134,160,204,236,254,277],"recorded,":[100],"graded":[101],"as":[102],"per":[103],"Common":[105],"Terminology":[106],"Criteria":[107],"Adverse":[109],"Events":[110],"grading,":[111],"analyzed.":[113],"One-hundred":[114],"one":[116],"median":[119],"age":[120],"6":[122],"(interquartile":[124],"range:":[125],"3,":[126,156,240],"11)":[127],"enrolled.":[129],"A":[130,226],"total":[131],"696":[133],"recorded":[136],"among":[137],"101":[138],"children,":[139],"418":[142],"(60.06%)":[143],"grades":[146,155],"3":[147],"above,":[149],"studied.":[152],"Number":[153],"4,":[157],"5":[159,167],"236":[162],"(33.91%),":[163],"176":[164],"(25.29%),":[165],"(0.72%),":[168],"respectively;":[169],"73.2%":[172],"hematological":[174,276],"26.8%":[176],"nonhematological.":[178],"Sixty-five":[179],"breaks":[181],"observed":[183,198,223,231],"51":[185],"(50.49%),":[187],"majority":[189],"(34%)":[190],"occurring":[191],"week":[193],"3.":[194],"Protocol":[195],"modification":[196],"10":[200],"(9.9%)":[201],"due":[202],"9":[206],"(8.9%)":[207],"required":[208],"intensive":[209],"care":[210],"admission.":[211],"Our":[212],"rate":[215],"8.9%,":[217],"infection-related":[220],"4.9%.":[225],"statistically":[227],"significant":[228],"association":[229],"risk":[233,244,259],"group":[234,245],"grade":[238],"\u2265":[239],"nonstandard":[243],"exhibiting":[246],"3.21":[247],"times":[248],"higher":[249],"odds":[250],"experiencing":[252],"these":[253],"compared":[255],"standard":[258],"group.":[260],"The":[261],"results":[262],"obtained":[263],"from":[264],"our":[265],"showed":[267],"prevalence":[269],"profile":[271],"toxicities,":[274],"being":[278,287],"most":[280],"prevalent":[281],"infections":[283],"delays":[286],"major":[288],"concerns.":[289],"High-risk":[290],"disease":[291],"associated":[293],"increased":[295],"toxicity,":[296],"reinforcing":[297],"importance":[299],"proactive":[301],"management":[302],"strategies.":[303]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}