{"id":"https://openalex.org/W4413480587","doi":"https://doi.org/10.1101/2025.08.19.25333802","title":"Nutritional interventions and Their Impact on Tuberculosis Treatment Outcomes in Tanzania: A Systematic Review of interventional and operational studies","display_name":"Nutritional interventions and Their Impact on Tuberculosis Treatment Outcomes in Tanzania: A Systematic Review of interventional and operational studies","publication_year":2025,"publication_date":"2025-08-24","ids":{"openalex":"https://openalex.org/W4413480587","doi":"https://doi.org/10.1101/2025.08.19.25333802"},"language":"en","primary_location":{"id":"doi:10.1101/2025.08.19.25333802","doi":"https://doi.org/10.1101/2025.08.19.25333802","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.08.19.25333802","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/08/24/2025.08.19.25333802.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2025/08/24/2025.08.19.25333802.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078992247","display_name":"Philbert Balichene Madoshi","orcid":"https://orcid.org/0000-0002-2470-1675","observed_orcids":["https://orcid.org/0000-0002-2470-1675"]},"institutions":[{"id":"https://openalex.org/I4405261229","display_name":"St. Francis University College of Health and Allied Sciences","ror":"https://ror.org/04zfvcz90","country_code":"TZ","type":"education","lineage":["https://openalex.org/I4405261229"]}],"countries":["TZ"],"is_corresponding":true,"raw_author_name":"Philbert Balichene Madoshi","raw_affiliation_strings":["Saint Francis University College of Health and Allied Sciences"],"raw_orcid":"https://orcid.org/0000-0002-2470-1675","affiliations":[{"raw_affiliation_string":"Saint Francis University College of Health and Allied Sciences","institution_ids":["https://openalex.org/I4405261229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001554592","display_name":"Jovin Rushagala Tibenderana","orcid":"https://orcid.org/0000-0002-3108-4302","observed_orcids":["https://orcid.org/0000-0002-3108-4302"]},"institutions":[{"id":"https://openalex.org/I4405261229","display_name":"St. Francis University College of Health and Allied Sciences","ror":"https://ror.org/04zfvcz90","country_code":"TZ","type":"education","lineage":["https://openalex.org/I4405261229"]}],"countries":["TZ"],"is_corresponding":false,"raw_author_name":"Jovin R. Tibenderana","raw_affiliation_strings":["St. Francis University College of Health and Allied Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Francis University College of Health and Allied Sciences","institution_ids":["https://openalex.org/I4405261229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000456880","display_name":"Godfrey C. Katusi","orcid":"https://orcid.org/0000-0002-4036-8243","observed_orcids":["https://orcid.org/0000-0002-4036-8243"]},"institutions":[{"id":"https://openalex.org/I4405261229","display_name":"St. Francis University College of Health and Allied Sciences","ror":"https://ror.org/04zfvcz90","country_code":"TZ","type":"education","lineage":["https://openalex.org/I4405261229"]}],"countries":["TZ"],"is_corresponding":false,"raw_author_name":"Godfrey Katusi","raw_affiliation_strings":["St. Francis University College of Health and Allied Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Francis University College of Health and Allied Sciences","institution_ids":["https://openalex.org/I4405261229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015280605","display_name":"Theresia Andrea Karuhanga","orcid":"https://orcid.org/0000-0002-8674-3133","observed_orcids":["https://orcid.org/0000-0002-8674-3133"]},"institutions":[{"id":"https://openalex.org/I4405261229","display_name":"St. Francis University College of Health and Allied Sciences","ror":"https://ror.org/04zfvcz90","country_code":"TZ","type":"education","lineage":["https://openalex.org/I4405261229"]}],"countries":["TZ"],"is_corresponding":false,"raw_author_name":"Theresia A. Karuhanga","raw_affiliation_strings":["St. Francis University College of Health and Allied Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Francis University College of Health and Allied Sciences","institution_ids":["https://openalex.org/I4405261229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047628825","display_name":"Robert