{"id":"https://openalex.org/W4413638484","doi":"https://doi.org/10.1007/s10875-025-01897-9","title":"Common Variable Immunodeficiency Disorder: A Decade of Insights from a Cohort of 150 Patients in India and the Use of Machine Learning Algorithms to Predict Severity","display_name":"Common Variable Immunodeficiency Disorder: A Decade of Insights from a Cohort of 150 Patients in India and the Use of Machine Learning Algorithms to Predict Severity","publication_year":2025,"publication_date":"2025-08-26","ids":{"openalex":"https://openalex.org/W4413638484","doi":"https://doi.org/10.1007/s10875-025-01897-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/40856873","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12380919"},"language":"en","primary_location":{"id":"doi:10.1007/s10875-025-01897-9","doi":"https://doi.org/10.1007/s10875-025-01897-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10875-025-01897-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10875-025-01897-9.pdf","source":{"id":"https://openalex.org/S57504206","display_name":"Journal of Clinical Immunology","issn_l":"0271-9142","issn":["0271-9142","1573-2592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10875-025-01897-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057267024","display_name":"Umair Ahmed Bargir","orcid":"https://orcid.org/0000-0001-6785-8042","observed_orcids":["https://orcid.org/0000-0001-6785-8042"]},"institutions":[{"id":"https://openalex.org/I4210108545","display_name":"ICMR - National Institute of Immunohaemotology","ror":"https://ror.org/01mfest76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210108545"]},{"id":"https://openalex.org/I4210148827","display_name":"Birla Institute of Technology and Science, Pilani - Goa Campus","ror":"https://ror.org/046sh6j17","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210148827","https://openalex.org/I74796645"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Umair Ahmed Bargir","raw_affiliation_strings":["Birla Institute of Technology and Science, Pilani - Goa Campus, Sancoale, India","ICMR National Institute of Immunohaematology, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birla Institute of Technology and Science, Pilani - Goa Campus, Sancoale, India","institution_ids":["https://openalex.org/I4210148827"]},{"raw_affiliation_string":"ICMR National Institute of Immunohaematology, Mumbai, India","institution_ids":["https://openalex.org/I4210108545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020413151","display_name":"Priyanka Setia","orcid":"https://orcid.org/0000-0003-0985-0303","observed_orcids":["https://orcid.org/0000-0003-0985-0303"]},"institutions":[{"id":"https://openalex.org/I4210108545","display_name":"ICMR - National Institute of Immunohaemotology","ror":"https://ror.org/01mfest76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210108545"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Priyanka Setia","raw_affiliation_strings":["ICMR National Institute of Immunohaematology, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR National Institute of Immunohaematology, Mumbai, India","institution_ids":["https://openalex.org/I4210108545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110007978","display_name":"Mukesh Desai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111325","display_name":"Bai Jerbai Wadia Hospital for Children","ror":"https://ror.org/02rw2zs46","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210111325"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mukesh Desai","raw_affiliation_strings":["Bai Jerbai Wadia Hospital for Children, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bai Jerbai Wadia Hospital for Children, Mumbai, India","institution_ids":["https://openalex.org/I4210111325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027123388","display_name":"Chandrakala Shanmukhaiah","orcid":"https://orcid.org/0000-0001-6414-866X","observed_orcids":["https://orcid.org/0000-0001-6414-866X"]},"institutions":[{"id":"https://openalex.org/I193353881","display_name":"King Edward Memorial Hospital and Seth G.S. Medical College","ror":"https://ror.org/03vcw1x21","country_code":"IN","type":"education","lineage":["https://openalex.org/I193353881"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chandrakala S","raw_affiliation_strings":["King Edward Memorial Hospital and Seth G.S. Medical College, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Edward Memorial Hospital and Seth G.S. Medical College, Mumbai, India","institution_ids":["https://openalex.org/I193353881"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013012003","display_name":"Aparna Dhondi Dalvi","orcid":"https://orcid.org/0009-0007-6972-6474","observed_orcids":["https://orcid.org/0009-0007-6972-6474"]},"institutions":[{"id":"https://openalex.org/I4210108545","display_name":"ICMR - National Institute of Immunohaemotology","ror":"https://ror.org/01mfest76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210108545"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aparna Dalvi","raw_affiliation_strings":["ICMR National Institute of Immunohaematology, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR National Institute of Immunohaematology, Mumbai, India","institution_ids":["https://openalex.org/I4210108545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033420497","display_name":"Shweta Shinde","orcid":"https://orcid.org/0009-0003-7012-7605","observed_orcids":["https://orcid.org/0009-0003-7012-7605"]},"institutions":[{"id":"https://openalex.org/I4210108545","display_name":"ICMR - National Institute of Immunohaemotology","ror":"https://ror.org/01mfest76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210108545"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shweta Shinde","raw_affiliation_strings":["ICMR National Institute of Immunohaematology, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR National Institute of Immunohaematology, Mumbai, India","institution_ids":["https://openalex.org/I4210108545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064659418","display_name":"Maya Gupta","orcid":"https://orcid.org/0009-0005-1747-977X","observed_orcids":["https://orcid.org/0009-0005-1747-977X"]},"institutions":[{"id":"https://openalex.org/I4210108545","display_name":"ICMR - National Institute of Immunohaemotology","ror":"https://ror.org/01mfest76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210108545"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Maya Gupta","raw_affiliation_strings":["ICMR National Institute of Immunohaematology, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR National Institute of Immunohaematology, Mumbai, India","institution_ids":["https://openalex.org/I4210108545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083301242","display_name":"Neha Jodhawat","orcid":"https://orcid.org/0000-0002-7752-3956","observed_orcids":["https://orcid.org/0000-0002-7752-3956"]},"institutions":[{"id":"https://openalex.org/I4210108545","display_name":"ICMR - National Institute of Immunohaemotology","ror":"https://ror.org/01mfest76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210108545"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Neha Jodhawat","raw_affiliation_strings":["ICMR National Institute of Immunohaematology, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR National Institute of Immunohaematology, Mumbai, India","institution_ids":["https://openalex.org/I4210108545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049884600","display_name":"Amrutha Jose","orcid":"https://orcid.org/0000-0002-1192-2217","observed_orcids":["https://orcid.org/0000-0002-1192-2217"]},"institutions":[{"id":"https://openalex.org/I4210108545","display_name":"ICMR - National Institute of Immunohaemotology","ror":"https://ror.org/01mfest76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210108545"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amrutha Jose","raw_affiliation_strings":["ICMR National Institute of Immunohaematology, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR National Institute of Immunohaematology, Mumbai, India","institution_ids":["https://openalex.org/I4210108545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033847185","display_name":"Mayuri Goriwale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108545","display_name":"ICMR - National Institute of Immunohaemotology","ror":"https://ror.org/01mfest76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210108545"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mayuri Goriwale","raw_affiliation_strings":["ICMR National Institute of Immunohaematology, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR National Institute of Immunohaematology, Mumbai, India","institution_ids":["https://openalex.org/I4210108545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063036148","display_name":"Reetika Malik Yadav","orcid":"https://orcid.org/0000-0002-5030-0437","observed_orcids":["https://orcid.org/0000-0002-5030-0437"]},"institutions":[{"id":"https://openalex.org/I4210108545","display_name":"ICMR - National Institute of Immunohaemotology","ror":"https://ror.org/01mfest76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210108545"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Reetika Malik Yadav","raw_affiliation_strings":["ICMR National Institute of Immunohaematology, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR National Institute of Immunohaematology, Mumbai, India","institution_ids":["https://openalex.org/I4210108545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081756610","display_name":"Disha Vedpathak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108545","display_name":"ICMR - National Institute of Immunohaemotology","ror":"https://ror.org/01mfest76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210108545"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Disha Vedpathak","raw_affiliation_strings":["ICMR National Institute of Immunohaematology, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR National Institute of Immunohaematology, Mumbai, India","institution_ids":["https://openalex.org/I4210108545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114383689","display_name":"Lavina Temkar","orcid":"https://orcid.org/0000-0002-3448-5638","observed_orcids":["https://orcid.org/0000-0002-3448-5638"]},"institutions":[{"id":"https://openalex.org/I4210108545","display_name":"ICMR - National Institute of Immunohaemotology","ror":"https://ror.org/01mfest76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210108545"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Lavina Temkar","raw_affiliation_strings":["ICMR National Institute of Immunohaematology, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR National Institute of Immunohaematology, Mumbai, India","institution_ids":["https://openalex.org/I4210108545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045184500","display_name":"Snehal