{"id":"https://openalex.org/W4413344345","doi":"https://doi.org/10.1101/2025.08.14.25333712","title":"Enrichment of patients with concomitant LATE on the Alzheimer\u2019s disease continuum using hippocampal volume","display_name":"Enrichment of patients with concomitant LATE on the Alzheimer\u2019s disease continuum using hippocampal volume","publication_year":2025,"publication_date":"2025-08-16","ids":{"openalex":"https://openalex.org/W4413344345","doi":"https://doi.org/10.1101/2025.08.14.25333712"},"language":"en","primary_location":{"id":"doi:10.1101/2025.08.14.25333712","doi":"https://doi.org/10.1101/2025.08.14.25333712","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.08.14.25333712","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/08/16/2025.08.14.25333712.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2025/08/16/2025.08.14.25333712.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050960562","display_name":"Nidhi S. Mundada","orcid":"https://orcid.org/0000-0003-3108-6751","observed_orcids":["https://orcid.org/0000-0003-3108-6751"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nidhi S. Mundada","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0003-3108-6751","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072319088","display_name":"Xueying Lyu","orcid":"https://orcid.org/0009-0008-0958-132X","observed_orcids":["https://orcid.org/0009-0008-0958-132X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xueying Lyu","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074432620","display_name":"Christopher Brown","orcid":"https://orcid.org/0000-0003-2057-3976","observed_orcids":["https://orcid.org/0000-0003-2057-3976"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher A. Brown","raw_affiliation_strings":["Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0003-2057-3976","affiliations":[{"raw_affiliation_string":"Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025541827","display_name":"Niyousha Sadeghpour","orcid":"https://orcid.org/0000-0001-8665-0335","observed_orcids":["https://orcid.org/0000-0001-8665-0335"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niyousha Sadeghpour","raw_affiliation_strings":["Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109782563","display_name":"Emily McGrew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily McGrew","raw_affiliation_strings":["Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011438418","display_name":"Long Xie","orcid":"https://orcid.org/0000-0002-7184-7028","observed_orcids":["https://orcid.org/0000-0002-7184-7028"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Long Xie","raw_affiliation_strings":["Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015338409","display_name":"Philip A. Cook","orcid":"https://orcid.org/0000-0002-1985-8475","observed_orcids":["https://orcid.org/0000-0002-1985-8475"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip A Cook","raw_affiliation_strings":["Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005451810","display_name":"James C. Gee","orcid":"https://orcid.org/0000-0002-2258-0187","observed_orcids":["https://orcid.org/0000-0002-2258-0187"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Gee","raw_affiliation_strings":["Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059550368","display_name":"Paul A. Yushkevich","orcid":"https://orcid.org/0000-0001-8543-4016","observed_orcids":["https://orcid.org/0000-0001-8543-4016"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul A. Yushkevich","raw_affiliation_strings":["Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0001-8543-4016","affiliations":[{"raw_affiliation_string":"Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047157013","display_name":"Sandhitsu R. Das","orcid":"https://orcid.org/0000-0003-0530-2887","observed_orcids":["https://orcid.org/0000-0003-0530-2887"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandhitsu R. Das","raw_affiliation_strings":["Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041387594","display_name":"David A. Wolk","orcid":"https://orcid.org/0000-0002-3554-3481","observed_orcids":["https://orcid.org/0000-0002-3554-3481"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David A. Wolk","raw_affiliation_strings":["Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":null,"display_name":"the Alzheimer\u2019s Disease Neuroimaging Initiative","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"the Alzheimer\u2019s Disease Neuroimaging Initiative","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041387594"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9240000247955322},{"id":"https://openalex.org/keywords/limbic-predominant-age-related-tdp-43-encephalopathy","display_name":"limbic-predominant age-related TDP-43 encephalopathy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hippocampal-volume","display_name":"hippocampal volume","score":0.9129999876022339},{"id":"https://openalex.org/keywords/clinical-trial-enrichment","display_name":"clinical trial enrichment","score":0.699999988079071},{"id":"https://openalex.org/keywords/amygdala-atrophy","display_name":"amygdala atrophy","score":0.8659999966621399},{"id":"https://openalex.org/keywords/medial-temporal-lobe-atrophy","display_name":"medial temporal lobe atrophy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/amyloid-pet","display_name":"amyloid PET","score":0.7609999775886536},{"id":"https://openalex.org/keywords/tau-pet","display_name":"tau