{"id":"https://openalex.org/W4413480300","doi":"https://doi.org/10.7554/elife.110942.3","title":"LFA-1 interaction with GBP-130 on Plasmodium falciparum-infected red blood cells mediates NK cell activation and parasite control","display_name":"LFA-1 interaction with GBP-130 on Plasmodium falciparum-infected red blood cells mediates NK cell activation and parasite control","publication_year":2026,"publication_date":"2026-05-20","ids":{"openalex":"https://openalex.org/W4413480300","doi":"https://doi.org/10.7554/elife.110942.3"},"language":"en","primary_location":{"id":"doi:10.7554/elife.110942.3","doi":"https://doi.org/10.7554/elife.110942.3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.110942.3","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.110942.3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Osama Mukhtar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IN","IT"],"is_corresponding":false,"raw_author_name":"Osama Mukhtar","raw_affiliation_strings":["Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi \u2013 110067, India","ICGEB, New Delhi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi \u2013 110067, India","institution_ids":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"raw_affiliation_string":"ICGEB, New Delhi","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032581067","display_name":"Ravi Dutt","orcid":"https://orcid.org/0009-0004-5998-5438","observed_orcids":["https://orcid.org/0009-0004-5998-5438"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ravi Dutt","raw_affiliation_strings":["Cellular Immunology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India","ICGEB, New Delhi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India","institution_ids":["https://openalex.org/I4210142124"]},{"raw_affiliation_string":"ICGEB, New Delhi","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103130124","display_name":"Ashutosh Panda","orcid":"https://orcid.org/0000-0001-8174-7648","observed_orcids":["https://orcid.org/0000-0001-8174-7648"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IN","IT"],"is_corresponding":false,"raw_author_name":"Ashutosh Panda","raw_affiliation_strings":["Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi \u2013 110067, India","ICGEB, New Delhi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi \u2013 110067, India","institution_ids":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"raw_affiliation_string":"ICGEB, New Delhi","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014452507","display_name":"Poonam Kumari","orcid":"https://orcid.org/0000-0001-9590-929X","observed_orcids":["https://orcid.org/0000-0001-9590-929X"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"id":"https://openalex.org/I4405263076","display_name":"Amity University Jaipur","ror":"https://ror.org/027sha433","country_code":"IN","type":"education","lineage":["https://openalex.org/I191972202","https://openalex.org/I4405263076"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IN","IT"],"is_corresponding":false,"raw_author_name":"Poonam Kumari","raw_affiliation_strings":["Amity Institute of Biotechnology (AIB), Amity University, Kant Kalwar, NH-11C, Jaipur, Rajasthan 303002, India","Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi \u2013 110067, India","Amity Institute of Biotechnology, Jaipur"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amity Institute of Biotechnology (AIB), Amity University, Kant Kalwar, NH-11C, Jaipur, Rajasthan 303002, India","institution_ids":["https://openalex.org/I4405263076"]},{"raw_affiliation_string":"Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi \u2013 110067, India","institution_ids":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"raw_affiliation_string":"Amity Institute of Biotechnology, Jaipur","institution_ids":["https://openalex.org/I4405263076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062346913","display_name":"Suneet Shekhar Singh","orcid":"https://orcid.org/0000-0001-7230-0094","observed_orcids":["https://orcid.org/0000-0001-7230-0094"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IN","IT"],"is_corresponding":false,"raw_author_name":"Suneet Shekhar Singh","raw_affiliation_strings":["Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi \u2013 110067, India","ICGEB, New Delhi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi \u2013 110067, India","institution_ids":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"raw_affiliation_string":"ICGEB, New Delhi","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082628497","display_name":"Gourab Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IN","IT"],"is_corresponding":false,"raw_author_name":"Gourab Paul","raw_affiliation_strings":["Department of Bioinformatics, Amity School of Biological science, Amity University Punjab","Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi \u2013 110067, India","Amity School of Biological science, Mohali, Punjab"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Amity School of Biological science, Amity University Punjab","institution_ids":[]},{"raw_affiliation_string":"Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi \u2013 110067, India","institution_ids":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"raw_affiliation_string":"Amity School of Biological science, Mohali, Punjab","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114222135","display_name":"Neha Prakash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Neha Prakash","raw_affiliation_strings":["Parasite Cell Biology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India","ICGEB, New Delhi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parasite Cell Biology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India","institution_ids":["https://openalex.org/I4210142124"]},{"raw_affiliation_string":"ICGEB, New Delhi","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Madiha Abbas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Madiha Abbas","raw_affiliation_strings":["Parasite Cell Biology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India","ICGEB, New Delhi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parasite Cell