{"id":"https://openalex.org/W4413636993","doi":"https://doi.org/10.1073/pnas.2508950122","title":"Specificities of chemosensory receptors in the human gut microbiota","display_name":"Specificities of chemosensory receptors in the human gut microbiota","publication_year":2025,"publication_date":"2025-08-26","ids":{"openalex":"https://openalex.org/W4413636993","doi":"https://doi.org/10.1073/pnas.2508950122","pmid":"https://pubmed.ncbi.nlm.nih.gov/40857311","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12415202"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2508950122","doi":"https://doi.org/10.1073/pnas.2508950122","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2508950122","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2508950122","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4413636993"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2508950122","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102773863","display_name":"Wenhao Xu","orcid":"https://orcid.org/0009-0003-2237-0870","observed_orcids":["https://orcid.org/0009-0003-2237-0870"]},"institutions":[{"id":"https://openalex.org/I4210144801","display_name":"Loewe Center for Synthetic Microbiology","ror":"https://ror.org/04e209f39","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210144801"]},{"id":"https://openalex.org/I4210166203","display_name":"Max Planck Institute for Terrestrial Microbiology","ror":"https://ror.org/05r7n9c40","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210166203"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Wenhao Xu","raw_affiliation_strings":["Center for Synthetic Microbiology","Max Planck Institute for Terrestrial Microbiology","Center for Synthetic Microbiology, Marburg 35043, Germany","Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany"],"raw_orcid":"https://orcid.org/0009-0003-2237-0870","affiliations":[{"raw_affiliation_string":"Center for Synthetic Microbiology","institution_ids":[]},{"raw_affiliation_string":"Max Planck Institute for Terrestrial Microbiology","institution_ids":["https://openalex.org/I4210166203"]},{"raw_affiliation_string":"Center for Synthetic Microbiology, Marburg 35043, Germany","institution_ids":["https://openalex.org/I4210144801"]},{"raw_affiliation_string":"Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany","institution_ids":["https://openalex.org/I4210166203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071124577","display_name":"Ekaterina Jalomo-Khayrova","orcid":"https://orcid.org/0000-0001-6363-341X","observed_orcids":["https://orcid.org/0000-0001-6363-341X"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I4210144801","display_name":"Loewe Center for Synthetic Microbiology","ror":"https://ror.org/04e209f39","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210144801"]},{"id":"https://openalex.org/I4210166203","display_name":"Max Planck Institute for Terrestrial Microbiology","ror":"https://ror.org/05r7n9c40","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210166203"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ekaterina Jalomo-Khayrova","raw_affiliation_strings":["Center for Synthetic Microbiology","Department of Chemistry, Philipps-University Marburg","Max Planck Institute for Terrestrial Microbiology","Center for Synthetic Microbiology, Marburg 35043, Germany","Department of Chemistry, Philipps-University Marburg, Marburg 35043, Germany","Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6363-341X","affiliations":[{"raw_affiliation_string":"Center for Synthetic Microbiology","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Philipps-University Marburg","institution_ids":["https://openalex.org/I161103922"]},{"raw_affiliation_string":"Max Planck Institute for Terrestrial Microbiology","institution_ids":["https://openalex.org/I4210166203"]},{"raw_affiliation_string":"Center for Synthetic Microbiology, Marburg 35043, Germany","institution_ids":["https://openalex.org/I4210144801"]},{"raw_affiliation_string":"Department of Chemistry, Philipps-University Marburg, Marburg 35043, Germany","institution_ids":["https://openalex.org/I161103922"]},{"raw_affiliation_string":"Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany","institution_ids":["https://openalex.org/I4210166203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031537173","display_name":"Vadim M. Gumerov","orcid":"https://orcid.org/0000-0003-1670-7679","observed_orcids":["https://orcid.org/0000-0003-1670-7679"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vadim M. Gumerov","raw_affiliation_strings":["Department of Microbiology and Translational Data Analytics Institute, The Ohio State University","Department of Microbiology and Translational Data Analytics Institute, The Ohio State University, Columbus, OH 43210"],"raw_orcid":"https://orcid.org/0000-0003-1670-7679","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Translational Data Analytics Institute, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Microbiology and Translational Data Analytics Institute, The Ohio State University, Columbus, OH 43210","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070323316","display_name":"Patricia A. Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia A. Ross","raw_affiliation_strings":["Department of Microbiology and Translational Data Analytics Institute, The Ohio State University","Department of Microbiology and Translational Data Analytics Institute, The Ohio State University, Columbus, OH 43210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Translational Data Analytics Institute, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Microbiology and Translational Data Analytics Institute, The Ohio State University, Columbus, OH 43210","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065896682","display_name":"Tania S. K\u00f6bel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166203","display_name":"Max Planck Institute for Terrestrial Microbiology","ror":"https://ror.org/05r7n9c40","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210166203"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tania S. K\u00f6bel","raw_affiliation_strings":["Max Planck Institute for Terrestrial Microbiology","Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Terrestrial Microbiology","institution_ids":["https://openalex.org/I4210166203"]},{"raw_affiliation_string":"Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany","institution_ids":["https://openalex.org/I4210166203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007314803","display_name":"Daniel Schindler","orcid":"https://orcid.org/0000-0001-7423-6540","observed_orcids":["https://orcid.org/0000-0001-7423-6540"]},"institutions":[{"id":"https://openalex.org/I4210144801","display_name":"Loewe Center for Synthetic Microbiology","ror":"https://ror.org/04e209f39","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210144801"]},{"id":"https://openalex.org/I4210166203","display_name":"Max Planck Institute for Terrestrial Microbiology","ror":"https://ror.org/05r7n9c40","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210166203"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Schindler","raw_affiliation_strings":["Center for Synthetic Microbiology","Max Planck Institute for Terrestrial Microbiology","Center for Synthetic Microbiology, Marburg 35043, Germany","Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7423-6540","affiliations":[{"raw_affiliation_string":"Center for Synthetic Microbiology","institution_ids":[]},{"raw_affiliation_string":"Max Planck Institute for Terrestrial Microbiology","institution_ids":["https://openalex.org/I4210166203"]},{"raw_affiliation_string":"Center for Synthetic Microbiology, Marburg 35043, Germany","institution_ids":["https://openalex.org/I4210144801"]},{"raw_affiliation_string":"Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany","institution_ids":["https://openalex.org/I4210166203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043302393","display_name":"Gert Bange","orcid":"https://orcid.org/0000-0002-7826-0932","observed_orcids":["https://orcid.org/0000-0002-7826-0932"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I4210144801","display_name":"Loewe Center for Synthetic Microbiology","ror":"https://ror.org/04e209f39","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210144801"]},{"id":"https://openalex.org/I4210166203","display_name":"Max Planck Institute for Terrestrial Microbiology","ror":"https://ror.org/05r7n9c40","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210166203"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Gert Bange","raw_affiliation_strings":["Center for Synthetic Microbiology","Department of Chemistry, Philipps-University Marburg","Max Planck Institute for Terrestrial Microbiology","Center for Synthetic Microbiology, Marburg 35043, Germany","Department of Chemistry, Philipps-University Marburg, Marburg 35043, Germany","Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7826-0932","affiliations":[{"raw_affiliation_string":"Center for Synthetic Microbiology","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Philipps-University Marburg","institution_ids":["https://openalex.org/I161103922"]},{"raw_affiliation_string":"Max Planck Institute for Terrestrial Microbiology","institution_ids":["https://openalex.org/I4210166203"]},{"raw_affiliation_string":"Center for Synthetic Microbiology, Marburg 35043, Germany","institution_ids":["https://openalex.org/I4210144801"]},{"raw_affiliation_string":"Department of Chemistry, Philipps-University Marburg, Marburg 