{"id":"https://openalex.org/W4413445484","doi":"https://doi.org/10.18060/29077","title":"Potential Role of Cigarette Smoke Exposure on Elastin Sensitization and Aortic Pathophysiology in a Mouse Model of Abdominal Aortic Aneurysm","display_name":"Potential Role of Cigarette Smoke Exposure on Elastin Sensitization and Aortic Pathophysiology in a Mouse Model of Abdominal Aortic Aneurysm","publication_year":2025,"publication_date":"2025-06-24","ids":{"openalex":"https://openalex.org/W4413445484","doi":"https://doi.org/10.18060/29077"},"language":"en","primary_location":{"id":"doi:10.18060/29077","doi":"https://doi.org/10.18060/29077","is_oa":true,"landing_page_url":"https://doi.org/10.18060/29077","pdf_url":"https://journals.indianapolis.iu.edu/index.php/IMPRS/article/download/29077/26017","source":{"id":"https://openalex.org/S4210207624","display_name":"Proceedings of IMPRS","issn_l":"2641-2470","issn":["2641-2470"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316553","host_organization_name":"Indiana University School of Medicine","host_organization_lineage":["https://openalex.org/P4310316553"],"host_organization_lineage_names":["Indiana University School of Medicine"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of IMPRS","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journals.indianapolis.iu.edu/index.php/IMPRS/article/download/29077/26017","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014073050","display_name":"Supriya Chittajallu","orcid":"https://orcid.org/0000-0001-6132-6571","observed_orcids":["https://orcid.org/0000-0001-6132-6571"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Supriya Chittajallu","raw_affiliation_strings":["Indiana University School of Medicine"],"raw_orcid":"https://orcid.org/0000-0001-6132-6571","affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016909107","display_name":"Theresa Doiron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa Doiron","raw_affiliation_strings":["Department of Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075682410","display_name":"Chang-Hyun Gil","orcid":"https://orcid.org/0000-0001-8323-5064","observed_orcids":["https://orcid.org/0000-0001-8323-5064"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chang-Hyun Gil","raw_affiliation_strings":["Department of Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038577586","display_name":"Jacob Saliba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Saliba","raw_affiliation_strings":["Department of Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092989569","display_name":"Jennifer Stashevsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Stashevsky","raw_affiliation_strings":["Department of Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Japdeep Kaur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Japdeep Kaur","raw_affiliation_strings":["Department of Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091996826","display_name":"Madelyn Fairbairn","orcid":"https://orcid.org/0009-0004-7884-8690","observed_orcids":["https://orcid.org/0009-0004-7884-8690"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madelyn Fairbairn","raw_affiliation_strings":["Department of Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119395094","display_name":"Cole Hennigan","orcid":"https://orcid.org/0009-0000-1549-1904","observed_orcids":["https://orcid.org/0009-0000-1549-1904"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cole Hennigan","raw_affiliation_strings":["Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106181325","display_name":"Steven J. Miller","orcid":"https://orcid.org/0000-0002-6842-2299","observed_orcids":["https://orcid.org/0000-0002-6842-2299"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven J. Miller","raw_affiliation_strings":["Department of Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080768760","display_name":"Mackenzie K. Madison","orcid":"https://orcid.org/0000-0002-1523-5473","observed_orcids":["https://orcid.org/0000-0002-1523-5473"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mackenzie Madison","raw_affiliation_strings":["Department of Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5115604391","display_name":"Michael P. Murphy","orcid":"https://orcid.org/0000-0003-3079-0659","observed_orcids":["https://orcid.org/0000-0003-3079-0659"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael P. Murphy","raw_affiliation_strings":["Department of Surgery, Indiana University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Indiana University School of Medicine","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4394709130"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25502281,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abdominal-aortic-aneurysm","display_name":"abdominal aortic aneurysm","score":0.984000027179718},{"id":"https://openalex.org/keywords/cigarette-smoke-exposure","display_name":"cigarette smoke exposure","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.7910000085830688},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9629999995231628},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.527999997138977},{"id":"https://openalex.org/keywords/aortitis","display_name":"aortitis","score":0.8370000123977661},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.8629060983657837},{"id":"https://openalex.org/C2779993416","wikidata":"https://www.wikidata.org/wiki/Q2256736","display_name":"Abdominal aortic aneurysm","level":3,"score":0.7938857078552246},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6820091605186462},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.6487398147583008},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.6313428282737732},{"id":"https://openalex.org/C2993351451","wikidata":"https://www.wikidata.org/wiki/Q2386268","display_name":"Cigarette