{"id":"https://openalex.org/W4413477299","doi":"https://doi.org/10.1016/j.jhsg.2025.100816","title":"Protecting the Nerve Coaptation: Connector-Assisted Nerve Repair in Complex Injuries","display_name":"Protecting the Nerve Coaptation: Connector-Assisted Nerve Repair in Complex Injuries","publication_year":2025,"publication_date":"2025-08-23","ids":{"openalex":"https://openalex.org/W4413477299","doi":"https://doi.org/10.1016/j.jhsg.2025.100816","pmid":"https://pubmed.ncbi.nlm.nih.gov/41356621","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12675810"},"language":"en","primary_location":{"id":"doi:10.1016/j.jhsg.2025.100816","doi":"https://doi.org/10.1016/j.jhsg.2025.100816","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jhsg.2025.100816","pdf_url":"https://www.jhsgo.org/article/S2589-5141(25)00136-7/pdf","source":{"id":"https://openalex.org/S4210203138","display_name":"Journal of Hand Surgery Global Online","issn_l":"2589-5141","issn":["2589-5141"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hand Surgery Global Online","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jhsgo.org/article/S2589-5141(25)00136-7/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076423617","display_name":"Nesreen Zoghoul Alsmadi","orcid":"https://orcid.org/0009-0007-9330-7659","observed_orcids":["https://orcid.org/0009-0007-9330-7659"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nesreen Zoghoul Alsmadi","raw_affiliation_strings":["Axogen Corporation, Research & Development, Tampa, FL"],"raw_orcid":"https://orcid.org/0009-0007-9330-7659","affiliations":[{"raw_affiliation_string":"Axogen Corporation, Research & Development, Tampa, FL","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028059482","display_name":"Curt A. Deister","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Curt Deister","raw_affiliation_strings":["Axogen Corporation, Research & Development, Tampa, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Axogen Corporation, Research & Development, Tampa, FL","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peter Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4210165757","display_name":"Martin Health System","ror":"https://ror.org/05dqqj338","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210165757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Evans","raw_affiliation_strings":["Cleveland Clinic Martin Health, Orthopaedic Surgery, Rehabilitation, and Sports Therapy, Stuart, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Martin Health, Orthopaedic Surgery, Rehabilitation, and Sports Therapy, Stuart, FL","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4210165757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087753900","display_name":"Tamer Ghanem","orcid":"https://orcid.org/0000-0002-5048-9241","observed_orcids":["https://orcid.org/0000-0002-5048-9241"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tamer Ghanem","raw_affiliation_strings":["Premier Head and Neck Surgery, Flint, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Premier Head and Neck Surgery, Flint, MI","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012772904","display_name":"Brandon S. Smetana","orcid":"https://orcid.org/0000-0001-5084-9051","observed_orcids":["https://orcid.org/0000-0001-5084-9051"]},"institutions":[{"id":"https://openalex.org/I4210149398","display_name":"Indiana Hand to Shoulder Center","ror":"https://ror.org/04681ap34","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210149398"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandon Smetana","raw_affiliation_strings":["Indiana Hand to Shoulder Center, Indianapolis, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana Hand to Shoulder Center, Indianapolis, IN","institution_ids":["https://openalex.org/I4210149398"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006097025","display_name":"Deana M. Mercer","orcid":"https://orcid.org/0000-0003-3641-7580","observed_orcids":["https://orcid.org/0000-0003-3641-7580"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deana Mercer","raw_affiliation_strings":["The University of New Mexico, UNM Orthopedics & Rehabilitation, Albuquerque, NM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of New Mexico, UNM Orthopedics & Rehabilitation, Albuquerque, NM","institution_ids":["https://openalex.org/I169521973"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5076423617"],"corresponding_institution_ids":[],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":0.6087,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.63577276,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"7","issue":"6","first_page":"100816","last_page":"100816"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12459","display_name":"Nerve Injury and Rehabilitation","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peripheral-nerve-regeneration","display_name":"peripheral nerve regeneration","score":0.8629999756813049},{"id":"https://openalex.org/keywords/sciatic-nerve-transection","display_name":"sciatic nerve transection","score":0.9129999876022339},{"id":"https://openalex.org/keywords/nerve-guidance-conduits","display_name":"nerve conduits","score":0.6299999952316284},{"id":"https://openalex.org/keywords/small-intestinal-submucosa","display_name":"small intestinal submucosa","score":0.9139999747276306},{"id":"https://openalex.org/keywords/nerve-coaptation","display_name":"nerve coaptation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.6349999904632568},{"id":"https://openalex.org/keywords/wallerian-degeneration","display_name":"Wallerian degeneration","score":0.9350000023841858},{"id":"https://openalex.org/keywords/nerve-adhesions","display_name":"nerve adhesions","score":0.6740000247955322},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5521961450576782},{"id":"https://openalex.org/C110925319","wikidata":"https://www.wikidata.org/wiki/Q12855","display_name":"Cable gland","level":2,"score":0.5015461444854736},{"id":"https://openalex.org/C93963793","wikidata":"https://www.wikidata.org/wiki/Q5383066","display_name":"Epineurial repair","level":3,"score":0.46435216069221497},{"id":"https://openalex.org/C3018498973","wikidata":"https://www.wikidata.org/wiki/Q9620","display_name":"Peripheral nerve","level":2,"score":0.45903280377388},{"id":"https://openalex.org/C2775991916","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Nerve injury","level":2,"score":0.43266844749450684},{"id":"https://openalex.org/C3020281888","wikidata":"https://www.wikidata.org/wiki/Q3335079","display_name":"Nerve repair","level":3,"score":0.4184216558933258},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.35247448086738586},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3281668424606323},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.23123490810394287},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.09539094567298889}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jhsg.2025.100816","doi":"https://doi.org/10.1016/j.jhsg.2025.100816","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jhsg.2025.100816","pdf_url":"https://www.jhsgo.org/article/S2589-5141(25)00136-7/pdf","source":{"id":"https://openalex.org/S4210203138","display_name":"Journal of Hand Surgery Global Online","issn_l":"2589-5141","issn":["2589-5141"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hand Surgery Global Online","raw_type":"journal-article"},{"id":"pmid:41356621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41356621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hand surgery global online","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:22c4de6d0f15403dad02319001856077","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/22c4de6d0f15403dad02319001856077","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Hand Surgery Global Online, Vol 7, Iss 6, Pp 100816- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jhsg.2025.100816","doi":"https://doi.org/10.1016/j.jhsg.2025.100816","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jhsg.2025.100816","pdf_url":"https://www.jhsgo.org/article/S2589-5141(25)00136-7/pdf","source":{"id":"https://openalex.org/S4210203138","display_name":"Journal of Hand Surgery Global Online","issn_l":"2589-5141","issn":["2589-5141"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hand Surgery Global Online","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413477299.pdf","grobid_xml":"https://content.openalex.org/works/W4413477299.