35043, Germany","institution_ids":["https://openalex.org/I161103922"]},{"raw_affiliation_string":"Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany","institution_ids":["https://openalex.org/I4210166203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008234669","display_name":"Igor B. Zhulin","orcid":"https://orcid.org/0000-0002-6708-5323","observed_orcids":["https://orcid.org/0000-0002-6708-5323"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Igor B. Zhulin","raw_affiliation_strings":["Department of Microbiology and Translational Data Analytics Institute, The Ohio State University","Department of Microbiology and Translational Data Analytics Institute, The Ohio State University, Columbus, OH 43210"],"raw_orcid":"https://orcid.org/0000-0002-6708-5323","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Translational Data Analytics Institute, The Ohio State University","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Microbiology and Translational Data Analytics Institute, The Ohio State University, Columbus, OH 43210","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039785599","display_name":"Victor Sourjik","orcid":"https://orcid.org/0000-0003-1053-9192","observed_orcids":["https://orcid.org/0000-0003-1053-9192"]},"institutions":[{"id":"https://openalex.org/I4210144801","display_name":"Loewe Center for Synthetic Microbiology","ror":"https://ror.org/04e209f39","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210144801"]},{"id":"https://openalex.org/I4210166203","display_name":"Max Planck Institute for Terrestrial Microbiology","ror":"https://ror.org/05r7n9c40","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210166203"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Victor Sourjik","raw_affiliation_strings":["Center for Synthetic Microbiology","Max Planck Institute for Terrestrial Microbiology","Center for Synthetic Microbiology, Marburg 35043, Germany","Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1053-9192","affiliations":[{"raw_affiliation_string":"Center for Synthetic Microbiology","institution_ids":[]},{"raw_affiliation_string":"Max Planck Institute for Terrestrial Microbiology","institution_ids":["https://openalex.org/I4210166203"]},{"raw_affiliation_string":"Center for Synthetic Microbiology, Marburg 35043, Germany","institution_ids":["https://openalex.org/I4210144801"]},{"raw_affiliation_string":"Max Planck Institute for Terrestrial Microbiology, Marburg 35043, Germany","institution_ids":["https://openalex.org/I4210166203"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008234669","https://openalex.org/A5039785599","https://openalex.org/A5043302393","https://openalex.org/A5071124577","https://openalex.org/A5102773863"],"corresponding_institution_ids":["https://openalex.org/I161103922","https://openalex.org/I4210144801","https://openalex.org/I4210166203","https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":3.5136,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.93131229,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"122","issue":"35","first_page":"e2508950122","last_page":"e2508950122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.1054999977350235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemosensory-receptors","display_name":"chemosensory receptors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/human-gut-microbiota","display_name":"human gut microbiome","score":0.8989999890327454},{"id":"https://openalex.org/keywords/ligand-specificity","display_name":"ligand specificity","score":0.8299999833106995},{"id":"https://openalex.org/keywords/chemotaxis-receptor","display_name":"chemotaxis receptor","score":0.7850000262260437},{"id":"https://openalex.org/keywords/histidine-kinase","display_name":"histidine kinase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/enzyme-biosensors","display_name":"enzyme biosensor","score":0.9729999899864197},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.9879999756813049},{"id":"https://openalex.org/keywords/lactate-sensing","display_name":"lactate sensing","score":0.9150000214576721},{"id":"https://openalex.org/keywords/carboxylic-acids","display_name":"carboxylic acids","score":0.8840000033378601},{"id":"https://openalex.org/keywords/clostridia","display_name":"Clostridia","score":0.8650000095367432},{"id":"https://openalex.org/keywords/bacterial-metabolites","display_name":"bacterial metabolites","score":0.8159999847412109},{"id":"https://openalex.org/keywords/gut-commensal-bacteria","display_name":"gut commensal bacteria","score":0.6269999742507935},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6245120167732239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5635949373245239},{"id":"https://openalex.org/C177857423","wikidata":"https://www.wikidata.org/wiki/Q17077315","display_name":"Gut\u2013brain