Shabrish","orcid":"https://orcid.org/0000-0002-6407-5082","observed_orcids":["https://orcid.org/0000-0002-6407-5082"]},"institutions":[{"id":"https://openalex.org/I4210108545","display_name":"ICMR - National Institute of Immunohaemotology","ror":"https://ror.org/01mfest76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210108545"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Snehal Shabrish","raw_affiliation_strings":["ICMR National Institute of Immunohaematology, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR National Institute of Immunohaematology, Mumbai, India","institution_ids":["https://openalex.org/I4210108545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054225995","display_name":"Gouri Hule","orcid":"https://orcid.org/0000-0003-0558-743X","observed_orcids":["https://orcid.org/0000-0003-0558-743X"]},"institutions":[{"id":"https://openalex.org/I4210108545","display_name":"ICMR - National Institute of Immunohaemotology","ror":"https://ror.org/01mfest76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210108545"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gouri Hule","raw_affiliation_strings":["ICMR National Institute of Immunohaematology, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR National Institute of Immunohaematology, Mumbai, India","institution_ids":["https://openalex.org/I4210108545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014796722","display_name":"Vijaya Gowri","orcid":"https://orcid.org/0000-0003-4811-4595","observed_orcids":["https://orcid.org/0000-0003-4811-4595"]},"institutions":[{"id":"https://openalex.org/I4210111325","display_name":"Bai Jerbai Wadia Hospital for Children","ror":"https://ror.org/02rw2zs46","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210111325"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vijaya Gowri","raw_affiliation_strings":["Bai Jerbai Wadia Hospital for Children, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bai Jerbai Wadia Hospital for Children, Mumbai, India","institution_ids":["https://openalex.org/I4210111325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110613830","display_name":"Prasad D. Taur","orcid":"https://orcid.org/0000-0002-3594-631X","observed_orcids":["https://orcid.org/0000-0002-3594-631X"]},"institutions":[{"id":"https://openalex.org/I4210111325","display_name":"Bai Jerbai Wadia Hospital for Children","ror":"https://ror.org/02rw2zs46","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210111325"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prasad Taur","raw_affiliation_strings":["Bai Jerbai Wadia Hospital for Children, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bai Jerbai Wadia Hospital for Children, Mumbai, India","institution_ids":["https://openalex.org/I4210111325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112077438","display_name":"Amita Umesh Athavale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193353881","display_name":"King Edward Memorial Hospital and Seth G.S. Medical College","ror":"https://ror.org/03vcw1x21","country_code":"IN","type":"education","lineage":["https://openalex.org/I193353881"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amita Athavale","raw_affiliation_strings":["King Edward Memorial Hospital and Seth G.S. Medical College, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Edward Memorial Hospital and Seth G.S. Medical College, Mumbai, India","institution_ids":["https://openalex.org/I193353881"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089646665","display_name":"Farah F. Jijina","orcid":"https://orcid.org/0000-0002-6568-5667","observed_orcids":["https://orcid.org/0000-0002-6568-5667"]},"institutions":[{"id":"https://openalex.org/I193353881","display_name":"King Edward Memorial Hospital and Seth G.S. Medical College","ror":"https://ror.org/03vcw1x21","country_code":"IN","type":"education","lineage":["https://openalex.org/I193353881"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Farah Jijina","raw_affiliation_strings":["King Edward Memorial Hospital and Seth G.S. Medical College, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Edward Memorial Hospital and Seth G.S. Medical College, Mumbai, India","institution_ids":["https://openalex.org/I193353881"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069901037","display_name":"Shobna J. Bhatia","orcid":"https://orcid.org/0000-0001-6132-0356","observed_orcids":["https://orcid.org/0000-0001-6132-0356"]},"institutions":[{"id":"https://openalex.org/I193353881","display_name":"King Edward Memorial Hospital and Seth G.S. Medical College","ror":"https://ror.org/03vcw1x21","country_code":"IN","type":"education","lineage":["https://openalex.org/I193353881"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shobna Bhatia","raw_affiliation_strings":["King Edward Memorial Hospital and Seth G.S. Medical College, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Edward Memorial Hospital and Seth G.S. Medical College, Mumbai, India","institution_ids":["https://openalex.org/I193353881"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034427331","display_name":"Akash Shukla","orcid":"https://orcid.org/0000-0001-7718-9452","observed_orcids":["https://orcid.org/0000-0001-7718-9452"]},"institutions":[{"id":"https://openalex.org/I193353881","display_name":"King Edward Memorial Hospital and Seth G.S. Medical College","ror":"https://ror.org/03vcw1x21","country_code":"IN","type":"education","lineage":["https://openalex.org/I193353881"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Akash