PET","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.9340000152587891}],"concepts":[{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.7606639862060547},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6384091377258301},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.5237388610839844},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5179063677787781},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4498039782047272},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.437540203332901},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4286383390426636},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3571356534957886},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34284695982933044},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.25539442896842957},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.1102266013622284}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2025.08.14.25333712","doi":"https://doi.org/10.1101/2025.08.14.25333712","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.08.14.25333712","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/08/16/2025.08.14.25333712.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2025.08.14.25333712","doi":"https://doi.org/10.1101/2025.08.14.25333712","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.08.14.25333712","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/08/16/2025.08.14.25333712.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413344345.pdf","grobid_xml":"https://content.openalex.org/works/W4413344345.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1970928383","https://openalex.org/W1983147688","https://openalex.org/W2046557060","https://openalex.org/W2066470779","https://openalex.org/W2134836371","https://openalex.org/W2138728868","https://openalex.org/W2154520196","https://openalex.org/W2167840686","https://openalex.org/W2260379945","https://openalex.org/W2574030000","https://openalex.org/W2789797660","https://openalex.org/W2793407859","https://openalex.org/W2805367282","https://openalex.org/W2806938337","https://openalex.org/W2807398417","https://openalex.org/W2907061143","https://openalex.org/W2942818360","https://openalex.org/W2943828894","https://openalex.org/W2962851149","https://openalex.org/W2975273504","https://openalex.org/W2977883299","https://openalex.org/W2998707549","https://openalex.org/W2999737624","https://openalex.org/W3018098624","https://openalex.org/W3047479945","https://openalex.org/W3135857182","https://openalex.org/W3184219868","https://openalex.org/W3203947995","https://openalex.org/W4281713370","https://openalex.org/W4282596629","https://openalex.org/W4285988197","https://openalex.org/W4291825280","https://openalex.org/W4311237378","https://openalex.org/W4323545808","https://openalex.org/W4324018451","https://openalex.org/W4378569287","https://openalex.org/W4406201340","https://openalex.org/W4406371084","https://openalex.org/W4406842956","https://openalex.org/W4411272828","https://openalex.org/W4412035881","https://openalex.org/W4412761984"],"related_works":["https://openalex.org/W4417304618","https://openalex.org/W7119475348","https://openalex.org/W4406223208","https://openalex.org/W4415525069","https://openalex.org/W7118814926","https://openalex.org/W7164167276","https://openalex.org/W7128163468","https://openalex.org/W7116691884","https://openalex.org/W7117252346","https://openalex.org/W4390192087"],"abstract_inverted_index":{"ABSTRACT":[0],"Introduction":[1],"Clinical":[2],"overlap":[3],"between":[4],"Alzheimer\u2019s":[5],"disease":[6],"(AD)":[7],"and":[8,47,51,63,65,81,88,92,98,113,119,126,129,150],"limbic-predominant":[9],"age-related":[10],"TDP-43":[11],"encephalopathy":[12],"(LATE),":[13],"combined":[14],"with":[15,35,61],"absence":[16],"of":[17,24],"validated":[18,102],"in":[19,103],"vivo":[20],"biomarkers,":[21],"complicates":[22],"identification":[23],"mixed":[25,147],"AD/LATE":[26,148],"pathology.":[27],"We":[28,55],"labeled":[29],"individuals":[30],"along":[31],"the":[32,40],"AD":[33],"continuum":[34],"suspected":[36,71],"concomitant":[37],"LATE":[38],"using":[39],"lower":[41],"quartile":[42,142],"hippocampal":[43,112],"volume":[44],"(HV)":[45],"cut-off":[46,143],"examined":[48],"associated":[49],"atrophy":[50,90,115,125],"cognitive":[52,93,136],"profiles.":[53],"Methods":[54],"studied":[56],"cognitively":[57],"impaired":[58],"ADNI":[59],"participants":[60],"T1-MRI":[62],"amyloid-":[64],"tau-PET.":[66],"Participants":[67],"were":[68,95],"classified":[69],"into":[70],"(s)":[72],"AD+sLATE-,":[73],"AD-sLATE+,":[74],"or":[75],"AD+sLATE+":[76,108,120,132],"based":[77],"on":[78],"amyloid":[79],"status":[80],"HV":[82,141],"quartiles.":[83],"Medial":[84],"temporal":[85],"lobe":[86],"(MTL)":[87],"whole-brain":[89],"patterns":[91],"profiles":[94],"compared":[96],"cross-sectionally":[97],"longitudinally.":[99],"Classification":[100],"was":[101],"an":[104],"autopsy":[105],"cohort.":[106],"Results":[107],"showed":[109,121],"greater":[110,122],"anterior":[111,123],"amygdala":[114],"than":[116],"AD+sLATE-.":[117],"AD-sLATE+":[118],"MTL":[124],"worse":[127],"memory":[128],"language":[130],"performance.":[131],"also":[133],"exhibited":[134],"faster":[135],"decline.":[137],"Discussion":[138],"A":[139],"simple":[140],"may":[144],"help":[145],"identify":[146],"pathology":[149],"support":[151],"clinical":[152],"trial":[153],"enrichment.":[154]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
