{"id":"https://openalex.org/W4413386232","doi":"https://doi.org/10.1016/j.vph.2025.107531","title":"Balancing act: Drp1 inhibition and mitochondrial homeostasis in cardiovascular diseases","display_name":"Balancing act: Drp1 inhibition and mitochondrial homeostasis in cardiovascular diseases","publication_year":2025,"publication_date":"2025-08-21","ids":{"openalex":"https://openalex.org/W4413386232","doi":"https://doi.org/10.1016/j.vph.2025.107531","pmid":"https://pubmed.ncbi.nlm.nih.gov/40848867"},"language":"en","primary_location":{"id":"doi:10.1016/j.vph.2025.107531","doi":"https://doi.org/10.1016/j.vph.2025.107531","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.vph.2025.107531","pdf_url":null,"source":{"id":"https://openalex.org/S189127420","display_name":"Vascular Pharmacology","issn_l":"1537-1891","issn":["1537-1891","1879-3649"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044913738","display_name":"Nandini Dubey","orcid":"https://orcid.org/0000-0003-3758-177X","observed_orcids":["https://orcid.org/0000-0003-3758-177X"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nandini Dubey","raw_affiliation_strings":["Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090328367","display_name":"Ahsas Goyal","orcid":"https://orcid.org/0000-0003-0110-9238","observed_orcids":["https://orcid.org/0000-0003-0110-9238"]},"institutions":[{"id":"https://openalex.org/I82571370","display_name":"GLA University","ror":"https://ror.org/05fnxgv12","country_code":"IN","type":"education","lineage":["https://openalex.org/I82571370"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ahsas Goyal","raw_affiliation_strings":["Institute of Pharmaceutical Research, GLA University, Mathura, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmaceutical Research, GLA University, Mathura, India","institution_ids":["https://openalex.org/I82571370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068634677","display_name":"Neeraj Parakh","orcid":"https://orcid.org/0000-0002-3463-4613","observed_orcids":["https://orcid.org/0000-0002-3463-4613"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Neeraj Parakh","raw_affiliation_strings":["Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075023352","display_name":"Rajiv Narang","orcid":"https://orcid.org/0000-0001-9634-5887","observed_orcids":["https://orcid.org/0000-0001-9634-5887"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajiv Narang","raw_affiliation_strings":["Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112261719","display_name":"Sudhir Kumar Arava","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sudhir Kumar Arava","raw_affiliation_strings":["Department of Pathology, All India Institute of Medical Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054045967","display_name":"Arvind Kumar","orcid":"https://orcid.org/0000-0002-8044-9195","observed_orcids":["https://orcid.org/0000-0002-8044-9195","https://orcid.org/0000-0002-3808-7338"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arvind Kumar","raw_affiliation_strings":["Department of Medicine, All India Institute of Medical Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071769101","display_name":"Mayank Yadav","orcid":"https://orcid.org/0000-0001-7310-3025","observed_orcids":["https://orcid.org/0000-0001-7310-3025"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mayank Yadav","raw_affiliation_strings":["Department of Cardiothoracic and Vascular Surgery, All India Institute of Medical Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic and Vascular Surgery, All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090410869","display_name":"Harlokesh Narayan Yadav","orcid":"https://orcid.org/0000-0002-5798-1431","observed_orcids":["https://orcid.org/0000-0002-5798-1431"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Harlokesh Narayan Yadav","raw_affiliation_strings":["Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India. Electronic address: hnyadav@aiims.gov.in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India. Electronic address: hnyadav@aiims.gov.in","institution_ids":["https://openalex.org/I63739035"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090410869"],"corresponding_institution_ids":["https://openalex.org/I63739035"],"apc_list":{"value":3670,"currency":"USD","value_usd":3670},"apc_paid":null,"fwci":0.7079,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.57722299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"160","issue":null,"first_page":"107531","last_page":"107531"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drp1","display_name":"Drp1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.6909999847412109},{"id":"https://openalex.org/keywords/mitochondrial-fission","display_name":"mitochondrial fission","score":0.7950000166893005},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9129999876022339},{"id":"https://openalex.org/keywords/mitochondrial-homeostasis","display_name":"mitochondrial homeostasis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8899999856948853},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.878000020980835},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.972000002861023},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9549999833106995},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.968999981880188},{"id":"https://openalex.org/keywords/cardiomyocyte-metabolism","display_name":"cardiomyocyte