S. Machang\u2019u","orcid":"https://orcid.org/0000-0001-7274-8243","observed_orcids":["https://orcid.org/0000-0001-7274-8243","https://orcid.org/0009-0007-0127-933X"]},"institutions":[{"id":"https://openalex.org/I4405261229","display_name":"St. Francis University College of Health and Allied Sciences","ror":"https://ror.org/04zfvcz90","country_code":"TZ","type":"education","lineage":["https://openalex.org/I4405261229"]}],"countries":["TZ"],"is_corresponding":false,"raw_author_name":"Robert S Machang\u2019u","raw_affiliation_strings":["St. Francis University College of Health and Allied Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Francis University College of Health and Allied Sciences","institution_ids":["https://openalex.org/I4405261229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078992247"],"corresponding_institution_ids":["https://openalex.org/I4405261229"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10596","display_name":"Child Nutrition and Water Access","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nutritional-support","display_name":"nutritional support","score":0.7089999914169312},{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.5759999752044678},{"id":"https://openalex.org/keywords/micronutrient-supplementation","display_name":"micronutrient supplementation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/therapeutic-feeding","display_name":"therapeutic feeding","score":0.9459999799728394},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.6159999966621399},{"id":"https://openalex.org/keywords/treatment-completion","display_name":"treatment completion","score":0.9340000152587891},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.8899999856948853},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.6460000276565552},{"id":"https://openalex.org/keywords/malnutrition","display_name":"malnutrition","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tanzania","display_name":"Tanzania","score":0.47099998593330383},{"id":"https://openalex.org/keywords/resource-limited-settings","display_name":"resource-limited settings","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C2779357621","wikidata":"https://www.wikidata.org/wiki/Q655495","display_name":"Tanzania","level":2,"score":0.885124921798706},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.7235766053199768},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5252187848091125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5248791575431824},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5131838917732239},{"id":"https://openalex.org/C91375879","wikidata":"https://www.wikidata.org/wiki/Q15473274","display_name":"Environmental planning","level":1,"score":0.23155418038368225},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.1837015450000763},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.1707974076271057},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09503787755966187}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2025.08.19.25333802","doi":"https://doi.org/10.1101/2025.08.19.25333802","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.08.19.25333802","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/08/24/2025.08.19.25333802.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2025.08.19.25333802","doi":"https://doi.org/10.1101/2025.08.19.25333802","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.08.19.25333802","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/08/24/2025.08.19.25333802.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/2","score":0.746399998664856,"display_name":"Zero hunger"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413480587.pdf","grobid_xml":"https://content.openalex.org/works/W4413480587.