{"id":"https://openalex.org/W4413379727","doi":"https://doi.org/10.3390/jcm14165781","title":"Association Between the Presence of Missed Canals, Detected Using CBCT, and Post-Treatment Apical Periodontitis in Root-Filled Teeth: A Systematic Review and Meta-Analysis","display_name":"Association Between the Presence of Missed Canals, Detected Using CBCT, and Post-Treatment Apical Periodontitis in Root-Filled Teeth: A Systematic Review and Meta-Analysis","publication_year":2025,"publication_date":"2025-08-15","ids":{"openalex":"https://openalex.org/W4413379727","doi":"https://doi.org/10.3390/jcm14165781","pmid":"https://pubmed.ncbi.nlm.nih.gov/40869607","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12386526"},"language":"en","primary_location":{"id":"doi:10.3390/jcm14165781","doi":"https://doi.org/10.3390/jcm14165781","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm14165781","pdf_url":"https://www.mdpi.com/2077-0383/14/16/5781/pdf?version=1755261412","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2077-0383/14/16/5781/pdf?version=1755261412","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065131266","display_name":"Mar\u00eda Le\u00f3n\u2010L\u00f3pez","orcid":"https://orcid.org/0009-0008-2151-4197","observed_orcids":["https://orcid.org/0009-0008-2151-4197"]},"institutions":[{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Le\u00f3n-L\u00f3pez","raw_affiliation_strings":["Endodontic Section, Department of Stomatology, School of Dentistry, University of Sevilla, C/Avicena s/n, 41009 Sevilla, Spain"],"raw_orcid":"https://orcid.org/0009-0008-2151-4197","affiliations":[{"raw_affiliation_string":"Endodontic Section, Department of Stomatology, School of Dentistry, University of Sevilla, C/Avicena s/n, 41009 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024405765","display_name":"Paloma Montero\u2010Miralles","orcid":"https://orcid.org/0000-0003-3288-267X","observed_orcids":["https://orcid.org/0000-0003-3288-267X"]},"institutions":[{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Paloma Montero-Miralles","raw_affiliation_strings":["Endodontic Section, Department of Stomatology, School of Dentistry, University of Sevilla, C/Avicena s/n, 41009 Sevilla, Spain"],"raw_orcid":"https://orcid.org/0000-0003-3288-267X","affiliations":[{"raw_affiliation_string":"Endodontic Section, Department of Stomatology, School of Dentistry, University of Sevilla, C/Avicena s/n, 41009 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049118261","display_name":"Daniel Cabanillas\u2010Balsera","orcid":"https://orcid.org/0000-0002-9978-6458","observed_orcids":["https://orcid.org/0000-0002-9978-6458"]},"institutions":[{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Daniel Cabanillas-Balsera","raw_affiliation_strings":["Endodontic Section, Department of Stomatology, School of Dentistry, University of Sevilla, C/Avicena s/n, 41009 Sevilla, Spain"],"raw_orcid":"https://orcid.org/0000-0002-9978-6458","affiliations":[{"raw_affiliation_string":"Endodontic Section, Department of Stomatology, School of Dentistry, University of Sevilla, C/Avicena s/n, 41009 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061512457","display_name":"Juan J. Sa\u00faco\u2010M\u00e1rquez","orcid":"https://orcid.org/0000-0002-8563-5675","observed_orcids":["https://orcid.org/0000-0002-8563-5675"]},"institutions":[{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan J. Sa\u00faco-M\u00e1rquez","raw_affiliation_strings":["Endodontic Section, Department of Stomatology, School of Dentistry, University of Sevilla, C/Avicena s/n, 41009 Sevilla, Spain"],"raw_orcid":"https://orcid.org/0000-0002-8563-5675","affiliations":[{"raw_affiliation_string":"Endodontic Section, Department of Stomatology, School of Dentistry, University of Sevilla, C/Avicena s/n, 41009 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081410010","display_name":"J\u00e9nifer Mart\u00edn-Gonz\u00e1lez","orcid":"https://orcid.org/0000-0001-9282-133X","observed_orcids":["https://orcid.org/0000-0001-9282-133X"]},"institutions":[{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jenifer Mart\u00edn-Gonz\u00e1lez","raw_affiliation_strings":["Endodontic Section, Department of Stomatology, School of Dentistry, University of Sevilla, C/Avicena s/n, 41009 Sevilla, Spain"],"raw_orcid":"https://orcid.org/0000-0001-9282-133X","affiliations":[{"raw_affiliation_string":"Endodontic Section, Department of Stomatology, School of Dentistry, University of Sevilla, C/Avicena s/n, 41009 