{"id":"https://openalex.org/W4413477995","doi":"https://doi.org/10.1021/acs.analchem.5c02797","title":"In Situ Imaging of Extracellular Vesicles and Non-Alcoholic Fatty Liver Disease with a Near-Infrared Fluorescent Viscosity Probe","display_name":"In Situ Imaging of Extracellular Vesicles and Non-Alcoholic Fatty Liver Disease with a Near-Infrared Fluorescent Viscosity Probe","publication_year":2025,"publication_date":"2025-08-24","ids":{"openalex":"https://openalex.org/W4413477995","doi":"https://doi.org/10.1021/acs.analchem.5c02797","pmid":"https://pubmed.ncbi.nlm.nih.gov/40849920"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.5c02797","doi":"https://doi.org/10.1021/acs.analchem.5c02797","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.5c02797","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100341910","display_name":"Zhijie Li","orcid":"https://orcid.org/0000-0002-5445-7976","observed_orcids":["https://orcid.org/0000-0002-5445-7976","https://orcid.org/0000-0003-4362-5652","https://orcid.org/0000-0001-7096-2158","https://orcid.org/0000-0002-2639-0698","https://orcid.org/0000-0003-1561-3435","https://orcid.org/0009-0002-6973-3782","https://orcid.org/0009-0003-9337-0675","https://orcid.org/0000-0003-1630-0668"]},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhijie Li","raw_affiliation_strings":["Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002831530","display_name":"Qianhua Li","orcid":"https://orcid.org/0000-0002-6031-0524","observed_orcids":["https://orcid.org/0000-0002-6031-0524"]},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianhua Li","raw_affiliation_strings":["Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100704423","display_name":"Yijia Liu","orcid":"https://orcid.org/0000-0001-5460-1539","observed_orcids":["https://orcid.org/0000-0001-5460-1539"]},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yijia Liu","raw_affiliation_strings":["Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394247","display_name":"Yao Chen","orcid":"https://orcid.org/0000-0002-3465-7380","observed_orcids":["https://orcid.org/0000-0002-3465-7380"]},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Chen","raw_affiliation_strings":["Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083414195","display_name":"Jinzheng Zhang","orcid":"https://orcid.org/0009-0000-4891-3827","observed_orcids":["https://orcid.org/0009-0000-4891-3827"]},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinzheng Zhang","raw_affiliation_strings":["Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100325490","display_name":"Haiyan Zhang","orcid":"https://orcid.org/0000-0002-3699-8672","observed_orcids":["https://orcid.org/0000-0002-3699-8672"]},"institutions":[{"id":"https://openalex.org/I14116566","display_name":"Wuhan Polytechnic University","ror":"https://ror.org/05w0e5j23","country_code":"CN","type":"education","lineage":["https://openalex.org/I14116566"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyan Zhang","raw_affiliation_strings":["School of Chemical and Environmental Engineering, Wuhan Polytechnic University, 68 Xuefu South Road, Wuhan 430023, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Environmental Engineering, Wuhan Polytechnic University, 68 Xuefu South Road, Wuhan 430023, China","institution_ids":["https://openalex.org/I14116566"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075222095","display_name":"Guoqiang Feng","orcid":"https://orcid.org/0000-0003-2548-7284","observed_orcids":["https://orcid.org/0000-0003-2548-7284"]},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guoqiang Feng","raw_affiliation_strings":["Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China"],"raw_orcid":"https://orcid.org/0000-0003-2548-7284","affiliations":[{"raw_affiliation_string":"Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China","institution_ids":["https://openalex.org/I40963666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075222095"],"corresponding_institution_ids":["https://openalex.org/I40963666"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.16,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.93842207,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"97","issue":"35","first_page":"19186","last_page":"19192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.7490000128746033,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":0.7490000128746033,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.17970000207424164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":1.0},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/near-infrared-fluorescence-imaging","display_name":"near-infrared fluorescence imaging","score":0.949999988079071},{"id":"https://openalex.org/keywords/in-situ-imaging","display_name":"in situ imaging","score":0.875},{"id":"https://openalex.org/keywords/liver-imaging","display_name":"liver imaging","score":0.5270000100135803},{"id":"https://openalex.org/keywords/wash-free-imaging","display_name":"wash-free imaging","score":0.6150000095367432},{"id":"https://openalex.org/keywords/intravenous-injection","display_name":"intravenous