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1972694758","https://openalex.org/W1992032485","https://openalex.org/W2027266940","https://openalex.org/W2039075187","https://openalex.org/W2044141284","https://openalex.org/W2062279016","https://openalex.org/W2131467623","https://openalex.org/W2156230735","https://openalex.org/W2157823046","https://openalex.org/W2165010366","https://openalex.org/W2166300707","https://openalex.org/W2166660813","https://openalex.org/W2402421755","https://openalex.org/W2531269403","https://openalex.org/W2567362164","https://openalex.org/W2974082440","https://openalex.org/W3118615836","https://openalex.org/W4225949294","https://openalex.org/W4232058719","https://openalex.org/W4250432185","https://openalex.org/W4322761088","https://openalex.org/W4379598782","https://openalex.org/W4385651852","https://openalex.org/W4401490331"],"related_works":["https://openalex.org/W7147515969","https://openalex.org/W4415945838","https://openalex.org/W4387115334","https://openalex.org/W4403532090","https://openalex.org/W7167791840","https://openalex.org/W4412450300","https://openalex.org/W4402930592","https://openalex.org/W4255232862","https://openalex.org/W4407327341","https://openalex.org/W7216456285"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Tuberculosis":[2],"(TB)":[3],"is":[4,15],"a":[5,37,232],"major":[6,83],"public":[7],"health":[8,253],"challenge":[9],"in":[10,73,151,220,225,235],"developing":[11,152],"countries,":[12],"where":[13],"Tanzania":[14],"one":[16],"of":[17,21,40,64,90,118,155,168,179],"them.":[18],"The":[19],"presence":[20],"under-nutrition":[22],"exacerbates":[23],"disease":[24],"progression":[25],"and":[26,48,71,92,112,127,140,157,187,199,209,222,240,265],"impairs":[27],"treatment":[28,69,132,137,189,193,238],"outcomes.":[29,254],"Nutritional":[30,229],"support":[31,246],"has":[32],"been":[33],"increasingly":[34],"recognized":[35],"as":[36,122],"vital":[38],"component":[39],"TB":[41,68,131,149,237,249],"care,":[42],"yet":[43],"the":[44,62,116,177],"evidence":[45,60],"from":[46,98],"interventional":[47],"operational":[49,113,258],"studies":[50,96,105,170,217,259],"remains":[51],"fragmented.":[52],"This":[53],"systematic":[54],"review":[55],"aims":[56],"to":[57,101,262],"synthesize":[58],"current":[59],"on":[61,67,130],"impact":[63],"nutritional":[65,119,185,245],"interventions":[66,186,211,230],"outcomes":[70,133,190],"recovery":[72,141],"Tanzania.":[74],"Methods":[75],"A":[76,166],"comprehensive":[77],"literature":[78],"search":[79],"was":[80],"conducted":[81],"across":[82],"databases":[84],"including":[85],"PubMed,":[86],"Embase,":[87],"Scopus,":[88],"Web":[89],"Science":[91],"others":[93],"which":[94,180],"covered":[95],"published":[97],"January":[99],"2000":[100],"June":[102],"2025.":[103],"Eligible":[104],"included":[106],"randomized":[107],"controlled":[108],"trials,":[109],"quasi-experimental":[110],"designs,":[111],"research":[114],"evaluating":[115],"effect":[117],"interventions,":[120],"such":[121],"food":[123],"supplements,":[124],"micronutrient":[125],"support,":[126],"therapeutic":[128],"feeding":[129],"(eg.":[134],"cure":[135],"rate,":[136],"completion,":[138],"mortality)":[139],"indicators":[142],"(e.g.,":[143],"weight":[144,197],"gain,":[145,198],"immune":[146],"response)":[147],"among":[148],"patients":[150],"countries.":[153],"Risks":[154],"bias":[156],"study":[158],"quality":[159],"were":[160],"assessed":[161],"using":[162],"standardized":[163],"tools.":[164],"Results":[165],"total":[167],"18":[169],"involving":[171],"approximately":[172],"5007":[173],"participants":[174],"are":[175,260],"included,":[176],"majority":[178],"reported":[181],"positive":[182],"associations":[183],"between":[184],"improved":[188],"including:":[191],"higher":[192],"completion":[194],"rates,":[195],"enhanced":[196],"reduced":[200],"mortality.":[201],"Micronutrient":[202],"supplementation":[203],"showed":[204],"variable":[205],"effects,":[206],"while":[207],"macronutrient":[208],"food-based":[210],"demonstrated":[212],"more":[213],"consistent":[214],"benefits.":[215],"Operational":[216],"revealed":[218],"challenges":[219],"implementation":[221],"sustainability,":[223],"particularly":[224],"resource-limited":[226],"settings.":[227],"Conclusions":[228],"play":[231],"critical":[233],"role":[234],"enhancing":[236],"success":[239],"patient":[241],"recovery.":[242],"Integrating":[243],"tailored":[244],"into":[247],"routine":[248],"care":[250],"could":[251],"improve":[252],"Further":[255],"large-scale,":[256],"high-quality":[257],"needed":[261],"guide":[263],"policy":[264],"program":[266],"implementation.":[267]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-10-10T00:00:00"}