Biology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India","institution_ids":["https://openalex.org/I4210142124"]},{"raw_affiliation_string":"ICGEB, New Delhi","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100679556","display_name":"Md. Muzahidul Islam","orcid":"https://orcid.org/0000-0003-0260-3449","observed_orcids":["https://orcid.org/0000-0003-0260-3449"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Md. Muzahidul Islam","raw_affiliation_strings":["Parasite Cell Biology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India","ICGEB, New Delhi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parasite Cell Biology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India","institution_ids":["https://openalex.org/I4210142124"]},{"raw_affiliation_string":"ICGEB, New Delhi","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070800800","display_name":"Priya Arora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Priya Arora","raw_affiliation_strings":["Parasite Cell Biology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India","ICGEB, New Delhi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parasite Cell Biology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India","institution_ids":["https://openalex.org/I4210142124"]},{"raw_affiliation_string":"ICGEB, New Delhi","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alma Tammour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IN","IT"],"is_corresponding":false,"raw_author_name":"Alma Tammour","raw_affiliation_strings":["Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi \u2013 110067, India","ICGEB, New Delhi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi \u2013 110067, India","institution_ids":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"raw_affiliation_string":"ICGEB, New Delhi","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041672031","display_name":"Asif Mohmmed","orcid":"https://orcid.org/0000-0002-0239-1979","observed_orcids":["https://orcid.org/0000-0002-0239-1979"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Asif Mohmmed","raw_affiliation_strings":["Parasite Cell Biology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India","ICGEB, New Delhi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parasite Cell Biology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India","institution_ids":["https://openalex.org/I4210142124"]},{"raw_affiliation_string":"ICGEB, New Delhi","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076624139","display_name":"Dhiraj Kumar","orcid":"https://orcid.org/0000-0001-7578-2930","observed_orcids":["https://orcid.org/0000-0001-7578-2930"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dhiraj Kumar","raw_affiliation_strings":["Cellular Immunology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India","ICGEB, New Delhi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India","institution_ids":["https://openalex.org/I4210142124"]},{"raw_affiliation_string":"ICGEB, New Delhi","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084700817","display_name":"Pawan Malhotra","orcid":"https://orcid.org/0000-0002-7384-6280","observed_orcids":["https://orcid.org/0000-0002-7384-6280"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]},{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IN","IT"],"is_corresponding":true,"raw_author_name":"Pawan Malhotra","raw_affiliation_strings":["Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi \u2013 110067, India"],"raw_orcid":"https://orcid.org/0000-0002-7384-6280","affiliations":[{"raw_affiliation_string":"Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi \u2013 110067, India","institution_ids":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5084700817"],"corresponding_institution_ids":["https://openalex.org/I4210142124","https://openalex.org/I91080651"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00192055,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.7240999937057495,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.7240999937057495,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.2612000107765198,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lfa-1","display_name":"LFA-1","score":0.949999988079071},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9739999771118164},{"id":"https://openalex.org/keywords/infected-red-blood-cells","display_name":"infected erythrocytes","score":0.8550000190734863},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8259999752044678},{"id":"https://openalex.org/keywords/nk-cell-activation","display_name":"NK cell activation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/integrin-ligands","display_name":"integrin ligands","score":0.6489999890327454},{"id":"https://openalex.org/keywords/i-domain","display_name":"I-domain","score":0.7919999957084656},{"id":"https://openalex.org/keywords/malaria-immunity","display_name":"malaria immunity","score":0.6200000047683716},{"id":"https://openalex.org/keywords/parasite-control","display_name":"parasite control","score":0.6800000071525574},{"id":"https://openalex.org/keywords/nk-cell-degranulation","display_name":"NK cell degranulation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/host-directed-therapy","display_name":"host-directed therapy","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.7899416089057922},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.6507126688957214},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.48442795872688293},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4771237373352051},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45549947023391724},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43047675490379333},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.414361834526062},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3963111639022827},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12510639429092407},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.7554/elife.110942.3","doi":"https://doi.org/10.7554/elife.110942.3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.110942.3","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"doi:10.7554/elife.110942.2","doi":"https://doi.org/10.7554/elife.110942.2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.110942.2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},{"id":"doi:10.1101/2025.08.20.671208","doi":"https://doi.org/10.1101/2025.08.20.671208","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.08.20.671208","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/08/24/2025.08.20.671208.