axis","level":3,"score":0.4872052073478699},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4744190573692322},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.38958919048309326},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3712822198867798},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.37088602781295776},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32281655073165894},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2914988398551941},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21148359775543213},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.15718045830726624}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005232","descriptor_name":"Fatty Acids, Volatile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1073/pnas.2508950122","doi":"https://doi.org/10.1073/pnas.2508950122","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2508950122","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2508950122","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"doi:10.1101/2025.02.11.637667","doi":"https://doi.org/10.1101/2025.02.11.637667","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.02.11.637667","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/02/11/2025.02.11.637667.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:39990360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39990360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:40857311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40857311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12415202","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12415202/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:11844446","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11844446","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11844446/pdf/nihpp-2025.02.11.637667v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:pure.mpg.de:item_3667167","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/21.11116/0000-0011-AFFD-C","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1073/pnas.2508950122","doi":"https://doi.org/10.1073/pnas.2508950122","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2508950122","pdf_url":"https://www.pnas.org/doi/pdf/10.1073/pnas.2508950122","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G115634154","display_name":null,"funder_award_id":"subproject A1)","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5793612874","display_name":"Zusammenspiel der Phagen phi29 und SPP1 mit der (p)ppGppAntwort von B. subtilis","funder_award_id":"464366151","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6479334997","display_name":null,"funder_award_id":"SPP2330","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G9000860044","display_name":"Computational Genomics of Signal Transduction","funder_award_id":"R35GM131760","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321961","display_name":"Hessisches Ministerium f\u00fcr Wissenschaft und Kunst","ror":"https://ror.org/00zd5gr55"},{"id":"https://openalex.org/F4320322434","display_name":"Max-Planck-Gesellschaft","ror":"https://ror.org/01hhn8329"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413636993.pdf","grobid_xml":"https://content.openalex.org/works/W4413636993.grobid-xml"},"referenced_works_count":91,"referenced_works":["https://openalex.org/W1515460086","https://openalex.org/W1546130662","https://openalex.org/W1547922007","https://openalex.org/W1920238277","https://openalex.org/W1963925513","https://openalex.org/W1971439989","https://openalex.org/W1971615938","https://openalex.org/W1987451188","https://openalex.org/W1997132664","https://openalex.org/W2000323554","https://openalex.org/W2003390634","https://openalex.org/W2016781345","https://openalex.org/W2047544230","https://openalex.org/W2052509575","https://openalex.org/W2052574628","https://openalex.org/W2064837899","https://openalex.org/W2064997088","https://openalex.org/W2074279517","https://openalex.org/W2078793434","https://openalex.org/W2108559568","https://openalex.org/W2112738213","https://openalex.org/W2113198717","https://openalex.org/W2115888213","https://openalex.org/W2120772351","https://openalex.org/W2124026197","https://openalex.org/W2129443011","https://openalex.org/W2134864306","https://openalex.org/W2139134537","https://openalex.org/W2147874841","https://openalex.org/W2148698435","https://openalex.org/W2160378127","https://openalex.org/W2163341755","https://openalex.org/W2333457203","https://openalex.org/W2414557377","https://openalex.org/W2518460556","https://openalex.org/W2530764722","https://openalex.org/W2586995851","https://openalex.org/W2606802599","https://openalex.org/W2626195186","https://openalex.org/W2751476102","https://openalex.org/W2765708854","https://openalex.org/W2765915958","https://openalex.org/W2766498245","https://openalex.org/W2772979724","https://openalex.org/W2792111916","https://openalex.org/W2792545373","https://