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065782988","display_name":"Juan Jos\u00e9 Segura-Egea","orcid":"https://orcid.org/0000-0002-0427-9059","observed_orcids":["https://orcid.org/0000-0002-0427-9059","https://orcid.org/0000-0003-0565-3791","https://orcid.org/0000-0002-9011-3695"]},"institutions":[{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Juan J. Segura-Egea","raw_affiliation_strings":["Endodontic Section, Department of Stomatology, School of Dentistry, University of Sevilla, C/Avicena s/n, 41009 Sevilla, Spain"],"raw_orcid":"https://orcid.org/0000-0002-0427-9059","affiliations":[{"raw_affiliation_string":"Endodontic Section, Department of Stomatology, School of Dentistry, University of Sevilla, C/Avicena s/n, 41009 Sevilla, Spain","institution_ids":["https://openalex.org/I79238269"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024405765","https://openalex.org/A5065782988"],"corresponding_institution_ids":["https://openalex.org/I79238269"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":2.5623,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.89445629,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"14","issue":"16","first_page":"5781","last_page":"5781"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11363","display_name":"Dental Radiography and Imaging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10113","display_name":"Dental materials and restorations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/missed-canals","display_name":"missed canals","score":0.8889999985694885},{"id":"https://openalex.org/keywords/endodontic-treatment-failure","display_name":"endodontic treatment failure","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cone-beam-computed-tomography","display_name":"cone-beam computed tomography","score":0.9729999899864197},{"id":"https://openalex.org/keywords/endodontically-treated-teeth","display_name":"endodontically treated teeth","score":0.8859999775886536},{"id":"https://openalex.org/keywords/canal-detection","display_name":"canal detection","score":0.6880000233650208},{"id":"https://openalex.org/keywords/maxillary-molars","display_name":"maxillary molars","score":0.9359999895095825},{"id":"https://openalex.org/keywords/first-molar","display_name":"first molar","score":0.7459999918937683},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9810730218887329},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.6992862820625305},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.6955587863922119},{"id":"https://openalex.org/C29694066","wikidata":"https://www.wikidata.org/wiki/Q118301","display_name":"Orthodontics","level":1,"score":0.4589482545852661}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/jcm14165781","doi":"https://doi.org/10.3390/jcm14165781","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm14165781","pdf_url":"https://www.mdpi.com/2077-0383/14/16/5781/pdf?version=1755261412","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11194259","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12386526","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40869607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40869607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12386526","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12386526/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/jcm14165781","doi":"https://doi.org/10.3390/jcm14165781","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm14165781","pdf_url":"https://www.mdpi.com/2077-0383/14/16/5781/pdf?version=1755261412","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413379727.pdf","grobid_xml":"https://content.openalex.org/works/W4413379727.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W65082647","https://openalex.org/W1568390176","https://openalex.org/W1971980198","https://openalex.org/W1981680557","https://openalex.org/W1987319584","https://openalex.org/W1992569019","https://openalex.org/W1999815310","https://openalex.org/W2005384222","https://openalex.org/W2040847925","https://openalex.org/W2049826253","https://openalex.org/W2052226761","https://openalex.org/W2064675571","https://openalex.org/W2087372187","https://openalex.org/W2091911972","https://openalex.org/W2092201809","https://openalex.org/W2109139482","https://openalex.org/W2111302020","https://openalex.org/W2112378712","https://openalex.org/W2122300957","https://openalex.org/W2126445978","https://openalex.org/W2126930838","https://openalex.org/W2127723704","https://openalex.org/W2132981607","https://openalex.org/W2133878887","https