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13218722","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13218722/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13218722/pdf/elife-110942.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:8bf9b4ea4fe64e6c888066cd80a0a7a9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8bf9b4ea4fe64e6c888066cd80a0a7a9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 15 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7554/elife.110942.3","doi":"https://doi.org/10.7554/elife.110942.3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.110942.3","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2802341269","display_name":null,"funder_award_id":"DST/20/015","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G4452428920","display_name":null,"funder_award_id":"BT/IC-06","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G6178185236","display_name":"Towards a malaria blood-stage vaccine: identification and structural analysis of key ligand complexes on Plasmodium falciparum merozoite through proteomic, cryoEM and immunological approaches","funder_award_id":"IA/TSG/22/1/600422","funder_id":"https://openalex.org/F4320325580","funder_display_name":"The Wellcome Trust DBT India Alliance"},{"id":"https://openalex.org/G6588893960","display_name":null,"funder_award_id":"DST/20/015","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G688011744","display_name":null,"funder_award_id":"BT/IC-06/003/91","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G689072600","display_name":null,"funder_award_id":"BT/IC\u201006/003/91","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G8497760104","display_name":null,"funder_award_id":"WTA/24/006","funder_id":"https://openalex.org/F4320325580","funder_display_name":"The Wellcome Trust DBT India Alliance"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320325580","display_name":"The Wellcome Trust DBT India Alliance","ror":"https://ror.org/04reqzt68"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413480300.pdf","grobid_xml":"https://content.openalex.org/works/W4413480300.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1528123089","https://openalex.org/W1669828090","https://openalex.org/W1969503178","https://openalex.org/W1970753581","https://openalex.org/W1979215660","https://openalex.org/W1982320535","https://openalex.org/W1993012211","https://openalex.org/W2035503835","https://openalex.org/W2036481539","https://openalex.org/W2039805883","https://openalex.org/W2039994188","https://openalex.org/W2053519260","https://openalex.org/W2067376389","https://openalex.org/W2084896925","https://openalex.org/W2107553760","https://openalex.org/W2122047942","https://openalex.org/W2125951290","https://openalex.org/W2139072868","https://openalex.org/W2157657263","https://openalex.org/W2164133670","https://openalex.org/W2170421654","https://openalex.org/W2302204082","https://openalex.org/W2512372054","https://openalex.org/W2526413860","https://openalex.org/W2580641909","https://openalex.org/W2751476102","https://openalex.org/W2792784285","https://openalex.org/W2795086423","https://openalex.org/W2894898302","https://openalex.org/W2945172910","https://openalex.org/W2974721045","https://openalex.org/W3017924655","https://openalex.org/W3177828909","https://openalex.org/W3182511770","https://openalex.org/W4281569235","https://openalex.org/W4365147522","https://openalex.org/W4378471523"],"related_works":["https://openalex.org/W2035909582","https://openalex.org/W2059641385","https://openalex.org/W4388487629","https://openalex.org/W2159164435","https://openalex.org/W2081180402","https://openalex.org/W2587203650","https://openalex.org/W4313383635","https://openalex.org/W7097921122","https://openalex.org/W2157657263","https://openalex.org/W2795086423"],"abstract_inverted_index":{"Abstract":[0],"Natural":[1],"Killer":[2],"(NK)":[3],"cells":[4,19,99],"contribute":[5],"to":[6,73,83],"early":[7],"immunity":[8,147],"against":[9,123],"Plasmodium":[10],"falciparum":[11],"by":[12,26],"recognizing":[13],"and":[14,75,97,115,150],"eliminating":[15],"infected":[16],"red":[17],"blood":[18],"(iRBCs),":[20],"a":[21,50,89,152],"process":[22],"mediated":[23],"in":[24,100,148],"part":[25],"the":[27,31,57,136],"integrin":[28],"LFA-1.":[29],"However,":[30],"cognate":[32],"parasite":[33],"ligand":[34,52,138],"for":[35,155],"LFA-1":[36,60,65,137],"has":[37],"remained":[38],"unknown.":[39],"Here,":[40],"we":[41,69],"identify":[42],"Glycophorin":[43],"Binding":[44],"Protein-130":[45],"(":[46],"Pf":[47,86,93,108,124,133],"GBP-130)":[48],"as":[49,88,135],"surface-expressed":[51],"on":[53,139],"iRBCs":[54],"that":[55,107],"binds":[56,95],"I-domain":[58],"of":[59,78,80,119],"(LFA-1":[61],"\u03b1I).":[62],"Using":[63],"an":[64,101],"\u03b1I-Fc":[66,81],"fusion":[67],"protein,":[68],"demonstrate":[70],"stage-specific":[71],"binding":[72],"iRBCs,":[74,140],"LC-MS/MS":[76],"analysis":[77],"immunopreciptates":[79],"bound":[82],"iRBC":[84],"revealed":[85],"GBP-130":[87,94,109,125,134],"high-confidence":[90],"interactor.":[91],"Recombinant":[92],"NK":[96,111,145],"THP-1":[98],"LFA-1-dependent":[102],"manner.":[103],"Co-culture":[104],"assays":[105],"show":[106],"promotes":[110],"cell":[112],"activation,":[113],"degranulation,":[114],"facilitates":[116],"contact-dependent":[117],"killing":[118],"iRBCs.":[120],"Neutralizing":[121],"antibodies":[122],"significantly":[126],"impair":[127],"these":[128],"responses.":[129],"Our":[130],"findings":[131],"establish":[132],"providing":[141],"new":[142],"insight":[143],"into":[144],"cell-mediated":[146],"malaria":[149],"identifying":[151],"potential":[153],"target":[154],"host-directed":[156],"interventions.":[157]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-08-25T00:00:00"}