Shukla","raw_affiliation_strings":["King Edward Memorial Hospital and Seth G.S. Medical College, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Edward Memorial Hospital and Seth G.S. Medical College, Mumbai, India","institution_ids":["https://openalex.org/I193353881"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002319978","display_name":"Manas Kalra","orcid":"https://orcid.org/0000-0003-2570-7750","observed_orcids":["https://orcid.org/0000-0003-2570-7750"]},"institutions":[{"id":"https://openalex.org/I4210113434","display_name":"Sir Ganga Ram Hospital","ror":"https://ror.org/01x18vk56","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210113434"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manas Kalra","raw_affiliation_strings":["Sir Ganga Ram Hospital, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir Ganga Ram Hospital, New Delhi, India","institution_ids":["https://openalex.org/I4210113434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064378477","display_name":"Meena Sivasankaran","orcid":"https://orcid.org/0000-0001-5759-125X","observed_orcids":["https://orcid.org/0000-0001-5759-125X"]},"institutions":[{"id":"https://openalex.org/I4210135524","display_name":"Kanchi Kamakoti CHILDS Trust Hospital","ror":"https://ror.org/04g3z9997","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210135524"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Meena Sivasankaran","raw_affiliation_strings":["Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India","institution_ids":["https://openalex.org/I4210135524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011105397","display_name":"Sarath Balaji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159337121","display_name":"Madras Medical College","ror":"https://ror.org/050ztxn78","country_code":"IN","type":"education","lineage":["https://openalex.org/I159337121"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sarath Balaji","raw_affiliation_strings":["Madras Medical College, Chennai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Madras Medical College, Chennai, India","institution_ids":["https://openalex.org/I159337121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075637290","display_name":"Punit L. Jain","orcid":"https://orcid.org/0000-0003-3711-1014","observed_orcids":["https://orcid.org/0000-0003-3711-1014"]},"institutions":[{"id":"https://openalex.org/I1327930874","display_name":"Apollo Hospitals","ror":"https://ror.org/02ew45630","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I1327930874"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Punit Jain","raw_affiliation_strings":["Apollo Hospitals, Chennai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Apollo Hospitals, Chennai, India","institution_ids":["https://openalex.org/I1327930874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108740718","display_name":"Sujata Sharma","orcid":"https://orcid.org/0000-0002-8446-1714","observed_orcids":["https://orcid.org/0000-0002-8446-1714"]},"institutions":[{"id":"https://openalex.org/I2800471911","display_name":"Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College","ror":"https://ror.org/03fvp2v86","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2800471911"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sujata Sharma","raw_affiliation_strings":["Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College, Mumbai, India","institution_ids":["https://openalex.org/I2800471911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009704063","display_name":"Harikrishnan Gangadharan","orcid":"https://orcid.org/0000-0001-5313-7316","observed_orcids":["https://orcid.org/0000-0001-5313-7316"]},"institutions":[{"id":"https://openalex.org/I180771373","display_name":"Government Medical College","ror":"https://ror.org/05w6g2m14","country_code":"IN","type":"education","lineage":["https://openalex.org/I180771373"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Harikrishnan Gangadharan","raw_affiliation_strings":["Government Medical College, Kottayam, Kottayam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Government Medical College, Kottayam, Kottayam, India","institution_ids":["https://openalex.org/I180771373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025181359","display_name":"Gaurav Narula","orcid":"https://orcid.org/0000-0002-8539-295X","observed_orcids":["https://orcid.org/0000-0002-8539-295X"]},"institutions":[{"id":"https://openalex.org/I2800098698","display_name":"Tata Memorial Hospital","ror":"https://ror.org/010842375","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2800098698"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gaurav Narula","raw_affiliation_strings":["Tata Memorial Hospital, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tata Memorial Hospital, Mumbai, India","institution_ids":["https://openalex.org/I2800098698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001648077","display_name":"Ratna Sharma","orcid":"https://orcid.org/0000-0001-6810-3514","observed_orcids":["https://orcid.org/0000-0001-6810-3514"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ratna Sharma","raw_affiliation_strings":["MCGM - Comprehensive Thalassemia Care, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCGM - Comprehensive Thalassemia Care, Mumbai, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112464363","display_name":"Pranoti Kini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pranoti