://openalex.org/W2140106125","https://openalex.org/W2146227876","https://openalex.org/W2146985104","https://openalex.org/W2152229436","https://openalex.org/W2161374186","https://openalex.org/W2268279278","https://openalex.org/W2286729153","https://openalex.org/W2315415481","https://openalex.org/W2327674407","https://openalex.org/W2616456691","https://openalex.org/W2770064767","https://openalex.org/W2889702549","https://openalex.org/W2895076114","https://openalex.org/W2984839463","https://openalex.org/W3017132575","https://openalex.org/W3042322024","https://openalex.org/W3081575058","https://openalex.org/W3114942846","https://openalex.org/W3121842516","https://openalex.org/W3144543375","https://openalex.org/W3176176992","https://openalex.org/W4220699137","https://openalex.org/W4247938048","https://openalex.org/W4281784324","https://openalex.org/W4283588435","https://openalex.org/W4289745483","https://openalex.org/W4293224345","https://openalex.org/W4321347323","https://openalex.org/W4378650074","https://openalex.org/W4385608596","https://openalex.org/W4386099092","https://openalex.org/W4386574506","https://openalex.org/W4387157202","https://openalex.org/W4392691469","https://openalex.org/W4400060863","https://openalex.org/W6683918711"],"related_works":["https://openalex.org/W7217570000","https://openalex.org/W3176176992","https://openalex.org/W2895076114","https://openalex.org/W4386574506","https://openalex.org/W2268279278","https://openalex.org/W4407008679","https://openalex.org/W4400060863","https://openalex.org/W4293462438","https://openalex.org/W7171418960","https://openalex.org/W7161634778"],"abstract_inverted_index":{"Background.":[0],"Post-treatment":[1],"apical":[2],"periodontitis":[3],"(PAP)":[4],"is":[5],"a":[6,105,160,176],"frequent":[7],"consequence":[8],"of":[9,85,114,142,213],"root":[10],"canal":[11,222],"treatment":[12,236],"(RCT)":[13],"failure,":[14],"often":[15],"caused":[16],"by":[17],"untreated":[18],"missed":[19,36,55,92,150,164,188,207],"canals":[20,56,93,151,165,208],"in":[21,52,87,136,147,215],"root-filled":[22],"teeth":[23],"(RFT).":[24],"While":[25],"cone-beam":[26],"computed":[27],"tomography":[28],"(CBCT)":[29],"has":[30],"been":[31],"used":[32],"to":[33,202,234],"find":[34],"these":[35],"canals,":[37],"the":[38,48,83,119,137,211,218],"results":[39],"are":[40],"controversial.":[41],"This":[42],"systematic":[43],"review":[44],"and":[45,54,68,90,122,166,196,224,231],"meta-analysis":[46,110,158],"investigates":[47],"association":[49,162],"between":[50,163],"PAP":[51,86,143,167,214],"RFT":[53,88,148],"detected":[57,94],"via":[58,95],"CBCT.":[59,96],"Methods.":[60],"Two":[61],"independent":[62],"reviewers":[63],"searched":[64],"PubMed,":[65],"Scopus,":[66],"Dialnet,":[67],"SciELO":[69],"for":[70,220],"relevant":[71],"articles":[72],"published":[73],"up":[74],"until":[75],"17":[76],"February":[77],"2025.":[78],"The":[79,97,139,157],"main":[80],"outcome":[81],"was":[82,102,116,124,144,191,199],"prevalence":[84,141],"with":[89,149],"without":[91,155],"overall":[98],"odds":[99],"ratio":[100],"(OR)":[101],"calculated":[103],"using":[104,118,126],"binary":[106],"random":[107],"effects":[108],"model":[109],"(OpenMeta":[111],"Analyst).":[112],"Risk":[113],"bias":[115],"assessed":[117],"Newcastle\u2013Ottawa":[120],"Scale,":[121],"certainty":[123,198],"evaluated":[125],"GRADE.":[127],"Results.":[128],"Eight":[129],"cross-sectional":[130],"studies":[131],"(9983":[132],"RFT)":[133],"were":[134],"included":[135],"review.":[138],"pooled":[140],"significantly":[145,209],"higher":[146],"(85.1%)":[152],"than":[153],"those":[154],"(56.3%).":[156],"showed":[159],"strong":[161],"(OR":[168],"=":[169,173,194],"7.17,":[170],"95%":[171],"CI":[172],"4.55\u201311.29),":[174],"indicating":[175],"sevenfold":[177],"increased":[178],"likelihood.":[179],"Maxillary":[180],"molars,":[181,184],"especially":[182],"first":[183],"most":[185],"commonly":[186],"had":[187],"canals.":[189],"Heterogeneity":[190],"high":[192],"(I2":[193],"86%),":[195],"evidence":[197],"low,":[200],"due":[201],"methodological":[203],"limitations.":[204],"Conclusions.":[205],"Untreated":[206],"increase":[210],"likelihood":[212],"RFT,":[216],"highlighting":[217],"need":[219],"thorough":[221],"detection":[223],"treatment.":[225],"Clinicians":[226],"should":[227],"prioritize":[228],"anatomical":[229],"knowledge":[230],"advanced":[232],"imaging":[233],"minimize":[235],"failure.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":15}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-10T00:00:00"}