{"id":"https://openalex.org/W4413406809","doi":"https://doi.org/10.1016/j.ymthe.2025.08.023","title":"Exploiting viral infection/vaccination to focus high-affinity T cell populations into tumors using oncolytic viro-immunotherapy","display_name":"Exploiting viral infection/vaccination to focus high-affinity T cell populations into tumors using oncolytic viro-immunotherapy","publication_year":2025,"publication_date":"2025-08-21","ids":{"openalex":"https://openalex.org/W4413406809","doi":"https://doi.org/10.1016/j.ymthe.2025.08.023","pmid":"https://pubmed.ncbi.nlm.nih.gov/40842156","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12502006"},"language":"en","primary_location":{"id":"doi:10.1016/j.ymthe.2025.08.023","doi":"https://doi.org/10.1016/j.ymthe.2025.08.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2025.08.023","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.ymthe.2025.08.023","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Alexa Veliz Rios","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexa Veliz Rios","raw_affiliation_strings":["Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091998227","display_name":"Muriel M. Metko","orcid":"https://orcid.org/0000-0003-1364-1352","observed_orcids":["https://orcid.org/0000-0003-1364-1352"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muriel Metko","raw_affiliation_strings":["Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087329982","display_name":"Jason M. Tonne","orcid":"https://orcid.org/0000-0002-7159-0058","observed_orcids":["https://orcid.org/0000-0002-7159-0058"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Tonne","raw_affiliation_strings":["Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048427923","display_name":"Jill Thompson","orcid":"https://orcid.org/0000-0001-5005-7257","observed_orcids":["https://orcid.org/0000-0001-5005-7257"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill Thompson","raw_affiliation_strings":["Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Benjamin Kendall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Kendall","raw_affiliation_strings":["Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100673393","display_name":"Alex Chen","orcid":"https://orcid.org/0009-0000-2259-1030","observed_orcids":["https://orcid.org/0009-0000-2259-1030"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Chen","raw_affiliation_strings":["Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074307320","display_name":"Haley E. Mudrick","orcid":"https://orcid.org/0000-0002-2716-5513","observed_orcids":["https://orcid.org/0000-0002-2716-5513"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haley Mudrick","raw_affiliation_strings":["Molecular Pharmacology and Experimental Therapeutics Program, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pharmacology and Experimental Therapeutics Program, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050735501","display_name":"David Masopust","orcid":"https://orcid.org/0000-0002-9440-3884","observed_orcids":["https://orcid.org/0000-0002-9440-3884"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Masopust","raw_affiliation_strings":["Department of Microbiology & Immunology, University of Minnesota Medical School, 2101 6th Street SE, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology & Immunology, University of Minnesota Medical School, 2101 6th Street SE, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084722080","display_name":"Sheeba Irshad","orcid":"https://orcid.org/0000-0002-4419-7162","observed_orcids":["https://orcid.org/0000-0002-4419-7162"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]},{"id":"https://openalex.org/I2799938689","display_name":"Breast Cancer Now","ror":"https://ror.org/02qa92s63","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2799938689"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sheeba Irshad","raw_affiliation_strings":["Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, King's College London, London, UK; Breast Cancer Now Research Unit, King's College London, London, UK; Guy's and St Thomas' NHS Foundation Trust, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, King's College London, London, UK; Breast Cancer Now Research Unit, King's College London, London, UK; Guy's and St Thomas' NHS Foundation Trust, London, UK","institution_ids":["https://openalex.org/I183935753","https://openalex.org/I200166805","https://openalex.org/I2799938689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111680461","display_name":"Mary Barry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Barry","raw_affiliation_strings":["Department of Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA","Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA; Department of Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA; Department of Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael A. Barry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Barry","raw_affiliation_strings":["Department of Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA","Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA; Department of Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA; Department of Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109094916","display_name":"Rosa Mar\u00eda D\u00edaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosa Maria