Kini","raw_affiliation_strings":["MCGM - Comprehensive Thalassemia Care, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCGM - Comprehensive Thalassemia Care, Mumbai, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114383690","display_name":"Mamta Mangalani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mamta Mangalani","raw_affiliation_strings":["MCGM - Comprehensive Thalassemia Care, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCGM - Comprehensive Thalassemia Care, Mumbai, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076075339","display_name":"Abhishek Arvind Zanwar","orcid":"https://orcid.org/0000-0002-9950-0384","observed_orcids":["https://orcid.org/0000-0002-9950-0384"]},"institutions":[{"id":"https://openalex.org/I2801897644","display_name":"Ruby Hall Clinic","ror":"https://ror.org/017bedv79","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2801897644"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abhishek Zanwar","raw_affiliation_strings":["Ruby Hall Clinic, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ruby Hall Clinic, Pune, India","institution_ids":["https://openalex.org/I2801897644"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Himanshi Chaudhary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801897644","display_name":"Ruby Hall Clinic","ror":"https://ror.org/017bedv79","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2801897644"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Himanshi Chaudhary","raw_affiliation_strings":["Ruby Hall Clinic, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ruby Hall Clinic, Pune, India","institution_ids":["https://openalex.org/I2801897644"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Narendra Kumar Chaudhary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106490","display_name":"All India Institute of Medical Sciences Bhopal","ror":"https://ror.org/01rs0zz87","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210106490"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Narendra Kumar Chaudhary","raw_affiliation_strings":["All India Institute of Medical Sciences Bhopal, Bhopal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All India Institute of Medical Sciences Bhopal, Bhopal, India","institution_ids":["https://openalex.org/I4210106490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073793731","display_name":"Ujjawal Khurana","orcid":"https://orcid.org/0000-0003-3913-7111","observed_orcids":["https://orcid.org/0000-0003-3913-7111"]},"institutions":[{"id":"https://openalex.org/I4210106490","display_name":"All India Institute of Medical Sciences Bhopal","ror":"https://ror.org/01rs0zz87","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210106490"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ujjawal Khurana","raw_affiliation_strings":["All India Institute of Medical Sciences Bhopal, Bhopal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All India Institute of Medical Sciences Bhopal, Bhopal, India","institution_ids":["https://openalex.org/I4210106490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047138862","display_name":"Ashish Bavdekar","orcid":"https://orcid.org/0009-0006-9466-4095","observed_orcids":["https://orcid.org/0009-0006-9466-4095"]},"institutions":[{"id":"https://openalex.org/I4210148958","display_name":"King Edward Memorial Hospital Research Centre","ror":"https://ror.org/056yyyw24","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210148958"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ashish Bavdekar","raw_affiliation_strings":["King Edward Memorial Hospital Research Centre, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Edward Memorial Hospital Research Centre, Pune, India","institution_ids":["https://openalex.org/I4210148958"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110665677","display_name":"Girish Subramaniam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Girish Subramaniam","raw_affiliation_strings":["Colours hospital, Nagpur, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Colours hospital, Nagpur, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017204598","display_name":"Revathi Raj","orcid":"https://orcid.org/0000-0003-1415-4142","observed_orcids":["https://orcid.org/0000-0003-1415-4142"]},"institutions":[{"id":"https://openalex.org/I1327930874","display_name":"Apollo Hospitals","ror":"https://ror.org/02ew45630","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I1327930874"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Revathi Raj","raw_affiliation_strings":["Apollo Hospitals Cancer Center, Chennai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Apollo Hospitals Cancer Center, Chennai, India","institution_ids":["https://openalex.org/I1327930874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114383691","display_name":"Subhaprakash Saniyal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122382","display_name":"Fortis Hospital","ror":"https://ror.org/02vxh6479","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210122382"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Subhaprakash Saniyal","raw_affiliation_strings":["Fortis Hospital, Noida, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fortis Hospital, Noida, India","institution_ids":["https://openalex.org/I4210122382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038587545","display_name":"Nitin Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800474033","display_name":"P. D. Hinduja Hospital and Medical