{"id":"https://openalex.org/W4413495373","doi":"https://doi.org/10.1038/s41551-025-01478-6","title":"A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity","display_name":"A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity","publication_year":2025,"publication_date":"2025-08-25","ids":{"openalex":"https://openalex.org/W4413495373","doi":"https://doi.org/10.1038/s41551-025-01478-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/40855125"},"language":"en","primary_location":{"id":"doi:10.1038/s41551-025-01478-6","doi":"https://doi.org/10.1038/s41551-025-01478-6","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41551-025-01478-6","pdf_url":null,"source":{"id":"https://openalex.org/S2764624792","display_name":"Nature Biomedical Engineering","issn_l":"2157-846X","issn":["2157-846X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Biomedical Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064901523","display_name":"Zhenhao Fang","orcid":"https://orcid.org/0000-0002-1246-3665","observed_orcids":["https://orcid.org/0000-0002-1246-3665"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhenhao Fang","raw_affiliation_strings":["Center for Cancer Systems Biology, Yale University, West Haven, CT, USA","Department of Genetics, Yale University School of Medicine, New Haven, CT, USA","Systems Biology Institute, Yale University, West Haven, CT, USA"],"raw_orcid":"https://orcid.org/0000-0002-1246-3665","affiliations":[{"raw_affiliation_string":"Center for Cancer Systems Biology, Yale University, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Genetics, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Systems Biology Institute, Yale University, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025052884","display_name":"Valter Silva Monteiro","orcid":"https://orcid.org/0000-0003-1785-6713","observed_orcids":["https://orcid.org/0000-0003-1785-6713"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valter S. Monteiro","raw_affiliation_strings":["Immunobiology Program, Yale University, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunobiology Program, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061371173","display_name":"Changin Oh","orcid":"https://orcid.org/0000-0003-2300-6360","observed_orcids":["https://orcid.org/0000-0003-2300-6360"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changin Oh","raw_affiliation_strings":["Department of Genetics, Yale University School of Medicine, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119411485","display_name":"Kawthar Al Janabi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kawthar Al Janabi","raw_affiliation_strings":["Center for Cancer Systems Biology, Yale University, West Haven, CT, USA","Department of Genetics, Yale University School of Medicine, New Haven, CT, USA","Systems Biology Institute, Yale University, West Haven, CT, USA","Yale College, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Systems Biology, Yale University, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Genetics, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Systems Biology Institute, Yale University, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale College, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Luciano Romero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luciano Romero","raw_affiliation_strings":["Center for Cancer Systems Biology, Yale University, West Haven, CT, USA","Department of Genetics, Yale University School of Medicine, New Haven, CT, USA","Systems Biology Institute, Yale University, West Haven, CT, USA","Yale College, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Systems Biology, Yale University, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Genetics, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Systems Biology Institute, Yale University, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale College, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nabihah Ahsan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nabihah Ahsan","raw_affiliation_strings":["Center for Cancer Systems Biology, Yale University, West Haven, CT, USA","Department of Genetics, Yale University School of Medicine, New Haven, CT, USA","Systems Biology Institute, Yale University, West Haven, CT, USA","Yale College, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Systems Biology, Yale University, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Genetics, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Systems Biology Institute, Yale University, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale College, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062045076","display_name":"Luojia Yang","orcid":"https://orcid.org/0000-0002-8007-6595","observed_orcids":["https://orcid.org/0000-0002-8007-6595"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luojia Yang","raw_affiliation_strings":["Center for Cancer Systems Biology, Yale University, West Haven, CT, USA","Department of Genetics, Yale University School of Medicine, New Haven, CT, USA","Molecular Cell Biology, Genetics, and Development Program, Yale University, New Haven, CT, USA","Systems Biology Institute, Yale University, West Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Systems Biology, Yale University, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Genetics, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Molecular Cell Biology, Genetics, and Development Program, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Systems Biology Institute, Yale University, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101695824","display_name":"Lei Peng","orcid":"https://orcid.org/0000-0001-8754-020X","observed_orcids":["https://orcid.org/0000-0001-8754-020X","https://orcid.org/0000-0003-4315-4897"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Peng","raw_affiliation_strings":["Center