Diaz","raw_affiliation_strings":["Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070554485","display_name":"Richard G. Vile","orcid":"https://orcid.org/0000-0003-2192-9372","observed_orcids":["https://orcid.org/0000-0003-2192-9372"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Richard Vile","raw_affiliation_strings":["Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, School of Immunology and Microbial Sciences, King's College London, London, UK. Electronic address: vile.richard@mayo.edu"],"raw_orcid":"https://orcid.org/0000-0003-2192-9372","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA; Comprehensive Cancer Centre, School of Cancer & Pharmaceutical Sciences, School of Immunology and Microbial Sciences, King's College London, London, UK. Electronic address: vile.richard@mayo.edu","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5070554485"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I183935753"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":4.6689,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.95841414,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"33","issue":"11","first_page":"5489","last_page":"5504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.7411999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.7411999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.1712999939918518,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.059300001710653305,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2-spike-protein","display_name":"SARS-CoV-2 spike protein","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.7250000238418579},{"id":"https://openalex.org/keywords/epitope-spreading","display_name":"epitope spreading","score":0.9779999852180481},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.6650000214576721},{"id":"https://openalex.org/keywords/booster-vaccination","display_name":"booster vaccination","score":0.3930000066757202},{"id":"https://openalex.org/keywords/tumor-infiltrating-t-cells","display_name":"tumor-infiltrating T cells","score":0.6449999809265137},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.9467648863792419},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.646604061126709},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5841594934463501},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49374088644981384},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.4923466444015503},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.45535966753959656},{"id":"https://openalex.org/C2994541485","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral infection","level":3,"score":0.44769608974456787},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4468374252319336},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.436884343624115},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3022259473800659},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2349691390991211},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.14924296736717224},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10242775082588196},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050130","descriptor_name":"Oncolytic Virotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D050504","descriptor_name":"Oncolytic Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050504","descriptor_name":"Oncolytic Viruses","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ymthe.2025.08.023","doi":"https://doi.org/10.1016/j.ymthe.2025.08.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2025.08.023","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},{"id":"pmid:40842156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40842156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy : the journal of the American Society of Gene Therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12502006","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12502006/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.ymthe.2025.08.023","doi":"https://doi.org/10.1016/j.ymthe.2025.08.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2025.08.023","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000219797","display_name":null,"funder_award_id":"CA210964-06A1 P3","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000866359","display_name":"Mayo Clinic Hepatobiliary SPORE","funder_award_id":"P50CA210964","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000880941","display_name":"Characterizing the role of CSDE1 as a critical co-factor for VSV replication.","funder_award_id":"R01AI170535","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000886531","display_name":"Re-purposing Oncolytic Virotherapy to Re-invigorate CAR T Cell Therapy for Solid Tumors.","funder_award_id":"R01CA269384","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000910943","display_name":"PhD Training Program in Virology and Gene Therapy","funder_award_id":"T32AI132165","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306143","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320309464","display_name":"Mayo Foundation for Medical Education and Research","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320309501","display_name":"Richard M. Schulze Family Foundation","ror":"https://ror.org/01jm2xz84"},{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"},{"id":"https://openalex.org/F4320320285","display_name":"King's