Research Centre","ror":"https://ror.org/00a6fbp85","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2800474033"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nitin Shah","raw_affiliation_strings":["P. D. Hinduja Hospital and Medical Research Centre, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P. D. Hinduja Hospital and Medical Research Centre, Mumbai, India","institution_ids":["https://openalex.org/I2800474033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114383692","display_name":"Tehsin Petiwala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tehsin Petiwala","raw_affiliation_strings":["Masina Hospital, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masina Hospital, Mumbai, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053413871","display_name":"Prawin Kumar","orcid":"https://orcid.org/0000-0002-2365-8097","observed_orcids":["https://orcid.org/0000-0002-2365-8097"]},"institutions":[{"id":"https://openalex.org/I216021267","display_name":"All India Institute of Medical Sciences Jodhpur","ror":"https://ror.org/05e15a779","country_code":"IN","type":"education","lineage":["https://openalex.org/I216021267","https://openalex.org/I2799351866","https://openalex.org/I4210148677"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prawin Kumar","raw_affiliation_strings":["All India Institute of Medical Sciences Jodhpur, Jodhpur, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All India Institute of Medical Sciences Jodhpur, Jodhpur, India","institution_ids":["https://openalex.org/I216021267"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000814848","display_name":"Venkatesh S Pai","orcid":"https://orcid.org/0000-0002-5935-8627","observed_orcids":["https://orcid.org/0000-0002-5935-8627"]},"institutions":[{"id":"https://openalex.org/I4387152206","display_name":"All India Institute of Medical Sciences Rishikesh","ror":"https://ror.org/05qjwb041","country_code":"IN","type":"government","lineage":["https://openalex.org/I4387152206"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Venkatesh Pai","raw_affiliation_strings":["All India Institute of Medical Sciences Rishikesh, Rishikesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All India Institute of Medical Sciences Rishikesh, Rishikesh, India","institution_ids":["https://openalex.org/I4387152206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085528417","display_name":"Sagar Bhattad","orcid":"https://orcid.org/0000-0002-5048-9727","observed_orcids":["https://orcid.org/0000-0002-5048-9727"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sagar Bhattad","raw_affiliation_strings":["Aster CMI Hospital, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aster CMI Hospital, Bangalore, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103999959","display_name":"Abhinav Sengupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abhinav Sengupta","raw_affiliation_strings":["All India Institute of Medical Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029216095","display_name":"Manish Soneja","orcid":"https://orcid.org/0000-0002-8619-7929","observed_orcids":["https://orcid.org/0000-0002-8619-7929","https://orcid.org/0000-0001-7904-4409"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manish Soneja","raw_affiliation_strings":["All India Institute of Medical Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114383693","display_name":"Dayanand Upase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201202376","display_name":"B. J. Medical College & Sassoon Hospital","ror":"https://ror.org/00bchtj94","country_code":"IN","type":"education","lineage":["https://openalex.org/I201202376"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dayanand Upase","raw_affiliation_strings":["Sassoon General Hospital, Pune, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sassoon General Hospital, Pune, India","institution_ids":["https://openalex.org/I201202376"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063012252","display_name":"Abhijeet Ganapule","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abhijeet Ganapule","raw_affiliation_strings":["Niche Haematology Care, Kolhapur, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Niche Haematology Care, Kolhapur, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Indrani Talukdar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148827","display_name":"Birla Institute of Technology and Science, Pilani - Goa Campus","ror":"https://ror.org/046sh6j17","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210148827","https://openalex.org/I74796645"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Indrani Talukdar","raw_affiliation_strings":["Birla Institute of Technology and Science, Pilani - Goa Campus, Sancoale, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Birla Institute of Technology and Science, Pilani - Goa Campus, Sancoale, India","institution_ids":["https://openalex.org/I4210148827"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029028924","display_name":"Manisha Rajan Madkaikar","orcid":"https://orcid.org/0000-0001-6380-3116","observed_orcids":["https://orcid.org/0000-0001-6380-3116","https://orcid.org/0009-0008-5604-6928"]},"institutions":[{"id":"https://openalex.org/I4210108545","display_name":"ICMR - National Institute of Immunohaemotology","ror":"https://ror.org/01mfest76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I4210108545"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Manisha Madkaikar","raw_affiliation_strings":["ICMR