{"id":"https://openalex.org/W4413412404","doi":"https://doi.org/10.1186/s13054-025-05623-0","title":"Impact of syndromic molecular diagnostics on antimicrobial adequacy and time to therapy in critically ill patients with pneumonia: a systematic review and meta-analysis of randomized trials","display_name":"Impact of syndromic molecular diagnostics on antimicrobial adequacy and time to therapy in critically ill patients with pneumonia: a systematic review and meta-analysis of randomized trials","publication_year":2025,"publication_date":"2025-08-22","ids":{"openalex":"https://openalex.org/W4413412404","doi":"https://doi.org/10.1186/s13054-025-05623-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/40847360","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12374470"},"language":"en","primary_location":{"id":"doi:10.1186/s13054-025-05623-0","doi":"https://doi.org/10.1186/s13054-025-05623-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13054-025-05623-0","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-025-05623-0","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-025-05623-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016720629","display_name":"Yuri de Albuquerque Pessoa dos Santos","orcid":"https://orcid.org/0000-0003-4169-6078","observed_orcids":["https://orcid.org/0000-0003-4169-6078"]},"institutions":[{"id":"https://openalex.org/I4210149843","display_name":"Hospital S\u00edrio-Liban\u00eas","ror":"https://ror.org/03r5mk904","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210149843"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Yuri de Albuquerque Pessoa dos Santos","raw_affiliation_strings":["Intensive Care Unit, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jafet, 91, Bela Vista, S\u00e3o Paulo, 01308-050, SP, Brazil. yuri.asantos@hsl.org.br","Intensive Care Unit, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jafet, 91, Bela Vista, S\u00e3o Paulo, 01308-050, SP, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-4169-6078","affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jafet, 91, Bela Vista, S\u00e3o Paulo, 01308-050, SP, Brazil. yuri.asantos@hsl.org.br","institution_ids":["https://openalex.org/I4210149843"]},{"raw_affiliation_string":"Intensive Care Unit, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jafet, 91, Bela Vista, S\u00e3o Paulo, 01308-050, SP, Brazil","institution_ids":["https://openalex.org/I4210149843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011224434","display_name":"Bruno Martins Tomazini","orcid":"https://orcid.org/0000-0001-6763-6132","observed_orcids":["https://orcid.org/0000-0001-6763-6132"]},"institutions":[{"id":"https://openalex.org/I4210140911","display_name":"Hospital do Cora\u00e7\u00e3o","ror":"https://ror.org/04dzaw261","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210140911"]},{"id":"https://openalex.org/I4210149843","display_name":"Hospital S\u00edrio-Liban\u00eas","ror":"https://ror.org/03r5mk904","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210149843"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bruno Martins Tomazini","raw_affiliation_strings":["Intensive Care Unit, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jafet, 91, Bela Vista, S\u00e3o Paulo, 01308-050, SP, Brazil","Research Institute, Hospital do Cora\u00e7\u00e3o (HCor), Rua Desembargador Eliseu Guilherme, 147, Para\u00edso, S\u00e3o Paulo, 04004-030, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jafet, 91, Bela Vista, S\u00e3o Paulo, 01308-050, SP, Brazil","institution_ids":["https://openalex.org/I4210149843"]},{"raw_affiliation_string":"Research Institute, Hospital do Cora\u00e7\u00e3o (HCor), Rua Desembargador Eliseu Guilherme, 147, Para\u00edso, S\u00e3o Paulo, 04004-030, SP, Brazil","institution_ids":["https://openalex.org/I4210140911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080611235","display_name":"Maur\u00edcio Henrique Claro dos Santos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149843","display_name":"Hospital S\u00edrio-Liban\u00eas","ror":"https://ror.org/03r5mk904","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210149843"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Maur\u00edcio Henrique Claro dos Santos","raw_affiliation_strings":["Intensive Care Unit, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jafet, 91, Bela Vista, S\u00e3o Paulo, 01308-050, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jafet, 91, Bela Vista, S\u00e3o Paulo, 