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1528712270","https://openalex.org/W1784352764","https://openalex.org/W1963898252","https://openalex.org/W1970004705","https://openalex.org/W1986214182","https://openalex.org/W2011398019","https://openalex.org/W2023904895","https://openalex.org/W2030691946","https://openalex.org/W2031930530","https://openalex.org/W2033291041","https://openalex.org/W2067199636","https://openalex.org/W2076818528","https://openalex.org/W2329638560","https://openalex.org/W2768265635","https://openalex.org/W2796427505","https://openalex.org/W2897487375","https://openalex.org/W3049546280","https://openalex.org/W3180796225","https://openalex.org/W4296847471","https://openalex.org/W4386993777","https://openalex.org/W4400459952"],"related_works":["https://openalex.org/W7125425258","https://openalex.org/W4386248192","https://openalex.org/W7106338032","https://openalex.org/W4416918873","https://openalex.org/W4400459952","https://openalex.org/W1978117484","https://openalex.org/W2083872869","https://openalex.org/W1966645403","https://openalex.org/W3127179321","https://openalex.org/W2088421950"],"abstract_inverted_index":{"Purpose:":[0],"This":[1,261],"study":[2,264],"evaluated":[3,100],"differences":[4,112,157],"in":[5,19,33,145,150,186,236,251,262,268],"outcomes":[6],"of":[7,29,85,96,125,133,193,214,249],"peripheral":[8,269],"nerve":[9,28,98,105,221,232,254],"repair":[10,13,17,106,114],"using":[11,66],"connector-assisted":[12],"(CAR)":[14],"or":[15,64,171,278],"direct":[16],"(DR)":[18],"an":[20],"injured":[21],"soft":[22],"tissue":[23],"bed.":[24],"Methods:":[25],"The":[26,117,201],"sciatic":[27],"the":[30,50,80,97,104,134,146,151,187,215,240,246,253,256],"right":[31],"leg":[32],"20":[34],"male":[35],"Lewis":[36],"rats":[37],"was":[38,89,99,177,191,228,234],"exposed":[39],"and":[40,79,128,143,160,183,197,209],"transected.":[41],"We":[42],"simulated":[43],"a":[44,55,121],"traumatized":[45],"wound":[46],"bed":[47,53],"by":[48,181],"cauterizing":[49],"underlying":[51],"muscle":[52,83,93,166,224],"with":[54,61,162,275],"bipolar":[56],"coagulator.":[57],"Nerves":[58],"were":[59,76,109,138,155],"repaired":[60],"either":[62,276],"DR":[63,118,152,159,216],"CAR":[65,135,147,161,188,202,250,277],"porcine":[67],"small":[68],"intestine":[69],"submucosa":[70],"conduits.":[71],"At":[72],"6":[73],"weeks,":[74],"adhesions":[75],"assessed":[77],"semiquantitiatively,":[78],"gastrocnemius":[81,165],"wet":[82,167],"weight":[84,225],"each":[86],"hind":[87],"limb":[88],"recorded":[90],"to":[91,103,164,212],"evaluate":[92],"atrophy.":[94],"Histology":[95],"immediately":[101],"distal":[102],"site.":[107],"Data":[108],"analyzed":[110],"for":[111],"between":[113,158,226],"methods.":[115],"Results:":[116],"group":[119,148,203],"had":[120,205],"considerably":[122,139],"higher":[123],"area":[124,179],"foamy":[126,184],"phagocytes":[127,185],"CD68-stained":[129],"macrophages":[130,182],"than":[131,149],"that":[132,213,231],"group.":[136,153],"There":[137,154,176],"more":[140,206,219],"blood":[141,207],"vessels":[142,208],"axons":[144,210],"no":[156],"respect":[163],"weight,":[168],"extraneural":[169],"adhesions,":[170],"intraneural":[172],"collagen-to-cell":[173],"ratio.":[174],"Conclusions:":[175],"less":[178],"occupied":[180],"group,":[189,217],"which":[190],"indicative":[192],"lower":[194],"inflammatory":[195],"response":[196],"resolving":[198],"Wallerian":[199],"degeneration.":[200],"also":[204],"compared":[211],"indicating":[218,230],"robust":[220],"regeneration.":[222],"Gastrocnemius":[223],"groups":[227,238],"similar,":[229],"regeneration":[233,272],"incomplete":[235],"both":[237],"at":[239],"6-week":[241],"timepoint.":[242],"These":[243],"results":[244],"highlight":[245],"potential":[247],"benefits":[248],"protecting":[252],"during":[255,271],"healing":[257],"process.":[258],"Clinical":[259],"relevance:":[260],"vivo":[263],"evaluates":[265],"histological":[266],"changes":[267],"nerves":[270],"following":[273],"transection":[274],"DR.":[279]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}