National Institute of Immunohaematology, Mumbai, India. madkaikarmanisha@gmail.com","ICMR National Institute of Immunohaematology, Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICMR National Institute of Immunohaematology, Mumbai, India. madkaikarmanisha@gmail.com","institution_ids":["https://openalex.org/I4210108545"]},{"raw_affiliation_string":"ICMR National Institute of Immunohaematology, Mumbai, India","institution_ids":["https://openalex.org/I4210108545"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":20,"corresponding_author_ids":["https://openalex.org/A5029028924"],"corresponding_institution_ids":["https://openalex.org/I4210108545"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":1.2462,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.75095082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"45","issue":"1","first_page":"127","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/common-variable-immunodeficiency","display_name":"common variable immunodeficiency","score":1.0},{"id":"https://openalex.org/keywords/disease-severity-prediction","display_name":"disease severity prediction","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hypogammaglobulinemia","display_name":"hypogammaglobulinemia","score":0.9240000247955322},{"id":"https://openalex.org/keywords/class-switched-memory-b-cells","display_name":"class-switched memory B cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/igm-levels","display_name":"IgM levels","score":0.5630000233650208},{"id":"https://openalex.org/keywords/iga-deficiency","display_name":"IgA deficiency","score":0.7699999809265137},{"id":"https://openalex.org/keywords/lrba-deficiency","display_name":"LRBA deficiency","score":0.8149999976158142},{"id":"https://openalex.org/keywords/recurrent-respiratory-tract-infections","display_name":"recurrent respiratory infections","score":0.6909999847412109},{"id":"https://openalex.org/keywords/gastrointestinal-complications","display_name":"gastrointestinal complications","score":0.9010000228881836},{"id":"https://openalex.org/keywords/autoimmune-manifestations","display_name":"autoimmune manifestations","score":0.9800000190734863},{"id":"https://openalex.org/keywords/random-forest","display_name":"random forest","score":0.621999979019165},{"id":"https://openalex.org/keywords/cd19","display_name":"CD19","score":0.8500000238418579},{"id":"https://openalex.org/keywords/indian-patients","display_name":"Indian patients","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C190139176","wikidata":"https://www.wikidata.org/wiki/Q598976","display_name":"Medical microbiology","level":2,"score":0.6950254440307617},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6017398238182068},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.506794273853302},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.5011627674102783},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4729580283164978},{"id":"https://openalex.org/C2776433325","wikidata":"https://www.wikidata.org/wiki/Q1472818","display_name":"Common variable immunodeficiency","level":3,"score":0.4551548659801483},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.39147114753723145},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3690890073776245},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34604841470718384},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2865408957004547},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19173967838287354},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007194","descriptor_name":"India","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017074","descriptor_name":"Common Variable Immunodeficiency","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D017074","descriptor_name":"Common Variable Immunodeficiency","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017074","descriptor_name":"Common Variable Immunodeficiency","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s10875-025-01897-9","doi":"https://doi.org/10.1007/s10875-025-01897-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10875-025-01897-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10875-025-01897-9.pdf","source":{"id":"https://openalex.org/S57504206","display_name":"Journal of Clinical Immunology","issn_l":"0271-9142","issn":["0271-9142","1573-2592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Immunology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-5208212/v1","doi":"https://doi.org/10.21203/rs.3.rs-5208212/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-5208212/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:12380919","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12380919","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12380919/pdf/10875_2025_Article_1897.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Immunol","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11189484","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12380919","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40856873","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40856873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s10875-025-01897-9","doi":"https://doi.org/10.1007/s10875-025-01897-9","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10875-025-01897-9","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10875-025-01897-9.pdf","source":{"id":"https://openalex.org/S57504206","display_name":"Journal of Clinical Immunology","issn_l":"0271-9142","issn":["0271-9142","1573-2592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413638484.pdf","grobid_xml":"https://content.openalex.org/works/W4413638484.