01308-050, SP, Brazil","institution_ids":["https://openalex.org/I4210149843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110218552","display_name":"Eduardo Lyra de Queiroz","orcid":"https://orcid.org/0009-0005-9653-8677","observed_orcids":["https://orcid.org/0009-0005-9653-8677"]},"institutions":[{"id":"https://openalex.org/I4210149843","display_name":"Hospital S\u00edrio-Liban\u00eas","ror":"https://ror.org/03r5mk904","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210149843"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eduardo Lyra de Queiroz","raw_affiliation_strings":["Intensive Care Unit, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jafet, 91, Bela Vista, S\u00e3o Paulo, 01308-050, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jafet, 91, Bela Vista, S\u00e3o Paulo, 01308-050, SP, Brazil","institution_ids":["https://openalex.org/I4210149843"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Laerte Pastore J\u00fanior","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149843","display_name":"Hospital S\u00edrio-Liban\u00eas","ror":"https://ror.org/03r5mk904","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210149843"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Laerte Pastore J\u00fanior","raw_affiliation_strings":["Intensive Care Unit, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jafet, 91, Bela Vista, S\u00e3o Paulo, 01308-050, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jafet, 91, Bela Vista, S\u00e3o Paulo, 01308-050, SP, Brazil","institution_ids":["https://openalex.org/I4210149843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080632335","display_name":"Eduardo Leite Vieira Costa","orcid":"https://orcid.org/0000-0002-6941-3626","observed_orcids":["https://orcid.org/0000-0002-6941-3626"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210149843","display_name":"Hospital S\u00edrio-Liban\u00eas","ror":"https://ror.org/03r5mk904","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210149843"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eduardo Leite Vieira Costa","raw_affiliation_strings":["Intensive Care Unit, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jafet, 91, Bela Vista, S\u00e3o Paulo, 01308-050, SP, Brazil","Respiratory Intensive Care Unit, School of Medicine, University of S\u00e3o Paulo, Av. Dr. Arnaldo, 455, Cerqueira C\u00e9sar, S\u00e3o Paulo, 01246-903, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jafet, 91, Bela Vista, S\u00e3o Paulo, 01308-050, SP, Brazil","institution_ids":["https://openalex.org/I4210149843"]},{"raw_affiliation_string":"Respiratory Intensive Care Unit, School of Medicine, University of S\u00e3o Paulo, Av. Dr. Arnaldo, 455, Cerqueira C\u00e9sar, S\u00e3o Paulo, 01246-903, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012950216","display_name":"Fernando Jos\u00e9 da Silva Ramos","orcid":"https://orcid.org/0000-0002-5277-4759","observed_orcids":["https://orcid.org/0000-0002-5277-4759"]},"institutions":[{"id":"https://openalex.org/I4210149843","display_name":"Hospital S\u00edrio-Liban\u00eas","ror":"https://ror.org/03r5mk904","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210149843"]},{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernando Jos\u00e9 da Silva Ramos","raw_affiliation_strings":["Intensive Care Department, Federal University of S\u00e3o Paulo (UNIFESP), Rua Napole\u00e3o de Barros, 715, Vila Clementino, S\u00e3o Paulo, 04024-002, SP, Brazil","Intensive Care Unit, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jafet, 91, Bela Vista, S\u00e3o Paulo, 01308-050, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Department, Federal University of S\u00e3o Paulo (UNIFESP), Rua Napole\u00e3o de Barros, 715, Vila Clementino, S\u00e3o Paulo, 04024-002, SP, Brazil","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Intensive Care Unit, Hospital S\u00edrio-Liban\u00eas, Rua Dona Adma Jafet, 91, Bela Vista, S\u00e3o Paulo, 01308-050, SP, Brazil","institution_ids":["https://openalex.org/I4210149843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5016720629","https://openalex.org/A5080611235"],"corresponding_institution_ids":["https://openalex.org/I4210149843"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":1.7733,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.85847589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"29","issue":"1","first_page":"379","last_page":"379"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.7261000275611877,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.7261000275611877,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.14810000360012054,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11681","display_name":"Nosocomial