for Cancer Systems Biology, Yale University, West Haven, CT, USA","Department of Genetics, Yale University School of Medicine, New Haven, CT, USA","Systems Biology Institute, Yale University, West Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Systems Biology, Yale University, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Genetics, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Systems Biology Institute, Yale University, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028430067","display_name":"Daniel DiMaio","orcid":"https://orcid.org/0000-0002-2060-5977","observed_orcids":["https://orcid.org/0000-0002-2060-5977"]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel DiMaio","raw_affiliation_strings":["Department of Genetics, Yale University School of Medicine, New Haven, CT, USA","Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA","Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA","Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA"],"raw_orcid":"https://orcid.org/0000-0002-2060-5977","affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I2802730090","https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058334777","display_name":"Carolina Gon\u00e7alves de Oliveira Lucas","orcid":"https://orcid.org/0000-0003-4590-2756","observed_orcids":["https://orcid.org/0000-0003-4590-2756"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carolina Lucas","raw_affiliation_strings":["Center for Infection and Immunity, Yale University, New Haven, CT, USA. Carolina.lucas@yale.edu","Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. Carolina.lucas@yale.edu","Immunobiology Program, Yale University, New Haven, CT, USA. Carolina.lucas@yale.edu","Immunobiology Program, Yale University, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Infection and Immunity, Yale University, New Haven, CT, USA. Carolina.lucas@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. Carolina.lucas@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Immunobiology Program, Yale University, New Haven, CT, USA. Carolina.lucas@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Immunobiology Program, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076821347","display_name":"Sidi Chen","orcid":"https://orcid.org/0000-0002-3819-5005","observed_orcids":["https://orcid.org/0000-0002-3819-5005"]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sidi Chen","raw_affiliation_strings":["Center for Biomedical Data Science, Yale University School of Medicine, New Haven, CT, USA. sidi.chen@yale.edu","Center for Cancer Systems Biology, Yale University, West Haven, CT, USA. sidi.chen@yale.edu","Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. sidi.chen@yale.edu","Immunobiology Program, Yale University, New Haven, CT, USA. sidi.chen@yale.edu","Molecular Cell Biology, Genetics, and Development Program, Yale University, New Haven, CT, USA. sidi.chen@yale.edu","Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA. sidi.chen@yale.edu","Systems Biology Institute, Yale University, West Haven, CT, USA. sidi.chen@yale.edu","Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA. sidi.chen@yale.edu","Yale College, New Haven, CT, USA. sidi.chen@yale.edu","Center for Cancer Systems Biology, Yale University, West Haven, CT, USA","Department of Genetics, Yale University School of Medicine, New Haven, CT, USA","Immunobiology Program, Yale University, New Haven, CT, USA","Molecular Cell Biology, Genetics, and Development Program, Yale University, New Haven, CT, USA","Systems Biology Institute, Yale University, West Haven, CT, USA","Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA","Yale College, New Haven, CT, USA"],"raw_orcid":"https://orcid.org/0000-0002-3819-5005","affiliations":[{"raw_affiliation_string":"Center for Biomedical Data Science, Yale University School of Medicine, New Haven, CT, USA. sidi.chen@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Center for Cancer Systems Biology, Yale University, West Haven, CT, USA. sidi.chen@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. sidi.chen@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Immunobiology Program, Yale University, New Haven, CT, USA. sidi.chen@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Molecular Cell Biology, Genetics, and Development Program, Yale University, New Haven, CT, USA. sidi.chen@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA. sidi.chen@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Systems Biology Institute, Yale University, West Haven, CT, USA. sidi.chen@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA. sidi.chen@yale.edu","institution_ids":["https://openalex.org/I2802730090","https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale College, New Haven, CT, USA. sidi.chen@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Center for Cancer Systems Biology, Yale University, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Genetics, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Immunobiology Program, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Molecular Cell Biology, Genetics, and Development Program, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Systems Biology Institute, Yale University, West Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA","institution_ids":["https://openalex.org/I2802730090","https://openalex.org/I32971472"]},{"raw_affiliation_string":"Yale College, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058334777","https://openalex.org/A5076821347"],"corresponding_institution_ids":["https://openalex.org/I2802730090","https://openalex.org/I32971472"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":1.7784,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.84836411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"10","issue":"3","first_page":"501","last_page":"516"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.5522000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.5522000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.36649999022483826,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-nanoparticle-mrna-vaccines","display_name":"lipid nanoparticle mRNA vaccine","score":0.824999988079071},{"id":"https://openalex.org/keywords/cell-surface-translocation","display_name":"cell surface translocation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/chimeric-antigen","display_name":"chimeric antigen","score":0.8339999914169312},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.5630000233650208},{"id":"https://openalex.org/keywords/monkeypox-virus","display_name":"monkeypox virus","score":0.8849999904632568},{"id":"https://openalex.org/keywords/mpox-vaccine","display_name":"mpox vaccine","score":0.527999997138977},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.7870000004768372},{"id":"https://openalex.org/keywords/viral-challenge-protection","display_name":"viral challenge protection","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.9251335859298706},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.6094174385070801},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5728870630264282},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.41961824893951416},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3770206570625305},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37044090032577515},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.36429354548454285},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3305509686470032},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3264698088169098},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28105804324150085},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2660614252090454},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21786406636238098},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.17859339714050293},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14062827825546265},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06948620080947876},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071497","descriptor_name":"Immunogenicity, Vaccine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000087503","descriptor_name":"mRNA Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050725","descriptor_name":"Papillomavirus E7 Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050725","descriptor_name":"Papillomavirus E7 Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/s41551-025-01478-6","doi":"https://doi.org/10.1038/s41551-025-01478-6","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41551-025-01478-6","pdf_url":null,"source":{"id":"https://openalex.org/S2764624792","display_name":"Nature Biomedical Engineering","issn_l":"2157-846X","issn":["2157-846X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:40855125","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40855125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature biomedical engineering","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8510822112","display_name":null,"funder_award_id":"CRI4964","funder_id":"https://openalex.org/F4320306155","funder_display_name":"Cancer Research Institute"}],"funders":[{"id":"https://openalex.org/F4320306155","display_name":"Cancer Research Institute","ror":"https://ror.org/02f3xk561"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1534923950","https://openalex.org/W1939433055","https://openalex.org/W2016363862","https://openalex.org/W2016648062","https://openalex.org/W2025980739","https://openalex.org/W2054515639","https://openalex.org/W2079696222","https://openalex.org/W2107476138","https://openalex.org/W2108957284","https://openalex.org/W2129883358","https://openalex.org/W2150436558","https://openalex.org/W2342147014","https://openalex.org/W2514929667","https://openalex.org/W2765584638","https://openalex.org/W2782708334","https://openalex.org/W2789915301","https://openalex.org/W2917919793","https://openalex.org/W2955231772","https://openalex.org/W2995903145","https://openalex.org/W3044891199","https://openalex.org/W3091061098","https://openalex.org/W3111255098","https://openalex.org/W3113734454","https://openalex.org/W3127832258","https://openalex.org/W3180908419","https://openalex.org/W3204457818","https://openalex.org/W4200069835","https://openalex.org/W4200290182","https://openalex.org/W4200574165","https://openalex.org/W4205483821","https://openalex.org/W4210542377","https://openalex.org/W4220991830","https://openalex.org/W4221014433","https://openalex.org/W4224943750","https://openalex.org/W4229015826","https://openalex.org/W4229452462","https://openalex.org/W4281757199","https://openalex.org/W4285797284","https://openalex.org/W4308510590","https://openalex.org/W4317488951","https://openalex.org/W4323031757","https://openalex.org/W4323322652","https://openalex.org/W4365447189","https://openalex.org/W4366606979","https://openalex.org/W4376133743","https://openalex.org/W4379768500","https://openalex.org/W4383646139","https://openalex.org/W4389817885","https://openalex.org/W4390187970","https://openalex.org/W4391067309","https://openalex.org/W4391850600","https://openalex.org/W4407864172"],"related_works":["https://openalex.org/W4410375064","https://openalex.org/W4408563113","https://openalex.org/W4323322652","https://openalex.org/W7124733148","https://openalex.org/W7214527440","https://openalex.org/W4415782982","https://openalex.org/W2912394453","https://openalex.org/W7155208107","https://openalex.org/W4383646139","https://openalex.org/W4414245106"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2025-10-10T00:00:00"}