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1573128760","https://openalex.org/W1995839977","https://openalex.org/W2001253726","https://openalex.org/W2035451300","https://openalex.org/W2043651710","https://openalex.org/W2049156141","https://openalex.org/W2065293336","https://openalex.org/W2095505747","https://openalex.org/W2098542011","https://openalex.org/W2157409321","https://openalex.org/W2168791265","https://openalex.org/W2235970093","https://openalex.org/W2291087001","https://openalex.org/W2291149141","https://openalex.org/W2416780290","https://openalex.org/W2521144288","https://openalex.org/W2767938693","https://openalex.org/W2917419158","https://openalex.org/W2935070166","https://openalex.org/W2966003590","https://openalex.org/W2971081730","https://openalex.org/W2996267070","https://openalex.org/W2998817435","https://openalex.org/W3123033408","https://openalex.org/W3135819408","https://openalex.org/W3136319625","https://openalex.org/W3151175124","https://openalex.org/W3170951402","https://openalex.org/W4206823903","https://openalex.org/W4213029195","https://openalex.org/W4248017847","https://openalex.org/W4310179919","https://openalex.org/W4366984002","https://openalex.org/W4380449839","https://openalex.org/W4389093035"],"related_works":["https://openalex.org/W2521144288","https://openalex.org/W4408223941","https://openalex.org/W2169366468","https://openalex.org/W2105313480","https://openalex.org/W1977851784","https://openalex.org/W4321261357","https://openalex.org/W3032683252","https://openalex.org/W2150864055","https://openalex.org/W3017273077","https://openalex.org/W3018790683"],"abstract_inverted_index":{"Common":[0],"Variable":[1],"Immunodeficiency":[2],"(CVID)":[3],"is":[4],"a":[5,33,50,53,68,78,188,300],"heterogeneous":[6],"disorder":[7],"characterized":[8],"by":[9],"impaired":[10],"antibody":[11],"production":[12],"and":[13,23,31,118,166,182,208,216,254,271,285],"recurrent":[14,82],"infections.":[15],"In":[16],"this":[17],"study":[18,266],"we":[19],"investigated":[20],"the":[21,87,173,258,268,280],"clinical":[22,90,225,270],"immunological":[24,272],"features":[25,273],"of":[26,62,74,99,127,239,274],"CVID":[27,48,196,275],"in":[28,57,97,106,125,163,179,276],"Indian":[29,277],"patients":[30,45,75,109,147],"develops":[32],"machine":[34,190,290],"learning":[35,291],"model":[36,194,292],"for":[37,195,219,262,282,303],"predicting":[38,220,304],"disease":[39,221,305],"severity.":[40],"We":[41,186],"retrospectively":[42],"analyzed":[43],"150":[44],"diagnosed":[46],"with":[47,67,81,115,139,149],"over":[49],"decade":[51],"at":[52],"tertiary":[54],"care":[55],"center":[56],"India.":[58],"The":[59,72,289],"median":[60],"age":[61],"diagnosis":[63,284],"was":[64,172],"18":[65],"years,":[66],"male":[69],"predominance":[70],"(62%).":[71],"majority":[73],"(66.6%)":[76],"had":[77,133],"severe":[79],"phenotype,":[80],"respiratory":[83],"tract":[84],"infections":[85],"being":[86],"most":[88,174,259],"common":[89,175],"manifestation":[91],"(84.2%).":[92],"Gastrointestinal":[93],"complications":[94],"were":[95,104,123],"observed":[96],"45%":[98],"patients,":[100,158,197,278],"while":[101],"autoimmune":[102],"manifestations":[103],"seen":[105],"21%.":[107],"All":[108],"exhibited":[110],"hypogammaglobulinemia.":[111],"IgA":[112],"levels":[113,122,211,256],"varied,":[114],"7.8%":[116],"normal":[117],"14.5%":[119],"undetectable.":[120],"IgM":[121,255],"decreased":[124],"85.5%":[126],"patients.":[128,169,185],"B-cell":[129],"analysis":[130,246],"revealed":[131],"64.4%":[132],"reduced":[134],"class-switched":[135,203],"memory":[136,204],"B":[137,205],"cells,":[138],"21.7%":[140],"showing":[141],"very":[142],"low":[143],"levels.":[144],"Nine":[145],"adult":[146,168,184],"presented":[148],"late-onset":[150],"combined":[151],"immunodeficiency.":[152],"Genetic":[153],"testing,":[154],"performed":[155],"on":[156],"52":[157],"identified":[159,250],"underlying":[160],"monogenic":[161],"causes":[162],"29":[164],"pediatric":[165,181],"15":[167],"LRBA":[170],"deficiency":[171],"genetic":[176],"defect,":[177],"found":[178],"seven":[180],"three":[183],"developed":[187,293],"novel":[189],"learning-based":[191],"severity":[192,222,226,263],"prediction":[193],"utilizing":[198],"readily":[199],"available":[200,296],"lymphocyte":[201],"subsets,":[202],"cell":[206],"counts,":[207],"serum":[209],"immunoglobulin":[210],"to":[212,311],"provide":[213,299],"an":[214,237],"accessible":[215],"robust":[217,301],"tool":[218,302],"using":[223,294],"Ameratunga's":[224],"score.":[227],"Random":[228],"Forest":[229],"outperformed":[230],"other":[231],"models":[232,249],"across":[233,247],"all":[234,248],"metrics,":[235],"achieving":[236],"accuracy":[238],"0.853":[240],"(95%":[241],"CI:":[242],"0.840-0.866).":[243],"Feature":[244],"importance":[245],"Th-Tc":[251],"ratio,":[252],"CD19,":[253],"as":[257],"influential":[260],"predictors":[261],"prediction.":[264],"Our":[265],"highlights":[267],"diverse":[269],"emphasizing":[279],"need":[281],"early":[283],"individualized":[286],"management":[287],"strategies.":[288],"commonly":[295],"immune":[297],"parameters":[298],"severity,":[306],"potentially":[307],"guiding":[308],"treatment":[309],"strategies":[310],"improve":[312],"patient":[313],"outcomes.":[314]},"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-10-10T00:00:00"}