metabolism","score":0.9599999785423279}],"concepts":[{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.6341254711151123},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33288219571113586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3216102123260498},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29414331912994385}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D034281","descriptor_name":"Dynamins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063154","descriptor_name":"Mitochondrial Dynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D063306","descriptor_name":"Mitophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.vph.2025.107531","doi":"https://doi.org/10.1016/j.vph.2025.107531","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.vph.2025.107531","pdf_url":null,"source":{"id":"https://openalex.org/S189127420","display_name":"Vascular Pharmacology","issn_l":"1537-1891","issn":["1537-1891","1879-3649"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:40848867","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40848867","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vascular pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":114,"referenced_works":["https://openalex.org/W47294309","https://openalex.org/W1908289777","https://openalex.org/W1943357032","https://openalex.org/W2005853038","https://openalex.org/W2014901923","https://openalex.org/W2016716143","https://openalex.org/W2027802092","https://openalex.org/W2053071718","https://openalex.org/W2065018825","https://openalex.org/W2074905627","https://openalex.org/W2076598575","https://openalex.org/W2091010103","https://openalex.org/W2152111896","https://openalex.org/W2171317360","https://openalex.org/W2171815113","https://openalex.org/W2181017482","https://openalex.org/W2200046622","https://openalex.org/W2219072828","https://openalex.org/W2269336718","https://openalex.org/W2531934030","https://openalex.org/W2602846991","https://openalex.org/W2605987852","https://openalex.org/W2625460619","https://openalex.org/W2626025616","https://openalex.org/W2743589927","https://openalex.org/W2747200758","https://openalex.org/W2761109619","https://openalex.org/W2765529672","https://openalex.org/W2772895375","https://openalex.org/W2774778286","https://openalex.org/W2777259639","https://openalex.org/W2783217206","https://openalex.org/W2790370995","https://openalex.org/W2808409755","https://openalex.org/W2809632591","https://openalex.org/W2885986730","https://openalex.org/W2891102818","https://openalex.org/W2902901041","https://openalex.org/W2903477139","https://openalex.org/W2913312881","https://openalex.org/W2919290468","https://openalex.org/W2936317983","https://openalex.org/W2939573775","https://openalex.org/W2955794303","https://openalex.org/W2966710204","https://openalex.org/W2968879719","https://openalex.org/W2973434555","https://openalex.org/W2989281995","https://openalex.org/W2989652555","https://openalex.org/W2990822273","https://openalex.org/W2998741974","https://openalex.org/W3003208414","https://openalex.org/W3007723686","https://openalex.org/W3008000594","https://openalex.org/W3011060500","https://openalex.org/W3013020157","https://openalex.org/W3014360908","https://openalex.org/W3016617952","https://openalex.org/W3017609100","https://openalex.org/W3021609058","https://openalex.org/W3031322180","https://openalex.org/W3033395249","https://openalex.org/W3034236107","https://openalex.org/W3044391256","https://openalex.org/W3044945334","https://openalex.org/W3048675746","https://openalex.org/W3051181437","https://openalex.org/W3084673165","https://openalex.org/W3096540881","https://openalex.org/W3112010515","https://openalex.org/W3114558611","https://openalex.org/W3126707751","https://openalex.org/W3129236024","https://openalex.org/W3134276703","https://openalex.org/W3155824129","https://openalex.org/W3184332270","https://openalex.org/W3193598686","https://openalex.org/W4200059826","https://openalex.org/W4200579298","https://openalex.org/W4210849642","https://openalex.org/W4211143906","https://openalex.org/W4221031285","https://openalex.org/W4280506014","https://openalex.org/W4282034135","https://openalex.org/W4290738881","https://openalex.org/W4297540010","https://openalex.org/W4298327014","https://openalex.org/W4300961870","https://openalex.org/W4311316949","https://openalex.org/W4311579271","https://openalex.org/W4315619251","https://openalex.org/W4322155298","https://openalex.org/W4378514962","https://openalex.org/W4378977606","https://openalex.org/W4380301769","https://openalex.org/W4382631630","https://openalex.org/W4385296771","https://openalex.org/W4386448978","https://openalex.org/W4386697913","https://openalex.org/W4387007475","https://openalex.org/W4387600710","https://openalex.org/W4387807509","https://openalex.org/W4389055924","https://openalex.org/W4390701093","https://openalex.org/W4391692890","https://openalex.org/W4397024245","https://openalex.org/W4406845258","https://openalex.org/W4408083911","https://openalex.org/W6687541773","https://openalex.org/W6746479164","https://openalex.org/W6765856181","https://openalex.org/W6809647020","https://openalex.org/W6857189962","https://openalex.org/W6860759335"],"related_works":["https://openalex.org/W3084673165","https://openalex.org/W4397024245","https://openalex.org/W7155098867","https://openalex.org/W4383562262","https://openalex.org/W7163033382","https://openalex.org/W2601960749","https://openalex.org/W4241756414","https://openalex.org/W4390115364","https://openalex.org/W3016617952","https://openalex.org/W4414086396"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-10-10T00:00:00"}