injection","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9596973657608032},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.6603384017944336},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.6023898720741272},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.5445986986160278},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5427837371826172},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.5046018362045288},{"id":"https://openalex.org/C127172972","wikidata":"https://www.wikidata.org/wiki/Q128709","display_name":"Viscosity","level":2,"score":0.48906856775283813},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.45763587951660156},{"id":"https://openalex.org/C158355884","wikidata":"https://www.wikidata.org/wiki/Q11388","display_name":"Infrared","level":2,"score":0.4490250051021576},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.41192498803138733},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27243757247924805},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.223038911819458},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1724570393562317},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.14763963222503662},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.10502257943153381},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10360053181648254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014783","descriptor_name":"Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.analchem.5c02797","doi":"https://doi.org/10.1021/acs.analchem.5c02797","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.analchem.5c02797","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:40849920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40849920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4046960909","display_name":null,"funder_award_id":"CCNU24JCPT021","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G4685888747","display_name":null,"funder_award_id":"22077044","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1950118853","https://openalex.org/W2000641576","https://openalex.org/W2080418767","https://openalex.org/W2098259366","https://openalex.org/W2301005860","https://openalex.org/W2338671470","https://openalex.org/W2612774616","https://openalex.org/W2759997926","https://openalex.org/W2786202610","https://openalex.org/W2791527635","https://openalex.org/W2889552839","https://openalex.org/W2904575550","https://openalex.org/W2984313764","https://openalex.org/W3037161671","https://openalex.org/W3091806589","https://openalex.org/W3112103684","https://openalex.org/W3119362551","https://openalex.org/W3154897461","https://openalex.org/W3164344780","https://openalex.org/W3180659190","https://openalex.org/W3209654392","https://openalex.org/W4206196136","https://openalex.org/W4211064536","https://openalex.org/W4283515998","https://openalex.org/W4288051424","https://openalex.org/W4292491336","https://openalex.org/W4294069094","https://openalex.org/W4295222612","https://openalex.org/W4304777617","https://openalex.org/W4306315468","https://openalex.org/W4311455437","https://openalex.org/W4312082468","https://openalex.org/W4315619045","https://openalex.org/W4318979798","https://openalex.org/W4361281698","https://openalex.org/W4361282519","https://openalex.org/W4367049898","https://openalex.org/W4367834868","https://openalex.org/W4386188323","https://openalex.org/W4386257822","https://openalex.org/W4386498686","https://openalex.org/W4387661756","https://openalex.org/W4389946632","https://openalex.org/W4391167033","https://openalex.org/W4393261668","https://openalex.org/W4396717293","https://openalex.org/W4396989210","https://openalex.org/W4399291885","https://openalex.org/W4404252769","https://openalex.org/W4406034344","https://openalex.org/W4406762263","https://openalex.org/W4407121423","https://openalex.org/W4408804499"],"related_works":["https://openalex.org/W3159715105","https://openalex.org/W3011771041","https://openalex.org/W2301005860","https://openalex.org/W3021506424","https://openalex.org/W3037161671","https://openalex.org/W4416294652","https://openalex.org/W7171096636","https://openalex.org/W3048969794","https://openalex.org/W3008175214","https://openalex.org/W4411679663"],"abstract_inverted_index":{"Extracellular":[0],"vesicles":[1],"(EVs)":[2],"have":[3],"significant":[4],"value":[5],"in":[6,40,45,57,80,124,151,158,175,205],"disease":[7,12],"diagnosis.":[8,207],"Non-alcoholic":[9],"fatty":[10],"liver":[11,134,160,177],"(NAFLD)":[13],"has":[14,94],"become":[15],"a":[16,68,95,142],"global":[17],"health":[18],"issue,":[19],"and":[20,62,99,127,131,171,194],"real-time":[21],"monitoring":[22],"of":[23,37,43,55,60,74,83,122,141,154,156,173,178],"NAFLD":[24,61,84,143,163,179,191,206],"is":[25,48,100,111],"crucial":[26],"to":[27,34,102],"prevent":[28],"its":[29,108],"further":[30],"deterioration.":[31],"However,":[32],"due":[33],"the":[35,53,58,79,86,105,133,139,159,162,169,176],"lack":[36],"effective":[38],"probes,":[39],"situ":[41,81,152],"detection":[42,82],"EVs":[44,56,90,123,157,174,185],"living":[46,125],"systems":[47],"still":[49],"challenging,":[50],"which":[51],"hinders":[52],"application":[54],"diagnosis":[59],"other":[63],"diseases.":[64],"Herein,":[65],"we":[66],"report":[67],"novel":[69],"fluorescent":[70],"probe,":[71],"ND-N,":[72,195],"capable":[73],"selectively":[75],"imaging":[76,121,153],"EVs,":[77,201],"achieving":[78],"for":[85,150,190,200],"first":[87],"time":[88],"using":[89],"as":[91,188,196],"biomarkers.":[92],"ND-N":[93,116,146],"good":[96],"water":[97],"solubility":[98],"sensitive":[101],"viscosity.":[103],"As":[104],"viscosity":[106,172],"increases,":[107],"near-infrared":[109],"fluorescence":[110,192],"significantly":[112,181],"enhanced.":[113],"More":[114],"importantly,":[115],"can":[117,128,186],"achieve":[118],"selective":[119],"wash-free":[120],"cells":[126],"also":[129],"target":[130],"image":[132],"through":[135],"intravenous":[136],"injection.":[137],"By":[138],"establishment":[140],"mouse":[144],"model,":[145],"was":[147],"successfully":[148],"applied":[149],"changes":[155],"during":[161],"process.":[164],"The":[165],"results":[166],"showed":[167],"that":[168,184],"number":[170],"mice":[180],"increased,":[182],"indicating":[183],"serve":[187],"biomarkers":[189],"imaging,":[193],"an":[197],"excellent":[198],"probe":[199],"shows":[202],"great":[203],"potential":[204]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2025-10-10T00:00:00"}