College London","ror":"https://ror.org/0220mzb33"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337586","display_name":"Hyundai Hope On Wheels","ror":"https://ror.org/01f6q3121"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W1574961005","https://openalex.org/W1979742563","https://openalex.org/W1988405871","https://openalex.org/W1990602451","https://openalex.org/W2004030192","https://openalex.org/W2023594496","https://openalex.org/W2029055826","https://openalex.org/W2032496897","https://openalex.org/W2036869628","https://openalex.org/W2040874987","https://openalex.org/W2040921647","https://openalex.org/W2041912362","https://openalex.org/W2085687864","https://openalex.org/W2089258482","https://openalex.org/W2094495139","https://openalex.org/W2109298302","https://openalex.org/W2115955652","https://openalex.org/W2128054910","https://openalex.org/W2128892990","https://openalex.org/W2132921981","https://openalex.org/W2150709141","https://openalex.org/W2167034585","https://openalex.org/W2566527653","https://openalex.org/W2586164131","https://openalex.org/W2787292387","https://openalex.org/W2802513889","https://openalex.org/W2903899730","https://openalex.org/W2904966405","https://openalex.org/W2914458679","https://openalex.org/W2960523686","https://openalex.org/W2972184766","https://openalex.org/W3012093716","https://openalex.org/W3023392702","https://openalex.org/W3024276903","https://openalex.org/W3037545893","https://openalex.org/W3046566329","https://openalex.org/W3084653951","https://openalex.org/W3088777520","https://openalex.org/W3128091173","https://openalex.org/W3128807007","https://openalex.org/W3161045232","https://openalex.org/W3165514001","https://openalex.org/W3183543809","https://openalex.org/W3200289956","https://openalex.org/W3203575974","https://openalex.org/W4200413360","https://openalex.org/W4206317936","https://openalex.org/W4210792795","https://openalex.org/W4211238487","https://openalex.org/W4214751921","https://openalex.org/W4224050212","https://openalex.org/W4304014325","https://openalex.org/W4319339279","https://openalex.org/W4365143025","https://openalex.org/W4375859102","https://openalex.org/W4384664721","https://openalex.org/W4385956055","https://openalex.org/W4386127543","https://openalex.org/W4387256229","https://openalex.org/W4388035659","https://openalex.org/W4389609244","https://openalex.org/W4391231786","https://openalex.org/W4392966971","https://openalex.org/W4394752969","https://openalex.org/W4399391097","https://openalex.org/W4400086974","https://openalex.org/W4403542774"],"related_works":["https://openalex.org/W7160513492","https://openalex.org/W4394752969","https://openalex.org/W7118073784","https://openalex.org/W4281252680","https://openalex.org/W4387773378","https://openalex.org/W4417129324","https://openalex.org/W4406717819","https://openalex.org/W6999107318","https://openalex.org/W3172915929","https://openalex.org/W4410460325"],"abstract_inverted_index":{"Immune":[0],"tolerance":[1],"restricts":[2],"the":[3],"number":[4],"of":[5,26,85],"T":[6,29,42,70,103,117,167,177],"cells":[7,43,131,146,168],"with":[8,121,152],"significant":[9],"affinity":[10,165],"for":[11],"self-tumor-associated":[12],"antigens":[13,64,87],"(TAAs),":[14],"thereby":[15],"limiting":[16],"successful":[17],"cancer":[18],"immunotherapy":[19],"through":[20],"an":[21],"inability":[22],"to":[23,54,65,93,100,137,156],"generate":[24],"populations":[25,179],"high-affinity":[27,38],"anti-tumor":[28,158,166],"cells.":[30],"In":[31],"contrast,":[32],"viral":[33,45,86],"infection/vaccination":[34],"primes":[35],"and":[36,40,97,160],"expands":[37],"effector":[39],"memory":[41,59],"against":[44,62,124],"antigens.":[46],"We":[47,126],"show":[48,128],"here":[49],"that":[50,88,129],"it":[51],"is":[52],"possible":[53],"exploit":[55],"population-wide":[56],"preexisting,":[57],"anti-viral":[58],"recall":[60],"responses":[61],"SARS-CoV-2":[63,109,133],"focus":[66],"a":[67,187],"high-affinity,":[68],"immunodominant":[69],"cell":[71,118,178],"response":[72],"into":[73],"tumors":[74,138,181],"by":[75],"oncolytic":[76],"virus":[77],"(OV)-mediated":[78],"or":[79,111,175],"chimeric":[80],"antigen":[81],"receptor":[82],"(CAR)-mediated":[83],"delivery":[84,185],"are":[89,169],"not":[90,170],"themselves":[91],"related":[92],"TAAs.":[94,125],"Heterologous":[95],"prime":[96],"OV/boost":[98],"led":[99],"CD8":[101],"+":[102],"cell-dependent":[104],"tumor":[105],"cures":[106],"using":[107,182],"either":[108],"Mem":[110],"Spike":[112],"(S)":[113],"proteins":[114],"as":[115],"vaccinating/tumor-focusing":[116],"targets,":[119],"associated":[120],"epitope":[122],"spreading":[123],"also":[127],"CAR-T":[130,145],"carry":[132],"antigen-expressing":[134],"vectors":[135],"systemically":[136],"even":[139],"in":[140,150],"pre-immune":[141],"mice.":[142],"Finally,":[143],"S-specific":[144],"could":[147],"be":[148],"boosted":[149],"vivo":[151],"S":[153],"protein":[154],"vaccines":[155],"enhance":[157],"activity":[159],"persistence.":[161],"Thus,":[162],"where":[163],"high":[164],"available,":[171],"boosting":[172],"preexisting":[173],"infection-":[174],"vaccination-induced":[176],"within":[180],"OV-mediated":[183],"immunogen":[184],"provides":[186],"therapeutically":[188],"valuable":[189],"alternative.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-10T00:00:00"}