smoke","level":2,"score":0.606050431728363},{"id":"https://openalex.org/C2777323849","wikidata":"https://www.wikidata.org/wiki/Q616003","display_name":"Aortic aneurysm","level":3,"score":0.5566954612731934},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4723288416862488},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4161986708641052},{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.324974924325943},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.259137898683548},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2589590549468994},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.21980637311935425},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09335854649543762},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18060/29077","doi":"https://doi.org/10.18060/29077","is_oa":true,"landing_page_url":"https://doi.org/10.18060/29077","pdf_url":"https://journals.indianapolis.iu.edu/index.php/IMPRS/article/download/29077/26017","source":{"id":"https://openalex.org/S4210207624","display_name":"Proceedings of IMPRS","issn_l":"2641-2470","issn":["2641-2470"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316553","host_organization_name":"Indiana University School of Medicine","host_organization_lineage":["https://openalex.org/P4310316553"],"host_organization_lineage_names":["Indiana University School of Medicine"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of IMPRS","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18060/29077","doi":"https://doi.org/10.18060/29077","is_oa":true,"landing_page_url":"https://doi.org/10.18060/29077","pdf_url":"https://journals.indianapolis.iu.edu/index.php/IMPRS/article/download/29077/26017","source":{"id":"https://openalex.org/S4210207624","display_name":"Proceedings of IMPRS","issn_l":"2641-2470","issn":["2641-2470"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310316553","host_organization_name":"Indiana University School of Medicine","host_organization_lineage":["https://openalex.org/P4310316553"],"host_organization_lineage_names":["Indiana University School of Medicine"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of IMPRS","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413445484.pdf","grobid_xml":"https://content.openalex.org/works/W4413445484.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4296394898","https://openalex.org/W2010606017","https://openalex.org/W3045335640","https://openalex.org/W3152361782","https://openalex.org/W2186960680","https://openalex.org/W4404851214","https://openalex.org/W2990317795","https://openalex.org/W4413400389","https://openalex.org/W2162313189","https://openalex.org/W4288076932"],"abstract_inverted_index":{"In":[0],"the":[1,76,82,103,120,170,182,191,244],"US,":[2],"200,000":[3],"people":[4],"annually":[5],"are":[6],"diagnosed":[7],"with":[8,112],"abdominal":[9,171],"aortic":[10,53,210],"aneurysm":[11,138],"(AAA)":[12],"and":[13,36,43,55,70,78,91,130,198,212],"it":[14],"accounts":[15],"for":[16,25,87,124,235],"over":[17],"15,000":[18],"deaths":[19],"per":[20],"year.":[21],"The":[22,177,220],"current":[23,178],"paradigm":[24],"AAA":[26,60,127,247],"progression":[27],"includes":[28],"cytotoxic":[29,66],"T":[30,67],"cell":[31],"activation":[32,153],"inducing":[33],"inflammatory":[34,167],"monocyte":[35],"macrophage":[37],"recruitment.":[38],"These":[39],"cells":[40,85],"secrete":[41],"collagen":[42],"elastin":[44,109,162,236],"degrading":[45],"enzymes,":[46],"leading":[47],"to":[48,108,136,208,218,228,241],"loss":[49],"of":[50,81,94,119,126,154,184,194,196,204,215,222,246],"structural":[51],"integrity,":[52],"dilatation,":[54],"eventual":[56],"rupture.":[57],"Studies":[58],"in":[59,65,75,110,128,140,158,169,174,188,248],"patients":[61,111],"show":[62],"an":[63,166,175,213],"increase":[64],"lymphocyte":[68],"number":[69,77],"activity,":[71],"a":[72,230],"significant":[73],"decrease":[74],"immuno-suppressive":[79],"activity":[80],"T-regulatory":[83],"(Treg)":[84],"responsible":[86],"governing":[88],"autoimmune":[89],"responses,":[90],"decreased":[92],"levels":[93,203],"circulating":[95],"IL-10.":[96],"Data":[97],"from":[98],"our":[99],"group":[100],"suggest":[101],"that":[102,146,164,237],"immune":[104],"system":[105],"is":[106,117,145],"sensitized":[107],"early":[113],"AAA.":[114],"Cigarette":[115],"smoking":[116],"one":[118],"strongest":[121],"risk":[122],"factors":[123],"development":[125],"humans":[129],"smoke":[131,148,186],"exposure":[132,187],"has":[133],"been":[134],"shown":[135],"exacerbate":[137],"formation":[139],"mice.":[141],"Our":[142],"working":[143],"hypothesis":[144],"cigarette":[147,185],"causes":[149],"lung":[150],"damage":[151],"via":[152],"tissue":[155],"proteases":[156],"which":[157],"turn":[159],"generates":[160],"antigenic":[161],"fragments":[163],"trigger":[165],"reaction":[168],"aorta":[172],"resulting":[173],"aneurysm.":[176],"study":[179,224],"will":[180,225],"evaluate":[181],"effect":[183],"mice":[189],"on":[190],"relative":[192],"ratios":[193],"populations":[195],"pro-inflammatory":[197],"anti-inflammatory":[199],"T-cell":[200],"subtypes,":[201],"serum":[202],"IL-10,":[205,209],"miRNA":[206],"related":[207],"pathology,":[211],"assessment":[214],"potential":[216],"self-sensitization":[217],"elastin.":[219],"results":[221],"this":[223],"be":[226,239],"used":[227,240],"develop":[229],"delayed":[231],"type":[232],"hypersensitivity":[233],"assay":[234],"could":[238],"easily":[242],"assess":[243],"presence":[245],"human":[249],"patients.":[250]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}