Infections in ICU","score":0.07490000128746033,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/pneumonia","display_name":"pneumonia","score":0.6790000200271606},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.9660000205039978},{"id":"https://openalex.org/keywords/in-hospital-mortality","display_name":"in-hospital mortality","score":0.9390000104904175},{"id":"https://openalex.org/keywords/antimicrobial-stewardship","display_name":"antimicrobial stewardship","score":0.9330000281333923},{"id":"https://openalex.org/keywords/ventilator-associated-pneumonia","display_name":"ventilator-associated pneumonia","score":0.7609999775886536},{"id":"https://openalex.org/keywords/hospital-acquired-pneumonia","display_name":"nosocomial pneumonia","score":0.9440000057220459},{"id":"https://openalex.org/keywords/community-acquired-pneumonia","display_name":"community-acquired pneumonia","score":0.9599999785423279},{"id":"https://openalex.org/keywords/pathogen-identification","display_name":"pathogen identification","score":0.7429999709129333},{"id":"https://openalex.org/keywords/antimicrobial-resistance-genes","display_name":"antimicrobial resistance genes","score":0.7450000047683716},{"id":"https://openalex.org/keywords/cultural-comparison","display_name":"cultural comparison","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9335113763809204},{"id":"https://openalex.org/C2991859549","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critically ill","level":2,"score":0.7944953441619873},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6912020444869995},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.6177711486816406},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5685566663742065},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5144174695014954},{"id":"https://openalex.org/C2777184939","wikidata":"https://www.wikidata.org/wiki/Q7920253","display_name":"Ventilator-associated pneumonia","level":3,"score":0.46473240852355957},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23702654242515564},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.17025604844093323}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D017052","descriptor_name":"Hospital Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025202","descriptor_name":"Molecular Diagnostic Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D025202","descriptor_name":"Molecular Diagnostic Techniques","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D061665","descriptor_name":"Time-to-Treatment","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D061665","descriptor_name":"Time-to-Treatment","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s13054-025-05623-0","doi":"https://doi.org/10.1186/s13054-025-05623-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13054-025-05623-0","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-025-05623-0","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-6951342/v1","doi":"https://doi.org/10.21203/rs.3.rs-6951342/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-6951342/v1","pdf_url":"https://www.researchsquare.com/article/rs-6951342/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:11183518","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12374470","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40847360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40847360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care (London, England)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12374470","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12374470/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crit Care","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13054-025-05623-0","doi":"https://doi.org/10.1186/s13054-025-05623-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13054-025-05623-0","pdf_url":"https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-025-05623-0","source":{"id":"https://openalex.org/S191417626","display_name":"Critical Care","issn_l":"1364-8535","issn":["1364-8535","1466-609X","1574-4280","1875-7081"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413412404.pdf","grobid_xml":"https://content.openalex.org/works/W4413412404.