openalex.org/W2794701282","https://openalex.org/W2810790876","https://openalex.org/W2821853716","https://openalex.org/W2891454794","https://openalex.org/W2944790464","https://openalex.org/W2948289264","https://openalex.org/W3002827274","https://openalex.org/W3036411220","https://openalex.org/W3041953549","https://openalex.org/W3083241614","https://openalex.org/W3091620605","https://openalex.org/W3118460285","https://openalex.org/W3147245681","https://openalex.org/W3179193501","https://openalex.org/W3193398656","https://openalex.org/W4214815742","https://openalex.org/W4220766074","https://openalex.org/W4220773787","https://openalex.org/W4220784257","https://openalex.org/W4225150322","https://openalex.org/W4225376926","https://openalex.org/W4280536110","https://openalex.org/W4285391488","https://openalex.org/W4288067258","https://openalex.org/W4297891358","https://openalex.org/W4302307901","https://openalex.org/W4307468223","https://openalex.org/W4360989968","https://openalex.org/W4378710453","https://openalex.org/W4381470452","https://openalex.org/W4382394523","https://openalex.org/W4384457623","https://openalex.org/W4385295242","https://openalex.org/W4387164156","https://openalex.org/W4387326026","https://openalex.org/W4387326813","https://openalex.org/W4387526307","https://openalex.org/W4389547067","https://openalex.org/W4396721167","https://openalex.org/W4397004397","https://openalex.org/W4400573468","https://openalex.org/W4406163805","https://openalex.org/W4406950091","https://openalex.org/W4407061773","https://openalex.org/W6926159905"],"related_works":["https://openalex.org/W4397004397","https://openalex.org/W7167990579","https://openalex.org/W2171635847","https://openalex.org/W7153589362","https://openalex.org/W2530764722","https://openalex.org/W2525012761","https://openalex.org/W2140252163","https://openalex.org/W4388126220","https://openalex.org/W4416929124","https://openalex.org/W1989855775"],"abstract_inverted_index":{"The":[0],"human":[1,54,226],"gut":[2,35,55,190,227],"is":[3,16],"rich":[4],"in":[5,33,187,224],"metabolites":[6,71,223],"and":[7,64,82,110,119,133,136,142,151,215,229],"harbors":[8],"a":[9,58,218],"complex":[10],"microbial":[11],"community,":[12],"yet":[13],"surprisingly":[14],"little":[15],"known":[17],"about":[18],"the":[19,26,34,41,53,62,117,146,182,188,200,206,225],"spectrum":[20],"of":[21,29,44,52,68,103,121,145,149,181,221],"chemical":[22,74],"signals":[23],"detected":[24],"by":[25],"large":[27],"variety":[28],"sensory":[30,47,90,163],"receptors":[31,185],"present":[32],"microbiome.":[36],"Here,":[37],"we":[38,172],"systematically":[39],"mapped":[40],"ligand":[42,122,158,202,210],"specificities":[43,211],"selected":[45,237],"extracytoplasmic":[46],"domains":[48,91],"from":[49,72,92,193],"twenty":[50],"members":[51],"microbiota,":[56],"with":[57,169,196,231],"primary":[59],"focus":[60],"on":[61,236],"abundant":[63],"physiologically":[65],"important":[66],"class":[67],"Clostridia.":[69],"Twenty-five":[70],"different":[73,157],"classes-including":[75],"amino":[76],"acids,":[77,132],"nucleobase":[78],"derivatives,":[79],"amines,":[80],"indole,":[81],"carboxylates-were":[83],"identified":[84],"as":[85],"specific":[86,128],"ligands":[87,177],"for":[88,129,134,213],"fifteen":[89],"nine":[93],"bacterial":[94,238],"species,":[95],"which":[96],"represent":[97],"all":[98],"three":[99],"major":[100],"functional":[101],"classes":[102],"transmembrane":[104],"receptors:":[105],"chemotaxis":[106,184],"receptors,":[107],"histidine":[108],"kinases,":[109],"enzymatic":[111],"sensors.":[112],"We":[113],"have":[114],"further":[115],"characterized":[116],"specificity":[118],"evolution":[120],"binding":[123],"to":[124,175,178],"Cache":[125],"superfamily":[126],"sensors":[127],"lactate,":[130],"dicarboxylic":[131],"uracil":[135,150],"short-chain":[137],"fatty":[138],"acids":[139,198],"(SCFAs).":[140],"Structural":[141],"biochemical":[143],"analysis":[144],"dCache":[147],"sensor":[148],"SCFAs":[152],"revealed":[153],"that":[154],"its":[155],"two":[156],"types":[159],"bind":[160],"at":[161],"distinct":[162],"modules.":[164],"Overall,":[165],"combining":[166],"experimental":[167],"identification":[168],"computational":[170],"analyses,":[171],"were":[173,212],"able":[174],"assign":[176],"approximately":[179],"half":[180],"Cache-type":[183],"found":[186,209],"eleven":[189],"commensal":[191],"genomes":[192],"our":[194],"set,":[195],"carboxylic":[197],"representing":[199],"largest":[201],"class.":[203],"Among":[204],"these,":[205],"most":[207],"commonly":[208],"lactate":[214],"formate,":[216],"indicating":[217],"particular":[219],"importance":[220],"these":[222],"microbiota":[228],"consistent":[230],"their":[232],"observed":[233],"growth-promoting":[234],"effects":[235],"commensals.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-10-10T00:00:00"}