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1534181333","https://openalex.org/W2159643438","https://openalex.org/W2170892587","https://openalex.org/W2473016454","https://openalex.org/W2548230123","https://openalex.org/W2752537900","https://openalex.org/W2763952741","https://openalex.org/W2892094751","https://openalex.org/W2912621545","https://openalex.org/W2964889934","https://openalex.org/W2970684805","https://openalex.org/W3012226879","https://openalex.org/W3013272133","https://openalex.org/W3021323231","https://openalex.org/W3036628551","https://openalex.org/W3191480438","https://openalex.org/W3193329895","https://openalex.org/W3202926783","https://openalex.org/W4200359907","https://openalex.org/W4281384654","https://openalex.org/W4281738356","https://openalex.org/W4295021540","https://openalex.org/W4386645946","https://openalex.org/W4390971741","https://openalex.org/W4403453253","https://openalex.org/W4405894071","https://openalex.org/W4407633410","https://openalex.org/W4412458317"],"related_works":["https://openalex.org/W4205663749","https://openalex.org/W4297262254","https://openalex.org/W4295021540","https://openalex.org/W7147116028","https://openalex.org/W4311745519","https://openalex.org/W3042848979","https://openalex.org/W4392505213","https://openalex.org/W4388635560","https://openalex.org/W3206675981","https://openalex.org/W4413340623"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pneumonia":[1],"is":[2],"a":[3,67,178,198,261],"leading":[4],"cause":[5],"of":[6,36,55,72,123,181,245,252],"ICU":[7,88],"admission":[8],"and":[9,13,24,38,70,104,127,197,249],"mortality,":[10,157],"requiring":[11],"prompt":[12],"adequate":[14,182],"antimicrobial":[15,125,184,247,266],"therapy":[16,126,185,248],"to":[17,109,129,202,215],"improve":[18],"outcomes.":[19],"Conventional":[20],"cultures":[21],"are":[22],"slow":[23],"often":[25],"insensitive,":[26],"delaying":[27],"targeted":[28],"treatment.":[29,254],"Syndromic":[30,149,225],"PCR":[31,150,173,226],"panels":[32],"offer":[33],"rapid":[34],"identification":[35],"pathogens":[37],"resistance":[39],"genes":[40],"directly":[41],"from":[42,107],"respiratory":[43],"samples,":[44],"potentially":[45],"improving":[46],"early":[47],"antibiotic":[48,131,204],"optimization.":[49],"However,":[50,172],"the":[51,158],"true":[52],"clinical":[53],"benefit":[54],"these":[56],"diagnostics":[57,80,227],"in":[58,85,101,200,233,264],"critically":[59,234],"ill":[60,235],"patients":[61,89,236],"remains":[62],"uncertain.":[63],"METHODS:":[64],"We":[65,140],"conducted":[66],"systematic":[68],"review":[69],"meta-analysis":[71],"randomized":[73,143],"controlled":[74,144],"trials":[75,145],"(RCTs)":[76],"comparing":[77],"PCR-based":[78],"molecular":[79],"with":[81,90,177,237,242],"standard":[82],"culture":[83],"techniques":[84],"predominantly":[86],"adult":[87],"severe":[91],"community-acquired,":[92],"hospital-acquired,":[93],"or":[94],"ventilator-associated":[95],"pneumonia.":[96],"Literature":[97],"searches":[98],"were":[99,134,240],"performed":[100],"PubMed,":[102],"Embase,":[103],"Cochrane":[105],"CENTRAL":[106],"inception":[108],"July":[110],"16,":[111],"2025.":[112],"The":[113],"primary":[114,159],"outcome":[115,160],"was":[116,175],"in-hospital":[117,156,231],"mortality.":[118],"Secondary":[119],"outcomes":[120],"included":[121,141],"adequacy":[122,244],"initial":[124,183,246],"time":[128,201],"effective":[130,203,253],"administration.":[132],"Data":[133],"synthesized":[135],"using":[136],"random-effects":[137],"models.":[138],"RESULTS:":[139],"five":[142],"comprising":[146],"2,466":[147],"patients.":[148],"testing":[151,174],"did":[152,228],"not":[153,229],"significantly":[154],"reduce":[155,230],"(RR":[161,186],"1.04;":[162],"95%":[163,188,211],"CI:":[164,189,212],"0.90\u20131.21;":[165],"p":[166,191,218],"=":[167,170,192,195,219,222],"0.57;":[168],"I\u00b2":[169,194,221],"0%).":[171],"associated":[176,241],"higher":[179],"rate":[180],"1.82;":[187],"1.10\u20133.00;":[190],"0.02;":[193],"97%)":[196],"reduction":[199],"administration":[205],"(mean":[206],"difference":[207],"\u2212":[208,213,216],"27.98":[209],"h;":[210],"46.07":[214],"9.89;":[217],"0.002;":[220],"94%).":[223],"CONCLUSIONS:":[224],"mortality":[232],"pneumonia":[238],"but":[239],"improved":[243],"faster":[250],"initiation":[251],"These":[255],"findings":[256],"support":[257],"their":[258],"role":[259],"as":[260],"complementary":[262],"tool":[263],"ICU-based":[265],"stewardship.":[267],"TRIAL":[268],"REGISTRATION":[269],":":[270],"PROSPERO":[271],"CRD420251006301.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-10T00:00:00"}
